Pin Xian Xu

Summary

Affiliation: Montana State University
Country: USA

Publications

  1. pmc Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
    Pin Xian Xu
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Development 129:3033-44. 2002
  2. pmc Six1 is required for the early organogenesis of mammalian kidney
    Pin Xian Xu
    McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 130:3085-94. 2003
  3. pmc Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Dev Biol 293:499-512. 2006
  4. pmc The role of Six1 in mammalian auditory system development
    Weiming Zheng
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 130:3989-4000. 2003
  5. pmc Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme
    Gangadharan Sajithlal
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Dev Biol 284:323-36. 2005
  6. pmc Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 131:5561-72. 2004
  7. pmc Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, MT 59405, USA
    Dev Biol 298:430-41. 2006
  8. pmc Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Hum Mol Genet 17:3340-56. 2008
  9. pmc Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype
    Raphaelle Grifone
    Departement Genetique, Developpement et Pathologie Moleculaire, Institut Cochin INSERM 567, CNRS UMR 8104, Universite Paris V, France
    Mol Cell Biol 24:6253-67. 2004
  10. pmc SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes
    Rainer G Ruf
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:8090-5. 2004

Collaborators

  • Li Huang
  • Bernd Fritzsch
  • Christine Laclef
  • Xin Xu
  • R Maas
  • Richard J Smith
  • Shrawan Kumar
  • K Kawakami
  • C A Stratakis
  • Friedhelm Hildebrandt
  • D Escalier
  • Dan Zou
  • Derek Silvius
  • Raphaelle Grifone
  • Pascal Maire
  • Bethan E Hoskins
  • Dominique Weil
  • Christine Petit
  • Richard M Raymond
  • Josiane Demignon
  • Edgar A Otto
  • Gangadharan Sajithlal
  • Rainer G Ruf
  • Weiming Zheng
  • Christopher Erickson
  • Eun Hee Kim
  • Dongzhu Jin
  • William J Kimberling
  • Claire Niro
  • Evelyne Souil
  • Dana J Orten
  • Florence Bertin
  • Carl H Cramer
  • Julien Giordani
  • Julie Davenport
  • Sven Enerback
  • Sandra Rodrigo-Blomqvist
  • Eva Maria Ruf
  • Charles Schwartz
  • Frank Beekmann
  • Jennifer Berkman
  • Basil J Petrof
  • Robert Kelly
  • Eugene H Chang
  • Jacques Emmanuel Guidotti
  • Markus J Kemper
  • Michael Gattas
  • Thomas J Neuhaus
  • Francois Spitz
  • Dominique Daegelen
  • Patrick D Brophy
  • Soledad Lopez
  • Ulla T Muerb
  • Jean Paul Concordet
  • Valentine Hyland
  • Bihui Tang
  • Zhu Bo Wei

Detail Information

Publications13

  1. pmc Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
    Pin Xian Xu
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Development 129:3033-44. 2002
    ..5 in Eya1(-/-) embryos. Our results indicate that Eya1 controls critical early inductive events involved in the morphogenesis of thymus, parathyroid and thyroid...
  2. pmc Six1 is required for the early organogenesis of mammalian kidney
    Pin Xian Xu
    McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 130:3085-94. 2003
    ..These analyses establish a role for Six1 in the initial inductive step for metanephric development...
  3. pmc Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Dev Biol 293:499-512. 2006
    ..Together, these analyses establish an essential role for Eya1 and Six genes in patterning the third pouch into organ-specific primordia...
  4. pmc The role of Six1 in mammalian auditory system development
    Weiming Zheng
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 130:3989-4000. 2003
    ..These analyses establish a role for Six1 in early growth and patterning of the otic vesicle...
  5. pmc Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme
    Gangadharan Sajithlal
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Dev Biol 284:323-36. 2005
    ....
  6. pmc Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 131:5561-72. 2004
    ..These analyses define a specific role for both genes in early differentiation and survival of the placodally derived cranial sensory neurons...
  7. pmc Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, MT 59405, USA
    Dev Biol 298:430-41. 2006
    ....
  8. pmc Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Hum Mol Genet 17:3340-56. 2008
    ..These results also provide a molecular mechanism for understanding how hypomorphic levels of EYA1 cause inner-ear defects in humans...
  9. pmc Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype
    Raphaelle Grifone
    Departement Genetique, Developpement et Pathologie Moleculaire, Institut Cochin INSERM 567, CNRS UMR 8104, Universite Paris V, France
    Mol Cell Biol 24:6253-67. 2004
    ..Collectively, these data identify Six1 and Eya1 as the first transcriptional complex that is able to reprogram adult slow-twitch oxidative fibers toward a fast-twitch glycolytic phenotype...
  10. pmc SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes
    Rainer G Ruf
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:8090-5. 2004
    ..Identification of SIX1 mutations as causing BOR/BO offers insights into the molecular basis of otic and renal developmental diseases in humans...
  11. ncbi request reprint Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo
    Raphaelle Grifone
    département génétique et développement, Institut Cochin Paris, INSERM, U567, Paris, F 75014 France
    Dev Biol 302:602-16. 2007
    ..These results establish a new hierarchy of genes controlling early steps of hypaxial myogenic commitment in the mouse embryo...
  12. pmc Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome
    Bethan E Hoskins
    Department of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    Am J Hum Genet 80:800-4. 2007
    ..We thereby identified heterozygous mutations in SIX5 as a novel cause of BOR...
  13. ncbi request reprint Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant
    Denise Escalier
    Histologie Fonctionnelle et Moléculaire, Université Paris 5 and INSERM U 407, France
    Mol Reprod Dev 65:298-308. 2003
    ..Flagellar anomalies of Ube2b null mice were previously described in infertile men indicating a possible genetic pathway for flagellar periaxonemal assembly in human...