Francis Eko

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. ncbi request reprint Recombinant Vibrio cholerae ghosts as a delivery vehicle for vaccinating against Chlamydia trachomatis
    Francis O Eko
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr Atlanta, GA 30310, USA
    Vaccine 21:1694-703. 2003
  2. pmc Evaluation of a broadly protective Chlamydia-cholera combination vaccine candidate
    F O Eko
    Morehouse School of Medicine, Atlanta, GA, United States
    Vaccine 29:3802-10. 2011
  3. ncbi request reprint A novel recombinant multisubunit vaccine against Chlamydia
    Francis O Eko
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 173:3375-82. 2004
  4. ncbi request reprint Evaluation of the protective efficacy of Vibrio cholerae ghost (VCG) candidate vaccines in rabbits
    Francis O Eko
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr, S W, Atlanta, GA 30310, USA
    Vaccine 21:3663-74. 2003
  5. pmc Induction of immune memory by a multisubunit chlamydial vaccine
    F O Eko
    Department of Microbiology, Immunology and Biochemistry, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Vaccine 29:1472-80. 2011
  6. ncbi request reprint Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens
    Terri Moore
    Morehouse School of Medicine, Atlanta, Georgia 30333, USA
    J Infect Dis 188:617-24. 2003
  7. pmc Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines
    Qing He
    National Center for Infectious Disease, CDC, Atlanta, GA, USA
    Immunology 122:28-37. 2007
  8. ncbi request reprint Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 174:4860-9. 2005
  9. ncbi request reprint A recombinant multivalent combination vaccine protects against Chlamydia and genital herpes
    LuCinda MacMillan
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    FEMS Immunol Med Microbiol 49:46-55. 2007
  10. pmc Role of T lymphocytes in the pathogenesis of Chlamydia disease
    Joseph U Igietseme
    Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Infect Dis 200:926-34. 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Recombinant Vibrio cholerae ghosts as a delivery vehicle for vaccinating against Chlamydia trachomatis
    Francis O Eko
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr Atlanta, GA 30310, USA
    Vaccine 21:1694-703. 2003
    ..trachomatis infection. Altogether, the potency and relatively low production cost of rVCG offer a significant technical advantage as a chlamydial vaccine...
  2. pmc Evaluation of a broadly protective Chlamydia-cholera combination vaccine candidate
    F O Eko
    Morehouse School of Medicine, Atlanta, GA, United States
    Vaccine 29:3802-10. 2011
    ....
  3. ncbi request reprint A novel recombinant multisubunit vaccine against Chlamydia
    Francis O Eko
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 173:3375-82. 2004
    ..These results support the operational theory that the ability of a vaccine to confer protective immunity against Chlamydia is a function of the level of Th1 response elicited...
  4. ncbi request reprint Evaluation of the protective efficacy of Vibrio cholerae ghost (VCG) candidate vaccines in rabbits
    Francis O Eko
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr, S W, Atlanta, GA 30310, USA
    Vaccine 21:3663-74. 2003
    ..These results indicate that VCGs represent a novel approach to cholera vaccine development and constitute an effective vaccine delivery vehicle...
  5. pmc Induction of immune memory by a multisubunit chlamydial vaccine
    F O Eko
    Department of Microbiology, Immunology and Biochemistry, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Vaccine 29:1472-80. 2011
    ..The data support further vaccine evaluation and testing for induction of long-term protective immunity...
  6. ncbi request reprint Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens
    Terri Moore
    Morehouse School of Medicine, Atlanta, Georgia 30333, USA
    J Infect Dis 188:617-24. 2003
    ..Findings offer a paradigm in host defense wherein different effector components function indirectly to maximize the principal effector mechanism...
  7. pmc Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines
    Qing He
    National Center for Infectious Disease, CDC, Atlanta, GA, USA
    Immunology 122:28-37. 2007
    ..Because live attenuated influenza virus vaccines are safe and acceptable for human use, they may provide a new and reliable approach to deliver efficacious vaccines against sexually transmitted diseases...
  8. ncbi request reprint Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 174:4860-9. 2005
    ..Collectively, these results provide a molecular basis for the high Th1-activating capacity of IL-10KO APC and may provide unique immunomodulation targets when designing vaccines against pathogens controlled by T cell immunity...
  9. ncbi request reprint A recombinant multivalent combination vaccine protects against Chlamydia and genital herpes
    LuCinda MacMillan
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    FEMS Immunol Med Microbiol 49:46-55. 2007
    ..Thus, the combination vaccine regimen delivered by rVCG elicited adequate immune effectors that simultaneously protected against the individual pathogens...
  10. pmc Role of T lymphocytes in the pathogenesis of Chlamydia disease
    Joseph U Igietseme
    Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Infect Dis 200:926-34. 2009
    ..Furthermore, T cell subsets, especially CD8 T cells, play a major role in Chlamydia-induced infertility. The results have important implications for the immunopathogenesis of chlamydial disease and new vaccine strategies...
  11. pmc Fc receptor regulation of protective immunity against Chlamydia trachomatis
    Terri Moore
    Department of Microbiology and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30320, USA
    Immunology 105:213-21. 2002
    ..These findings suggest that a future anti-chlamydial vaccine should elicit both humoral and T-cell-mediated immune responses for optimal memory response and vaccine efficacy...
  12. pmc A Vibrio cholerae ghost-based subunit vaccine induces cross-protective chlamydial immunity that is enhanced by CTA2B, the nontoxic derivative of cholera toxin
    Eno E Ekong
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    FEMS Immunol Med Microbiol 55:280-91. 2009
    ....
  13. ncbi request reprint Contemporary approaches to designing and evaluating vaccines against Chlamydia
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Expert Rev Vaccines 2:129-46. 2003
    ....
  14. ncbi request reprint Delivery of Chlamydia vaccines
    Joseph Igietseme
    National Center for Infectious Disease CDC, Atlanta, GA 30333, USA
    Expert Opin Drug Deliv 2:549-62. 2005
    ..The application of these novel delivery strategies to Chlamydia vaccine design could culminate in timely achievement of an efficacious vaccine...
  15. pmc Involvement of LEK1 in dendritic cell regulation of T cell immunity against Chlamydia
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 181:4037-42. 2008
    ..Targeted modulation of LEK1 expression provides a novel strategy for augmenting the immunostimulatory function of DCs for inducing an effective immunity against pathogens...
  16. pmc Exploiting cholera vaccines as a versatile antigen delivery platform
    Anisia J Silva
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr, SW Atlanta, GA 30310, USA
    Biotechnol Lett 30:571-9. 2008
    ..cholerae during infection creates unprecedented opportunities to develop an improved generation of vaccine vectors to induce immune protection against a broad range of pathogenic organisms...
  17. pmc Immunolocalization and challenge studies using a recombinant Vibrio cholerae ghost expressing Trypanosoma brucei Ca(2+) ATPase (TBCA2) antigen
    Kiantra Ramey
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Am J Trop Med Hyg 81:407-15. 2009
    ..Thus, immunization of mice produced robust parasite-specific antibodies but failed to protect mice against parasite challenge...
  18. ncbi request reprint Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccine
    Godwin O Ifere
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Microbiol Immunol Infect 40:188-200. 2007
    ..We examined whether a vaccine composed of a combination of the major outer membrane protein (MOMP) and porin B protein (PorB) of C. trachomatis would have a protective advantage over a single subunit construct...
  19. ncbi request reprint Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletion
    Erika L Barr
    Clark Atlanta University, Atlanta, GA 30333, USA
    J Microbiol Immunol Infect 38:244-54. 2005
    ..Thus, in mice and humans the inflammation associated with CCR5 function may predispose to development of complications of chlamydial infection, such as TFI...
  20. ncbi request reprint Developing effective delivery systems for Chlamydia vaccines
    Joseph U Igietseme
    National Center for Infectious Disease, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Curr Opin Mol Ther 6:182-94. 2004
    ..These efforts will likely culminate in an efficacious chlamydial vaccine in the near future...
  21. pmc Chemokine and chemokine receptor dynamics during genital chlamydial infection
    Tesfaye Belay
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 70:844-50. 2002
    ..Future studies will focus on how selective modulation of chemokines and their receptors can be used to optimize long-term immunity against CHLAMYDIA:..
  22. ncbi request reprint Antigen discovery and delivery of subunit vaccines by nonliving bacterial ghost vectors
    Petra Walcher
    Institute of Microbiology and Genetics, Department Microbiology and Biotechnology, University of Vienna, UZA II, 2B255, Althanstrasse 14, A 1090 Wien, Austria
    Expert Rev Vaccines 3:681-91. 2004
    ..The potency, safety and relatively low production cost of BGs offer a significant technical advantage over currently utilized vaccine technologies...
  23. ncbi request reprint Antibody regulation of Tcell immunity: implications for vaccine strategies against intracellular pathogens
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention CDC, 1600 Clifton Road, Mailstop C17, Atlanta, GA 30333 USA
    Expert Rev Vaccines 3:23-34. 2004
    ..The immunobiological implications are discussed in the context of vaccine design, delivery and evaluation against intracellular microbial pathogens of bacteria, fungi and parasitic origin...
  24. ncbi request reprint Bacterial ghosts as carrier and targeting systems for mucosal antigen delivery
    Katri Jalava
    BIRD C GmbH and CoKEG, Wien, Austria
    Expert Rev Vaccines 2:45-51. 2003
    ..The potency, safety and relatively low production cost of bacterial ghosts offer a significant technical advantage, especially when used as combination vaccines...
  25. ncbi request reprint Combination vaccines: design strategies and future trends
    Joseph U Igietseme
    Expert Rev Vaccines 5:739-45. 2006

