Research Topics
Genomes and Genes | Gianluca TosiniSummaryAffiliation: Morehouse School of Medicine Country: USA Publications
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Publications
N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brainGianluca Tosini
Morehouse School of Medicine, Atlanta, GA 30310, USA
Neuroscientist 18:645-53. 2012..In this review, the authors discuss the literature about this exciting and underappreciated molecule...- Melatonin: an underappreciated player in retinal physiology and pathophysiologyGianluca Tosini
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
Exp Eye Res 103:82-9. 2012..Administration of exogenous melatonin at night may also be beneficial for ocular health, but additional investigation is needed to establish its potential... 
Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retinaGianluca Tosini
Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
Chronobiol Int 23:381-91. 2006..Finally, it is important to mention that AANAT, in addition to its role in melatonin synthesis, may play a detoxification role in the vertebrate retina by acetylating arylalkylamines that may react with retinaldehyde...- Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degenerationGianluca Tosini
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr, Atlanta, GA 30310 1495, USA
Brain Res 1159:134-40. 2007.... - Localization of a circadian clock in mammalian photoreceptorsGianluca Tosini
Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
FASEB J 21:3866-71. 2007..These results demonstrate that mammalian photoreceptors contain the circadian pacemaker driving rhythmic melatonin synthesis... - The circadian clock system in the mammalian retinaGianluca Tosini
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute Morehouse School of Medicine, Atlanta, GA, USA
Bioessays 30:624-33. 2008..BioEssays 30:624-633, 2008. (c) 2008 Wiley Periodicals, Inc... - Effect of photoreceptor degeneration on circadian photoreception and free-running period in the Royal College of Surgeons ratGianluca Tosini
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
Brain Res 1148:76-82. 2007..01) than in rdy(+), thus suggesting that photoreceptor degeneration may affect the free-running period of the locomotor activity rhythm... - Effect of long-term exposure to constant dim light on the circadian system of ratsChiaki Fukuhara
Morehouse Sch Med, Atlanta, GA
Neurosignals 14:117-25. 2005..Our data suggest that long-term exposure to constant red dim light may induce desynchronization between the circadian rhythm of locomotor activity and serum melatonin levels... - Intraocular injection of kainic acid does not abolish the circadian rhythm of arylalkylamine N-acetyltransferase mRNA in rat photoreceptorsKatsuhiko Sakamoto
Neuroscience Institute and National Science Foundation Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA
Mol Vis 12:117-24. 2006..Our data also indicate that Per1 and Per2 are rhythmically transcribed in the rat retina and KA treatment has a dramatic effect on the overall levels of Per2 mRNA... - Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cellsKatsuhiko Sakamoto
Neuroscience Institute and NSF Center for Behavioural Neuroscience, Morehouse School of Medicine, 720, Atlanta, GA 30310 1495, USA
Eur J Neurosci 22:3129-36. 2005..Our study also suggests that DA may have an important role in mediating the light signals that are used for circadian entrainment and for other responses that are mediated by the nonimage-forming visual system... - Paradoxical effects of NPY in the suprachiasmatic nucleusKaren L Gamble
Department of Psychology, Georgia State University, Atlanta, GA, USA
Eur J Neurosci 23:2488-94. 2006..Thus, these data are the first to demonstrate the paradoxical effects of NPY within the SCN. NPY mimics the effects of light on pineal melatonin and inhibits the effects of light on the induction of Per1 mRNA... - Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retinaChiaki Fukuhara
Neuroscience Institute and National Science Foundation Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
J Neurosci 24:1803-11. 2004..Thus, clock control of the cAMP signaling cascade may play a central role in the integration of circadian signals that control physiology and behavior... - AMPA/kainate receptor antagonist DNQX blocks the acute increase of Per2 mRNA levels in most but not all areas of the SCNKetema N Paul
Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302, USA
Brain Res Mol Brain Res 139:129-36. 2005.... - Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptorKenkichi Baba
Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
Proc Natl Acad Sci U S A 106:15043-8. 2009..These data demonstrate the functional significance of melatonin and MT1 receptors in the mammalian retina and create the basis for future studies on the therapeutic use of melatonin in retinal degeneration... - Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levelsAnamika Sengupta
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute and Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
PLoS ONE 6:e24483. 2011..Finally our data suggest that the circadian regulation of dopamine turnover does not drive the photopic ERG rhythm... - Tetrodotoxin administration in the suprachiasmatic nucleus prevents NMDA-induced reductions in pineal melatonin without influencing Per1 and Per2 mRNA levelsKetema N Paul
