Research Topics
Species | Mark H EinsteinSummaryAffiliation: Montefiore Medical Center Country: USA Publications
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Publications
Clinician's guide to human papillomavirus immunology: knowns and unknownsMark H Einstein
Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
Lancet Infect Dis 9:347-56. 2009..However, despite our growing understanding, many aspects of the interactions between HPV and the host immune system remain unknown, and this Review draws attention to several of these unresolved issues and their implications...- Phase II trial of adjuvant pelvic radiation "sandwiched" between combination paclitaxel and carboplatin in women with uterine papillary serous carcinomaMark H Einstein
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, NY, USA
Gynecol Oncol 124:21-5. 2012..To evaluate the safety and survival in women treated with adjuvant pelvic radiation "sandwiched" between six cycles of paclitaxel and carboplatin chemotherapy with completely resected UPSC... 
Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 vaccine and HPV-6/11/16/18 vaccine: follow-up from months 12-24 in a Phase III randomized study of healthy women aged 18-45 yearsMark H Einstein
Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
Hum Vaccin 7:1343-58. 2011..Both vaccines were generally well tolerated. Although an immunological correlate of protection has not been defined, differences in the magnitude of immune response between vaccines may represent determinants of duration of protection...- Comparison of the immunogenicity of the human papillomavirus (HPV)-16/18 vaccine and the HPV-6/11/16/18 vaccine for oncogenic non-vaccine types HPV-31 and HPV-45 in healthy women aged 18-45 yearsMark H Einstein
Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
Hum Vaccin 7:1359-73. 2011..Considering the differences in cross-protective efficacy between the two vaccines, the results might provide insights into the underlying mechanism(s) of protection... - Heat shock fusion protein-based immunotherapy for treatment of cervical intraepithelial neoplasia IIIMark H Einstein
Albert Einstein College of Medicine, and Albert Einstein Cancer Center, Bronx, NY 10461, USA
Gynecol Oncol 106:453-60. 2007..bovis BCG heat shock protein (Hsp65) covalently linked to the entire sequence of HPV 16 E7. This trial was designed to evaluate the efficacy and toxicities of HspE7 in women with CIN III... - Clinical validation of the Cervista HPV HR and 16/18 genotyping tests for use in women with ASC-US cytologyMark H Einstein
Montefiore Medical Center and Albert Einstein College of Medicine, 1695 Eastchester Road, Bronx, NY 10461, USA
Gynecol Oncol 118:116-22. 2010..This study evaluated the clinical performance of the Cervista HPV HR and 16/18 genotyping tests for detection of HPV in cervical cytology specimens... 
Acquired immune response to oncogenic human papillomavirus associated with prophylactic cervical cancer vaccinesMark H Einstein
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine and Montefiore Medical Center, 1695 Eastchester Rd, Suite 601, Bronx, NY 10461, USA
Cancer Immunol Immunother 57:443-51. 2008..This article reviews the known data regarding natural immune responses to HPV and those developed by prophylactic vaccination...- Survival and toxicity differences between 5-day and weekly cisplatin in patients with locally advanced cervical cancerMark H Einstein
Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Montefiore Medical Center, Bronx, New York, USA
Cancer 109:48-53. 2007..This study was designed to test for differences in progression-free survival (PFS) and toxicity between the 2 regimens... - Combined human papillomavirus DNA and human papillomavirus-like particle serologic assay to identify women at risk for high-grade cervical intraepithelial neoplasiaMark H Einstein
Albert Einstein College of Medicine, Bronx, NY 10461, USA
Int J Cancer 120:55-9. 2007..HPV VLP assays may be useful as an adjunct to HPV DNA testing in a subset of patients that needs to be defined by further studies... - Age-stratified performance of the Cervista HPV 16/18 genotyping test in women with ASC-US cytologyMark H Einstein
Albert Einstein College of Medicine and Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10461, USA
Cancer Epidemiol Biomarkers Prev 20:1185-9. 2011..The objective of this study was to evaluate the clinical performance of the Cervista HPV 16/18 genotyping test for detection of human papilloma virus (HPV) 16 and 18 in cervical cytology specimens in women stratified by age... - Comparison of the immunogenicity and safety of Cervarix and Gardasil human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 yearsMark H Einstein
Montefiore Medical Center, Albert Einstein College of Medicine, Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Bronx, NY, USA
