David Pascual

Summary

Affiliation: Montana State University
Country: USA

Publications

  1. pmc IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE)
    Agnieszka Rynda
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America
    PLoS ONE 5:e8720. 2010
  2. pmc Loss of sialic acid binding domain redirects protein σ1 to enhance M cell-directed vaccination
    Dagmara Zlotkowska
    Department of Food Chemistry, Institute of Food Research, Polish Academy of Science, Olsztyn, Poland
    PLoS ONE 7:e36182. 2012
  3. pmc Murine and bovine γδ T cells enhance innate immunity against Brucella abortus infections
    Jerod A Skyberg
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America
    PLoS ONE 6:e21978. 2011
  4. pmc IFN-γ-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis
    Jerod A Skyberg
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    J Leukoc Biol 92:375-87. 2012
  5. pmc Adenovirus F protein as a delivery vehicle for botulinum B
    Beata Clapp
    Montana State University, Bozeman, 59717 3610, USA
    BMC Immunol 11:36. 2010
  6. pmc Vaccines are for dinner
    David W Pascual
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Proc Natl Acad Sci U S A 104:10757-8. 2007
  7. ncbi request reprint Tolerance in the absence of autoantigen
    D W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717 3610, USA
    Endocr Metab Immune Disord Drug Targets 7:203-10. 2007
  8. pmc The absence of lymphoid CD8+ dendritic cell maturation in L-selectin-/- respiratory compartment attenuates antiviral immunity
    David W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    J Immunol 181:1345-56. 2008
  9. pmc Enhanced immunoglobulin A response and protection against Salmonella enterica serovar typhimurium in the absence of the substance P receptor
    Nancy Walters
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Infect Immun 73:317-24. 2005
  10. pmc Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response
    D W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717 3610, USA
    Infect Immun 67:6249-56. 1999

Research Grants

  1. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2000
  2. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2006
  3. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2006
  4. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2006
  5. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2007
  6. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2007
  7. CAM Intervention for Rheumatoid Arthritis
    David Pascual; Fiscal Year: 2007
  8. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2009
  9. Mucosal Therapy for Autoimmunity
    David Pascual; Fiscal Year: 2009
  10. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2005