Center for Behavioural Neuroscience, and Department of Biology, Georgia State University, Atlanta, 30303, USA
Eur J Neurosci 19:2808-14. 2004.... - N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived micePradoldej Sompol
Department of Pathology and Laboratory Medicine and Ophthalmology and Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 108:8844-9. 2011..Thus, our finding demonstrates a unique function of NAS in promoting robust NPC proliferation, which may contribute to hippocampal plasticity during sleeping period... - Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retinaP Michael Iuvone
Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, rm 5107, Atlanta, GA 30322, USA
Prog Retin Eye Res 24:433-56. 2005..The review will cover evidence that cAMP is a major output of the circadian clock in photoreceptor cells; and recent advances indicating that clocks and clock networks occur in multiple cell types of the retina... - Circadian rhythms in the retina of rats with photoreceptor degenerationKatsuhiko Sakamoto
Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, Georgia, USA
J Neurochem 90:1019-24. 2004..These data are the first direct demonstration that circadian rhythmicity in the mammalian retina can be generated independently from the photoreceptors and the suprachiasmatic nuclei of the hypothalamus... - Analysis of daily and circadian gene expression in the rat pineal glandChiaki Fukuhara
Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
Neurosci Res 60:192-8. 2008..The results obtained with microarray analysis were well correlated with data obtained using real time quantitative RT-PCR. The present results provide new materials to dissect and understand the pineal physiology... - Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retinaNikita Pozdeyev
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA
Eur J Neurosci 27:2691-700. 2008..Thus, dopamine release in response to light and circadian clocks drives daily rhythms of protein phosphorylation in photoreceptor cells... - N-acetylserotonin activates TrkB receptor in a circadian rhythmSung Wuk Jang
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 107:3876-81. 2010..Hence, our findings support that NAS is more than a melatonin precursor, and that it can potently activate TrkB receptor... - Age-related changes in the daily rhythm of photoreceptor functioning and circuitry in a melatonin-proficient mouse strainKenkichi Baba
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Department of Anatomy and Neurobiology, Morehouse School of Medicine, CNR, Pisa, Italy
PLoS ONE 7:e37799. 2012..This suggests that the responsiveness of the photoreceptors to exogenous melatonin is reduced during aging... - Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissectionCuimei Liu
Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310-1495, USA
Cell Tissue Res 315:197-201. 2004..However, the rhythmic expression of Aa-nat mRNA was observed only in photoreceptor cells... - Classical photoreceptors regulate melanopsin mRNA levels in the rat retinaKatsuhiko Sakamoto
Neuroscience Institute and National Science Foundation Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
J Neurosci 24:9693-7. 2004..Because RCS/N-rdy rats are a model for studies on retinitis pigmentosa in human, our data may provide an important insight on melanopsin function in patients affected by retinitis pigmentosa... - Circadian regulation of the PERIOD 2::LUCIFERASE bioluminescence rhythm in the mouse retinal pigment epithelium-choroidKenkichi Baba
Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30130, USA
Mol Vis 16:2605-11. 2010.... - Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retinaJian Liang
Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
Neuroreport 15:1497-500. 2004..Tph1 and Tph2 transcripts showed robust diurnal rhythms of abundance, with highest levels at night. Our results support the hypothesis that Tph1 is involved in melatonin synthesis in retinal photoreceptor cells... - Analysis of gene expression following norepinephrine stimulation in the rat pineal gland using DNA microarray techniqueChiaki Fukuhara
Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310, USA
J Pineal Res 35:196-203. 2003..Genes encoding enzymes involved in metabolism and structural proteins were decreased following NE stimulation. Identification of genes affected by NE stimulation would provide valuable information to understanding pineal biology fully... - Regulation of period 1 expression in cultured rat pinealChiaki Fukuhara
Morehouse Sch Med, Atlanta, GA
Neurosignals 11:103-14. 2002..Per1 transcription in pinealocytes was activated by BMAL1/CLOCK. Our results indicate that important differences are present in the regulation of these genes in the mammalian pineal... - Induction of photosensitivity in cultured rat pineal affects Aa-nat regulationChiaki Fukuhara
Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Dr. SW, Atlanta, GA 30310-1495, USA
Brain Res Dev Brain Res 142:219-21. 2003.... - The mammalian retina as a clockGianluca Tosini
Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
