Audrey Bernstein

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Concentration-dependent effects of transforming growth factor β1 on corneal wound healing
    Lingyan Wang
    Mount Sinai School of Medicine, Dept of Ophthalmology, New York, NY 10029, USA
    Mol Vis 17:2835-46. 2011
  2. pmc Degradation of internalized αvβ5 integrin is controlled by uPAR bound uPA: effect on β1 integrin activity and α-SMA stress fiber assembly
    Lingyan Wang
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e33915. 2012
  3. ncbi request reprint Urokinase anchors uPAR to the actin cytoskeleton
    Audrey M Bernstein
    Department of Ophthalmology, Monut Sinai School of Medicine, New York, New York 10029 6574, USA
    Invest Ophthalmol Vis Sci 45:2967-77. 2004
  4. pmc Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation
    Audrey M Bernstein
    Departments of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Biol Cell 18:2716-27. 2007
  5. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
  6. ncbi request reprint FAK-dependent regulation of myofibroblast differentiation
    Roseanne S Greenberg
    Department of Ophthalmology, Box 1183, Mount Sinai School of Medicine, 1 Gustave Levy Pl, New York, New York 10029 6574, USA
    FASEB J 20:1006-8. 2006
  7. pmc TGF-β-stimulated CTGF production enhanced by collagen and associated with biogenesis of a novel 31-kDa CTGF form in human corneal fibroblasts
    Edward G Tall
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Invest Ophthalmol Vis Sci 51:5002-11. 2010
  8. ncbi request reprint ZO-1: lamellipodial localization in a corneal fibroblast wound model
    Lavinia Taliana
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Invest Ophthalmol Vis Sci 46:96-103. 2005
  9. ncbi request reprint Differential conversion of plasminogen to angiostatin by human corneal cell populations
    Debra J Warejcka
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Vis 11:859-68. 2005

Research Grants

  1. Corneal Repair: uPA and extracellular matrix
    Audrey M Bernstein; Fiscal Year: 2010

Collaborators

Detail Information

Publications9

  1. pmc Concentration-dependent effects of transforming growth factor β1 on corneal wound healing
    Lingyan Wang
    Mount Sinai School of Medicine, Dept of Ophthalmology, New York, NY 10029, USA
    Mol Vis 17:2835-46. 2011
    ..Although high concentrations of TGFβ1 leads to scarring, we asked whether low concentrations of TGFβ1 could promote wound healing without generating a large fibrotic response...
  2. pmc Degradation of internalized αvβ5 integrin is controlled by uPAR bound uPA: effect on β1 integrin activity and α-SMA stress fiber assembly
    Lingyan Wang
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e33915. 2012
    ..Our data support a novel mechanism by which downregulation of uPA/uPAR results in increased integrin αvβ5 cell-surface protein levels that regulate the activity of β1 integrins, promoting characteristics of the persistent Mf...
  3. ncbi request reprint Urokinase anchors uPAR to the actin cytoskeleton
    Audrey M Bernstein
    Department of Ophthalmology, Monut Sinai School of Medicine, New York, New York 10029 6574, USA
    Invest Ophthalmol Vis Sci 45:2967-77. 2004
    ..To investigate the expression and localization of urokinase plasminogen activator (uPA) and its receptor (uPAR) and their interaction with the actin cytoskeleton in human corneal fibroblasts...
  4. pmc Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation
    Audrey M Bernstein
    Departments of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Biol Cell 18:2716-27. 2007
    ..These data support a novel hypothesis that maintaining full-length uPAR on the cell surface regulates the fibroblast to myofibroblast transition and that down-regulation of uPAR is necessary for myofibroblast differentiation...
  5. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
    ..6-fold increase in collagen deposition over wild type cells. These data suggest that PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease...
  6. ncbi request reprint FAK-dependent regulation of myofibroblast differentiation
    Roseanne S Greenberg
    Department of Ophthalmology, Box 1183, Mount Sinai School of Medicine, 1 Gustave Levy Pl, New York, New York 10029 6574, USA
    FASEB J 20:1006-8. 2006
    ..FAK activation could contribute to regulating myofibroblast differentiation, thereby ameliorating fibrosis...
  7. pmc TGF-β-stimulated CTGF production enhanced by collagen and associated with biogenesis of a novel 31-kDa CTGF form in human corneal fibroblasts
    Edward G Tall
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Invest Ophthalmol Vis Sci 51:5002-11. 2010
    ..Connective tissue growth factor (CTGF) is induced by transforming growth factor-beta (TGF-β) after corneal wounding. This study addressed the role of the extracellular matrix in the induction of CTGF by TGF-β...
  8. ncbi request reprint ZO-1: lamellipodial localization in a corneal fibroblast wound model
    Lavinia Taliana
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Invest Ophthalmol Vis Sci 46:96-103. 2005
    ..To explore the roles of ZO-1 in corneal fibroblasts and myofibroblasts in a model of wounding...
  9. ncbi request reprint Differential conversion of plasminogen to angiostatin by human corneal cell populations
    Debra J Warejcka
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Vis 11:859-68. 2005
    ..The purpose of this paper is to determine the ability of corneal cells to convert plasminogen to angiostatins and to compare these products with those made by intact corneas...

Research Grants1

  1. Corneal Repair: uPA and extracellular matrix
    Audrey M Bernstein; Fiscal Year: 2010
    ..4) uPAR cleavage into a non-uPA binding form inhibits cell migration and induces myofibroblast differentiation. The results of these studies will lead to a better understanding of the mechanisms that guide regenerative wound repair. ..