Collaborators

Detail Information

Publications48

  1. pmc IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE)
    Agnieszka Rynda
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America
    PLoS ONE 5:e8720. 2010
    ..Thus, psigma1-based therapy can resolve EAE independently of or dependently upon CD25 and assigns IL-28 as an alternative therapy for autoimmunity...
  2. pmc Loss of sialic acid binding domain redirects protein σ1 to enhance M cell-directed vaccination
    Dagmara Zlotkowska
    Department of Food Chemistry, Institute of Food Research, Polish Academy of Science, Olsztyn, Poland
    PLoS ONE 7:e36182. 2012
    ..Thus, these studies show that pσ1(s) can be fused to vaccines to effectively elicit improved SIgA responses...
  3. pmc Murine and bovine γδ T cells enhance innate immunity against Brucella abortus infections
    Jerod A Skyberg
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America
    PLoS ONE 6:e21978. 2011
    ..abortus via IFN-γ. Collectively, these results demonstrate γδ T cells are important for early protection to B. abortus infections...
  4. pmc IFN-γ-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis
    Jerod A Skyberg
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    J Leukoc Biol 92:375-87. 2012
    ....
  5. pmc Adenovirus F protein as a delivery vehicle for botulinum B
    Beata Clapp
    Montana State University, Bozeman, 59717 3610, USA
    BMC Immunol 11:36. 2010
    ....
  6. pmc Vaccines are for dinner
    David W Pascual
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Proc Natl Acad Sci U S A 104:10757-8. 2007
  7. ncbi request reprint Tolerance in the absence of autoantigen
    D W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717 3610, USA
    Endocr Metab Immune Disord Drug Targets 7:203-10. 2007
    ..Thus, these data show that T(reg) cells are induced by oral vaccination with Salmonella-CFA/I contributing to the efficacious treatment of autoimmune disease...
  8. pmc The absence of lymphoid CD8+ dendritic cell maturation in L-selectin-/- respiratory compartment attenuates antiviral immunity
    David W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    J Immunol 181:1345-56. 2008
    ..These studies show that impairment of L-Sel(-/-) DC maturation results in insufficient mature DCs that require microbial activation to restore increases in respiratory CD8(+) DCs to support CTL responses...
  9. pmc Enhanced immunoglobulin A response and protection against Salmonella enterica serovar typhimurium in the absence of the substance P receptor
    Nancy Walters
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Infect Immun 73:317-24. 2005
    ..Thus, these studies suggest that SP mediation contributes to proinflammatory responses to Salmonella infections...
  10. pmc Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response
    D W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717 3610, USA
    Infect Immun 67:6249-56. 1999
    ..This biphasic response offers an alternative strategy for directing Salmonella vector-induced host immunity along a Th2 cell-dependent pathway, allowing for early promotion of mucosal and systemic Abs...
  11. pmc Fimbriated Salmonella enterica serovar typhimurium abates initial inflammatory responses by macrophages
    David W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman 59717 3610, USA
    Infect Immun 70:4273-81. 2002
    ..This evidence shows that the expression of CFA/I fimbriae alters how macrophages recognize or process salmonellae and prevents the rapid onset of proinflammatory cytokines which is typical during Salmonella infections...
  12. ncbi request reprint Distal IgA immunity can be sustained by alphaEbeta7+ B cells in L-selectin-/- mice following oral immunization
    D W Pascual
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, USA
    Mucosal Immunol 1:68-77. 2008
    ..These studies show that HNLN B cells express alpha(E)beta(7) in the absence of L-selectin to sustain distal IgA responses...
  13. ncbi request reprint The protective role of interleukin-18 in Salmonella infection
    D W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717 3610, USA
    Curr Opin Infect Dis 14:265-71. 2001
    ..Nonetheless, an understanding of how some pathogens have evolved to circumvent interleukin-18 and of how interleukin-18 can be effectively induced are essential to our ability to develop better vaccines against enteric pathogens...
  14. pmc Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression
    Jerod A Skyberg
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA
    J Leukoc Biol 90:1043-54. 2011
    ..Collectively, these results show that oral administration of APP protects against experimental colitis and diminishes proinflammatory cytokine expression via T cells...
  15. ncbi request reprint Segregation of mechanisms for cytotoxic T lymphocyte killing between lungs and regional lymph nodes subsequent to intratracheal delivery of adenovirus 2 vector
    Xinhai Wang
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717 3610, USA
    Viral Immunol 16:525-39. 2003
    ..Ad2-restimulated cells showed bias toward IL-2 and IFN-gamma, while betagal-restimulated cells showed bias toward IL-4 and IL-10...
  16. pmc A nasal interleukin-12 DNA vaccine coexpressing Yersinia pestis F1-V fusion protein confers protection against pneumonic plague
    Hitoki Yamanaka
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717 3610, USA
    Infect Immun 76:4564-73. 2008
    ..These results show that IL-12 can be used as a molecular adjuvant to enhance protective immunity against pneumonic plague, but in a dose-dependent fashion...
  17. pmc Attenuated Coxiella burnetii phase II causes a febrile response in gamma interferon knockout and Toll-like receptor 2 knockout mice and protects against reinfection
    Javier Ochoa-Repáraz
    Veterinary Molecular Biology, Montana State University, P O Box 173610, Bozeman, MT 59717 3610, USA
