Michael Otto

Summary

Affiliation: Montana State University
Country: USA

Publications

  1. pmc Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection
    Tyler K Nygaard
    Department of Immunology and Infectious Diseases, Montana State University Bozeman, Montana, United States of America
    PLoS ONE 7:e36532. 2012
  2. pmc The SaeR/S gene regulatory system induces a pro-inflammatory cytokine response during Staphylococcus aureus infection
    Robert L Watkins
    Department of Immunology Infectious Diseases, Montana State University Bozeman, Bozeman, Montana, United States of America
    PLoS ONE 6:e19939. 2011
  3. pmc The impact of α-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300
    Tyler K Nygaard
    1 Lewis Hall, Montana State University, Bozeman, MT 59717, USA
    J Leukoc Biol 94:971-9. 2013
  4. pmc The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus
    Jovanka M Voyich
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Infect Dis 199:1698-706. 2009
  5. pmc Global changes in Staphylococcus aureus gene expression in human blood
    Natalia Malachowa
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e18617. 2011
  6. pmc Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, and Bethesda, Maryland, USA
    J Infect Dis 204:937-41. 2011
  7. ncbi request reprint Genomewide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into the pathophysiology of S. epidermidis biofilms and the role of phenol-soluble modulins in formation of biofilms
    Yufeng Yao
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 191:289-98. 2005
  8. ncbi request reprint The antimicrobial peptide-sensing system aps of Staphylococcus aureus
    Min Li
    Laboratory of Human Bacterial Pathogenesis, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana, USA
    Mol Microbiol 66:1136-47. 2007
  9. ncbi request reprint Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo
    Cuong Vuong
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 190:1498-505. 2004
  10. pmc SpyA, a C3-like ADP-ribosyltransferase, contributes to virulence in a mouse subcutaneous model of Streptococcus pyogenes infection
    Jessica S Hoff
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Infect Immun 79:2404-11. 2011

