E N Harris

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. ncbi request reprint Antirheumatic drugs in pregnancy
    E N Harris
    Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 11:683-9. 2002
  2. ncbi request reprint Primary, Secondary, Catastrophic Antiphospholipid Syndrome: is there a difference?
    E Nigel Harris
    Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Thromb Res 114:357-61. 2004
  3. ncbi request reprint Revisiting the anticardiolipin test and its standardization
    E N Harris
    Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Lupus 11:269-75. 2002
  4. ncbi request reprint Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    S S Pierangeli
    Department of Microbiology and Immunology, Antiphospholipid Standardization Laboratory, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Circulation 99:1997-2002. 1999
  5. ncbi request reprint GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 163:2922-7. 1999
  6. ncbi request reprint E-Selectin mediates pathogenic effects of antiphospholipid antibodies
    R G Espinola
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Thromb Haemost 1:843-8. 2003
  7. ncbi request reprint Identification of an Fc gamma receptor-independent mechanism by which intravenous immunoglobulin ameliorates antiphospholipid antibody-induced thrombogenic phenotype
    S S Pierangeli
    Morehouse School of Medicine, Atlanta, Georgia 30310-1495, USA
    Arthritis Rheum 44:876-83. 2001
  8. ncbi request reprint Testing for antiphospholipid antibodies: problems and solutions
    S S Pierangeli
    Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Clin Obstet Gynecol 44:48-57; quiz 58-9. 2001
  9. ncbi request reprint Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
  10. ncbi request reprint New developments in viral peptides and APL induction
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Autoimmun 15:227-30. 2000

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Antirheumatic drugs in pregnancy
    E N Harris
    Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Lupus 11:683-9. 2002
  2. ncbi request reprint Primary, Secondary, Catastrophic Antiphospholipid Syndrome: is there a difference?
    E Nigel Harris
    Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Thromb Res 114:357-61. 2004
    ....
  3. ncbi request reprint Revisiting the anticardiolipin test and its standardization
    E N Harris
    Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Lupus 11:269-75. 2002
    ..Whether using a kit or a bench assay, meticulous attention to detail offers the best opportunity for precision and reproducibility...
  4. ncbi request reprint Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    S S Pierangeli
    Department of Microbiology and Immunology, Antiphospholipid Standardization Laboratory, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    Circulation 99:1997-2002. 1999
    ..Adhesion molecule expression on human umbilical vein endothelial cells (HUVECs) after aPL exposure was performed to confirm EC activation in vitro...
  5. ncbi request reprint GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 163:2922-7. 1999
    ..These data indicate that aPL induced by immunization with the phospholipid binding site of beta2GPI are thrombogenic and activate endothelial cells...
  6. ncbi request reprint E-Selectin mediates pathogenic effects of antiphospholipid antibodies
    R G Espinola
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Thromb Haemost 1:843-8. 2003
    ..This enhancement in thrombus size by aPL antibodies was abrogated in E-selectin-deficient mice treated with aPL antibodies...
  7. ncbi request reprint Identification of an Fc gamma receptor-independent mechanism by which intravenous immunoglobulin ameliorates antiphospholipid antibody-induced thrombogenic phenotype
    S S Pierangeli
    Morehouse School of Medicine, Atlanta, Georgia 30310-1495, USA
    Arthritis Rheum 44:876-83. 2001
    ..These results have implications in the management of thrombosis in APS and may have applications for pregnant patients with a history of APS...
  8. ncbi request reprint Testing for antiphospholipid antibodies: problems and solutions
    S S Pierangeli
    Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Clin Obstet Gynecol 44:48-57; quiz 58-9. 2001
    ..We thank Dr Isabel Abreu and Dr Mittermeyer B. Santiago for performing some of the studies reported in this review...
  9. ncbi request reprint Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
    ..Hence, the interplay between aPL antibodies and ECs is important inthe pathogenesis of thrombosis in APS...
  10. ncbi request reprint New developments in viral peptides and APL induction
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Autoimmun 15:227-30. 2000
    ..We hypothesize that in APS patients aPL is induced by beta(2)-GPL-like PL-binding products of human common bacteria or viruses...
  11. ncbi request reprint Origin of antiphospholipid antibodies
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA
    Rheum Dis Clin North Am 27:551-63. 2001
    ..Identification of those bacterial or viral agents may help to find strategies for the prevention of production of "pathogenic" aPL. Alternatively, free peptides may be used to induce tolerance against aPL production...
  12. ncbi request reprint Mechanisms of pregnancy loss in antiphospholipid syndrome
    A E Gharavi
    Department of Medicine, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310 1495, USA
    Clin Obstet Gynecol 44:11-9. 2001
    ....
  13. ncbi request reprint Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells
    D E Ferrara
    Antiphospholipid Standardization Laboratory, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Thromb Haemost 2:1558-63. 2004
    ..In a recent study, fluvastatin inhibited thrombogenic and proinflammatory properties of aPL antibodies in in vivo models. The aim of this study was to determine whether fluvastatin has an effect on aPL-induced expression of TF on ECs...
