Beatrice E Gee
Affiliation: Morehouse School of Medicine
- Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell diseaseSolomon F Ofori-Acquah
Department of Pediatrics, Division of Hematology Oncology, Emory University School of Medicine, 2015 Uppergate Dr NE, Atlanta, GA 30322, USA
Anemia 2012:156598. 2012..Despite having a higher number of angiogenic progenitor cells, children with Hemoglobin SS had slower migration of cultured mononuclear cells...
- Biologic complexity in sickle cell disease: implications for developing targeted therapeuticsBeatrice E Gee
Department of Pediatrics, Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
ScientificWorldJournal 2013:694146. 2013..The relevance of individual pathways to important sickle cell outcomes needs to be demonstrated in vivo before investing in expensive and labor-intensive clinical trials...
- Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemiaHyacinth I Hyacinth
Genomics and Hemoglobinopathies Training Program, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, USA
Cytokine 60:302-8. 2012..Stroke incidence and high TCD velocity were associated with elevated BDNF and PDGF-AA. These findings suggest a role for BDNF and PDGF-AA in the patho-physiological mechanism of cerebrovascular disease in SCA...
- Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke riskHyacinth I Hyacinth
Stroke Center, Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia
Am J Hematol 89:47-51. 2014..Beyond improving hemoglobin levels, our results suggest that the protective effects of PRBC transfusion on reducing stroke in SCD may result from reduced thrombogenesis and vascular remodeling...
- Proinflammatory cytokines and the hypermetabolism of children with sickle cell diseaseJacqueline M Hibbert
Microbiology Biochemistry Immunology Pediatrics, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, Georgia 30310 1495, USA
Exp Biol Med (Maywood) 230:68-74. 2005....
- Plasma interleukin-1beta concentration is associated with stroke in sickle cell diseaseKwaku Asare
Morehouse School of Medicine, Atlanta, GA 30310, USA
Cytokine 49:39-44. 2010..This result demonstrates a strong association of systemic inflammation with stroke development in HbSS via moderately increased plasma IL-1beta concentration, which is furthermore associated with a decreased likelihood of stroke in HbSS...
- Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemiaJacqueline M Hibbert
Department of Biochemistry, Morehouse School of Medicine, Atlanta, GA, USA
J Pediatr Gastroenterol Nutr 43:680-7. 2006..We hypothesized that an elevated hemoglobin synthesis rate (SynHb) and myocardial oxygen consumption (MVO2) contribute to the excess protein and energy metabolism reported in children with sickle cell anemia...
- Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS StudyWinfred C Wang
Hematology Division, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Pediatr 140:225-9. 2002..We report the growth characteristics of patients in the Phase I-II pediatric hydroxyurea trial (HUG-KIDS) before and during treatment at the maximum tolerated dose for one year...
- Vascular responses in transgenic sickle cell miceBeatrice Gee; Fiscal Year: 2007..Co-mentors, Drs. Freeman and Townes at Univ. of Alabama, Birmingham, are also experts in their fields. ..