Research Grants6

  1. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis Eko; Fiscal Year: 2001
    ..trachomatis. Results from these studies will likely lead to the development of a reliable vaccine regimen against Chlamydia, which should have major implications for the genital, ocular, and lung infections and their complications. ..
  2. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis Eko; Fiscal Year: 2002
    ..trachomatis. Results from these studies will likely lead to the development of a reliable vaccine regimen against Chlamydia, which should have major implications for the genital, ocular, and lung infections and their complications. ..
  3. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis Eko; Fiscal Year: 2003
    ..trachomatis. Results from these studies will likely lead to the development of a reliable vaccine regimen against Chlamydia, which should have major implications for the genital, ocular, and lung infections and their complications. ..
  4. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis Eko; Fiscal Year: 2004
    ..trachomatis. Results from these studies will likely lead to the development of a reliable vaccine regimen against Chlamydia, which should have major implications for the genital, ocular, and lung infections and their complications. ..
  5. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis Eko; Fiscal Year: 2005
    ..trachomatis. Results from these studies will likely lead to the development of a reliable vaccine regimen against Chlamydia, which should have major implications for the genital, ocular, and lung infections and their complications. ..
  6. INDUCTION OF PROTECTIVE IMMUNITY AGAINST CHLAMYDIA
    Francis O Eko; Fiscal Year: 2010
    ....