Cell Tissue Res 309:119-26. 2002..The present review will focus on the current knowledge of the retinal rhythmicity and the mechanisms responsible for its control... - Peripheral circadian oscillators and their rhythmic regulationChiaki Fukuhara
Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
Front Biosci 8:d642-51. 2003..The aim of this review is to summarize the most recent findings on functioning of these extra-SCN oscillators and the mechanisms the SCN controls peripheral oscillators... - Chronic sleep deprivation markedly reduces coagulation factor VII expressionMirko Pinotti
Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr, Atlanta, GA 30310, USA
Haematologica 95:1429-32. 2010..For the first time, we demonstrate that chronic sleep deprivation on its own reduces, in a reversible manner, the FVII expression levels, thus influencing the TF/FVIIa activation pathway efficiency... - Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cellsJuanita Dortch-Carnes
Department of Pharmacology and Toxicology Morehouse School of Medicine, 720 Westview Drive, SW, Atlanta, GA 30310 1495, USA
Exp Eye Res 107:1-10. 2013..These actions may play a role in melatonin agonist-induced regulation of aqueous humor secretion and IOP... - The role of retinal photoreceptors in the regulation of circadian rhythmsKetema N Paul
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
Rev Endocr Metab Disord 10:271-8. 2009.... - Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouseSusana Alcantara-Contreras
Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute and Department of Pharmacology and Toxicology, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30130, United States
Neurosci Lett 494:61-4. 2011.... - Effect of space flight on circadian rhythmsGianluca Tosini
Morehouse Sch Med, Atlanta, GA
Adv Space Biol Med 10:165-74. 2005 - Removal of melatonin receptor type 1 induces insulin resistance in the mouseSusana Contreras-Alcantara
Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia, USA
Obesity (Silver Spring) 18:1861-3. 2010..Our data suggest that MT1 receptors are implicated in the pathogenesis of T2D and open the door for a detailed exploration on the mechanisms by which MT1 receptors signaling may affect glucose metabolism... - Locomotor activity in rodentsGianluca Tosini
Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA
Methods Mol Biol 362:95-101. 2007..In the past few years several companies have developed hardware and software systems that allow the collection and the analysis of activity data using a personal computer... - Time keeping by the quail's eye: circadian regulation of melatonin productionChristopher T Steele
Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
Gen Comp Endocrinol 145:232-6. 2006..The quail retina is proving to be a valuable in vitro model for investigating properties of circadian pacemakers... - Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebratesJames Bellingham
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
PLoS Biol 4:e254. 2006.... - Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillatorsCristiano Bertolucci
Dipartimento di Biochimica e Biologia Molecolare, Universita di Ferrara, Via Fossato di Mortara 74, 44100 Ferrara, Italia
Mol Cell Biol 28:3070-5. 2008..Our data provide the first evidence in peripheral oscillators for an overlapping role of CLOCK and NPAS2 in the regulation of circadianly controlled genes... - Seasonal and diurnal melatonin production in exercising sled dogsKriya L Dunlap
Department of Chemistry and Biochemistry, Box 756160, University of Alaska Fairbanks, Fairbanks, AK 99775, USA
Comp Biochem Physiol A Mol Integr Physiol 147:863-7. 2007..Surprisingly, sled dogs in Alaska had lower melatonin levels than sled dogs in New York...
Research Grants
- Photic and Circadian Regulation of Retinal MelatoninGianluca Tosini; Fiscal Year: 2010..Modern life style has tremendously changed the time at which we expose ourselves to light;hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
- Photic and circadian regulation of retinal melatonin.Gianluca Tosini; Fiscal Year: 2003..Modem life style has tremendously changed our daily exposure to light and darkness and thus it is important to understand the effect that such exposure may have on the organism and, in particular, retinal function. ..
- Photic and circadian regulation of retinal melatonin.Gianluca Tosini; Fiscal Year: 2006..Modem life style has tremendously changed our daily exposure to light and darkness and thus it is important to understand the effect that such exposure may have on the organism and, in particular, retinal function. ..
- Photic and Circadian Regulation of Retinal MelatoninGianluca Tosini; Fiscal Year: 2007..Modern life style has tremendously changed the time at which we expose ourselves to light; hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
- Photic and Circadian Regulation of Retinal MelatoninGianluca Tosini; Fiscal Year: 2009..Modern life style has tremendously changed the time at which we expose ourselves to light; hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
- Photic and Circadian Regulation of Retinal MelatoninGianluca Tosini; Fiscal Year: 2010..Modern life style has tremendously changed the time at which we expose ourselves to light;hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..