Han Mou Tsai

Summary

Affiliation: Montefiore Medical Center
Country: USA

Publications

  1. ncbi request reprint von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome
    H M Tsai
    Montefiore Medical Center Albert Einstein College of Medicine, Division of Hematology, Bronx, NY 10467, USA
    Pediatr Res 49:653-9. 2001
  2. ncbi request reprint Shear stress and von Willebrand factor in health and disease
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Semin Thromb Hemost 29:479-88. 2003
  3. ncbi request reprint A journey from sickle cell anemia to ADAMTS13
    H M Tsai
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
    J Thromb Haemost 2:1510-4. 2004
  4. ncbi request reprint Molecular mechanisms in thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
    Semin Thromb Hemost 30:549-57. 2004
  5. pmc Current concepts in thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
    Annu Rev Med 57:419-36. 2006
  6. pmc ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center, Bronx, NY 10467, USA
    Thromb Haemost 95:886-92. 2006
  7. pmc The molecular biology of thrombotic microangiopathy
    H M Tsai
    Division of Hematology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Kidney Int 70:16-23. 2006
  8. pmc ADAMTS13 and microvascular thrombosis
    Han Mou Tsai
    Montefiore Medical Center and Albert Einstein College of Medicine, Unified Division of Hematology, Bronx, New York, NY, USA
    Expert Rev Cardiovasc Ther 4:813-25. 2006
  9. pmc Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency
    Han Mou Tsai
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    Hematol Oncol Clin North Am 21:609-32, v. 2007
  10. pmc The kidney in thrombotic thrombocytopenic purpura
    H M Tsai
    Montefiore Medical Center, Division of Hematology, Bronx, New York, NY 10467, USA
    Minerva Med 98:731-47. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome
    H M Tsai
    Montefiore Medical Center Albert Einstein College of Medicine, Division of Hematology, Bronx, NY 10467, USA
    Pediatr Res 49:653-9. 2001
    ..A decrease in large von Willebrand factor multimers, presumably caused by enhanced proteolysis from abnormal shear stress in the microcirculation, is common in HUS...
  2. ncbi request reprint Shear stress and von Willebrand factor in health and disease
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Semin Thromb Hemost 29:479-88. 2003
    ..Conversely, a deficiency in ADAMTS13 because of genetic mutations or autoimmune inhibitors causes vWF- and platelet-rich microvascular thrombosis characteristic of thrombotic thrombocytopenic purpura...
  3. ncbi request reprint A journey from sickle cell anemia to ADAMTS13
    H M Tsai
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
    J Thromb Haemost 2:1510-4. 2004
  4. ncbi request reprint Molecular mechanisms in thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA
    Semin Thromb Hemost 30:549-57. 2004
    ..The identification of the molecular defect in TTP raises the prospect that this hitherto mysterious disorder will be managed with a more rationally designed strategy in the near future...
  5. pmc Current concepts in thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
    Annu Rev Med 57:419-36. 2006
    ..It also discusses how the new knowledge may improve the diagnosis and treatment of this previously mysterious disorder...
  6. pmc ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center, Bronx, NY 10467, USA
    Thromb Haemost 95:886-92. 2006
    ..Analysis of ADAMTS13-binding IgG is helpful for the diagnosis and management of TTP...
  7. pmc The molecular biology of thrombotic microangiopathy
    H M Tsai
    Division of Hematology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Kidney Int 70:16-23. 2006
    ..These advances illustrate that dysregulation of VWF homeostasis or complement activation owing to genetic or autoimmune mechanisms may lead to the syndrome of thrombotic microangiopathy...
  8. pmc ADAMTS13 and microvascular thrombosis
    Han Mou Tsai
    Montefiore Medical Center and Albert Einstein College of Medicine, Unified Division of Hematology, Bronx, New York, NY, USA
    Expert Rev Cardiovasc Ther 4:813-25. 2006
    ..Cloning of ADAMTS13 and structure-function analyses of the enzyme are leading to exciting advances in the diagnosis and therapy of this hitherto mysterious disease...
  9. pmc Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency
    Han Mou Tsai
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    Hematol Oncol Clin North Am 21:609-32, v. 2007
    ..This new knowledge will provide clues to improve the diagnosis and management of this intriguing disease...
  10. pmc The kidney in thrombotic thrombocytopenic purpura
    H M Tsai
    Montefiore Medical Center, Division of Hematology, Bronx, New York, NY 10467, USA
    Minerva Med 98:731-47. 2007
    ..Therapy of hereditary TTP should aim not only to prevent acute exacerbations but also to minimize the risk of irreversible renal injury...
  11. ncbi request reprint Deficiency of ADAMTS-13 in thrombotic and thrombocytopenic purpura
    H M Tsai
    Montefiore Medical Center, Division of Hematology, Bronx, NY 10467, USA
    J Thromb Haemost 1:2038-40; discussion 2040-5. 2003
  12. ncbi request reprint Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? Yes
