Research Topics
| Han Mou TsaiSummaryAffiliation: Montefiore Medical Center Country: USA Publications
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Detail Information
Publications
von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndromeH M Tsai
Montefiore Medical Center Albert Einstein College of Medicine, Division of Hematology, Bronx, NY 10467, USA
Pediatr Res 49:653-9. 2001..A decrease in large von Willebrand factor multimers, presumably caused by enhanced proteolysis from abnormal shear stress in the microcirculation, is common in HUS...
The kidney in thrombotic thrombocytopenic purpuraH M Tsai
Montefiore Medical Center, Division of Hematology, Bronx, New York, NY 10467, USA
Minerva Med 98:731-47. 2007..Therapy of hereditary TTP should aim not only to prevent acute exacerbations but also to minimize the risk of irreversible renal injury...- Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiencyHan Mou Tsai
Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
Hematol Oncol Clin North Am 21:609-32, v. 2007..This new knowledge will provide clues to improve the diagnosis and management of this intriguing disease... - ADAMTS13 and microvascular thrombosisHan Mou Tsai
Montefiore Medical Center and Albert Einstein College of Medicine, Unified Division of Hematology, Bronx, New York, NY, USA
Expert Rev Cardiovasc Ther 4:813-25. 2006..Cloning of ADAMTS13 and structure-function analyses of the enzyme are leading to exciting advances in the diagnosis and therapy of this hitherto mysterious disease... - The molecular biology of thrombotic microangiopathyH M Tsai
Division of Hematology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
Kidney Int 70:16-23. 2006..These advances illustrate that dysregulation of VWF homeostasis or complement activation owing to genetic or autoimmune mechanisms may lead to the syndrome of thrombotic microangiopathy... - ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpuraHan Mou Tsai
Division of Hematology, Montefiore Medical Center, Bronx, NY 10467, USA
Thromb Haemost 95:886-92. 2006..Analysis of ADAMTS13-binding IgG is helpful for the diagnosis and management of TTP... - Current concepts in thrombotic thrombocytopenic purpuraHan Mou Tsai
Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
Annu Rev Med 57:419-36. 2006..It also discusses how the new knowledge may improve the diagnosis and treatment of this previously mysterious disorder... - Molecular mechanisms in thrombotic thrombocytopenic purpuraHan Mou Tsai
Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
Semin Thromb Hemost 30:549-57. 2004..The identification of the molecular defect in TTP raises the prospect that this hitherto mysterious disorder will be managed with a more rationally designed strategy in the near future... - A journey from sickle cell anemia to ADAMTS13H-M Tsai
Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
J Thromb Haemost 2:1510-4. 2004 - Shear stress and von Willebrand factor in health and diseaseHan Mou Tsai
Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
Semin Thromb Hemost 29:479-88. 2003..Conversely, a deficiency in ADAMTS13 because of genetic mutations or autoimmune inhibitors causes vWF- and platelet-rich microvascular thrombosis characteristic of thrombotic thrombocytopenic purpura... - Inhibitors of von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpuraH M Tsai
Division of Hematology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY 10467, USA
Clin Lab 47:387-92. 2001..This study shows that inhibitors of vWF-cleaving protease are of low titers in most cases of acquired TTP. A higher inhibitor titer is associated with a more advanced stage of the disease and may delay the response to plasma exchange... - Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpuraHan Mou Tsai
Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, 111 East 210th Street, Bronx, New York 10467, USA
J Mol Med (Berl) 80:639-47. 2002..These findings support the view that vWF proteolysis is critical in regulating vWF-platelet interaction and set the stage for improving the diagnosis and treatment of thrombotic thrombocytopenic purpura... - Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord bloodHan Mou Tsai
Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, 111 East 210th Street, Bronx, NY 10467, USA
Thromb Res 108:121-5. 2002..Previously, ultralarge multimers of VWF were detected in the fetuses, the umbilical cords and the newborns. However, the significance of this finding is unknown... - Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpuraHan Mou Tsai
Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USA
Eur J Haematol 70:183-5. 2003..This report describes the experience of a case of atypical thrombotic thrombocytopenic purpura (TTP) whose diagnosis was based on severe deficiency of the von Willebrand factor (vWF) cleaving metalloprotease ADAMTS13... - Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpuraHan Mou Tsai
Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, 111 E 210th St, Bronx, NY, USA
Arterioscler Thromb Vasc Biol 23:388-96. 2003.... - Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? YesH M Tsai
Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
J Thromb Haemost 1:625-31. 2003 - Deficiency of ADAMTS-13 in thrombotic and thrombocytopenic purpuraH-M Tsai
Montefiore Medical Center, Division of Hematology, Bronx, NY 10467, USA
J Thromb Haemost 1:2038-40; discussion 2040-5. 2003 - Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?Wenhua Zhou
Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
J Biol Chem 280:39934-41. 2005..This raises the possibility that resistant ADAMTS13 variants may be exploited to circumvent inhibitory antibodies that cause TTP... - An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimersWenhua Zhou
Division of Hematology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA
Blood 110:886-93. 2007..In summary, the carboxyl terminus TSR sequence is important for cleaving VWF multimers. Assay results should be interpreted with caution when peptide substrates are used for analysis of variant ADAMTS13 proteins... - ADAMTS13 is expressed in hepatic stellate cellsWenhua Zhou
Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
Lab Invest 85:780-8. 2005.... - Evolution of ADAMTS13 antibodies in a fatal case of thrombotic thrombocytopenic purpuraLingli Dong
Unified Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
Am J Hematol 83:815-7. 2008..These changes suggest that the course of TTP may be exacerbated by complex immune reactions. Further characterization of the factors contributing to this exacerbation may have important pathogenetic and therapeutic implications...