Lia Baki

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
    Lia Baki
    Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    EMBO J 23:2586-96. 2004
  2. ncbi request reprint Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling
    Lia Baki
    Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 28:483-90. 2008
  3. pmc Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability
    Geo Serban
    Department of Psychiatry, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
    J Biol Chem 280:36007-12. 2005
  4. pmc Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
    Anastasios Georgakopoulos
    Department of Psychiatry, Mount Sinai School of Medicine, NYU, New York, NY 10029, USA
    EMBO J 25:1242-52. 2006
  5. ncbi request reprint FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta
    Junichi Shioi
    Department of Psychiatry, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    J Neurochem 101:674-81. 2007
  6. pmc A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
    Philippe Marambaud
    Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    EMBO J 21:1948-56. 2002
  7. pmc Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation
    Ioannis E Michailidis
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY, USA
    Pflugers Arch 461:387-97. 2011

Collaborators

Detail Information

Publications7

  1. pmc PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
    Lia Baki
    Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    EMBO J 23:2586-96. 2004
    ..Our data raise the possibility that PS1 may prevent development of AD pathology by activating the PI3K/Akt signaling pathway. In contrast, FAD mutations may promote AD pathology by inhibiting this pathway...
  2. ncbi request reprint Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling
    Lia Baki
    Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 28:483-90. 2008
    ..These observations suggest that stimulation of PI3K/Akt signaling may be beneficial to FAD patients...
  3. pmc Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability
    Geo Serban
    Department of Psychiatry, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
    J Biol Chem 280:36007-12. 2005
    ..Thus, cadherins mediate both the association of PS1 and beta-catenin and the effects of PS1 on the cellular levels of beta-catenin...
  4. pmc Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
    Anastasios Georgakopoulos
    Department of Psychiatry, Mount Sinai School of Medicine, NYU, New York, NY 10029, USA
    EMBO J 25:1242-52. 2006
    ..PS1 FAD and gamma-secretase dominant-negative mutants inhibited the EphB-induced cleavage of ephrinB2 and Src autophosphorylation, raising the possibility that FAD mutants interfere with the functions of Src and ephrinB2 in the CNS...
  5. ncbi request reprint FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta
    Junichi Shioi
    Department of Psychiatry, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    J Neurochem 101:674-81. 2007
    ..Our data suggest that the mechanism by which FAD mutations promote neurodegeneration and AD may be independent of their effects on Abeta production...
  6. pmc A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
    Philippe Marambaud
    Department of Psychiatry and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    EMBO J 21:1948-56. 2002
    ..Thus, the PS1/gamma-secretase system stimulates disassembly of the E-cadherin- catenin complex and increases the cytosolic pool of beta-catenin, a key regulator of the Wnt signaling pathway...
  7. pmc Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation
    Ioannis E Michailidis
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY, USA
    Pflugers Arch 461:387-97. 2011
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