Research Topics
Genomes and GenesSpecies | Jonine L BernsteinSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancerJ L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1043, New York, NY 10029 6574, USA
Br J Cancer 89:1513-6. 2003....
Factors influencing mortality among young women with second primary breast carcinomaJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Cancer 95:2051-8. 2002....- Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancerJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Hum Mutat 21:542-50. 2003..Finally, we report novel mutations in the ATM gene identified both in patients with ataxia-telangiectasia and in patients with unilateral or bilateral breast cancer... - The descriptive epidemiology of second primary breast cancerJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Epidemiology 14:552-8. 2003..This study describes the epidemiology of second primary breast cancer among a population-based cohort of 305,533 U.S. women diagnosed with breast cancer between 1973 and 1998... - Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE studyJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
Breast Cancer Res 6:R199-214. 2004..Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated... - Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology studyJonine L Bernstein
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd St Fl 3, New York, NY 10065, USA
J Natl Cancer Inst 102:475-83. 2010..We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women... - Variation of breast cancer risk among BRCA1/2 carriersColin B Begg
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
JAMA 299:194-201. 2008..The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers... 
Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's Environmental Cancer and Radiation Epidemiology StudyAnne S Reiner
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Clin Oncol 31:433-9. 2013..To fully characterize the risk of contralateral breast cancer (CBC) in patients with breast cancer with a family history who test negative for BRCA1 and BRCA2 mutations...- Reproductive status at first diagnosis influences risk of radiation-induced second primary contralateral breast cancer in the WECARE studyJennifer D Brooks
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Int J Radiat Oncol Biol Phys 84:917-24. 2012..Our study examined whether reproductive and hormonal factors before, at the time of, or after radiation treatment for a first primary breast cancer modify the risk of radiation-induced second primary breast cancer... - Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE studyJennifer D Brooks
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Hum Mutat 33:158-64. 2012..This suggests that carriers of this haplotype may be susceptible to the DNA-damaging effects of radiation therapy associated with radiation-induced breast cancer... - Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapyAlice Y Ho
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 69:677-84. 2007..The ATM gene product is a central component of cell cycle regulation and genomic surveillance. We hypothesized that DNA sequence alterations in ATM predict for adverse effects after external beam radiotherapy for early breast cancer... - Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modelingMarinela Capanu
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Genet Epidemiol 35:389-97. 2011..Hierarchical modeling is a strategy that has promise for interpreting the evidence from future association studies that involve sequencing of known or suspected cancer genes... - Body mass index and risk of second primary breast cancer: the WECARE StudyJennifer D Brooks
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd Street, 3rd Floor, New York, NY, USA
Breast Cancer Res Treat 131:571-80. 2012..Our finding of an over five-fold higher risk of CBC in a small subgroup of obese postmenopausal women with an ER-negative first primary breast cancer is based on limited numbers and requires confirmation in a larger study... - The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family RegistryJonine L Bernstein
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 3rd Floor, 307 East 63rd Street, New York, New York 10021, USA
Cancer Epidemiol Biomarkers Prev 15:348-52. 2006..63; 95% CI, 1.25-10.52). These data supporting the biological relevance of CHEK2 in breast carcinogenesis suggest that further studies examining the joint roles of CHEK2*1100delC carrier status and radiation exposure may be warranted... - Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002Jonine L Bernstein
Department of Community Medicine, Mount Sinai School of Medicine, New York, USA
Breast Cancer Res 4:249-52. 2002..In the present meeting report, the aims of each project are described... - ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancerJamie A Cesaretti
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Radiat Oncol Biol Phys 61:196-202. 2005.... - Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2Deborah Goldfrank
Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Epidemiol Biomarkers Prev 15:2311-3. 2006..08; P = 0.03). These findings indicate that screening mammography is unlikely to be associated with a large increase in breast cancer risk in this population... - Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissueJonine L Bernstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Cancer Epidemiol Biomarkers Prev 11:809-14. 2002..We concluded that DNA derived from PET that archived for less than 18 years can be used successfully for detecting BRCA1 gene mutations if quality control is strictly maintained... - Background parenchymal enhancement at breast MR imaging and breast cancer riskValencia King
Department of Radiology, Memorial Sloan Kettering Cancer Center, Evelyn H Lauder Breast Center, 300 E 66th St, Room 715, New York, NY 10065, USA
Radiology 260:50-60. 2011..To examine the relationships between breast cancer and both amount of fibroglandular tissue (FGT) and level of background parenchymal enhancement (BPE) at magnetic resonance (MR) imaging... - Identification of mammaglobin as a novel serum marker for breast cancerJonine L Bernstein
Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
Clin Cancer Res 11:6528-35. 2005..The present studies were undertaken to develop the mammaglobin protein as a serum biomarker for detection of breast cancer... - Variants in the ATM gene associated with a reduced risk of contralateral breast cancerPatrick Concannon
Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
Cancer Res 68:6486-91. 2008..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53... - Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE StudyL Mellemkjaer
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
Br J Cancer 98:728-33. 2008..However, the sampling variability was such that modest increases in risk could not be excluded. Nonetheless, because this is a rare mutation, it is unlikely to explain a major fraction of CBC in the population... - Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study GroupJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
J Clin Oncol 26:1411-8. 2008..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years... - Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology StudyLisbeth Bertelsen
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
J Natl Cancer Inst 100:32-40. 2008..However, less is known about how long the risk is reduced and the impact of factors such as age and menopausal status... - GLIOGENE an International Consortium to Understand Familial GliomaBeatrice Malmer
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, P O Box 301439, Houston, TX 77230 1439, USA
Cancer Epidemiol Biomarkers Prev 16:1730-4. 2007..Here, we review the rationale for studying familial glioma and our proposed strategy for the GLIOGENE study... - Reproductive history and risk of second primary breast cancer: the WECARE studyJoan A Largent
Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697 7555, USA
Cancer Epidemiol Biomarkers Prev 16:906-11. 2007..Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results... - On the proposed association of the ATM variants 5557G>A and IVS38-8T>C and bilateral breast cancerBryan Langholz
Int J Cancer 119:724-5. 2006 - A road map for efficient and reliable human genome epidemiologyJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
Nat Genet 38:3-5. 2006..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...