L Dianne Bradford

Summary

Affiliation: Morehouse School of Medicine
Country: USA

Publications

  1. ncbi request reprint CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    L Dianne Bradford
    Department of Psychiatry and Medicine, Morehouse School of Medicine, 720 Westview Dr S W, Atlanta, GA, 30310 1495, USA
    Pharmacogenomics 3:229-43. 2002
  2. ncbi request reprint Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
    Andrea Gaedigk
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital and Clinics, Kansas City, MO 64108 USA
    Clin Pharmacol Ther 72:76-89. 2002
  3. ncbi request reprint CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism
    Andrea Gaedigk
    Division of Developmental Pharmacology and Medical Toxicology, The Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Clin Chem 49:1008-11. 2003
  4. ncbi request reprint Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects
    Andrea Gaedigk
    Clin Pharmacol Ther 73:575-6. 2003
  5. ncbi request reprint Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects
    Andrea Gaedigk
    Clin Pharmacol Ther 77:228-30; author reply 230-1. 2005
  6. pmc Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
    A Gaedigk
    Division of Clinical Pharmacology and Experimental Therapeutics, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Pharmacogenomics J 5:173-82. 2005
  7. ncbi request reprint CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status
    Andrea Gaedigk
    Section of Developmental Pharmacology and Experimental Therapeutics, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
    Drug Metab Dispos 34:563-9. 2006

Research Grants

  1. Schizophrenia Liability Genes among African Americans
    L Dianne Bradford; Fiscal Year: 2002
  2. Schizophrenia Liability Genes among African Americans
    L Dianne Bradford; Fiscal Year: 2006
  3. Fostering Mental Health Research in Psychiatry Residents
    L Dianne Bradford; Fiscal Year: 2007

Collaborators

Detail Information

Publications7

  1. ncbi request reprint CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    L Dianne Bradford
    Department of Psychiatry and Medicine, Morehouse School of Medicine, 720 Westview Dr S W, Atlanta, GA, 30310 1495, USA
    Pharmacogenomics 3:229-43. 2002
    ....
  2. ncbi request reprint Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
    Andrea Gaedigk
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital and Clinics, Kansas City, MO 64108 USA
    Clin Pharmacol Ther 72:76-89. 2002
    ..Although CYP2D6 has been studied extensively in different population groups, relatively little is known for black Americans...
  3. ncbi request reprint CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism
    Andrea Gaedigk
    Division of Developmental Pharmacology and Medical Toxicology, The Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Clin Chem 49:1008-11. 2003
  4. ncbi request reprint Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects
    Andrea Gaedigk
    Clin Pharmacol Ther 73:575-6. 2003
  5. ncbi request reprint Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects
    Andrea Gaedigk
    Clin Pharmacol Ther 77:228-30; author reply 230-1. 2005
  6. pmc Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
    A Gaedigk
    Division of Clinical Pharmacology and Experimental Therapeutics, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Pharmacogenomics J 5:173-82. 2005
    ..CYP2D6(*)45 and (*)46 have a combined frequency of 4% and can be identified by a common SNP. Carriers are predicted to exhibit an extensive or intermediate CYP2D6 phenotype...
  7. ncbi request reprint CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status
    Andrea Gaedigk
    Section of Developmental Pharmacology and Experimental Therapeutics, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
    Drug Metab Dispos 34:563-9. 2006
    ..Given a combined frequency of between 0.5 and 3% in African Americans and Asians, genotyping for CYP2D6*36 should improve the accuracy of genotype-based phenotype prediction in these populations...

Research Grants7

  1. Schizophrenia Liability Genes among African Americans
    L Dianne Bradford; Fiscal Year: 2002
    ..Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics. ..
  2. Schizophrenia Liability Genes among African Americans
    L Dianne Bradford; Fiscal Year: 2006
    ..Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics. ..
  3. Fostering Mental Health Research in Psychiatry Residents
    L Dianne Bradford; Fiscal Year: 2007
    ....