Hum Vaccin 5:705-19. 2009..Long-term studies evaluating duration of efficacy after vaccination are needed for both vaccines... - Phase II trial of adjuvant pelvic radiation "sandwiched" between ifosfamide or ifosfamide plus cisplatin in women with uterine carcinosarcomaMark H Einstein
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, NY, USA
Gynecol Oncol 124:26-30. 2012..This is the first report describing the efficacy and toxicity of adjuvant ifosfamide or ifosfamide plus cisplatin "sandwiched" with RT in patients with surgically staged and completely resected uterine carcinosarcoma... - Efficacy and toxicity of concomitant cisplatin with external beam pelvic radiotherapy and two high-dose-rate brachytherapy insertions for the treatment of locally advanced cervical cancerAkiva P Novetsky
Albert Einstein College of Medicine, Bronx, NY, USA
Gynecol Oncol 105:635-40. 2007.... - Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasiaKoenraad Van Doorslaer
Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Gynecol Oncol 116:208-12. 2010..The induction of a B-cell response by HspE7 and its association with clinical outcome is unknown, and is the purpose of this study... - Radioimmunotherapy with an antibody to the HPV16 E6 oncoprotein is effective in an experimental cervical tumor expressing low levels of E6Rébécca Phaeton
Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, NY, USA
Cancer Biol Ther 10:1041-7. 2010..However, that study opened the question whether radioimmunotherapy can suppress the growth of cervical tumors with low E6 and E7 expression, such as may be seen in patients... - Association of bactericidal activity of genital tract secretions with Escherichia coli colonization in pregnancyJeny P Ghartey
Department of Obstetrics and Gynecology and Women s Health, Montefiore Medical Center, Bronx, NY, USA
Am J Obstet Gynecol 207:297.e1-8. 2012..Genital tract secretions exhibit bactericidal activity against Escherichia coli. We hypothesized that this defense may be modulated during pregnancy... - Paclitaxel plus oxaliplatin for recurrent or metastatic cervical cancer: a New York Cancer Consortium StudyDennis Yi Shin Kuo
Montefiore Medical Center Albert Einstein College of Medicine, Suite 601, Bronx, NY 10461, USA
Gynecol Oncol 116:442-6. 2010..Our objective is to determine the efficacy and toxicity of paclitaxel and oxaliplatin in patients with recurrent or metastatic cervical cancer... - Outcomes after an excisional procedure for cervical intraepithelial neoplasia in HIV-infected womenLaura L Reimers
Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Belfer Educational Center, Room 501, Bronx, NY 10461, USA
Gynecol Oncol 119:92-7. 2010..To determine predictors of treatment failure and recurrence after surgical excisional procedures for CIN in HIV-infected women... - High-grade anal intraepithelial neoplasia among HIV-1-infected men screening for a multicenter clinical trial of a human papillomavirus vaccineTimothy Wilkin
Division of Infectious Diseases, Weill Cornell Medical College, New York, New York 10011, USA
HIV Clin Trials 14:75-9. 2013..High-grade anal intraepithelial neoplasia (HGAIN) is the precursor lesion to invasive anal cancer. Human papillomavirus (HPV) vaccination holds great promise for preventing anal cancer... - Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcomaGloria S Huang
Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA
Gynecol Oncol 107:513-7. 2007..The purpose of this study was to determine the clinical utility of CA125 measurement in patients with uterine carcinosarcoma (CS)... - A phase II study of weekly topotecan and docetaxel in heavily treated patients with recurrent uterine and ovarian cancersDivya Gupta
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA
Gynecol Oncol 113:327-30. 2009..A phase II trial designed to evaluate the safety and efficacy of weekly topotecan and docetaxel in heavily treated patients with recurrent uterine or epithelial ovarian cancers... - Risk factors for persistent cervical intraepithelial neoplasia grades 1 and 2: managed by watchful waitingGloria Y F Ho
Departments of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, USA
J Low Genit Tract Dis 15:268-75. 2011..This study examines risk factors for persistent cervical intraepithelial neoplasia (CIN) and examines whether human papillomavirus (HPV) testing predicts persistent lesions... - Histopathologic differences account for racial disparity in uterine cancer survivalDAVID SMOTKIN
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, NY, USA
Gynecol Oncol 127:616-9. 2012..Reasons for the higher mortality among black women are not completely understood. The aim of our study is to examine the relationship between race/ethnicity, histopathologic subtype, and survival in uterine cancer... - Genetic variants in TAP are associated with high-grade cervical neoplasiaMark H Einstein
