Shailesh Singh

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. pmc Chemokines: key players in cancer progression and metastasis
    Rajesh Singh
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Front Biosci (Schol Ed) 3:1569-82. 2011
  2. pmc CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion
    Erica L Johnson
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    J Ovarian Res 3:15. 2010
  3. pmc CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis
    Udai P Singh
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, USA
    BMC Immunol 9:25. 2008
  4. pmc Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A
    Rajesh Singh
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 5:e9432. 2010
  5. pmc CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion
    Erica L Johnson
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    World J Surg Oncol 8:62. 2010
  6. ncbi request reprint CCL5 modulates pneumococcal immunity and carriage
    Ravichandran Palaniappan
    Mercer University, Atlanta, GA 30341, USA
    J Immunol 176:2346-56. 2006
  7. ncbi request reprint Expression and functional role of CCR9 in prostate cancer cell migration and invasion
    Shailesh Singh
    Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Clin Cancer Res 10:8743-50. 2004
  8. pmc CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibition
    Udai P Singh
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Interferon Cytokine Res 28:31-43. 2008
  9. ncbi request reprint Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts
    Udai P Singh
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 173:5509-16. 2004
  10. pmc Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer
    Rajesh Singh
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Int J Oncol 39:373-81. 2011

Collaborators

Detail Information

Publications19

  1. pmc Chemokines: key players in cancer progression and metastasis
    Rajesh Singh
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Front Biosci (Schol Ed) 3:1569-82. 2011
    ..In this review, we have discussed current advances in understanding the role of the chemokines and their corresponding receptor in tumor progression and metastasis...
  2. pmc CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion
    Erica L Johnson
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    J Ovarian Res 3:15. 2010
    ..In this study, we investigated the potential role and molecular mechanisms of CCR9-mediated inhibition of cisplatin-induced apoptosis in OvCa cells...
  3. pmc CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis
    Udai P Singh
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, USA
    BMC Immunol 9:25. 2008
    ..The present study dissects some of the common cellular and molecular mechanism that drive Mycobacteria-mediated and spontaneous colitis in IL-10-/- mice...
  4. pmc Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A
    Rajesh Singh
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 5:e9432. 2010
    ....
  5. pmc CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion
    Erica L Johnson
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    World J Surg Oncol 8:62. 2010
    ..The current study shows OvCa tissue and cells significantly express CCR9, which interacts with CCL25 to support carcinoma cell migration and invasion...
  6. ncbi request reprint CCL5 modulates pneumococcal immunity and carriage
    Ravichandran Palaniappan
    Mercer University, Atlanta, GA 30341, USA
    J Immunol 176:2346-56. 2006
    ..These data suggest that CCL5 is an essential factor for the induction and maintenance of protective pneumococcal immunity...
  7. ncbi request reprint Expression and functional role of CCR9 in prostate cancer cell migration and invasion
    Shailesh Singh
    Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Clin Cancer Res 10:8743-50. 2004
    ..The current study evaluates the molecular mechanisms of CCL25 and CCR9 in prostate cancer cell migration and invasion...
  8. pmc CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibition
    Udai P Singh
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Interferon Cytokine Res 28:31-43. 2008
    ..Our data also support the premise that CXCL10 blockade can attenuate chronic colitis by preventing the activation and recruitment of CXCR3+ leukocytes during IBD...
  9. ncbi request reprint Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts
    Udai P Singh
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 173:5509-16. 2004
    ..Taken together, these studies suggest that CCR8 ligands direct host Th2 responses, and vMIP-II up-regulates IL-10 responses and limits costimulatory molecule expression to mitigate host immunity...
  10. pmc Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer
    Rajesh Singh
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Int J Oncol 39:373-81. 2011
    ..Expression of this chemokine receptor and its ligand CCL25 within primary tumor tissue further suggests a potential role of this chemokine-receptor axis in ovarian cancer progression...
  11. pmc CCL5-independent helper T lymphocyte responses to immuno-dominant pneumococcal surface protein A epitopes
    Rajesh Singh
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Vaccine 30:1181-90. 2012
    ..These data confirm CCL5 is an essential factor for optimal pneumococcal adaptive immunity and show CD4(+) T cell responses to PspA(199-246) are largely resistant to CCL5 deficiency...
  12. pmc CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion
    Crystal Johnson-Holiday
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Int J Oncol 38:1279-85. 2011
    ....
  13. pmc CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion
    Crystal Johnson-Holiday
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 USA
    World J Surg Oncol 9:46. 2011
    ..In this study we have shown potential role of CCR9-CCL25 axis in breast cancer cell survival and therapeutic efficacy of cisplatin...
  14. ncbi request reprint Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta interactions
    Udai P Singh
    Department of Microbiology, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Leukoc Biol 76:1240-7. 2004
    ..In contrast, cytokine and costimulatory molecule enhancement by GCP-2 was not induced by lymphocytes from IL-8Rbeta-/- mice, suggesting that GCP-2 modulates cellular immunity in part through IL-8Rbeta interactions...
  15. ncbi request reprint CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion
    Shailesh Singh
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    Lab Invest 84:1666-76. 2004
    ..These studies reveal important cellular and molecular mechanisms of CXCR4/CXCL12-mediated prostate cancer cell migration and invasion...
  16. ncbi request reprint Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 174:4860-9. 2005
    ..Collectively, these results provide a molecular basis for the high Th1-activating capacity of IL-10KO APC and may provide unique immunomodulation targets when designing vaccines against pathogens controlled by T cell immunity...
  17. pmc Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage
    Ravichandran Palaniappan
    Department of Pharmaceutical Sciences, Southern School of Pharmacy, Atlanta, GA 30310 1495, USA
    Infect Immun 73:1006-13. 2005
    ..Taken together, these findings suggest that PsaA- and PspA-specific mucosal responses as well as systemic humoral and T helper cell cytokine responses are predominantly yet differentially induced during pneumococcal carriage...
  18. pmc Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression
    Teri L Larkins
    Department of Microbiology, Immunology and Biochemistry Morehouse School of Medicine Atlanta, GA 30310 1495, USA
    BMC Cancer 6:181. 2006
    ..Here, we correlate the inhibition of COX-2 activity with decreased breast cancer cell proliferation, migration, invasion and matrix metalloproteinase (MMP) expression...
  19. ncbi request reprint IFN-gamma-inducible chemokines enhance adaptive immunity and colitis
    Udai P Singh
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Interferon Cytokine Res 23:591-600. 2003
    ..Taken together, these studies suggest that IP-10, MIG, I-TAC, and CXCR3 interactions are involved in mucosal immune responses required for the induction of CD...