Jingxiang Bai

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Toxicol Sci 91:365-71. 2006
  2. ncbi Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Pharmacol Exp Ther 319:1435-43. 2006
  3. ncbi Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:5128-36. 2006
  4. ncbi Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York 10029, USA
    Mol Cell Biochem 262:165-76. 2004
  5. ncbi Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1
    Montserrat Mari
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Pharmacol Exp Ther 301:111-8. 2002
  6. ncbi Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:4660-7. 2003
  7. ncbi Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
  8. ncbi Catalase and estradiol inhibit mitochondrial protein S-glutathionylation
    Bin Hu
    Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biochem 367:51-8. 2012
  9. ncbi Apoptosis and the liver: relation to autoimmunity and related conditions
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, 1 G. Levy Place, P.O. Box 1123, New York, NY 10029, USA
    Autoimmun Rev 2:36-42. 2003

Research Grants

  1. Overexpression of CYP2E1 and Alcohol Liver Disease
    Jingxiang Bai; Fiscal Year: 2006

Detail Information

Publications9

  1. ncbi Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Toxicol Sci 91:365-71. 2006
    ..These results show that adenovirus-mediated overexpression of CYP2E1 could induce liver toxicity in mice and suggests a mechanism involving oxidative/nitrosative stress...
  2. ncbi Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Pharmacol Exp Ther 319:1435-43. 2006
    ..In summary, CHX protects HepG2 cells from serum withdrawal-induced apoptosis through inhibiting the synthesis of p53 and the phosphorylation of p53...
  3. ncbi Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:5128-36. 2006
    ..The accumulation of CYP2E1 in hepatic mitochondria induced by ethanol consumption might play an important role in alcohol liver disease...
  4. ncbi Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York 10029, USA
    Mol Cell Biochem 262:165-76. 2004
    ..The Ad-CYP2E1 may be useful for studies designed to investigate the role of CYP2E1 in APAP and alcoholic liver injury and to further characterize the actions and effects of CYP2E1...
  5. ncbi Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1
    Montserrat Mari
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Pharmacol Exp Ther 301:111-8. 2002
    ..Damage to mitochondria may be a critical step for cellular toxicity by CYP2E1-derived reactive oxygen species...
  6. ncbi Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:4660-7. 2003
    ..This suggests that the level of catalase may play a critical role in cell-induced resistance to the effects of anti-cancer drugs which up-regulate p53...
  7. ncbi Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
    ....
  8. ncbi Catalase and estradiol inhibit mitochondrial protein S-glutathionylation
    Bin Hu
    Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biochem 367:51-8. 2012
    ..This effect may play a role in ninefold greater prevalence of autoantibodies against PDC-E2 in women with primary biliary cirrhosis...
  9. ncbi Apoptosis and the liver: relation to autoimmunity and related conditions
    Jingxiang Bai
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, 1 G. Levy Place, P.O. Box 1123, New York, NY 10029, USA
    Autoimmun Rev 2:36-42. 2003
    ..Overexpression of anti-apoptotic proteins and FasL allow liver tumor cells to evade tumor specific cytotoxic lymphocytes. Agents that modulate apoptosis may be of future therapeutic benefit in a number of liver diseases...

Research Grants1

  1. Overexpression of CYP2E1 and Alcohol Liver Disease
    Jingxiang Bai; Fiscal Year: 2006
    ..We hope this study could make a significant contribution to the prevention and therapy for alcohol liver disease, benefiting millions of such patients worldwide. ..