M Cecilia Berin

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Immunophysiology of experimental food allergy
    M C Berin
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York, USA
    Mucosal Immunol 2:24-32. 2009
  2. pmc Mucosal immunology of food allergy
    M Cecilia Berin
    Pediatric Allergy and Immunology, Box 1198, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 23:R389-400. 2013
  3. pmc Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity
    M C Berin
    Pediatric Allergy and Immunology, Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    Mucosal Immunol 6:114-21. 2013
  4. pmc Can we produce true tolerance in patients with food allergy?
    M Cecilia Berin
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 131:14-22. 2013
  5. pmc Mucosal antibodies in the regulation of tolerance and allergy to foods
    M Cecilia Berin
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Semin Immunopathol 34:633-42. 2012
  6. doi request reprint Mechanisms of allergic sensitization to foods: bypassing immune tolerance pathways
    M Cecilia Berin
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, Box 1198, One Gustave L Levy Place, New York, NY 10029, USA
    Immunol Allergy Clin North Am 32:1-10. 2012
  7. ncbi request reprint Antibody-mediated antigen sampling across intestinal epithelial barriers
    M Cecilia Berin
    Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Ann N Y Acad Sci 1072:253-61. 2006
  8. pmc A functional role for CCR6 on proallergic T cells in the gastrointestinal tract
    Ana Belen Blazquez
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 138:275-84.e1-4. 2010
  9. doi request reprint Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance
    Ana Belen Blazquez
    The Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 139:1301-9. 2010
  10. pmc Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa
    Stephanie A Leonard
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 129:1579-1587.e1. 2012