    Infect Immun 75:5845-58. 2007
    ..Thus, our data show that NMII is capable of eliciting disease in immunocompromised mice, which may help in evaluation of vaccine candidates as well as the study of host-pathogen interactions...
  18. ncbi request reprint Absence of L-selectin delays mucosal B cell responses in nonintestinal effector tissues
    Keri L Csencsits
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 169:5649-59. 2002
    ..Yet, these increases in CONALT AFC correlated with restoration of immunity in L-Sel(-/-) nasal passages and reproductive tracts...
  19. ncbi request reprint Development of a transient CD4(+)CD8(+) T cell subset in the cervical lymph nodes following intratracheal instillation with an adenovirus vector
    Peter Hillemeyer
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Cell Immunol 215:173-85. 2002
    ..Such co-stimulation also favored the production of IFN-gamma and IL-10 where CD4(+) T cells were more inclined to produce IFN-gamma and IL-2...
  20. ncbi request reprint Nasal immunization with recombinant Brucella melitensis bp26 and trigger factor with cholera toxin reduces B. melitensis colonization
    Xinghong Yang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Vaccine 25:2261-8. 2007
    ..When immunized mice were challenged with B. melitensis 16M, bp26-plus Tf-immunized mice showed no difference in splenic weights but harbored three-fold less bacterial CFU when compared to sPBS-immunized control mice...
  21. pmc Partially assembled K99 fimbriae are required for protection
    Miguel A Ascón
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Infect Immun 73:7274-80. 2005
    ..Thus, these studies showed that retention of K99 fimbrial subunit as native fimbriae or with the deletion of fanGH is sufficient to confer protection...
  22. ncbi request reprint Mucosal addressin expression and binding-interactions with naive lymphocytes vary among the cranial, oral, and nasal-associated lymphoid tissues
    Keri L Csencsits
    Montana State University, Bozeman, USA
    Eur J Immunol 32:3029-39. 2002
    ....
  23. pmc A parenteral DNA vaccine protects against pneumonic plague
    Hitoki Yamanaka
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    Vaccine 28:3219-30. 2010
    ..m. immunization. These results show that LTN can be used as a molecular adjuvant to enhance protective immunity against plague...
  24. pmc An IL-12 DNA vaccine co-expressing Yersinia pestis antigens protects against pneumonic plague
    Hitoki Yamanaka
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Vaccine 27:80-7. 2009
    ..These results show that IL-12 can be used as a molecular adjuvant to enhance protective immunity against pneumonic plague...
  25. doi request reprint DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate
    Xinghong Yang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Vaccine 28:1069-74. 2010
    ..abortus 2308 conferred 0.79 log protection, similar to S19 as did a single dose of DeltaznuA B. abortus 2308. Thus, this study shows the DeltaznuA DeltapurE B. abortus 2308 strain to be a potential livestock vaccine candidate...
  26. pmc Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1
    Agnieszka Rynda
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718, USA
    J Immunol 180:5187-200. 2008
    ..These data demonstrate the feasibility of using psigma1 as a mucosal delivery platform specifically for low-dose tolerance induction...
  27. pmc IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10
    Irina Kochetkova
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 184:7144-53. 2010
    ..IL-35 treatments of IL-10-/- mice failed to induce protective CD39+CD4+ T cells, demonstrating the effector role of IL-10 by IL-35 immunosuppression...
  28. pmc Selection of protective epitopes for Brucella melitensis by DNA vaccination
    Xinghong Yang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Infect Immun 73:7297-303. 2005
    ..These collective results suggest that both bp26 and TF are excellent candidates for use in future vaccination studies against brucellosis...
  29. ncbi request reprint M cell DNA vaccination for CTL immunity to HIV
    Xinhai Wang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 171:4717-25. 2003
    ..Thus, compared with live vectors, protein sigma1-mediated DNA delivery represents an alternative mucosal formulation for inducing cellular immunity against HIV-1...
  30. ncbi request reprint Transgene vaccination using Ulex europaeus agglutinin I (UEA-1) for targeted mucosal immunization against HIV-1 envelope
    Xinhai Wang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Vaccine 23:3836-42. 2005
    ..Likewise, elevated envelope-specific CTLs were induced. Thus, UEA-1 mediated DNA delivery represents an alternative mucosal formulation for inducing humoral and cellular immunity against HIV-1...
  31. ncbi request reprint A live diarrheal vaccine imprints a Th2 cell bias and acts as an anti-inflammatory vaccine
    SangMu Jun
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    J Immunol 175:6733-40. 2005
    ....
  32. pmc Deletion of znuA virulence factor attenuates Brucella abortus and confers protection against wild-type challenge
    Xinghong Yang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Infect Immun 74:3874-9. 2006
    ..Protection studies confirmed the DeltaznuA mutant as a potential live vaccine, since protection against wild-type B. abortus 2308 challenge was as effective as that obtained with the RB51 or S19 vaccine strain...
  33. pmc IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen
    Javier Ochoa-Repáraz
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 181:954-68. 2008
    ..Importantly, these T(reg) cells can be induced to high potency by simply vaccinating against irrelevant Ags, offering a novel approach to treat autoimmune diseases independently of the autoantigen...