    H M Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Thromb Haemost 1:625-31. 2003
  13. ncbi request reprint Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord blood
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, 111 East 210th Street, Bronx, NY 10467, USA
    Thromb Res 108:121-5. 2002
    ..Previously, ultralarge multimers of VWF were detected in the fetuses, the umbilical cords and the newborns. However, the significance of this finding is unknown...
  14. ncbi request reprint Inhibitors of von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura
    H M Tsai
    Division of Hematology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Clin Lab 47:387-92. 2001
    ..This study shows that inhibitors of vWF-cleaving protease are of low titers in most cases of acquired TTP. A higher inhibitor titer is associated with a more advanced stage of the disease and may delay the response to plasma exchange...
  15. ncbi request reprint Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, 111 E 210th St, Bronx, NY, USA
    Arterioscler Thromb Vasc Biol 23:388-96. 2003
    ....
  16. ncbi request reprint Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Eur J Haematol 70:183-5. 2003
    ..This report describes the experience of a case of atypical thrombotic thrombocytopenic purpura (TTP) whose diagnosis was based on severe deficiency of the von Willebrand factor (vWF) cleaving metalloprotease ADAMTS13...
  17. ncbi request reprint Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, 111 East 210th Street, Bronx, New York 10467, USA
    J Mol Med (Berl) 80:639-47. 2002
    ..These findings support the view that vWF proteolysis is critical in regulating vWF-platelet interaction and set the stage for improving the diagnosis and treatment of thrombotic thrombocytopenic purpura...
  18. pmc Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?
    Wenhua Zhou
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10467, USA
    J Biol Chem 280:39934-41. 2005
    ..This raises the possibility that resistant ADAMTS13 variants may be exploited to circumvent inhibitory antibodies that cause TTP...
  19. pmc An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers
    Wenhua Zhou
    Division of Hematology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Blood 110:886-93. 2007
    ..In summary, the carboxyl terminus TSR sequence is important for cleaving VWF multimers. Assay results should be interpreted with caution when peptide substrates are used for analysis of variant ADAMTS13 proteins...
  20. pmc ADAMTS13 is expressed in hepatic stellate cells
    Wenhua Zhou
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
    Lab Invest 85:780-8. 2005
    ....
  21. pmc Evolution of ADAMTS13 antibodies in a fatal case of thrombotic thrombocytopenic purpura
    Lingli Dong
    Unified Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Am J Hematol 83:815-7. 2008
    ..These changes suggest that the course of TTP may be exacerbated by complex immune reactions. Further characterization of the factors contributing to this exacerbation may have important pathogenetic and therapeutic implications...
  22. ncbi request reprint An enzyme immunoassay of ADAMTS13 distinguishes patients with thrombotic thrombocytopenic purpura from normal individuals and carriers of ADAMTS13 mutations
    Wenhua Zhou
    Division of Hematology, Montefiore Medical Center, 111 East 210th Street, Bronx, New York, 10467, USA
    Thromb Haemost 91:806-11. 2004
    ..These results suggest the EIA method based on the VWF fusion protein is a simple but promising alternative for measuring ADAMTS13 activity...
  23. ncbi request reprint Presence of ADAMTS13 activity in a patient with metastatic cancer and thrombotic microangiopathy
    Robin B Forman
    Beth Israel Medical Center, New York, NY, USA
    Acta Haematol 109:150-2. 2003
    ..Despite similarity in clinical manifestation, microangiopathic hemolysis in patients with metastatic cancers may not be caused by ADAMTS13 deficiency and the role of plasma exchange in such patients should be reevaluated...
  24. ncbi request reprint Thrombotic thrombocytopenic purpura in a newborn
    Paul T Jubinsky
    Division of Pediatric Hematology Oncology, Albert Einstein College of Medicine Montefiore Medical Center, Bronx, NY 10461, USA
    J Perinatol 23:85-7. 2003
    ..Early diagnosis may have important implications for the patients...
  25. ncbi request reprint Deficiency of ADAMTS13 in thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine Bronx, New York, USA
    Int J Hematol 76:132-8. 2002
    ..These advances in knowledge provide the basis for a rational approach to improving the diagnosis and treatment of thrombotic thrombocytopenic purpura...
  26. ncbi request reprint Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura
    Han Mou Tsai
    Division of Hematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Am Soc Nephrol 14:1072-81. 2003
    ....
  27. ncbi request reprint Transfusion of polymerised human haemoglobin in a patient with severe sickle-cell anaemia
    Joshua P Raff
    Division of Haematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Lancet 360:464-5. 2002
    ..Increased oxygen delivery to the microcirculation might have contributed to the rapid resolution of pain after the transfusion...