Research Grants

Collaborators

Detail Information

Publications24

  1. doi request reprint Immunophysiology of experimental food allergy
    M C Berin
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York, USA
    Mucosal Immunol 2:24-32. 2009
    ..Studies on systemic anaphylaxis or local gastrointestinal manifestations of food allergy in mice have highlighted the contribution of IgE, mast cells, and pathogenic Th2 lymphocytes in experimental food allergy...
  2. pmc Mucosal immunology of food allergy
    M Cecilia Berin
    Pediatric Allergy and Immunology, Box 1198, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 23:R389-400. 2013
    ..New experimental tools, particularly in the field of genomics and the microbiome, are likely to shed light on factors responsible for the growing clinical problem of food allergy...
  3. pmc Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity
    M C Berin
    Pediatric Allergy and Immunology, Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    Mucosal Immunol 6:114-21. 2013
    ..Our results demonstrate that TLR9 on an unknown cell type is required for the development of IgE-producing B cells, and we conclude that TLR9 signaling indirectly shapes the immune response for optimal IgE production...
  4. pmc Can we produce true tolerance in patients with food allergy?
    M Cecilia Berin
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 131:14-22. 2013
    ..The current challenge is to understand the mechanisms responsible for restoration of natural or induced tolerance so that interventions can be developed to more successfully induce tolerance in the majority of patients with food allergy...
  5. pmc Mucosal antibodies in the regulation of tolerance and allergy to foods
    M Cecilia Berin
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Semin Immunopathol 34:633-42. 2012
    ..This review will focus on the role of intestinal immunoglobulins in the development of clinical tolerance and allergy to food antigens...
  6. doi request reprint Mechanisms of allergic sensitization to foods: bypassing immune tolerance pathways
    M Cecilia Berin
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, Box 1198, One Gustave L Levy Place, New York, NY 10029, USA
    Immunol Allergy Clin North Am 32:1-10. 2012
    ..This article discusses the implications of these approaches for understanding the mechanisms of sensitization to food allergens in human disease...
  7. ncbi request reprint Antibody-mediated antigen sampling across intestinal epithelial barriers
    M Cecilia Berin
    Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Ann N Y Acad Sci 1072:253-61. 2006
    ....
  8. pmc A functional role for CCR6 on proallergic T cells in the gastrointestinal tract
    Ana Belen Blazquez
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 138:275-84.e1-4. 2010
    ..T cells expressing T helper cell (Th) 2 cytokines are critical for experimental food allergy, and we hypothesized that CCL20 is involved in the localization of these cells to the gut...
  9. doi request reprint Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance
    Ana Belen Blazquez
    The Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 139:1301-9. 2010
    ..We tested the functional role of TSLP in mouse models of gastrointestinal allergy and tolerance...
  10. pmc Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa
    Stephanie A Leonard
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 129:1579-1587.e1. 2012
    ..Studies are needed to elucidate mechanisms of clinical protection and to identify safer and potentially more efficacious methods for desensitizing patients to food allergens...
  11. pmc Allergen-IgE complexes trigger CD23-dependent CCL20 release from human intestinal epithelial cells
    Hongxing Li
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 133:1905-15. 2007
    ..We hypothesized that allergen-IgE complexes could also signal via CD23 to trigger an inflammatory cascade in the local environment...
  12. doi request reprint Transforming growth factor β signaling controls activities of human intestinal CD8(+)T suppressor cells
    Keren M Rabinowitz
    Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gastroenterology 144:601-612.e1. 2013
    ..Disruption of Ts cell activities can lead to mucosal inflammation. We investigated what factors were required for expansion of the Ts cell population or loss of their activity in patients with Crohn's disease (CD)...
  13. ncbi request reprint Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy
    Hongxing Li
    Department of Medicine Division of Clinical Immunology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 131:47-58. 2006
    ..We examined whether IgE also could facilitate transepithelial antigen sampling...
  14. ncbi request reprint Gastrointestinal dendritic cells promote Th2 skewing via OX40L
    Ana Belen Blazquez
    Division of Pediatric Allergy and Immunology, and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:4441-50. 2008
    ..Th2 skewing is mediated by OX40L, and we speculate that this molecule may be an important inducer of allergic sensitization to food allergens...
  15. ncbi request reprint CD4 T cells activated in the mesenteric lymph node mediate gastrointestinal food allergy in mice
    Adina Kay Knight
    The Division of Allergy and Immunology Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1234-43. 2007
    ..A gut-homing phenotype induced in the MLN and selective upregulation of Th2 chemoattractants are likely important factors in the gastrointestinal recruitment of pathological Th2-skewed CD4(+) T cells in food allergy...
  16. pmc Mucosal immunology of tolerance and allergy in the gastrointestinal tract
    Lauren Steele
    Mount Sinai School of Medicine, Immunology Institute, New York, NY 10029, USA
    Immunol Res 54:75-82. 2012
    ..Recent work in the understanding of mucosal immunology of tolerance and allergy in the gastrointestinal tract will be discussed...
  17. doi request reprint T(H)2 adjuvants: implications for food allergy
    M Cecilia Berin
    Department of Pediatrics, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 121:1311-20; quiz 1321-2. 2008
    ....
  18. pmc Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans
    Stephanie Dahan
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 140:550-9. 2011
    ..The absence of LPLs in mice, such as in RAG1(-/-) mice, results in defects in epithelial cell differentiation. We investigated the role of lymphoepithelial interactions in epithelial differentiation and barrier function...
  19. doi request reprint Food allergy: mechanisms and therapeutics
    M Cecilia Berin
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Curr Opin Immunol 23:794-800. 2011
    ..Here, we review selected findings published since 2009 that advance our understanding of mechanisms and new therapeutics for IgE-mediated food allergy...
  20. pmc Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner
    David Dunkin
    Division of Pediatric Gastroenterology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 128:1251-1258.e2. 2011
    ..Oral exposure to food allergens may be limited in infancy, and the initial site of antigen exposure likely plays an important role in food allergy induction...
  21. pmc Mechanisms underlying differential food allergy response to heated egg
    Gustavo Martos
    Department of Pediatrics and Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 127:990-7.e1-2. 2011
    ..Egg white proteins are usually subjected to heating, making them edible for the majority of children with egg allergy...
  22. doi request reprint Food allergy: an enigmatic epidemic
    M Cecilia Berin
    Jaffe Food Allergy Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Trends Immunol 34:390-7. 2013
    ..The purpose of this review is to highlight significant gaps in our knowledge that need answers to stem the progression of this disorder that is reaching epidemic proportions. ..
  23. ncbi request reprint Factors regulating the effect of IL-4 on intestinal epithelial barrier function
    Vincenza Di Leo
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ont, Canada
    Int Arch Allergy Immunol 129:219-27. 2002
    ..Here, we characterized the mechanism of action of IL-4 on cultured epithelial cells and examined if the anti-inflammatory cytokines, TGF-beta or IL-10, can modulate the effects of IL-4...
  24. ncbi request reprint Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8
    M Cecilia Berin
    Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093 0623, USA
    Cell Microbiol 4:635-48. 2002
    ..The activation of proinflammatory signals in human colon epithelial cells in response to this non-invasive pathogen appears to depend to a significant extent on H7 flagellin...

Research Grants1

  1. Gut Dendritic Cells and Allergic Sensitization
    M Berin; Fiscal Year: 2006
    ..The results from these experiments will provide a better understanding of how a normally tolerogenic response to a food protein deviates toward allergic sensitization. ..