  34. pmc Antibody selection for immobilizing living bacteria
    Zhiyong Suo
    Department of Physics, Montana State University, Bozeman, Montana 59717, USA
    Anal Chem 81:7571-8. 2009
    ..The microarrays of living S. Typhimurium cells immobilized in this manner remained viable and effective for at least 2 weeks in growth medium before a thick biofilm covered the whole surface...
  35. pmc Mucosal lymphatic-derived gammadelta T cells respond early to experimental Salmonella enterocolitis by increasing expression of IL-2R alpha
    Jodi F Hedges
    Veterinary Molecular Biology, Montana State University, 960 Technology Boulevard, Bozeman, MT 59718, USA
    Cell Immunol 246:8-16. 2007
    ..Together with gene expression trends in vivo, these data support early priming activation of target tissue gammadelta T cells during Salmonella serovar Typhimurium infection...
  36. pmc Protective live oral brucellosis vaccines stimulate Th1 and th17 cell responses
    Beata Clapp
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, MT 59718 3610, USA
    Infect Immun 79:4165-74. 2011
    ..These data suggest that oral immunization with the live, attenuated ΔznuA B. melitensis vaccine provides an attractive strategy to protect against inhalational infection with virulent B. melitensis...
  37. ncbi request reprint Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A
    Massimo Maddaloni
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    J Immunol 177:5524-32. 2006
    ..This study shows that the Hcbetatre structure can confer protective immunity and that use of Hcbetatre-Ad2F gives more rapid and sustained mucosal and plasma Ab responses...
  38. pmc Efficient immobilization and patterning of live bacterial cells
    Zhiyong Suo
    Imaging and Chemical Analysis Laboratory, Department of Physics, and Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    Langmuir 24:4161-7. 2008
    ..This method was successfully used to sort a targeted bacterial species from a mixed culture within 2 h...
  39. doi request reprint Bacteria survive multiple puncturings of their cell walls
    Zhiyong Suo
    Imaging and Chemical Analysis Laboratory, Department of Physics, Montana State University, Bozeman, MT 59717, USA
    Langmuir 25:4588-94. 2009
    ..The results are explained on the basis of the concept of the self-repairing of lipid bilayers and the peptidoglycan layer...
  40. ncbi request reprint Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague
    Xinghong Yang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 178:1059-67. 2007
    ..pestis. These results show that a single Salmonella vaccine can deliver both F1- and V-Ags to effect both systemic and mucosal immune protection against Y. pestis...
  41. pmc Vaccination without autoantigen protects against collagen II-induced arthritis via immune deviation and regulatory T cells
    Irina Kochetkova
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 181:2741-52. 2008
    ..These data show that Salmonella-CFA/I vaccination of DBA/1 mice protects against collagen-induced arthritis by stimulating TGF-beta- and IL-4-producing regulatory CD4(+) T cells...
  42. ncbi request reprint HEPES-stabilized encapsulation of Salmonella typhimurium
    Zhiyong Suo
    Imaging and Chemical Analysis Laboratory, Department of Physics, Montana State University, Bozeman, MT 59717, USA
    Langmuir 23:1365-74. 2007
    ....
  43. ncbi request reprint The role of tachykinins on bacterial infections
    David W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Front Biosci 9:3209-17. 2004
    ..Thus, tachykinins introduce new circuits to immune regulation suggesting that these neuropeptides exhibit cytokine- and chemokine-like action...
  44. pmc Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells
    Hideaki Suzuki
    Department of Pediatric Dentistry, The Immunobiology Vaccine Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 135:917-25. 2008
    ..In this study, we examined whether M-cell targeting using a protein antigen (Ag) delivery system would induce oral tolerance instead of enhancement of Ag-specific mucosal antibody (Ab) responses...
  45. ncbi request reprint Mucosal vaccine development for botulinum intoxication
    Kohtaro Fujihashi
    Department of Pediatric Dentistry, The Immunobiology Vaccine Center, The University of Alabama at Birmingham, AL, USA
    Expert Rev Vaccines 6:35-45. 2007
    ..In this article, we will discuss the importance of the development of a mucosal vaccine against botulinum and introduce current aspects of BoNT mucosal vaccines, which show that they effectively prevent mucosal BoNT intoxication...
  46. ncbi request reprint Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis
    Javier Ochoa-Repáraz
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 178:1791-9. 2007
    ..These data show that T(reg) cells can be induced to high potency to non-disease-inducing Ags using a bacterial vaccine...
  47. ncbi request reprint A novel neurotoxoid vaccine prevents mucosal botulism
    Ryoki Kobayashi
    Department of Pediatric Dentistry, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 174:2190-5. 2005
    ..The fecal extract samples from nasally vaccinated mice were found to contain neutralizing secretory IgA Abs. Taken together, these results show that nasal BoNT/A vaccine effectively prevents mucosal BoNT intoxication...
  48. ncbi request reprint Expression and immunogenicity of an Escherichia coli K99 fimbriae subunit antigen in soybean
    Kenneth J Piller
    Department of Biology, University of North Carolina Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
    Planta 222:6-18. 2005
    ..These experiments are the first to demonstrate the expression and immunogenicity of a model subunit antigen in the soybean system, and mark the first steps toward the development of a K99 edible vaccine to protect against ETEC...

