Etsuko Abe

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD+ sensor
    Li Sun
    Mount Sinai Bone Program, Department of Medicine, and Bronx Veterans Affairs Geriatrics Research Education and Clinical Center GRECC, New York, New York 10029, USA
    FASEB J 16:302-14. 2002
  2. ncbi request reprint Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor
    Baljit S Moonga
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, New York 10029, USA
    Am J Physiol Renal Physiol 282:F921-32. 2002
  3. ncbi request reprint Function of BMPs and BMP antagonists in adult bone
    Etsuko Abe
    Division of Endocrinology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1055, New York, NY 10029, USA
    Ann N Y Acad Sci 1068:41-53. 2006
  4. ncbi request reprint Bone loss in thyroid disease: role of low TSH and high thyroid hormone
    Etsuko Abe
    Mount Sinai Bone Program and The Thyroid Research Unit at the James Peter s Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1116:383-91. 2007
  5. pmc TNFalpha mediates the skeletal effects of thyroid-stimulating hormone
    Hidenori Hase
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:12849-54. 2006
  6. ncbi request reprint TSH is a negative regulator of skeletal remodeling
    Etsuko Abe
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 115:151-62. 2003
  7. ncbi request reprint Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption
    Li Sun
    Mount Sinai Bone Program and Department of Medicine and Geriatrics, Mount Sinai School of Medicine, and Division of Endocrinology and Geriatric Research Education and Clinical Center GRECC, Veterans Affairs Medical Center, New York, New York 10029, USA
    FASEB J 17:369-75. 2003
  8. pmc Calcineurin regulates bone formation by the osteoblast
    Li Sun
    Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 102:17130-5. 2005
  9. ncbi request reprint Cellular and molecular consequences of calcineurin A alpha gene deletion
    Li Sun
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1116:216-26. 2007
  10. ncbi request reprint Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts
    Li Sun
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Renal Physiol 292:F285-91. 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD+ sensor
    Li Sun
    Mount Sinai Bone Program, Department of Medicine, and Bronx Veterans Affairs Geriatrics Research Education and Clinical Center GRECC, New York, New York 10029, USA
    FASEB J 16:302-14. 2002
    ..Finally, ryanodine inhibited Ca2+ signaling, indicating the downstream activation of ryanodine receptors by cADPr. We conclude that intracellularly expressed CD38 might link cellular NAD+ production to cytosolic Ca2+ signaling...
  2. ncbi request reprint Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor
    Baljit S Moonga
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, New York 10029, USA
    Am J Physiol Renal Physiol 282:F921-32. 2002
    ..It is likely therefore that the surface RyR-2 not only gates Ca(2+) influx but also functions as a sensor for extracellular divalent cations...
  3. ncbi request reprint Function of BMPs and BMP antagonists in adult bone
    Etsuko Abe
    Division of Endocrinology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1055, New York, NY 10029, USA
    Ann N Y Acad Sci 1068:41-53. 2006
    ..Advanced technologies using gene manipulation were used to study their roles in adulthood. In addition, findings of new BMP antagonists and the effect of Wnt-canonical pathways on bone features also provided new insights in bone studies...
  4. ncbi request reprint Bone loss in thyroid disease: role of low TSH and high thyroid hormone
    Etsuko Abe
    Mount Sinai Bone Program and The Thyroid Research Unit at the James Peter s Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1116:383-91. 2007
    ..We can now provide results that not thyroid hormones but also TSH itself has an equally important role to play in bone remodeling...
  5. pmc TNFalpha mediates the skeletal effects of thyroid-stimulating hormone
    Hidenori Hase
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:12849-54. 2006
    ..The results suggest that TNFalpha is the critical cytokine mediating the downstream antiresorptive effects of TSH on the skeleton...
  6. ncbi request reprint TSH is a negative regulator of skeletal remodeling
    Etsuko Abe
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 115:151-62. 2003
    ..These studies define a role for TSH as a single molecular switch in the independent control of both bone formation and resorption...
  7. ncbi request reprint Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption
    Li Sun
    Mount Sinai Bone Program and Department of Medicine and Geriatrics, Mount Sinai School of Medicine, and Division of Endocrinology and Geriatric Research Education and Clinical Center GRECC, Veterans Affairs Medical Center, New York, New York 10029, USA
    FASEB J 17:369-75. 2003
    ..These findings establish a critical role for CD38 in osteoclast formation and bone resorption. We speculate that CD38 functions as a cellular NAD+ "sensor," particularly during periods of active motility and secretion...
