S S Pierangeli

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. ncbi Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin
    S S Pierangeli
    Department of Microbiology and Immunology, Morehouse School of Medicine Atlanta, GA 30310 1495, USA
    Circ Res 88:245-50. 2001
  2. ncbi A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr SW, Rm 331 BSMB, Atlanta, GA 30310 1495, USA
    J Autoimmun 22:217-25. 2004
  3. ncbi Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Thromb Res 114:467-76. 2004
  4. ncbi Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
  5. ncbi Testing for antiphospholipid antibodies: problems and solutions
    S S Pierangeli
    Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Clin Obstet Gynecol 44:48-57; quiz 58-9. 2001
  6. ncbi Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models
    S S Pierangeli
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Thromb Haemost 84:388-95. 2000
  7. ncbi Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    S S Pierangeli
    Department of Microbiology and Immunology, Antiphospholipid Standardization Laboratory, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Circulation 99:1997-2002. 1999
  8. ncbi Origin of antiphospholipid antibodies: induction of aPL by viral peptides
    A E Gharavi
    Morehouse School of Medicine, Department of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 7:S52-4. 1998
  9. ncbi Identification of an Fc gamma receptor-independent mechanism by which intravenous immunoglobulin ameliorates antiphospholipid antibody-induced thrombogenic phenotype
    S S Pierangeli
    Morehouse School of Medicine, Atlanta, Georgia 30310-1495, USA
    Arthritis Rheum 44:876-83. 2001
  10. ncbi E-Selectin mediates pathogenic effects of antiphospholipid antibodies
    R G Espinola
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Thromb Haemost 1:843-8. 2003