Albert Einstein College of Medicine, Bronx, New York, USA
Clin Cancer Res 15:1019-23. 2009..Consistent with heterogeneity in MHC expression is the individual variability in clearing detectable HPV infections. Genetic polymorphisms in TAP genes may affect protein structure, function, and the ability to clear HPV infection... - Cervical intraepithelial neoplasia is associated with genital tract mucosal inflammationMohak Mhatre
Departments of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
Sex Transm Dis 39:591-7. 2012..We hypothesize that women with cervical intraepithelial neoplasia (CIN) will exhibit changes in soluble mucosal immunity that may promote HPV persistence and facilitate HIV infection... - High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancerJune Y Hou
Department of Obstetrics and Gynecology and Women s Health, Montefiore Medical Center, Bronx, NY 10461, USA
J Acquir Immune Defic Syndr 60:169-72. 2012..Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered... - How does public policy impact cervical screening and vaccination strategies?Thomas J Herzog
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Gynecol Oncol 119:175-80. 2010..To examine the current approaches to cervical screening and points to consider for improving HPV vaccination acceptance and uptake in the US... - Vaccine strategies for human papillomavirus-associated cancersAnna S Kadish
Departments of Pathology, Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, 1695 Eastchester Road, Suite 601, Bronx, NY 10461, USA
Curr Opin Oncol 17:456-61. 2005..To review novel immunologic strategies for the prevention and treatment of human papillomavirus infection and associated diseases. Both animal model systems and human protocols are discussed... - Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumorsGloria S Huang
Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
Am J Obstet Gynecol 196:243.e1-5. 2007..This study was undertaken to evaluate the ability of preoperative endometrial sampling to accurately diagnose high-grade endometrial tumors... - Anogenital neoplasia in AIDSMark H Einstein
Albert Einstein College of Medicine, Bronx, New York 10461, USA
Curr Opin Oncol 16:455-62. 2004..Current treatment strategies are not effective in clearing anogenital HPV infection and need improvement. Immunotherapy with novel vaccines will provide both prevention and therapy for these common malignancies... - Human papillomavirus and cervical neoplasiaMark H Einstein
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA
Cancer Invest 20:1080-5. 2002..The low rate of HPV-negative cancers implies an effective HPV vaccine might have the ability to eradicate cervical cancer worldwide... - Issues in cervical cancer incidence and treatment in HIVMark H Einstein
Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center, Bronx, New York, USA
Curr Opin Oncol 22:449-55. 2010..This review discusses the multiple issues surrounding HIV-associated cervical cancer. Also, the unique treatment-related issues in HIV-associated cervical cancer are addressed... - A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancerMarc J Gunter
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
Cancer Epidemiol Biomarkers Prev 17:921-9. 2008..Free IGF-I levels were inversely associated with endometrioid adenocarcinoma, consistent with prior cross-sectional data... - Utilization of the human genome sequence localizes human papillomavirus type 16 DNA integrated into the TNFAIP2 gene in a fatal cervical cancer from a 39-year-old womanMark H Einstein
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Clin Cancer Res 8:549-54. 2002..Availability of the human genome sequence will facilitate identification of cellular genes involved in cervical cancer by high-throughput analysis of viral integration sites... - Phase I randomized safety study of twice daily dosing of acidform vaginal gel: candidate antimicrobial contraceptiveMarla J Keller
Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America
PLoS ONE 7:e46901. 2012..This study was designed to evaluate the safety of vaginal dosing and effects of Acidform on mucosal immune mediators, antimicrobial properties of genital secretions, and vaginal microbiota... - Arteriovenous malformations of the uterus: long-term follow-upPeer Dar
Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
Gynecol Obstet Invest 66:157-61. 2008..The purpose of this study was to describe our experience with diagnosis, management and long-term follow-up of cases with different clinical presentations of uterine AVMs... - A multidisciplinary approach to fertility-sparing therapy for a rare vulvar tumorCary L Dicken
Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York, USA