  8. pmc Calcineurin regulates bone formation by the osteoblast
    Li Sun
    Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 102:17130-5. 2005
    ..Together, the gain- and loss-of-function experiments indicate that calcineurin regulates bone formation through an effect on osteoblast differentiation...
  9. ncbi request reprint Cellular and molecular consequences of calcineurin A alpha gene deletion
    Li Sun
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1116:216-26. 2007
    ..We speculate that the so-called "calcineurin inhibitors" may interact with molecules other than calcineurin. The clinical relevance of these observations is explored...
  10. ncbi request reprint Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts
    Li Sun
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Renal Physiol 292:F285-91. 2007
    ..Together, the gain- and loss-of-function experiments establish that calcineurin Aalpha is necessary for osteoclast formation from its precursor and that this occurs via an NFATc1-dependent mechanism...
  11. pmc Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss
    Li Sun
    The Mount Sinai Bone Program and The Thyroid Research Unit at the Bronx Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:4289-94. 2008
    ..In contrast, loss of function of a mutant TSHR (Pro --> Leu at 556) in congenital hypothyroid mice activates osteoclast differentiation, confirming once again our premise that TSHRs have a critical role in regulating bone remodeling...
  12. ncbi request reprint TSH and bone loss
    Li Sun
    Department of Medicine, Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1068:309-18. 2006
    ..The evidence that low TSH levels predispose to osteoporosis in hyperthyroidism is discussed in view of the emerging role of pituitary hormones in bone biology...
  13. pmc High-mobility group box proteins modulate tumor necrosis factor-alpha expression in osteoclastogenesis via a novel deoxyribonucleic acid sequence
    Kosj Yamoah
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 22:1141-53. 2008
    ..Taken together, we conclude that HMGB and TNFalpha play critical roles in the regulation of osteoclastogenesis and the remodeling of bone...
  14. pmc Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
    Xue Bin Wu
    Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1055, New York, New York 10029, USA
    J Clin Invest 112:924-34. 2003
    ..Thus, the overproduction of noggin during biological aging may result in impaired osteoblast formation and function and hence, net bone loss...
  15. ncbi request reprint Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics
    Mone Zaidi
    Department of Medicine, Geriatrics and Physiology and The Mount Sinai Bone Program, Bronx VA Geriatrics Research Education and Clinical Center, New York, New York, USA
    J Bone Miner Res 18:599-609. 2003
    ..The main outstanding issues, basic and translational, will be considered in relation to the osteoclast as a target for antiresorptive therapies...
  16. ncbi request reprint Transduction of TAT fusion proteins into osteoclasts and osteoblasts
    Svetlana Dolgilevich
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, and Bronx Veterans Affairs Medical Center GRECC, One Gustave L Levy Place, PO 1055, Endocrinology, New York, NY 10029, USA
    Biochem Biophys Res Commun 299:505-9. 2002
    ..We expect that our studies will provide a firm basis for the future development of TAT fusion proteins for critical molecules involved in bone cell differentiation and function...
  17. pmc Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth
    Rebecca A Mosig
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Mol Genet 16:1113-23. 2007
    ..Thus, Mmp2-/- mice provide a valuable biological resource for studying the pathophysiological mechanisms underlying the human disease and defining the in vivo physiological role of MMP-2...
  18. ncbi request reprint Molecular cloning, expression, and function of osteoclastic calcineurin Aalpha
    Li Sun
    Mount Sinai Bone Program and Division of Endocrinology, Mount Sinai School of Medicine, New York, 10029, USA
    Am J Physiol Renal Physiol 284:F575-83. 2003
    ....
  19. ncbi request reprint Skeletal morphofunctional considerations and the pituitary-thyroid axis
    Jameel Iqbal
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
    Front Biosci (Schol Ed) 1:92-107. 2009
    ..The current review describes these molecular mechanisms in relation to the way thyroid hormones, and the pituitary hormone thyrotropin (TSH), regulate skeletal morphogenesis and remodeling...
  20. pmc Calcitonin and bone formation: a knockout full of surprises
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 110:1769-71. 2002
  21. ncbi request reprint Bisphosphonates induce inflammation and rupture of atherosclerotic plaques in apolipoprotein-E null mice
    Mona Shimshi
    Department of Medicine, The Mount Sinai Bone Program, The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 07936 1080, USA
    Biochem Biophys Res Commun 328:790-3. 2005
    ..Our finding of plaque inflammation and rupture in bisphosphonate-treated Apo-E-/- mice may provide the first animal model for studies aimed at characterizing mechanisms of plaque rupture in animal models...
  22. ncbi request reprint Low TSH triggers bone loss: fact or fiction?
    Mone Zaidi
    Thyroid 16:1075-6. 2006