J U Igietseme

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. pmc Chlamydial infection in inducible nitric oxide synthase knockout mice
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 66:1282-6. 1998
  2. ncbi request reprint Chlamydia vaccines: strategies and status
    Joseph U Igietseme
    Microbiology and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, Georgia 30310, USA
    BioDrugs 16:19-35. 2002
  3. pmc Inflammation and clearance of Chlamydia trachomatis in enteric and nonenteric mucosae
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 69:1832-40. 2001
  4. pmc Induction of protective immunity against Chlamydia trachomatis genital infection by a vaccine based on major outer membrane protein-lipophilic immune response-stimulating complexes
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 68:6798-806. 2000
  5. pmc Route of infection that induces a high intensity of gamma interferon-secreting T cells in the genital tract produces optimal protection against Chlamydia trachomatis infection in mice
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 66:4030-5. 1998
  6. ncbi request reprint Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 164:4212-9. 2000
  7. pmc Induction of immune memory by a multisubunit chlamydial vaccine
    F O Eko
    Department of Microbiology, Immunology and Biochemistry, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Vaccine 29:1472-80. 2011
  8. pmc Evaluation of a broadly protective Chlamydia-cholera combination vaccine candidate
    F O Eko
    Morehouse School of Medicine, Atlanta, GA, United States
    Vaccine 29:3802-10. 2011
  9. ncbi request reprint Immune control of Chlamydial growth in the human epithelial cell line RT4 involves multiple mechanisms that include nitric oxide induction, tryptophan catabolism and iron deprivation
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Microbiol Immunol 42:617-25. 1998
  10. pmc The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice
    J U Igietseme
    Department of Microbiology, Morehouse School of Medicine, Spelman College, Atlanta, GA, USA
    Immunology 98:510-9. 1999

Detail Information

Publications11

  1. pmc Chlamydial infection in inducible nitric oxide synthase knockout mice
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 66:1282-6. 1998
    ..trachomatis by infected macrophages...
  2. ncbi request reprint Chlamydia vaccines: strategies and status
    Joseph U Igietseme
    Microbiology and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, Georgia 30310, USA
    BioDrugs 16:19-35. 2002
    ..However, more research efforts and support are needed to achieve the worthy goal of protecting a significant number of the world's population from the devastating consequences of chlamydial invasion of the human mucosal epithelia...
  3. pmc Inflammation and clearance of Chlamydia trachomatis in enteric and nonenteric mucosae
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 69:1832-40. 2001
    ..The implications of these data for the common mucosal immune system and the delivery of vaccines against mucosal pathogens are discussed...
  4. pmc Induction of protective immunity against Chlamydia trachomatis genital infection by a vaccine based on major outer membrane protein-lipophilic immune response-stimulating complexes
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 68:6798-806. 2000
    ..Altogether, the results suggested that IM delivery of MOMP-ISCOMs may be a suitable vaccine regimen potentially capable of inducing protective mucosal immunity against C. trachomatis infection...
  5. pmc Route of infection that induces a high intensity of gamma interferon-secreting T cells in the genital tract produces optimal protection against Chlamydia trachomatis infection in mice
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 66:4030-5. 1998
    ..Therefore, i.n. immunization is a potential delivery route of choice in the development of a vaccine against Chlamydia...
  6. ncbi request reprint Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 164:4212-9. 2000
    ..These findings may furnish a novel immunotherapeutic strategy for boosting the Th1 response against T cell-controlled pathogens and tumors, using IL-10-deficient APCs as vaccine delivery agents...
  7. pmc Induction of immune memory by a multisubunit chlamydial vaccine
    F O Eko
    Department of Microbiology, Immunology and Biochemistry, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Vaccine 29:1472-80. 2011
    ..The data support further vaccine evaluation and testing for induction of long-term protective immunity...
  8. pmc Evaluation of a broadly protective Chlamydia-cholera combination vaccine candidate
    F O Eko
    Morehouse School of Medicine, Atlanta, GA, United States
    Vaccine 29:3802-10. 2011
    ....
  9. ncbi request reprint Immune control of Chlamydial growth in the human epithelial cell line RT4 involves multiple mechanisms that include nitric oxide induction, tryptophan catabolism and iron deprivation
    J U Igietseme
    Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Microbiol Immunol 42:617-25. 1998
    ..These results indicate that immune control of chlamydial growth in human epithelial cells may involve multiple mechanisms that include NO induction, tryptophan catabolism and Fe deprivation...
  10. pmc The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice
    J U Igietseme
    Department of Microbiology, Morehouse School of Medicine, Spelman College, Atlanta, GA, USA
    Immunology 98:510-9. 1999
    ..Taken together, these results indicated that ICAM-1 is crucial for rapid T-cell activation, early recruitment and control of genitally acquired Chlamydia trachomatis...
  11. ncbi request reprint Sequence analysis of HIV-1 insertion sites in peripheral blood lymphocytes
    D Lyn
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Cell Mol Biol (Noisy-le-grand) 47:981-6. 2001
    ..Altogether, it is expected that this approach will yield new information on sites of integration by HIV-1 that may be associated with the pathogenic manifestations of disease progression...