Gianluca Tosini

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. pmc Age-related changes in the daily rhythm of photoreceptor functioning and circuitry in a melatonin-proficient mouse strain
    Kenkichi Baba
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Department of Anatomy and Neurobiology, Morehouse School of Medicine, CNR, Pisa, Italy
    PLoS ONE 7:e37799. 2012
  2. pmc Circadian regulation of the PERIOD 2::LUCIFERASE bioluminescence rhythm in the mouse retinal pigment epithelium-choroid
    Kenkichi Baba
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30130, USA
    Mol Vis 16:2605-11. 2010
  3. pmc Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels
    Anamika Sengupta
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute and Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 6:e24483. 2011
  4. pmc N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain
    Gianluca Tosini
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    Neuroscientist 18:645-53. 2012
  5. pmc Melatonin: an underappreciated player in retinal physiology and pathophysiology
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Exp Eye Res 103:82-9. 2012
  6. pmc Localization of a circadian clock in mammalian photoreceptors
    Gianluca Tosini
    Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    FASEB J 21:3866-71. 2007
  7. pmc Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degeneration
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr, Atlanta, GA 30310 1495, USA
    Brain Res 1159:134-40. 2007
  8. pmc The circadian clock system in the mammalian retina
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute Morehouse School of Medicine, Atlanta, GA, USA
    Bioessays 30:624-33. 2008
  9. pmc Effect of photoreceptor degeneration on circadian photoreception and free-running period in the Royal College of Surgeons rat
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Brain Res 1148:76-82. 2007
  10. ncbi request reprint Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retina
    Gianluca Tosini
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Chronobiol Int 23:381-91. 2006