Collaborators

Detail Information

Publications42

  1. ncbi Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin
    S S Pierangeli
    Department of Microbiology and Immunology, Morehouse School of Medicine Atlanta, GA 30310 1495, USA
    Circ Res 88:245-50. 2001
    ..The data indicate that ICAM-1, P-selectin, and VCAM-1 expression are important in thrombotic complications by aPL antibodies and may provide novel targets for therapy in patients with APS...
  2. ncbi A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr SW, Rm 331 BSMB, Atlanta, GA 30310 1495, USA
    J Autoimmun 22:217-25. 2004
    ..Peptide A is also found in region I/II of beta2GPI. A scrambled form of peptide A (named scA, GTKGCPNVRLT) was used as a control...
  3. ncbi Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Thromb Res 114:467-76. 2004
    ....
  4. ncbi Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
    ..Hence, the interplay between aPL antibodies and ECs is important inthe pathogenesis of thrombosis in APS...
  5. ncbi Testing for antiphospholipid antibodies: problems and solutions
    S S Pierangeli
    Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Clin Obstet Gynecol 44:48-57; quiz 58-9. 2001
    ..We thank Dr Isabel Abreu and Dr Mittermeyer B. Santiago for performing some of the studies reported in this review...
  6. ncbi Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models
    S S Pierangeli
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Thromb Haemost 84:388-95. 2000
    ..These data show that about 2/3 patient-derived IgG monoclonal aCL are thrombogenic and suggest that some thrombogenic IgG aCL exert their effects through activating EC...
  7. ncbi Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    S S Pierangeli
    Department of Microbiology and Immunology, Antiphospholipid Standardization Laboratory, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Circulation 99:1997-2002. 1999
    ..Adhesion molecule expression on human umbilical vein endothelial cells (HUVECs) after aPL exposure was performed to confirm EC activation in vitro...
  8. ncbi Origin of antiphospholipid antibodies: induction of aPL by viral peptides
    A E Gharavi
    Morehouse School of Medicine, Department of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 7:S52-4. 1998
    ..We also induced aPL and anti-beta2-GPI in mice by immunization with PL-binding viral peptides and hypothesized that in APS patients, aPL may be induced by beta2GPI-like-PL-binding products of common human bacteria and viruses...
  9. ncbi Identification of an Fc gamma receptor-independent mechanism by which intravenous immunoglobulin ameliorates antiphospholipid antibody-induced thrombogenic phenotype
    S S Pierangeli
    Morehouse School of Medicine, Atlanta, Georgia 30310-1495, USA
    Arthritis Rheum 44:876-83. 2001
    ..These results have implications in the management of thrombosis in APS and may have applications for pregnant patients with a history of APS...
  10. ncbi E-Selectin mediates pathogenic effects of antiphospholipid antibodies
    R G Espinola
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Thromb Haemost 1:843-8. 2003
    ..This enhancement in thrombus size by aPL antibodies was abrogated in E-selectin-deficient mice treated with aPL antibodies...
  11. ncbi Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation
    M E Vega-Ostertag
    Antiphospholipid Standardization Laboratory, Morehouse School of Medicine, Atlanta, GA, USA
    J Thromb Haemost 5:1828-34. 2007
    ..The purpose of this study was to examine whether SB 203580, a p38 mitogen-activated protein kinase (MAPK) inhibitor, is effective in reversing the pathogenic effects of antiphospholipid antibodies...
  12. ncbi GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 163:2922-7. 1999
    ..These data indicate that aPL induced by immunization with the phospholipid binding site of beta2GPI are thrombogenic and activate endothelial cells...
  13. ncbi A peptide that mimics the Vth region of beta-2-glycoprotein I reverses antiphospholipid-mediated thrombosis in mice
    M Vega Ostertag
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 15:358-65. 2006
    ..The data indicate that TIFI abrogates thrombogenic properties of aPL in mice by competing with beta2GPI and preventing its binding to target cells. This may be important in designing new modalities for the treatment of thrombosis in APS...
  14. ncbi Origin of antiphospholipid antibodies
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA
    Rheum Dis Clin North Am 27:551-63. 2001
    ..Identification of those bacterial or viral agents may help to find strategies for the prevention of production of "pathogenic" aPL. Alternatively, free peptides may be used to induce tolerance against aPL production...
  15. ncbi Intrauterine fetal death in mice caused by cytomegalovirus-derived peptide induced aPL antibodies
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    Lupus 13:17-23. 2004
    ....
  16. ncbi New developments in viral peptides and APL induction
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Autoimmun 15:227-30. 2000
    ..We hypothesize that in APS patients aPL is induced by beta(2)-GPL-like PL-binding products of human common bacteria or viruses...
  17. pmc Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies
    Silvia S Pierangeli
    Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1165, USA
    Ann Rheum Dis 66:1327-33. 2007
    ....
  18. ncbi Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells
    D E Ferrara
    Antiphospholipid Standardization Laboratory, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Thromb Haemost 2:1558-63. 2004
    ..In a recent study, fluvastatin inhibited thrombogenic and proinflammatory properties of aPL antibodies in in vivo models. The aim of this study was to determine whether fluvastatin has an effect on aPL-induced expression of TF on ECs...
  19. ncbi Mechanisms of pregnancy loss in antiphospholipid syndrome
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Clin Obstet Gynecol 44:11-9. 2001
    ....
  20. ncbi Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model
    Dardo E Ferrara
    Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Arthritis Rheum 48:3272-9. 2003
    ..This study uses an in vivo mouse model to investigate whether fluvastatin has an effect on decreasing both the adhesion of leukocytes to ECs and the thrombus formation induced by aPL...
  21. ncbi Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    Ricardo G Espinola
    Department of Microbiology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Thromb Haemost 87:518-22. 2002
    ..0125 mM). This suggests at least one possible mechanism by which HQ may prevent thrombosis. This may have important implications in treatment of thrombosis in APS patients...
  22. ncbi Revisiting the anticardiolipin test and its standardization
    E N Harris
    Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Lupus 11:269-75. 2002