  14. ncbi request reprint Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin
    S S Pierangeli
    Department of Microbiology and Immunology, Morehouse School of Medicine Atlanta, GA 30310 1495, USA
    Circ Res 88:245-50. 2001
    ..The data indicate that ICAM-1, P-selectin, and VCAM-1 expression are important in thrombotic complications by aPL antibodies and may provide novel targets for therapy in patients with APS...
  15. ncbi request reprint Catastrophic antiphospholipid syndrome in the intensive care unit
    Gloria E Westney
    Pulmonary Critical Care Section, Department of Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    Crit Care Clin 18:805-17. 2002
    ..A variety of therapeutic modalities have been used in an attempt to offset the widespread thrombosis and organ damage from high aCL levels. Anticoagulation therapy and high dosages of steroids seem to have a positive effect on survival...
  16. ncbi request reprint Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Thromb Res 114:467-76. 2004
    ....
  17. ncbi request reprint Clinical laboratory testing for the antiphospholipid syndrome
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, USA
    Clin Chim Acta 357:17-33. 2005
    ..Therefore, it is now recommended to include both tests, IgA aCL and IgG, IgM and IgA anti-beta2GPI to confirm diagnosis of APS...
  18. ncbi request reprint Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    Ricardo G Espinola
    Department of Microbiology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Thromb Haemost 87:518-22. 2002
    ..0125 mM). This suggests at least one possible mechanism by which HQ may prevent thrombosis. This may have important implications in treatment of thrombosis in APS patients...
  19. ncbi request reprint Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo
    Azzudin E Gharavi
    Department of Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Arthritis Rheum 46:545-52. 2002
    ..To characterize the binding and functional properties of antiphospholipid antibodies (aPL) induced by immunization with a viral peptide and to determine whether aPL are pathogenic in vivo...
  20. ncbi request reprint A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr SW, Rm 331 BSMB, Atlanta, GA 30310 1495, USA
    J Autoimmun 22:217-25. 2004
    ..Peptide A is also found in region I/II of beta2GPI. A scrambled form of peptide A (named scA, GTKGCPNVRLT) was used as a control...
  21. ncbi request reprint Antiphospholipid antibodies and cerebral lupus
    E N Harris
    Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Ann N Y Acad Sci 823:270-8. 1997
    ....
  22. ncbi request reprint Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model
    Dardo E Ferrara
    Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Arthritis Rheum 48:3272-9. 2003
    ..This study uses an in vivo mouse model to investigate whether fluvastatin has an effect on decreasing both the adhesion of leukocytes to ECs and the thrombus formation induced by aPL...
  23. ncbi request reprint Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin
    Mariano Vega-Ostertag
    Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Arthritis Rheum 50:2911-9. 2004
    ..The intracellular events involved in aPL-mediated platelet activation are not fully understood and are therefore the subject of this study...
  24. ncbi request reprint Viral origin of antiphospholipid antibodies: endothelial cell activation and thrombus enhancement by CMV peptide-induced APL antibodies
    Azzudin E Gharavi
    Dept of Medicine, Morehouse School of Medicine, University of Atlanta, Atlanta Georgia 30310 1495, USA
    Immunobiology 207:37-42. 2003
    ..Identification of these bacterial and/ or viral agents may help to find strategies for the prevention of production of aPL "pathogenic" antibodies. Alternatively, free peptides may be used to induce tolerance against aPL production...
  25. ncbi request reprint "Black swan in the kidney": renal involvement in the antiphospholipid antibody syndrome
    Chike M Nzerue
    Department of Medicine, Renal Section, Morehouse School of Medicine, Pathology Department, Emory University School of Medicine, Atlanta, GA, USA
    Kidney Int 62:733-44. 2002
    ..This article presents a historical review of the renal involvement in the antiphospholipid syndrome and discusses therapeutic options. Further research is needed...
  26. ncbi request reprint Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies
    Mariano Vega-Ostertag
    Morehouse School of Medicine, Atlanta, Georgia, USA
    Arthritis Rheum 52:1545-54. 2005
    ....
  27. ncbi request reprint Antiphospholipid syndrome: diagnosis, pathogenesis, and management
    E Nigel Harris
    J Med Assoc Ga 91:31-4. 2002
  28. ncbi request reprint Anticardiolipin test and the antiphospholipid (Hughes) syndrome: 20 years and counting!
    E Nigel Harris
    J Rheumatol 31:2099-101. 2004
  29. doi request reprint A quarter of a century in anticardiolipin antibody testing and attempted standardization has led us to here, which is?
    Silvia S Pierangeli
    Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1165, USA
    Semin Thromb Hemost 34:313-28. 2008
    ....
  30. ncbi request reprint Rheumatic diseases in minority populations
    Gail S Kerr
    Rheumatology Section, Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA
    Med Clin North Am 89:829-68, ix. 2005
    ..This article reviews the features that are unique to various rheumatic diseases within minority populations...