Research Grants28

  1. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2000
    ..abstract_text> ..
  2. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2006
    ..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
  3. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2006
    ..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
  4. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2006
    ..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
  5. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2007
    ..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
  6. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2007
    ..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
  7. CAM Intervention for Rheumatoid Arthritis
    David Pascual; Fiscal Year: 2007
    ..This application is responsive to RFA-AT-06-005: "Mechanisms of Immune Modulation" by addressing the requested research areas in understanding CAMs' mechanisms of action upon the induction and expansion of T cell regulatory populations. ..
  8. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2009
    ..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
  9. Mucosal Therapy for Autoimmunity
    David Pascual; Fiscal Year: 2009
    ..Thus, once we are able to establish the ps1 delivery technology, we will move forward to use current models for Sj"gren's Syndrome to test if disease progression can be reduced. ..
  10. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2005
    ..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
  11. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2005
    ..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
  12. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2000
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  13. MUCOSAL TRANSGENE VACCINATION FOR HIV
    David Pascual; Fiscal Year: 2001
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity via the common mucosal immune system. ..
  14. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2001
    ..abstract_text> ..
  15. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2001
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  16. MUCOSAL TRANSGENE VACCINATION FOR HIV
    David Pascual; Fiscal Year: 2002
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity via the common mucosal immune system. ..
  17. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2002
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  18. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2003
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  19. MUCOSAL TRANSGENE VACCINATION FOR HIV
    David Pascual; Fiscal Year: 2003
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity via the common mucosal immune system. ..
  20. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2004
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  21. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2004
    ..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
  22. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2004
    ..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
  23. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2005
    ..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
  24. Mucosal Therapy for Autoimmunity
    David W Pascual; Fiscal Year: 2010
    ..Thus, once we are able to establish the ps1 delivery technology, we will move forward to use current models for Sj"gren's Syndrome to test if disease progression can be reduced. ..