    ..Whether using a kit or a bench assay, meticulous attention to detail offers the best opportunity for precision and reproducibility...
  23. ncbi In search for a receptor for antiphospholipid antibodies on target cells
    S S Pierangeli
    Division of Rheumatology, Department of Medicine, University of Texas Medical Branch, Galveston, TX, USA
    J Thromb Haemost 4:1678-9. 2006
  24. ncbi Antiphospholipid antibodies and the antiphospholipid syndrome: an update on treatment and pathogenic mechanisms
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology Morehouse School of Medicine, Atlanta, GA 30310 1459, USA
    Curr Opin Hematol 13:366-75. 2006
    ..Since its recognition in the 1980s, growing interest in the field, not only with respect to diagnosis and treatment, but also regarding the pathogenesis of antiphospholipid antibodies, has emerged...
  25. ncbi Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo
    Azzudin E Gharavi
    Department of Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Arthritis Rheum 46:545-52. 2002
    ..To characterize the binding and functional properties of antiphospholipid antibodies (aPL) induced by immunization with a viral peptide and to determine whether aPL are pathogenic in vivo...
  26. ncbi Complement activation: a novel pathogenic mechanism in the antiphospholipid syndrome
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Ann N Y Acad Sci 1051:413-20. 2005
    ..Our data show that complement activation mediates two important effectors of aPL antibodies: induction of thrombosis and endothelial activation...
  27. ncbi Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Arthritis Rheum 52:2120-4. 2005
    ..In this study, we tested the hypothesis that aPL are responsible for activation of complement, thus generating split products that induce thrombosis...
  28. ncbi Clinical laboratory testing for the antiphospholipid syndrome
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, USA
    Clin Chim Acta 357:17-33. 2005
    ..Therefore, it is now recommended to include both tests, IgA aCL and IgG, IgM and IgA anti-beta2GPI to confirm diagnosis of APS...
  29. ncbi Primary, Secondary, Catastrophic Antiphospholipid Syndrome: is there a difference?
    E Nigel Harris
    Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Thromb Res 114:357-61. 2004
    ....
  30. ncbi Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin
    Mariano Vega-Ostertag
    Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Arthritis Rheum 50:2911-9. 2004
    ..The intracellular events involved in aPL-mediated platelet activation are not fully understood and are therefore the subject of this study...
  31. doi 'Criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas, April 2010
    S S Pierangeli
    Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 0883, USA
    Lupus 20:182-90. 2011
    ..This report summarizes the findings, conclusions, and recommendations of this Task Force...
  32. doi A quarter of a century in anticardiolipin antibody testing and attempted standardization has led us to here, which is?
    Silvia S Pierangeli
    Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1165, USA
    Semin Thromb Hemost 34:313-28. 2008
    ....
  33. ncbi Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies
    Mariano Vega-Ostertag
    Morehouse School of Medicine, Atlanta, Georgia, USA
    Arthritis Rheum 52:1545-54. 2005
    ....
  34. ncbi Viral origin of antiphospholipid antibodies: endothelial cell activation and thrombus enhancement by CMV peptide-induced APL antibodies
    Azzudin E Gharavi
    Dept of Medicine, Morehouse School of Medicine, University of Atlanta, Atlanta Georgia 30310 1495, USA
    Immunobiology 207:37-42. 2003
    ..Identification of these bacterial and/ or viral agents may help to find strategies for the prevention of production of aPL "pathogenic" antibodies. Alternatively, free peptides may be used to induce tolerance against aPL production...
  35. doi Statins for the treatment of antiphospholipid syndrome?
    Praveen Jajoria
    Department of Internal Medicine, Antiphospholipid Standardization Laboratory, University of Texas Medical Branch, Galveston, Texas 77555 0883, USA
    Ann N Y Acad Sci 1173:736-45. 2009
    ..The data from this study show that statins may be beneficial in aPL-positive patients and warrant larger clinical trials to confirm the efficacy of the drug for the treatment of APS clinical manifestations...
  36. ncbi Mechanisms of aPL-mediated thrombosis: effects of aPL on endothelium and platelets
    Mariano E Vega-Ostertag
    Laboratory of Hemostasia and Thrombosis, Instituto Fares Taie, Rivadavia, Mar del Plata, Buenos Aires, Argentina
    Curr Rheumatol Rep 9:190-7. 2007
    ..This review discusses and summarizes the most current data available on molecular interactions and pathogenic mechanisms in antiphospholipid syndrome...
  37. pmc Complement C3 activation is required for antiphospholipid antibody-induced fetal loss
    V Michael Holers
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Exp Med 195:211-20. 2002
    ..While antigenic epitopes recognized by aPL antibodies are important in the pathogenesis of APS, our data show that in vivo complement activation is required for aPL antibody-induced fetal loss and growth retardation...
  38. ncbi New targeted therapies for treatment of thrombosis in antiphospholipid syndrome
    Silvia S Pierangeli
    Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1165, USA
    Expert Rev Mol Med 9:1-15. 2007
    ..Based on this information and on additional scientific evidence using in vitro and in vivo models, new potential targeted therapies for treatment and/or prevention of thrombosis in APS are proposed and discussed...
  39. ncbi A protocol for determination of anticardiolipin antibodies by ELISA
    Silvia S Pierangeli
    Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Nat Protoc 3:840-8. 2008
    ..This article details a procedure that takes approximately 2 h and summarizes the information available on the aCL ELISA test...
  40. ncbi Diverse effects of statins on endothelial cells?
    Dardo E Ferrara
    Thromb Haemost 93:186-8. 2005
  41. ncbi C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies
    Zurina Romay-Penabad
    Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1165, USA
    Ann N Y Acad Sci 1108:554-66. 2007
    ..The data indicate that C5aR-/- mice are protected from the thrombogenic effects of some aPL antibodies...
  42. ncbi B lymphocyte stimulator protein-associated increase in circulating autoantibody levels may require CD4+ T cells: lessons from HIV-infected patients
    William Stohl
    Division of Rheumatology, Department of Medicine, Los Angeles County, Los Angeles, CA, USA
    Clin Immunol 104:115-22. 2002
    ..This raises the possibility that the combination of a BLyS protein antagonist with an agent that targets (helper) T cells may have salutary synergistic effects on autoantibody production in diseases such as systemic lupus erythematosus...