Research Grants

Collaborators

Detail Information

Publications46

  1. pmc Age-related changes in the daily rhythm of photoreceptor functioning and circuitry in a melatonin-proficient mouse strain
    Kenkichi Baba
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Department of Anatomy and Neurobiology, Morehouse School of Medicine, CNR, Pisa, Italy
    PLoS ONE 7:e37799. 2012
    ..This suggests that the responsiveness of the photoreceptors to exogenous melatonin is reduced during aging...
  2. pmc Circadian regulation of the PERIOD 2::LUCIFERASE bioluminescence rhythm in the mouse retinal pigment epithelium-choroid
    Kenkichi Baba
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30130, USA
    Mol Vis 16:2605-11. 2010
    ....
  3. pmc Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels
    Anamika Sengupta
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute and Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 6:e24483. 2011
    ..Finally our data suggest that the circadian regulation of dopamine turnover does not drive the photopic ERG rhythm...
  4. pmc N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain
    Gianluca Tosini
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    Neuroscientist 18:645-53. 2012
    ..In this review, the authors discuss the literature about this exciting and underappreciated molecule...
  5. pmc Melatonin: an underappreciated player in retinal physiology and pathophysiology
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Exp Eye Res 103:82-9. 2012
    ..Administration of exogenous melatonin at night may also be beneficial for ocular health, but additional investigation is needed to establish its potential...
  6. pmc Localization of a circadian clock in mammalian photoreceptors
    Gianluca Tosini
    Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    FASEB J 21:3866-71. 2007
    ..These results demonstrate that mammalian photoreceptors contain the circadian pacemaker driving rhythmic melatonin synthesis...
  7. pmc Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degeneration
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr, Atlanta, GA 30310 1495, USA
    Brain Res 1159:134-40. 2007
    ....
  8. pmc The circadian clock system in the mammalian retina
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute Morehouse School of Medicine, Atlanta, GA, USA
    Bioessays 30:624-33. 2008
    ..BioEssays 30:624-633, 2008. (c) 2008 Wiley Periodicals, Inc...
  9. pmc Effect of photoreceptor degeneration on circadian photoreception and free-running period in the Royal College of Surgeons rat
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Brain Res 1148:76-82. 2007
    ..01) than in rdy(+), thus suggesting that photoreceptor degeneration may affect the free-running period of the locomotor activity rhythm...
  10. ncbi request reprint Regulation of arylalkylamine N-acetyltransferase (AANAT) in the retina
    Gianluca Tosini
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Chronobiol Int 23:381-91. 2006
    ..Finally, it is important to mention that AANAT, in addition to its role in melatonin synthesis, may play a detoxification role in the vertebrate retina by acetylating arylalkylamines that may react with retinaldehyde...
  11. pmc Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor
    Kenkichi Baba
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Proc Natl Acad Sci U S A 106:15043-8. 2009
    ..These data demonstrate the functional significance of melatonin and MT1 receptors in the mammalian retina and create the basis for future studies on the therapeutic use of melatonin in retinal degeneration...
  12. ncbi request reprint Effect of long-term exposure to constant dim light on the circadian system of rats
    Chiaki Fukuhara
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Neurosignals 14:117-25. 2005
    ..Our data suggest that long-term exposure to constant red dim light may induce desynchronization between the circadian rhythm of locomotor activity and serum melatonin levels...
  13. ncbi request reprint Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells
    Katsuhiko Sakamoto
    Neuroscience Institute and NSF Center for Behavioural Neuroscience, Morehouse School of Medicine, 720, Atlanta, GA 30310 1495, USA
    Eur J Neurosci 22:3129-36. 2005
    ..Our study also suggests that DA may have an important role in mediating the light signals that are used for circadian entrainment and for other responses that are mediated by the nonimage-forming visual system...
  14. ncbi request reprint Intraocular injection of kainic acid does not abolish the circadian rhythm of arylalkylamine N-acetyltransferase mRNA in rat photoreceptors
    Katsuhiko Sakamoto
    Neuroscience Institute and National Science Foundation Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Mol Vis 12:117-24. 2006
    ..Recent studies have suggested that retinal dopaminergic neurons contain a circadian pacemaker, and dopamine is the neurotransmitter that drives circadian rhythmicity in the mammalian retina...
  15. ncbi request reprint Paradoxical effects of NPY in the suprachiasmatic nucleus
    Karen L Gamble
    Department of Psychology, Georgia State University, Atlanta, GA, USA
    Eur J Neurosci 23:2488-94. 2006
    ..Thus, these data are the first to demonstrate the paradoxical effects of NPY within the SCN. NPY mimics the effects of light on pineal melatonin and inhibits the effects of light on the induction of Per1 mRNA...
  16. ncbi request reprint Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina
    Chiaki Fukuhara
    Neuroscience Institute and National Science Foundation Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Neurosci 24:1803-11. 2004
    ..Thus, clock control of the cAMP signaling cascade may play a central role in the integration of circadian signals that control physiology and behavior...
  17. ncbi request reprint AMPA/kainate receptor antagonist DNQX blocks the acute increase of Per2 mRNA levels in most but not all areas of the SCN
