DAVID BECHHOFER

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Processing of Bacillus subtilis small cytoplasmic RNA: evidence for an additional endonuclease cleavage site
    Shiyi Yao
    Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Nucleic Acids Res 35:4464-73. 2007
  2. doi request reprint Bacillus subtilis mRNA decay: new parts in the toolkit
    David H Bechhofer
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    Wiley Interdiscip Rev RNA 2:387-94. 2011
  3. pmc Decay of a model mRNA in Bacillus subtilis by a combination of RNase J1 5' exonuclease and RNase Y endonuclease activities
    Shiyi Yao
    Department of Pharmacology and Systems Therapeutics, Box 1603, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Bacteriol 193:6384-6. 2011

Research Grants

  1. INITIATION OF MRNA DECAY IN BACILLUS SUBTILIS
    David H Bechhofer; Fiscal Year: 2010

Collaborators

  • Shiyi Yao
  • Joel G Belasco
  • Jamie Richards
  • Joshua B Blaustein

Detail Information

Publications3

  1. pmc Processing of Bacillus subtilis small cytoplasmic RNA: evidence for an additional endonuclease cleavage site
    Shiyi Yao
    Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Nucleic Acids Res 35:4464-73. 2007
    ..RNase J1 is responsible for much of the cleavage that releases scRNA from downstream sequences. The subsequent exonucleolytic processing is carried out largely by RNase PH...
  2. doi request reprint Bacillus subtilis mRNA decay: new parts in the toolkit
    David H Bechhofer
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    Wiley Interdiscip Rev RNA 2:387-94. 2011
    ..The presence of these ribonucleases in B. subtilis predicts significant differences from the well-established model of mRNA decay in Escherichia coli...
  3. pmc Decay of a model mRNA in Bacillus subtilis by a combination of RNase J1 5' exonuclease and RNase Y endonuclease activities
    Shiyi Yao
    Department of Pharmacology and Systems Therapeutics, Box 1603, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Bacteriol 193:6384-6. 2011
    ..Evidence is presented that both of these activities determine the half-life of ΔermC mRNA...

Research Grants1

  1. INITIATION OF MRNA DECAY IN BACILLUS SUBTILIS
    David H Bechhofer; Fiscal Year: 2010
    ..Elucidating the mechanism of mRNA in this bacterium could lead to the design of new antibiotics that inhibit the mRNA decay process and thereby prevent successful bacterial colonization of human tissues. ..