J T Flynn

..This review will examine these aspects of acute renal failure management, with the goal of providing practical guidance regarding modality selection to the physician involved in the management of pediatric acute renal failure...

..These data provide direction for further study, including timing of tacrolimus conversion and interaction with other therapies...

..Investigators involved in such studies must ensure that the unique aspects of using antihypertensive drugs in children are adequately addressed...

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..To determine whether ambulatory blood pressure monitoring (ABPM) can help differentiate children with secondary hypertension from those with primary hypertension...

..We conclude that isradipine successfully lowers BP in hypertensive children with secondary forms of hypertension. Use of isradipine suspension allows infants and young children to be treated as readily as older children...

..Future studies should focus on further defining the pathophysiology of primary hypertension in children, including the roles of renin and insulin resistance, so that improved methods of prevention and treatment can be developed...

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..Usually a combination of pharmacologic and nonpharmacologic measures will result in satisfactory control of hypertension while permitting a normal quality of life...

..Against this background, and with a strong emphasis on protection of this vulnerable patient population, a strict set of conditions for use of placebos in pediatric antihypertensive trials is proposed...

..Each of these three areas will no doubt develop further over the years ahead, resulting in further advances in the field of childhood hypertension...

..Further studies are necessary to determine what effects if any long-term calcium channel blocker treatment has on the growth and development of children with hypertension...

..While the use of continuous renal replacement therapies in the management of children with acute renal failure (ARF) has increased, the role of peritoneal dialysis (PD) in the treatment of pediatric ARF has received less attention...

..Patients with more severe HSP-associated glomerulonephritis may develop chronic renal failure. Currently, no widely accepted treatment protocols exist for patients with significant renal involvement...

..Larger prospective studies should be conducted to confirm these findings...

..We conclude that Sandoglobulin may not only be useful for CMV prophylaxis but also as an adjunct to routine immunosuppression...

..Twice-daily dosing may be required in many children to achieve BP control. Detailed pharmacokinetic studies are needed to confirm these observations...

..We sought to determine if there are differences in clinical, laboratory, or echocardiographic characteristics among children with primary hypertension from different racial groups...

..This inexpensive intervention may delay the need for renal replacement therapy, growth hormone treatment, or both in many of these children and may be used in any clinical setting...

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..5 hours for the first patient and 26 hours for the second patient. We conclude that hemodialysis followed by CVVHD is a safe and effective approach to the management of lithium intoxication in children...

..Ambulatory blood pressure monitoring (ABPM) is widely utilized for the evaluation and management of hypertension in adults but has not been routinely used in the care of hypertensive children...

..The outcome of children receiving PD will be markedly improved only when ongoing and future research efforts reveal the optimal solutions to these important issues...

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..CONCLUSIONS: Amlodipine effectively lowers systolic BP in a dose-dependent manner in hypertensive children who require drug treatment...

..Pending results of ongoing studies of the safety and efficacy of VZV vaccine in children with CRF, we recommend that VZV vaccine be given to all children with CRF...

..A wide range of therapeutic agents are now available for management of neonatal hypertension in both the acute and chronic settings. In most cases hypertension will resolve, but some infants may require prolonged treatment...

..Elevated BP was 10 times more frequent in obese minority youth, emphasizing the importance of screening for hypertension in this high-risk population...

..Weight-adjusted CL/F and V/F of amlodipine in younger children were significantly greater than in older children, suggesting a need for higher doses when treating young children with amlodipine...

..Clinicians caring for children with SP-HUS should be aware of these differences and modify therapy appropriately to avoid known risk factors for poor outcome, specifically the use of unwashed blood products...

..On the other hand, delayed use may be associated with a greater risk of infection. Further studies involving larger numbers of children will be necessary to confirm these findings...

..01). CONCLUSIONS: Routine administration of sodium ferric gluconate is equivalent if not superior to use of oral iron plus iron dextran for maintenance of iron stores in adolescents on hemodialysis, but more expensive...

..In this review we present an updated approach to the outpatient management of hypertension in the child or adolescent, utilizing representative cases to illustrate important principles as well as possible controversies...

..Wider use of NIVM-guided ultrafiltration may decrease cardiovascular morbidity in pediatric hemodialysis patients...

..These findings highlight the need for further studies to determine whether recommendations for treatment of hypertension in adults should be followed in children...

..Given this, it may be more appropriate to treat severe hypertension in children with intravenous antihypertensive agents that can be titrated to produce controlled reductions in blood pressure...

..This paper discusses the possible causes, management and complications of recurrent chyloperitoneum...

..Adiponectin inversely correlate with ABP parameters in obese adolescents. Larger studies are needed to examine the relationship between adiponectin and mechanisms of BP regulation...

..05). Current practice does not appear to follow recent consensus recommendations. Interventions designed to address the issues identified in this survey may lead to improved care for pediatric patients with HTN...

..Decreased BMI and cardiovascular disease may be associated with increased mortality in children with HIV on RRT...

..To illustrate the process we have included two examples of current clinical protocols utilized by our division...

..1 versus 5.1%, P = .008) and compared with the control subjects (2.6%, P < .001). CONCLUSION: As in adults, adolescents with T2DM exhibit abnormalities of ABP, dyslipidemia, and microalbuminuria...

..Strategies for reno-protection are discussed, and treatment recommendations are made for control of hypertension in this patient population...

..Treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers may improve BP control in these patients...

..In this study, the first trial of an antihypertensive agent conducted in children <6 years of age, valsartan effectively lowered SBP and diastolic blood pressure compared with placebo...

..It may serve as an alternative method of administration to local instillation and may be used to restore patency before resorting to surgical revisions...

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..ARF, should it occur in such children, appears to respond well to treatment with high-efficiency hemodialysis...

..Adding PV-B19 testing of the donor and recipient to the standard pretransplant evaluation may be beneficial in diagnosing and managing a potential infection. If IVIg is to be used it may be safer to use a sucrose-free IVIg preparation...

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