Qing He

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. ncbi request reprint Biodegradable calcium phosphate nanoparticles as a new vehicle for delivery of a potential ocular hypotensive agent
    Teh Ching Chu
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Ocul Pharmacol Ther 18:507-14. 2002
  2. ncbi request reprint Delivery of Chlamydia vaccines
    Joseph Igietseme
    National Center for Infectious Disease CDC, Atlanta, GA 30333, USA
    Expert Opin Drug Deliv 2:549-62. 2005
  3. pmc Calcium phosphate nanoparticles induce mucosal immunity and protection against herpes simplex virus type 2
    Qing He
    BioSante Pharmaceuticals, Inc, Smyrna, Georgia 30082, USA
    Clin Diagn Lab Immunol 9:1021-4. 2002
  4. ncbi request reprint A recombinant multivalent combination vaccine protects against Chlamydia and genital herpes
    LuCinda MacMillan
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    FEMS Immunol Med Microbiol 49:46-55. 2007
  5. doi request reprint Chlamydial infection in vitamin D receptor knockout mice is more intense and prolonged than in wild-type mice
    Qing He
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Steroid Biochem Mol Biol 135:7-14. 2013
  6. pmc Involvement of LEK1 in dendritic cell regulation of T cell immunity against Chlamydia
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 181:4037-42. 2008
  7. ncbi request reprint Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccine
    Godwin O Ifere
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Microbiol Immunol Infect 40:188-200. 2007
  8. pmc Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines
    Qing He
    National Center for Infectious Disease, CDC, Atlanta, GA, USA
    Immunology 122:28-37. 2007
  9. ncbi request reprint Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 174:4860-9. 2005
  10. pmc Role of T lymphocytes in the pathogenesis of Chlamydia disease
    Joseph U Igietseme
    Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Infect Dis 200:926-34. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Biodegradable calcium phosphate nanoparticles as a new vehicle for delivery of a potential ocular hypotensive agent
    Teh Ching Chu
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Ocul Pharmacol Ther 18:507-14. 2002
    ..It is concluded that CAP, as a delivery system, enhances activity by 7-OH-DPAT in pigmented rabbit eyes suggesting that CAP is potentially useful for achieving controlled and targeted drug delivery for treatment of ocular diseases...
  2. ncbi request reprint Delivery of Chlamydia vaccines
    Joseph Igietseme
    National Center for Infectious Disease CDC, Atlanta, GA 30333, USA
    Expert Opin Drug Deliv 2:549-62. 2005
    ..The application of these novel delivery strategies to Chlamydia vaccine design could culminate in timely achievement of an efficacious vaccine...
  3. pmc Calcium phosphate nanoparticles induce mucosal immunity and protection against herpes simplex virus type 2
    Qing He
    BioSante Pharmaceuticals, Inc, Smyrna, Georgia 30082, USA
    Clin Diagn Lab Immunol 9:1021-4. 2002
    ..In conclusion, these preclinical data support the hypothesis that CAP may be an effective mucosal adjuvant that protects against viral infection...
  4. ncbi request reprint A recombinant multivalent combination vaccine protects against Chlamydia and genital herpes
    LuCinda MacMillan
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    FEMS Immunol Med Microbiol 49:46-55. 2007
    ..Thus, the combination vaccine regimen delivered by rVCG elicited adequate immune effectors that simultaneously protected against the individual pathogens...
  5. doi request reprint Chlamydial infection in vitamin D receptor knockout mice is more intense and prolonged than in wild-type mice
    Qing He
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Steroid Biochem Mol Biol 135:7-14. 2013
    ..We conclude that the vitamin D endocrine system reduces the risk for prolonged chlamydial infections through regulation of several proteins and that LEI is involved in its anti-inflammatory activity...
  6. pmc Involvement of LEK1 in dendritic cell regulation of T cell immunity against Chlamydia
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 181:4037-42. 2008
    ..Targeted modulation of LEK1 expression provides a novel strategy for augmenting the immunostimulatory function of DCs for inducing an effective immunity against pathogens...