Fertil Steril 93:267.e5-7. 2010..Case report of a young woman with a rare vulvar malignancy who received treatment with a personalized multidisciplinary approach to balance management of her malignancy without compromising survival with her desire for future pregnancy... - Performance of implementing guideline-driven cervical cancer screening measures in an inner-city hospital systemDaryl L Wieland
Department of Obstetrics and Gynecology, Jacobi Medical Center Bronx, NY, USA
J Low Genit Tract Dis 15:296-302. 2011..We report the prospective performance of a comprehensive tracking, evidence-based algorithmically driven call back, and appointment scheduling system for cervical cancer screening in a resource-limited inner-city population... - Total pelvic exenteration: the Albert Einstein College of Medicine/Montefiore Medical Center Experience (1987 to 2003)Gary L Goldberg
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
Gynecol Oncol 101:261-8. 2006..To review the trends, modifications and results of 103 consecutive total pelvic exenterations (TPE) performed at the Montefiore Medical Center and Albert Einstein College of Medicine from 1987 to 2003... - Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in HIV-1-infected menTimothy Wilkin
Division of Infectious Diseases, Weill Cornell Medical College, Montefiore Medical Center, New York, New York, USA
J Infect Dis 202:1246-53. 2010..Human immunodeficiency virus type 1 (HIV-1)-infected men are at increased risk for anal cancer. Human papillomavirus (HPV) vaccination may prevent anal cancer caused by vaccine types... - The influence of proteasome inhibitor MG132, external radiation, and unlabeled antibody on the tumor uptake and biodistribution of (188)re-labeled anti-E6 C1P5 antibody in cervical cancer in miceRébécca Phaeton
Department of Obstetrics and Gynecology and Women s Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, NY 10461, USA
Cancer 116:1067-74. 2010..They hypothesized that the pretreatment of tumor cells with various agents that cause cell death and/or elevation of E6 levels would increase the accumulation of radiolabeled antibodies to E6 in cervical tumors... - Cervical intraepithelial neoplasia: an overview of diagnosis and managementMark D Levie
Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA
Cancer Invest 20:769-76. 2002 - Uterine artery embolization in the management of vaginal bleeding from cervical pregnancy: a case seriesJonathan J Trambert
Department of Radiology, Montefiore Medical Center and Albert Einstein College of Medicine, New York, New York, USA
J Reprod Med 50:844-50. 2005..To report our experience of selective embolotherapy in 8 consecutive patients with cervical pregnancy (CxP) presenting with vaginal bleeding... - 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursorsL Stewart Massad
Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, St Louis, MO, USA
J Low Genit Tract Dis 17:S1-S27. 2013.... - Expression of COX-2, Ki-67, cyclin D1, and P21 in endometrial endometrioid carcinomasQ Jackie Cao
Department of Pathology, Albert Einstein College of Medicine and Jack D. Weiler Hospital of Montefiore Medical Center, Bronx, New York 10461, USA
Int J Gynecol Pathol 21:147-54. 2002.... - What is the role of HPV typing in the United States now and in the next five years in a vaccinated population?Warner Huh
Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 117:481-5. 2010..To review the current state of HPV typing of the vaccinated population in the United States and potential for typing of this population over the next 5 years... - Pilot phase II trial of radiation "sandwiched" between combination paclitaxel/platinum chemotherapy in patients with uterine papillary serous carcinoma (UPSC)Abbie L Fields
Virginia Gynecologic Oncology, 7603 Forest Avenue, Suite 207, Richmond, VA 23229, USA
Gynecol Oncol 108:201-6. 2008.... - American Cancer Society Guideline for human papillomavirus (HPV) vaccine use to prevent cervical cancer and its precursorsDebbie Saslow
Cancer Control Science Department, American Cancer Society, Altanta, GA, USA
CA Cancer J Clin 57:7-28. 2007..They address the use of prophylactic HPV vaccines, including who should be vaccinated and at what age, as well as a summary of policy and implementation issues. Implications for screening are also discussed... - Cervical cancer prevention in the era of prophylactic vaccines: a preview for gynecologic oncologistsYvonne Collins
University of Illinois, Chicago, IL, USA
Gynecol Oncol 102:552-62. 2006..Gynecologic oncologists will continue to play an important role in promoting optimal prevention practices...
Research Grants
- Expanded Phase II Trial of Carraguard for Prevention of HPV InfectionMark H Einstein; Fiscal Year: 2010..Decreasing HPV rates would have a significant impact on reducing persistent HPV infection, abnormal Pap tests, and cervical cancer nationally and worldwide. ..