David W Pascual
Affiliation: Montana State University
Pascual D, Trunkle T, Sura J. Fimbriated Salmonella enterica serovar typhimurium abates initial inflammatory responses by macrophages. Infect Immun. 2002;70:4273-81 pubmed
..This evidence shows that the expression of CFA/I fimbriae alters how macrophages recognize or process salmonellae and prevents the rapid onset of proinflammatory cytokines which is typical during Salmonella infections. ..
Pascual D, Ochoa Reparaz J, Rynda A, Yang X. Tolerance in the absence of autoantigen. Endocr Metab Immune Disord Drug Targets. 2007;7:203-10 pubmed
..Thus, these data show that T(reg) cells are induced by oral vaccination with Salmonella-CFA/I contributing to the efficacious treatment of autoimmune disease. ..
Clapp B, Golden S, Maddaloni M, Staats H, Pascual D. Adenovirus F protein as a delivery vehicle for botulinum B. BMC Immunol. 2010;11:36 pubmed publisher
..0 LD50. These results demonstrate that Hcbetatre-based immunogens are highly immunogenic, especially when genetically fused to Ad2F, and Ad2F can be exploited as a vaccine delivery platform to the mucosa. ..
Walters N, Trunkle T, Sura M, Pascual D. Enhanced immunoglobulin A response and protection against Salmonella enterica serovar typhimurium in the absence of the substance P receptor. Infect Immun. 2005;73:317-24 pubmed
..Thus, these studies suggest that SP mediation contributes to proinflammatory responses to Salmonella infections. ..
Pascual D, Wang X, Kochetkova I, Callis G, Riccardi C. The absence of lymphoid CD8+ dendritic cell maturation in L-selectin-/- respiratory compartment attenuates antiviral immunity. J Immunol. 2008;181:1345-56 pubmed
..These studies show that impairment of L-Sel(-/-) DC maturation results in insufficient mature DCs that require microbial activation to restore increases in respiratory CD8(+) DCs to support CTL responses. ..