    Ketema N Paul
    Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302, USA
    Brain Res Mol Brain Res 139:129-36. 2005
    ....
  18. ncbi request reprint Tetrodotoxin administration in the suprachiasmatic nucleus prevents NMDA-induced reductions in pineal melatonin without influencing Per1 and Per2 mRNA levels
    Ketema N Paul
    Center for Behavioural Neuroscience, and Department of Biology, Georgia State University, Atlanta, 30303, USA
    Eur J Neurosci 19:2808-14. 2004
    ....
  19. pmc N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice
    Pradoldej Sompol
    Department of Pathology and Laboratory Medicine and Ophthalmology and Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 108:8844-9. 2011
    ..Thus, our finding demonstrates a unique function of NAS in promoting robust NPC proliferation, which may contribute to hippocampal plasticity during sleeping period...
  20. ncbi request reprint Circadian rhythms in the retina of rats with photoreceptor degeneration
    Katsuhiko Sakamoto
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, Georgia, USA
    J Neurochem 90:1019-24. 2004
    ..These data are the first direct demonstration that circadian rhythmicity in the mammalian retina can be generated independently from the photoreceptors and the suprachiasmatic nuclei of the hypothalamus...
  21. ncbi request reprint Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina
    P Michael Iuvone
    Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, rm 5107, Atlanta, GA 30322, USA
    Prog Retin Eye Res 24:433-56. 2005
    ..The review will cover evidence that cAMP is a major output of the circadian clock in photoreceptor cells; and recent advances indicating that clocks and clock networks occur in multiple cell types of the retina...
  22. pmc N-acetylserotonin activates TrkB receptor in a circadian rhythm
    Sung Wuk Jang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:3876-81. 2010
    ..Hence, our findings support that NAS is more than a melatonin precursor, and that it can potently activate TrkB receptor...
  23. pmc Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina
    Nikita Pozdeyev
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA
    Eur J Neurosci 27:2691-700. 2008
    ..Thus, dopamine release in response to light and circadian clocks drives daily rhythms of protein phosphorylation in photoreceptor cells...
  24. pmc Analysis of daily and circadian gene expression in the rat pineal gland
    Chiaki Fukuhara
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Neurosci Res 60:192-8. 2008
    ..The results obtained with microarray analysis were well correlated with data obtained using real time quantitative RT-PCR. The present results provide new materials to dissect and understand the pineal physiology...
  25. ncbi request reprint Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection
    Cuimei Liu
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Cell Tissue Res 315:197-201. 2004
    ..However, the rhythmic expression of Aa-nat mRNA was observed only in photoreceptor cells...
  26. ncbi request reprint Classical photoreceptors regulate melanopsin mRNA levels in the rat retina
    Katsuhiko Sakamoto
    Neuroscience Institute and National Science Foundation Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Neurosci 24:9693-7. 2004
    ..Because RCS/N-rdy rats are a model for studies on retinitis pigmentosa in human, our data may provide an important insight on melanopsin function in patients affected by retinitis pigmentosa...
  27. ncbi request reprint Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina
    Jian Liang
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Neuroreport 15:1497-500. 2004
    ..Tph1 and Tph2 transcripts showed robust diurnal rhythms of abundance, with highest levels at night. Our results support the hypothesis that Tph1 is involved in melatonin synthesis in retinal photoreceptor cells...
  28. ncbi request reprint Induction of photosensitivity in cultured rat pineal affects Aa-nat regulation
    Chiaki Fukuhara
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Brain Res Dev Brain Res 142:219-21. 2003
    ....
  29. ncbi request reprint Analysis of gene expression following norepinephrine stimulation in the rat pineal gland using DNA microarray technique
    Chiaki Fukuhara
    Neuroscience Institute and NSF Center for Behavioral Neuroscience, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Pineal Res 35:196-203. 2003
    ..Genes encoding enzymes involved in metabolism and structural proteins were decreased following NE stimulation. Identification of genes affected by NE stimulation would provide valuable information to understanding pineal biology fully...
  30. ncbi request reprint Regulation of period 1 expression in cultured rat pineal
    Chiaki Fukuhara
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Neurosignals 11:103-14. 2002
    ..Per1 transcription in pinealocytes was activated by BMAL1/CLOCK. Our results indicate that important differences are present in the regulation of these genes in the mammalian pineal...
  31. ncbi request reprint The mammalian retina as a clock
    Gianluca Tosini
    Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Cell Tissue Res 309:119-26. 2002
    ..The present review will focus on the current knowledge of the retinal rhythmicity and the mechanisms responsible for its control...
  32. ncbi request reprint Peripheral circadian oscillators and their rhythmic regulation
    Chiaki Fukuhara
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Front Biosci 8:d642-51. 2003
    ..The aim of this review is to summarize the most recent findings on functioning of these extra-SCN oscillators and the mechanisms the SCN controls peripheral oscillators...
  33. pmc Chronic sleep deprivation markedly reduces coagulation factor VII expression
    Mirko Pinotti
    Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr, Atlanta, GA 30310, USA
