Beatrice E Gee

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. pmc Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell disease
    Solomon F Ofori-Acquah
    Department of Pediatrics, Division of Hematology Oncology, Emory University School of Medicine, 2015 Uppergate Dr NE, Atlanta, GA 30322, USA
    Anemia 2012:156598. 2012
  2. pmc Biologic complexity in sickle cell disease: implications for developing targeted therapeutics
    Beatrice E Gee
    Department of Pediatrics, Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    ScientificWorldJournal 2013:694146. 2013
  3. pmc Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia
    Hyacinth I Hyacinth
    Genomics and Hemoglobinopathies Training Program, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, USA
    Cytokine 60:302-8. 2012
  4. ncbi request reprint Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk
    Hyacinth I Hyacinth
    Stroke Center, Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia
    Am J Hematol 89:47-51. 2014
  5. ncbi request reprint Proinflammatory cytokines and the hypermetabolism of children with sickle cell disease
    Jacqueline M Hibbert
    Microbiology Biochemistry Immunology Pediatrics, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, Georgia 30310 1495, USA
    Exp Biol Med (Maywood) 230:68-74. 2005
  6. pmc Plasma interleukin-1beta concentration is associated with stroke in sickle cell disease
    Kwaku Asare
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    Cytokine 49:39-44. 2010
  7. ncbi request reprint Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemia
    Jacqueline M Hibbert
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, GA, USA
    J Pediatr Gastroenterol Nutr 43:680-7. 2006
  8. ncbi request reprint Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS Study
    Winfred C Wang
    Hematology Division, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr 140:225-9. 2002

Research Grants

Collaborators

Detail Information

Publications8

  1. pmc Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell disease
    Solomon F Ofori-Acquah
    Department of Pediatrics, Division of Hematology Oncology, Emory University School of Medicine, 2015 Uppergate Dr NE, Atlanta, GA 30322, USA
    Anemia 2012:156598. 2012
    ..Despite having a higher number of angiogenic progenitor cells, children with Hemoglobin SS had slower migration of cultured mononuclear cells...
  2. pmc Biologic complexity in sickle cell disease: implications for developing targeted therapeutics
    Beatrice E Gee
    Department of Pediatrics, Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    ScientificWorldJournal 2013:694146. 2013
    ..The relevance of individual pathways to important sickle cell outcomes needs to be demonstrated in vivo before investing in expensive and labor-intensive clinical trials...
  3. pmc Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia
    Hyacinth I Hyacinth
    Genomics and Hemoglobinopathies Training Program, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, USA
    Cytokine 60:302-8. 2012
    ..Stroke incidence and high TCD velocity were associated with elevated BDNF and PDGF-AA. These findings suggest a role for BDNF and PDGF-AA in the patho-physiological mechanism of cerebrovascular disease in SCA...
  4. ncbi request reprint Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk
    Hyacinth I Hyacinth
    Stroke Center, Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia
    Am J Hematol 89:47-51. 2014
    ..Beyond improving hemoglobin levels, our results suggest that the protective effects of PRBC transfusion on reducing stroke in SCD may result from reduced thrombogenesis and vascular remodeling...
  5. ncbi request reprint Proinflammatory cytokines and the hypermetabolism of children with sickle cell disease
    Jacqueline M Hibbert
    Microbiology Biochemistry Immunology Pediatrics, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, Georgia 30310 1495, USA
    Exp Biol Med (Maywood) 230:68-74. 2005
    ....
  6. pmc Plasma interleukin-1beta concentration is associated with stroke in sickle cell disease
    Kwaku Asare
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    Cytokine 49:39-44. 2010
    ..This result demonstrates a strong association of systemic inflammation with stroke development in HbSS via moderately increased plasma IL-1beta concentration, which is furthermore associated with a decreased likelihood of stroke in HbSS...
  7. ncbi request reprint Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemia
    Jacqueline M Hibbert
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, GA, USA
    J Pediatr Gastroenterol Nutr 43:680-7. 2006
    ..We hypothesized that an elevated hemoglobin synthesis rate (SynHb) and myocardial oxygen consumption (MVO2) contribute to the excess protein and energy metabolism reported in children with sickle cell anemia...
  8. ncbi request reprint Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS Study
    Winfred C Wang
    Hematology Division, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Pediatr 140:225-9. 2002
    ..We report the growth characteristics of patients in the Phase I-II pediatric hydroxyurea trial (HUG-KIDS) before and during treatment at the maximum tolerated dose for one year...

Research Grants1

  1. Vascular responses in transgenic sickle cell mice
    Beatrice Gee; Fiscal Year: 2007
    ..Co-mentors, Drs. Freeman and Townes at Univ. of Alabama, Birmingham, are also experts in their fields. ..