Xueying Zhao

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. ncbi Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy
    Xueying Zhao
    Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Am J Nephrol 34:268-80. 2011
  2. ncbi PPAR-alpha agonist fenofibrate induces renal CYP enzymes and reduces blood pressure and glomerular hypertrophy in Zucker diabetic fatty rats
    Xueying Zhao
    Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Am J Nephrol 28:598-606. 2008
  3. ncbi Fenofibrate attenuates tubulointerstitial fibrosis and inflammation through suppression of nuclear factor-κB and transforming growth factor-β1/Smad3 in diabetic nephropathy
    Lingyun Li
    Department of Physiology, Atlanta, GA 30310, USA
    Exp Biol Med (Maywood) 235:383-91. 2010
  4. ncbi Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage
    Xueying Zhao
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, USA
    J Am Soc Nephrol 15:1244-53. 2004
  5. ncbi Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade
    Jan Michael Williams
    Department of Physiology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 46:366-71. 2005
  6. ncbi Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertension
    Mong Heng Wang
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Hypertension 42:594-9. 2003
  7. ncbi Cytochrome P450 epoxygenases provide a novel mechanism for penile erection
    Liming Jin
    Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
    FASEB J 20:539-41. 2006
  8. ncbi Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats
    Liming Jin
    Department of Physiology, Medical College of Georgia, Augusta, GA, USA
    J Pharmacol Exp Ther 318:288-95. 2006
  9. ncbi The Bradykinin B2 receptor is required for full expression of renal COX-2 and renin
    John D Imig
    Department of Physiology, Medical College of Georgia, Vascular Biology Center, Augusta, GA 30912 2500, USA
    Peptides 24:1141-7. 2003
  10. ncbi Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension
    John D Imig
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 39:690-4. 2002

Detail Information

Publications18

  1. ncbi Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy
    Xueying Zhao
    Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Am J Nephrol 34:268-80. 2011
    ..Studies have shown that kidney injury molecule-1 (KIM-1) is upregulated in damaged renal proximal tubules. In this study, we examined KIM-1 expression in glomerular epithelial cells in diabetic glomerulopathy...
  2. ncbi PPAR-alpha agonist fenofibrate induces renal CYP enzymes and reduces blood pressure and glomerular hypertrophy in Zucker diabetic fatty rats
    Xueying Zhao
    Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Am J Nephrol 28:598-606. 2008
    ....
  3. ncbi Fenofibrate attenuates tubulointerstitial fibrosis and inflammation through suppression of nuclear factor-κB and transforming growth factor-β1/Smad3 in diabetic nephropathy
    Lingyun Li
    Department of Physiology, Atlanta, GA 30310, USA
    Exp Biol Med (Maywood) 235:383-91. 2010
    ..Taken together, fenofibrate suppressed NF-kappaB and TGF-beta1/Smad3 signaling pathways and reduced renal inflammation and tubulointerstitial fibrosis in diabetic ZD animals...
  4. ncbi Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage
    Xueying Zhao
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, USA
    J Am Soc Nephrol 15:1244-53. 2004
    ..These data demonstrate that SEH inhibition has antihypertensive and renal vascular protective effects in angiotensin hypertension and suggests that SEH inhibitors may be a useful therapeutic intervention for cardiovascular diseases...
  5. ncbi Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade
    Jan Michael Williams
    Department of Physiology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 46:366-71. 2005
    ..This suggests a possible relationship between ETB receptor activation and the maintenance of CYP4A protein expression in the kidney of rats fed a high-salt diet...
  6. ncbi Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertension
    Mong Heng Wang
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Hypertension 42:594-9. 2003
    ..The reduction in the synthesis of these eicosanoids may play an important role in the regulation of renal function and blood pressure in obesity-induced hypertension...
  7. ncbi Cytochrome P450 epoxygenases provide a novel mechanism for penile erection
    Liming Jin
    Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA
    FASEB J 20:539-41. 2006
    ..Inhibition of this pathway attenuated erectile function, suggesting that EETs are required for normal erection...
  8. ncbi Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats
    Liming Jin
    Department of Physiology, Medical College of Georgia, Augusta, GA, USA
    J Pharmacol Exp Ther 318:288-95. 2006
    ..Increased NADPH oxidase-dependent reactive oxygen species may be one of the mechanisms mediating the RhoA/Rho-kinase activation...
  9. ncbi The Bradykinin B2 receptor is required for full expression of renal COX-2 and renin
    John D Imig
    Department of Physiology, Medical College of Georgia, Vascular Biology Center, Augusta, GA 30912 2500, USA
    Peptides 24:1141-7. 2003
    ..The results of these studies demonstrate suppression of renal renin synthesis in mice lacking the bradykinin B2R and support the notion that B2R regulation of COX-2 participates in the steady-state control of renin gene expression...
  10. ncbi Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension
    John D Imig
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 39:690-4. 2002
    ..Moreover, sEH plays a role in the regulation of blood pressure, and inhibition of sEH during Ang II hypertension is antihypertensive...
  11. ncbi Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats
    Xueying Zhao
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
    Am J Physiol Regul Integr Comp Physiol 288:R188-96. 2005
    ....
  12. ncbi PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats
    Xueying Zhao
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500
    Am J Physiol Heart Circ Physiol 290:H2187-95. 2006
    ..These results demonstrate that the PPAR-alpha agonist fenofibrate increased renal CYP-derived eicosanoids and restored endothelial dilator function in obese Zucker rats...
  13. ncbi Salt-sensitive hypertension after exposure to angiotensin is associated with inability to upregulate renal epoxygenases
    Xueying Zhao
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
    Hypertension 42:775-80. 2003
    ..These results support the hypothesis that angiotensin II infusion induces persistent salt-sensitive hypertension after withdrawal of angiotensin II that may be due to downregulation of CYP2C and CYP2J epoxygenases in renal microvessels...
  14. ncbi Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension
    Xueying Zhao
    Vascular Biology Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912-3000, USA
    Hypertension 46:562-8. 2005
    ..These results indicate that the impaired autoregulatory response observed in Ang II-dependent hypertension can be attributed to impairment of P2X1 receptor-mediated signal transduction...
  15. ncbi P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid
    Xueying Zhao
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
    J Pharmacol Exp Ther 311:1211-7. 2004
    ..These results demonstrate that 20-HETE plays a significant role in the renal microvascular smooth muscle cell [Ca2+]i response to P2X receptor activation...
  16. ncbi 12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channels
    Shih Shen Yiu
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Lipid Res 44:2391-9. 2003
    ....
  17. ncbi Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension
    Xueying Zhao
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912-2500, USA
    Hypertension 41:709-14. 2003
    ....
  18. ncbi An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension
    John D Imig
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Hypertension 46:975-81. 2005
    ..These data demonstrate that sEH inhibition lowers blood pressure and ameliorates renal damage in angiotensin-dependent, salt-sensitive hypertension...