J J Halperin


Affiliation: Morristown Memorial Hospital
Country: USA


  1. Halperin J. Nervous system Lyme disease. Infect Dis Clin North Am. 2008;22:261-74, vi pubmed publisher
    ..In severe cases, 2 to 4 weeks of parenteral therapy is necessary. All available evidence indicates that treatment of more than 4 weeks' duration carries substantial risk but minimal if any additional benefit...
  2. Halperin J. Neuroborreliosis. Neurol Clin. 2018;36:821-830 pubmed publisher
    ..CNS infection is often evidenced by a cerebrospinal fluid pleocytosis and intrathecal production of specific antibody. ..
  3. Halperin J. Lyme disease: a multisystem infection that affects the nervous system. Continuum (Minneap Minn). 2012;18:1338-50 pubmed publisher
    ..However, oral antibiotics are probably effective in patients with meningitis and other forms of involvement, with the likely exception of parenchymal CNS infection. ..
  4. Halperin J, Baker P, Wormser G. Common misconceptions about Lyme disease. Am J Med. 2013;126:264.e1-7 pubmed publisher
    ..In this article we review the principal misconceptions, discussing their origins and the best currently available scientific evidence related to each one. ..
  5. Halperin J. Nervous system lyme disease. Curr Infect Dis Rep. 2015;17:445 pubmed publisher
    ..Treatment is generally with oral antimicrobials such as doxycycline. Parenteral regimens are usually necessary only for the most severe cases. ..
  6. Halperin J. Nervous system Lyme disease. Infect Dis Clin North Am. 2015;29:241-53 pubmed publisher
    ..Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease. ..
  7. Halperin J. Nervous system Lyme disease, chronic Lyme disease, and none of the above. Acta Neurol Belg. 2016;116:1-6 pubmed publisher
    ..burgdorferi infection, is inappropriate and unfortunate, leading not only to unneeded treatment and its associated complications, but also to missed opportunities for more appropriate management of patients' often disabling symptoms. ..
  8. Halperin J. Nervous System Lyme Disease. Clin Lab Med. 2015;35:779-95 pubmed publisher
    ..Most cases of neuroborreliosis can be cured with oral doxycycline; parenteral regimens should be reserved for patients with particularly severe disease. ..
  9. Halperin J, Moran S, Prasek D, Richards A, Ruggiero C, Maund C. Reducing Hospital-Acquired Infections Among the Neurologically Critically Ill. Neurocrit Care. 2016;25:170-7 pubmed publisher
    ..Combining a multidisciplinary approach with rigorous analysis of objective data, we decreased total HAIs by 53 % over 18 months. Key drivers were decreased urinary catheter use and decreased patient transport from the ICU for imaging. ..

More Information


  1. Halperin J. Neuroborreliosis. J Neurol. 2017;264:1292-1297 pubmed publisher
    ..The pathophysiology of neuroborreliosis remains unclear, but appears to involve both a requirement for viable micro-organisms and significant immune amplification. ..
  2. Halperin J. Nervous System Abnormalities and Legionnaire's Disease. Infect Dis Clin North Am. 2017;31:55-68 pubmed publisher
    ..Patients with Legionnaire's may be at increased risk of, and rarely develop, immune-mediated multifocal brain (acute disseminated encephalomyelitis) or peripheral nerve disease (Guillain-Barré syndrome). ..
  3. Halperin J. Diagnosis and management of acute encephalitis. Handb Clin Neurol. 2017;140:337-347 pubmed publisher
    ..Overall long-term outcomes are favorable in the majority of patients with encephalitis, a proportion that hopefully will improve with further advances in diagnostic technology and therapeutic interventions. ..
  4. Belt G, Felberg R, Rubin J, Halperin J. In-Transit Telemedicine Speeds Ischemic Stroke Treatment: Preliminary Results. Stroke. 2016;47:2413-5 pubmed publisher
    ..Improvement in time to treat seems comparable with in-transit telestroke and mobile stroke transport units. The low cost/unit makes this approach scalable, potentially providing rapid management of more patients. ..
  5. Halperin J. Nervous system Lyme disease. J R Coll Physicians Edinb. 2010;40:248-55 pubmed publisher
    ..Treatment with any of several standard regimens of oral or parenteral antimicrobials is highly effective. Prolonged treatment beyond four weeks is rarely if ever warranted, and carries significant risk...