  7. ncbi request reprint Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccine
    Godwin O Ifere
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Microbiol Immunol Infect 40:188-200. 2007
    ..We examined whether a vaccine composed of a combination of the major outer membrane protein (MOMP) and porin B protein (PorB) of C. trachomatis would have a protective advantage over a single subunit construct...
  8. pmc Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines
    Qing He
    National Center for Infectious Disease, CDC, Atlanta, GA, USA
    Immunology 122:28-37. 2007
    ..Because live attenuated influenza virus vaccines are safe and acceptable for human use, they may provide a new and reliable approach to deliver efficacious vaccines against sexually transmitted diseases...
  9. ncbi request reprint Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 174:4860-9. 2005
    ..Collectively, these results provide a molecular basis for the high Th1-activating capacity of IL-10KO APC and may provide unique immunomodulation targets when designing vaccines against pathogens controlled by T cell immunity...
  10. pmc Role of T lymphocytes in the pathogenesis of Chlamydia disease
    Joseph U Igietseme
    Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Infect Dis 200:926-34. 2009
    ..Furthermore, T cell subsets, especially CD8 T cells, play a major role in Chlamydia-induced infertility. The results have important implications for the immunopathogenesis of chlamydial disease and new vaccine strategies...
  11. pmc A Vibrio cholerae ghost-based subunit vaccine induces cross-protective chlamydial immunity that is enhanced by CTA2B, the nontoxic derivative of cholera toxin
    Eno E Ekong
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    FEMS Immunol Med Microbiol 55:280-91. 2009
    ....
  12. pmc Prevention of Chlamydia-induced infertility by inhibition of local caspase activity
    Joseph U Igietseme
    National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    J Infect Dis 207:1095-104. 2013
    ..These results provide new insight into the molecular pathogenesis of TFI with significant implications for new strategies for treatment and prevention of chlamydial complications...
  13. ncbi request reprint Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletion
    Erika L Barr
    Clark Atlanta University, Atlanta, GA 30333, USA
    J Microbiol Immunol Infect 38:244-54. 2005
    ..Thus, in mice and humans the inflammation associated with CCR5 function may predispose to development of complications of chlamydial infection, such as TFI...
  14. ncbi request reprint A novel recombinant multisubunit vaccine against Chlamydia
    Francis O Eko
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 173:3375-82. 2004
    ..These results support the operational theory that the ability of a vaccine to confer protective immunity against Chlamydia is a function of the level of Th1 response elicited...
  15. ncbi request reprint Developing effective delivery systems for Chlamydia vaccines
    Joseph U Igietseme
    National Center for Infectious Disease, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Curr Opin Mol Ther 6:182-94. 2004
    ..These efforts will likely culminate in an efficacious chlamydial vaccine in the near future...
  16. ncbi request reprint Antibody regulation of Tcell immunity: implications for vaccine strategies against intracellular pathogens
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention CDC, 1600 Clifton Road, Mailstop C17, Atlanta, GA 30333 USA
    Expert Rev Vaccines 3:23-34. 2004
    ..The immunobiological implications are discussed in the context of vaccine design, delivery and evaluation against intracellular microbial pathogens of bacteria, fungi and parasitic origin...
  17. ncbi request reprint Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARgamma
    Heng Ge
    Department of Cardiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Vascul Pharmacol 46:114-21. 2007
    ..In conclusion, resveratrol can down-regulate EMMPRIN expression by macrophages via activating PPARgamma. This may be a primary mechanism of its inhibitory effect on MMP-9...
  18. ncbi request reprint Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    Jianping Ye
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 293:E1118-28. 2007
    ..These data suggest a potential role of hypoxia in the induction of chronic inflammation and inhibition of adiponectin in the adipose tissue in obesity...
  19. pmc Higher insulin, triglycerides, and blood pressure with greater trunk fat in Tanner 1 Chinese
    Qing He
    St Luke s Roosevelt Hospital, Obesity Research Center, and Institute of Human Nutrition, Columbia University New York, NY 10025, USA
    Obesity (Silver Spring) 15:1004-11. 2007
    ..The aims of this study were to investigate the body fat distribution pattern in prepubertal Chinese children and to investigate the relationship between central fat distribution and specific biomarkers of cardiovascular disease...