GEORGE ATWEH

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Pharmacologic induction of fetal hemoglobin: raising the therapeutic bar in sickle cell disease
    G F Atweh
    Division of Hematology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Curr Opin Hematol 8:123-30. 2001
  2. ncbi Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia
    Anna Rita Migliaccio
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Int J Biochem Cell Biol 40:2341-7. 2008
  3. ncbi Targeting stathmin in prostate cancer
    Sucharita J Mistry
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Cancer Ther 4:1821-9. 2005
  4. ncbi Epigenetic analysis of the human alpha- and beta-globin gene clusters
    Hassana Fathallah
    Mount Sinai School of Medicine, Division of Hematology Medical Oncology, Box 1079, One, Gustave L Levy Place, New York, NY 10029, USA
    Blood Cells Mol Dis 40:166-73. 2008
  5. ncbi Synergistic antiangiogenic effects of stathmin inhibition and taxol exposure
    Sucharita J Mistry
    Division of Hematology Oncology, Department of Medicine, Box 1079, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Cancer Res 5:773-82. 2007
  6. ncbi Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin
    Hassana Fathallah
    Division of Hematology and Medical Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Blood 110:3391-7. 2007
  7. ncbi Therapeutic interactions between stathmin inhibition and chemotherapeutic agents in prostate cancer
    Sucharita J Mistry
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1079, New York, NY 10029, USA
    Mol Cancer Ther 5:3248-57. 2006
  8. ncbi DNA hypomethylation therapy for hemoglobin disorders: molecular mechanisms and clinical applications
    Hassana Fathallah
    Division of Hematology and Oncology, Box 1079, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Blood Rev 20:227-34. 2006
  9. ncbi Pharmacological induction of fetal hemoglobin: Why haven't we been more successful in thalassemia?
    Hassana Fathallah
    Division of Hematology Oncology, Box 1079, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Ann N Y Acad Sci 1054:228-37. 2005
  10. ncbi Butyrate increases the efficiency of translation of gamma-globin mRNA
    Rona S Weinberg
    Department of Medicine, Division of Hematology Oncology, Mount Sinai School of Medicine, New York, NY, USA
    Blood 105:1807-9. 2005

Research Grants

  1. Reversal of Epigenetic Silencing of the G-Globin Gene
    GEORGE ATWEH; Fiscal Year: 2006

Collaborators

Detail Information

Publications15

  1. ncbi Pharmacologic induction of fetal hemoglobin: raising the therapeutic bar in sickle cell disease
    G F Atweh
    Division of Hematology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Curr Opin Hematol 8:123-30. 2001
    ..Now that multiple therapeutic agents are available for Hb F induction, the use of combination therapy to increase Hb F levels sufficiently to prevent all the complications of sickle cell disease has become a realistic goal...
  2. ncbi Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia
    Anna Rita Migliaccio
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Int J Biochem Cell Biol 40:2341-7. 2008
    ....
  3. ncbi Targeting stathmin in prostate cancer
    Sucharita J Mistry
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Cancer Ther 4:1821-9. 2005
    ..If these findings are confirmed in vivo, it may provide an effective approach for the treatment of prostate cancer...
  4. ncbi Epigenetic analysis of the human alpha- and beta-globin gene clusters
    Hassana Fathallah
    Mount Sinai School of Medicine, Division of Hematology Medical Oncology, Box 1079, One, Gustave L Levy Place, New York, NY 10029, USA
    Blood Cells Mol Dis 40:166-73. 2008
    ..This is another example of the important differences in the molecular mechanisms of regulation of the genes of the alpha- and beta-like globin clusters...
  5. ncbi Synergistic antiangiogenic effects of stathmin inhibition and taxol exposure
    Sucharita J Mistry
    Division of Hematology Oncology, Department of Medicine, Box 1079, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Cancer Res 5:773-82. 2007
    ..Thus, this novel combination may provide an attractive therapeutic strategy that combines a synergistic antitumor activity with a synergistic antiangiogenic activity...
  6. ncbi Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin
    Hassana Fathallah
    Division of Hematology and Medical Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Blood 110:3391-7. 2007
    ..These studies provide strong support for the role of epigenetic modifications in the normal developmental and tissue-specific regulation of globin gene expression and in the butyrate-mediated pharmacologic induction of HbF production...
  7. ncbi Therapeutic interactions between stathmin inhibition and chemotherapeutic agents in prostate cancer
    Sucharita J Mistry
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1079, New York, NY 10029, USA
    Mol Cancer Ther 5:3248-57. 2006
    ..Thus, this combination may provide a novel form of prostate cancer therapy that would avoid toxicities associated with the use of multiple chemotherapeutic agents at full therapeutic doses...
  8. ncbi DNA hypomethylation therapy for hemoglobin disorders: molecular mechanisms and clinical applications
    Hassana Fathallah
    Division of Hematology and Oncology, Box 1079, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Blood Rev 20:227-34. 2006
    ....
  9. ncbi Pharmacological induction of fetal hemoglobin: Why haven't we been more successful in thalassemia?
    Hassana Fathallah
    Division of Hematology Oncology, Box 1079, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Ann N Y Acad Sci 1054:228-37. 2005
    ..We also describe several areas for future investigation that may be critically important for the development of an effective therapy for thalassemia...
  10. ncbi Butyrate increases the efficiency of translation of gamma-globin mRNA
    Rona S Weinberg
    Department of Medicine, Division of Hematology Oncology, Mount Sinai School of Medicine, New York, NY, USA
    Blood 105:1807-9. 2005
    ..Thus, the induction of Hb F by butyrate may be mediated by translational effects in addition to its well-known effects on transcription of the gamma-globin genes...
  11. ncbi Role of stathmin in the regulation of the mitotic spindle: potential applications in cancer therapy
    Sucharita J Mistry
    Department of Medicine, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA
    Mt Sinai J Med 69:299-304. 2002
    ..In this review, we describe the current understanding of the role of stathmin in the regulation of the mitotic spindle and discuss its potential as a therapeutic target of cancer therapy...
  12. ncbi Sickle cell disease: old discoveries, new concepts, and future promise
    Paul S Frenette
    Division of Hematology Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:850-8. 2007
    ..In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances...
  13. ncbi Stathmin prevents the transition from a normal to an endomitotic cell cycle during megakaryocytic differentiation
    Camelia Iancu-Rubin
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cell Cycle 4:1774-82. 2005
    ..These observations support a model in which downregulation of stathmin expression in megakaryocytes and other polyploid cells may be a critically important factor in endomitosis and polyploidy...
  14. ncbi The role of stathmin in the regulation of the cell cycle
    Camelia Iancu Rubin
    Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Cell Biochem 93:242-50. 2004
    ....
  15. ncbi Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy
    Camelia Iancu Rubin
    Division of Hematology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Hematol 31:389-97. 2003
    ..We hypothesized that the absence of stathmin expression in megakaryocytes might be important for their abortive mitosis...

Research Grants4

  1. Reversal of Epigenetic Silencing of the G-Globin Gene
    GEORGE ATWEH; Fiscal Year: 2006
    ..We believe these studies will shed important light on the normal mechanisms of silencing of the gamma-globin genes and their reversal by pharmacological therapies. ..