L Dianne Bradford
Affiliation: Morehouse School of Medicine
- CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendantsL Dianne Bradford
Department of Psychiatry and Medicine, Morehouse School of Medicine, 720 Westview Dr S W, Atlanta, GA, 30310 1495, USA
Pharmacogenomics 3:229-43. 2002....
- Unique CYP2D6 activity distribution and genotype-phenotype discordance in black AmericansAndrea Gaedigk
Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital and Clinics, Kansas City, MO 64108 USA
Clin Pharmacol Ther 72:76-89. 2002..Although CYP2D6 has been studied extensively in different population groups, relatively little is known for black Americans...
- CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphismAndrea Gaedigk
Division of Developmental Pharmacology and Medical Toxicology, The Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
Clin Chem 49:1008-11. 2003
- Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjectsAndrea Gaedigk
Clin Pharmacol Ther 73:575-6. 2003
- Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjectsAndrea Gaedigk
Clin Pharmacol Ther 77:228-30; author reply 230-1. 2005
- Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African AmericansA Gaedigk
Division of Clinical Pharmacology and Experimental Therapeutics, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
Pharmacogenomics J 5:173-82. 2005..CYP2D6(*)45 and (*)46 have a combined frequency of 4% and can be identified by a common SNP. Carriers are predicted to exhibit an extensive or intermediate CYP2D6 phenotype...
- CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer statusAndrea Gaedigk
Section of Developmental Pharmacology and Experimental Therapeutics, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
Drug Metab Dispos 34:563-9. 2006..Given a combined frequency of between 0.5 and 3% in African Americans and Asians, genotyping for CYP2D6*36 should improve the accuracy of genotype-based phenotype prediction in these populations...
- Schizophrenia Liability Genes among African AmericansL Dianne Bradford; Fiscal Year: 2006..Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics. ..