Genomes and Genes
Jacqueline M Hibbert
Affiliation: Morehouse School of Medicine
- Proinflammatory cytokines and the hypermetabolism of children with sickle cell diseaseJacqueline M Hibbert
Microbiology Biochemistry Immunology Pediatrics, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, Georgia 30310 1495, USA
Exp Biol Med (Maywood) 230:68-74. 2005....
- Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemiaJacqueline M Hibbert
Department of Biochemistry, Morehouse School of Medicine, Atlanta, GA, USA
J Pediatr Gastroenterol Nutr 43:680-7. 2006..We hypothesized that an elevated hemoglobin synthesis rate (SynHb) and myocardial oxygen consumption (MVO2) contribute to the excess protein and energy metabolism reported in children with sickle cell anemia...
- Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemiaHyacinth I Hyacinth
Genomics and Hemoglobinopathies Training Program, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, USA
Cytokine 60:302-8. 2012..Stroke incidence and high TCD velocity were associated with elevated BDNF and PDGF-AA. These findings suggest a role for BDNF and PDGF-AA in the patho-physiological mechanism of cerebrovascular disease in SCA...
- Elevated IL-1α and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestrationAdel Driss
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA
Dis Markers 32:295-300. 2012..These observations are consistent with acute splenic sequestration having a distinct phenotype which may be helpful in predicting those at risk of this complication and suggest that the mechanism of these differences merit further study...
- Pregnancy outcomes among patients with sickle cell disease at Korle-Bu Teaching Hospital, Accra, Ghana: retrospective cohort studyNana O Wilson
Morehouse School of Medicine, Department of Microbiology, Biochemistry and Immunology, Atlanta, GA 30310, USA
Am J Trop Med Hyg 86:936-42. 2012..Improved maternal and fetal outcomes in Ghanaian women with SCD can be achieved through effective intervention by health care providers with thorough knowledge about predisposing factors toward adverse outcomes...
- Plasma interleukin-1beta concentration is associated with stroke in sickle cell diseaseKwaku Asare
Morehouse School of Medicine, Atlanta, GA 30310, USA
Cytokine 49:39-44. 2010..This result demonstrates a strong association of systemic inflammation with stroke development in HbSS via moderately increased plasma IL-1beta concentration, which is furthermore associated with a decreased likelihood of stroke in HbSS...
- C-reactive protein and interleukin-6 are decreased in transgenic sickle cell mice fed a high protein dietDavid R Archer
Emory University School of Medicine and the Aflac Cancer Center and Blood Disorders Service, Atlanta, GA 30322, USA
J Nutr 138:1148-52. 2008..Dietary L-arginine availability was investigated as a possible mechanism for increased nitric oxide production and consequent reduced inflammation...
- Heme mediated STAT3 activation in severe malariaMingli Liu
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
PLoS ONE 7:e34280. 2012..We therefore tested the hypothesis that these factors share common signaling pathways and may be mutually regulated...
- Genetic polymorphisms linked to susceptibility to malariaAdel Driss
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
Malar J 10:271. 2011....
- CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implicationsMingli Liu
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
Cytokine Growth Factor Rev 22:121-30. 2011..The potential utilization of CXCL10 as a therapeutic target for infectious diseases is discussed...