L Dianne Bradford

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. ncbi CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    L Dianne Bradford
    Department of Psychiatry and Medicine, Morehouse School of Medicine, 720 Westview Dr S W, Atlanta, GA, 30310 1495, USA
    Pharmacogenomics 3:229-43. 2002
  2. ncbi Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
    Andrea Gaedigk
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital and Clinics, Kansas City, MO 64108 USA
    Clin Pharmacol Ther 72:76-89. 2002
  3. ncbi CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism
    Andrea Gaedigk
    Division of Developmental Pharmacology and Medical Toxicology, The Children's Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Clin Chem 49:1008-11. 2003
  4. ncbi Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects
    Andrea Gaedigk
    Clin Pharmacol Ther 73:575-6. 2003
  5. ncbi Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects
    Andrea Gaedigk
    Clin Pharmacol Ther 77:228-30; author reply 230-1. 2005
  6. ncbi Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
    A Gaedigk
    Division of Clinical Pharmacology and Experimental Therapeutics, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Pharmacogenomics J 5:173-82. 2005
  7. ncbi CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status
    Andrea Gaedigk
    Section of Developmental Pharmacology and Experimental Therapeutics, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
    Drug Metab Dispos 34:563-9. 2006

Research Grants

  1. Schizophrenia Liability Genes among African Americans
    L Dianne Bradford; Fiscal Year: 2002
  2. Schizophrenia Liability Genes among African Americans
    L Dianne Bradford; Fiscal Year: 2006
  3. Fostering Mental Health Research in Psychiatry Residents
    L Dianne Bradford; Fiscal Year: 2007

Collaborators

Detail Information

Publications7

  1. ncbi CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    L Dianne Bradford
    Department of Psychiatry and Medicine, Morehouse School of Medicine, 720 Westview Dr S W, Atlanta, GA, 30310 1495, USA
    Pharmacogenomics 3:229-43. 2002
    ....
  2. ncbi Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
    Andrea Gaedigk
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital and Clinics, Kansas City, MO 64108 USA
    Clin Pharmacol Ther 72:76-89. 2002
    ..Although CYP2D6 has been studied extensively in different population groups, relatively little is known for black Americans...
  3. ncbi CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism
    Andrea Gaedigk
    Division of Developmental Pharmacology and Medical Toxicology, The Children's Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Clin Chem 49:1008-11. 2003
  4. ncbi Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects
    Andrea Gaedigk
    Clin Pharmacol Ther 73:575-6. 2003
  5. ncbi Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects
    Andrea Gaedigk
    Clin Pharmacol Ther 77:228-30; author reply 230-1. 2005
  6. ncbi Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
    A Gaedigk
    Division of Clinical Pharmacology and Experimental Therapeutics, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Pharmacogenomics J 5:173-82. 2005
    ..CYP2D6(*)45 and (*)46 have a combined frequency of 4% and can be identified by a common SNP. Carriers are predicted to exhibit an extensive or intermediate CYP2D6 phenotype...
  7. ncbi CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status
    Andrea Gaedigk
    Section of Developmental Pharmacology and Experimental Therapeutics, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
    Drug Metab Dispos 34:563-9. 2006
    ..Given a combined frequency of between 0.5 and 3% in African Americans and Asians, genotyping for CYP2D6*36 should improve the accuracy of genotype-based phenotype prediction in these populations...

Research Grants7

  1. Schizophrenia Liability Genes among African Americans
    L Dianne Bradford; Fiscal Year: 2002
    ..Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics. ..
  2. Schizophrenia Liability Genes among African Americans
    L Dianne Bradford; Fiscal Year: 2006
    ..Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics. ..
  3. Fostering Mental Health Research in Psychiatry Residents
    L Dianne Bradford; Fiscal Year: 2007
    ....