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection
    Tyler K Nygaard
    Department of Immunology and Infectious Diseases, Montana State University Bozeman, Montana, United States of America
    PLoS ONE 7:e36532. 2012
    ..aureus infection of human tissue and specifically demonstrate Hla activity during USA300 infection triggers programmed cell death of human monocytes, T cells and B cells that leads to plasma membrane permeability...
  2. pmc The SaeR/S gene regulatory system induces a pro-inflammatory cytokine response during Staphylococcus aureus infection
    Robert L Watkins
    Department of Immunology Infectious Diseases, Montana State University Bozeman, Bozeman, Montana, United States of America
    PLoS ONE 6:e19939. 2011
    ..aureus during staphylococcal disease and characterizes a relationship between a bacterial global regulator of virulence and the production of pro-inflammatory mediators...
  3. pmc The impact of α-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300
    Tyler K Nygaard
    1 Lewis Hall, Montana State University, Bozeman, MT 59717, USA
    J Leukoc Biol 94:971-9. 2013
    ....
  4. pmc The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus
    Jovanka M Voyich
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Infect Dis 199:1698-706. 2009
    ..These data provide new insight into how virulence is regulated in S. aureus and associates a specific staphylococcal gene-regulatory system with invasive staphylococcal disease...
  5. pmc Global changes in Staphylococcus aureus gene expression in human blood
    Natalia Malachowa
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 6:e18617. 2011
    ..These findings, along with a requirement of specific growth conditions for leukotoxin expression, may explain the apparent limited contribution of any single two-component leukotoxin to USA300 immune evasion and virulence...
  6. pmc Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, and Bethesda, Maryland, USA
    J Infect Dis 204:937-41. 2011
    ..The data indicate that Hla, PSMα, and Agr contribute to the pathogenesis of USA300 skin infections in rabbits, whereas a role for PVL could not be detected...
  7. ncbi request reprint Genomewide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into the pathophysiology of S. epidermidis biofilms and the role of phenol-soluble modulins in formation of biofilms
    Yufeng Yao
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 191:289-98. 2005
    ..The observed physiological characteristics of the biofilm mode of growth--in particular, the contribution of surfactant-like peptides--might serve as a model for a variety of biofilm-forming pathogens...
  8. ncbi request reprint The antimicrobial peptide-sensing system aps of Staphylococcus aureus
    Min Li
    Laboratory of Human Bacterial Pathogenesis, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana, USA
    Mol Microbiol 66:1136-47. 2007
    ..aureus...
  9. ncbi request reprint Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo
    Cuong Vuong
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 190:1498-505. 2004
    ..epidermidis during infection of indwelling medical devices. The permanent elimination of quorum-sensing regulation used by S. epidermidis represents a surprising and unusual means to adapt to a certain environment and type of infection...
  10. pmc SpyA, a C3-like ADP-ribosyltransferase, contributes to virulence in a mouse subcutaneous model of Streptococcus pyogenes infection
    Jessica S Hoff
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Infect Immun 79:2404-11. 2011
    ..We conclude that SpyA contributes to streptococcal pathogenesis in the mouse subcutaneous infection model. Our observations suggest that the presence of SpyA delays wound healing in this model...
  11. pmc Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 100:1996-2001. 2003
    ..The gene regulatory program revealed by our studies identifies previously undescribed potential vaccine antigens and targets for therapeutic interventions designed to control GAS infections...
  12. pmc Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response
    Sean D Reid
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Bacteriol 184:6316-24. 2002
    ..These results are additional evidence that postgenomic strategies provide new ways to identify and investigate novel bacterial proteins that may participate in host-pathogen interactions or serve as targets for therapeutics research...
  13. pmc Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes
    Benfang Lei
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 70:4494-500. 2002
    ..The shp gene was cotranscribed with eight contiguous genes, including homologues of an ABC transporter involved in iron uptake in gram-negative bacteria. Our results indicate that Shp is a novel cell surface heme-associated protein...
  14. pmc Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes
    Benfang Lei
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Infect Immun 71:5962-9. 2003
    ..Our results suggest that HtsABC is an ABC transporter that may participate in heme acquisition in GAS...
  15. ncbi request reprint Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    J Immunol 175:3907-19. 2005
    ..Our studies reveal a gene transcription program in a prominent human pathogen that likely contributes to evasion of innate host defense...
  16. pmc Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis
    Stanislava Kocianova
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases NIAID, NIH, Hamilton, Montana 59840, USA
    J Clin Invest 115:688-94. 2005
    ..Our study presents important novel biological functions for PGA and indicates that PGA represents an excellent target for therapeutic maneuvers aimed at treating disease caused by S. epidermidis and related staphylococci...
  17. ncbi request reprint A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence
    Cuong Vuong
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 279:54881-6. 2004
    ..Notably, this general virulence mechanism is likely similar for other pathogenic bacteria and constitutes an excellent target for therapeutic maneuvers aimed at combating biofilm-associated infection...
  18. ncbi request reprint Streptococcus pyogenes and human neutrophils: a paradigm for evasion of innate host defense by bacterial pathogens
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, MT 59840, USA
    Microbes Infect 6:1117-23. 2004
    ..This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms...
  19. ncbi request reprint Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain
    David J Banks
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 190:727-38. 2004
    ..Our studies add to the theme that GAS prophage-encoded extracellular proteins contribute to host-pathogen interactions in a strain-specific fashion...
  20. ncbi request reprint Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 173:1194-201. 2004
    ..Importantly, our studies identify specific genes in the pathogen survival response as potential targets to control human infections...
  21. pmc Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins
    Sean D Reid
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 71:7043-52. 2003
    ..These studies characterize the first GAS LRR protein as an extracellular virulence factor that contributes to pathogenesis and may participate in evasion of the innate host defense...
  22. pmc Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 100:10948-53. 2003
    ..pyogenes alters the apoptosis differentiation program in neutrophils, resulting in pathogen survival and disease...
  23. ncbi request reprint Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 170:3357-68. 2003
    ..These findings provide new insight into the molecular events that resolve inflammation following PMN activation in humans...
  24. pmc Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexes
    Benfang Lei
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 70:6880-90. 2002
    ..Taken together, the data add to the emerging theme in GAS pathogenesis that allelic variation in virulence genes contributes to fundamental differences in host-pathogen interactions among strains...
  25. pmc Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells
    Nancy P Hoe
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 99:7646-51. 2002
    ..Sic enhances bacterial survival by enabling the pathogen to avoid the intracellular environment. This process contributes to the abundance of M1 GAS in human infections and their ability to cause epidemics...

Research Grants1

  1. Role of the saeR/S gene regulatory system in S. aureus pathogenesis
    Jovanka Voyich; Fiscal Year: 2007
    ..aureus pathogenesis. Perhaps more importantly, the proposed research should identify pathogenic strategies used by S. aureus to initiate infection. ..