    Haematologica 95:1429-32. 2010
    ..For the first time, we demonstrate that chronic sleep deprivation on its own reduces, in a reversible manner, the FVII expression levels, thus influencing the TF/FVIIa activation pathway efficiency...
  34. pmc Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function
    Kenkichi Baba
    1Neuroscience Institute and Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Sci Signal 6:ra89. 2013
    ..Thus, the MT1/MT2 heteromer complex may provide a specific pharmacological target to improve photoreceptor function. ..
  35. doi request reprint N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain
    P Michael Iuvone
    Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA
    Adv Exp Med Biol 801:765-71. 2014
    ..Hence, NAS may function as an endogenous circadian neurotrophin-like compound and HIOC is a good lead compound for further drug development for treatment of retinal degenerative diseases. ..
  36. pmc Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells
    Juanita Dortch-Carnes
    Department of Pharmacology and Toxicology Morehouse School of Medicine, 720 Westview Drive, SW, Atlanta, GA 30310 1495, USA
    Exp Eye Res 107:1-10. 2013
    ..These actions may play a role in melatonin agonist-induced regulation of aqueous humor secretion and IOP...
  37. pmc The role of retinal photoreceptors in the regulation of circadian rhythms
    Ketema N Paul
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Rev Endocr Metab Disord 10:271-8. 2009
    ....
  38. pmc Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse
    Susana Alcantara-Contreras
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute and Department of Pharmacology and Toxicology, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30130, United States
    Neurosci Lett 494:61-4. 2011
    ....
  39. ncbi request reprint Effect of space flight on circadian rhythms
    Gianluca Tosini
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA
    Adv Space Biol Med 10:165-74. 2005
  40. pmc Removal of melatonin receptor type 1 induces insulin resistance in the mouse
    Susana Contreras-Alcantara
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Obesity (Silver Spring) 18:1861-3. 2010
    ..Our data suggest that MT1 receptors are implicated in the pathogenesis of T2D and open the door for a detailed exploration on the mechanisms by which MT1 receptors signaling may affect glucose metabolism...
  41. ncbi request reprint Locomotor activity in rodents
    Gianluca Tosini
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA
    Methods Mol Biol 362:95-101. 2007
    ..In the past few years several companies have developed hardware and software systems that allow the collection and the analysis of activity data using a personal computer...
  42. doi request reprint Is the melatonin receptor type 1 involved in the pathogenesis of glaucoma?
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine Atlanta, GA, USA
    J Glaucoma 22:S49-50. 2013
    ..These new studies suggest that dysfunctional melatonin signaling may be considered a possible risk factor in the pathogenesis of glaucoma and that mice deficient in MT1 receptors may be an animal model of glaucoma...
  43. ncbi request reprint Time keeping by the quail's eye: circadian regulation of melatonin production
    Christopher T Steele
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Gen Comp Endocrinol 145:232-6. 2006
    ..The quail retina is proving to be a valuable in vitro model for investigating properties of circadian pacemakers...
  44. pmc Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators
    Cristiano Bertolucci
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Ferrara, Via Fossato di Mortara 74, 44100 Ferrara, Italia
    Mol Cell Biol 28:3070-5. 2008
    ..Our data provide the first evidence in peripheral oscillators for an overlapping role of CLOCK and NPAS2 in the regulation of circadianly controlled genes...
  45. pmc Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates
    James Bellingham
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS Biol 4:e254. 2006
    ....
  46. ncbi request reprint Seasonal and diurnal melatonin production in exercising sled dogs
    Kriya L Dunlap
    Department of Chemistry and Biochemistry, Box 756160, University of Alaska Fairbanks, Fairbanks, AK 99775, USA
    Comp Biochem Physiol A Mol Integr Physiol 147:863-7. 2007
    ..Surprisingly, sled dogs in Alaska had lower melatonin levels than sled dogs in New York...

Research Grants9

  1. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2010
    ..Modern life style has tremendously changed the time at which we expose ourselves to light;hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  2. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2010
    ..Modern life style has tremendously changed the time at which we expose ourselves to light;hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  3. Photic and circadian regulation of retinal melatonin.
    Gianluca Tosini; Fiscal Year: 2003
    ..Modem life style has tremendously changed our daily exposure to light and darkness and thus it is important to understand the effect that such exposure may have on the organism and, in particular, retinal function. ..
  4. Photic and circadian regulation of retinal melatonin.
    Gianluca Tosini; Fiscal Year: 2006
    ..Modem life style has tremendously changed our daily exposure to light and darkness and thus it is important to understand the effect that such exposure may have on the organism and, in particular, retinal function. ..
  5. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2007
    ..Modern life style has tremendously changed the time at which we expose ourselves to light; hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  6. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2009
    ..Modern life style has tremendously changed the time at which we expose ourselves to light; hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..