Research Topics

CHARLES MARTIN LAWRENCE

Summary

Affiliation: Montana State University
Country: USA

Publications

  1. ncbi Recognition of archaeal CRISPR RNA: No P in the alindromic repeat?
    C Martin Lawrence
    Department of Chemistry and Biochemistry and Thermal Biology Institute, Montana State University, Bozeman, MT 59717, USA
    Structure 19:142-4. 2011
  2. ncbi Structural and functional studies of archaeal viruses
    C Martin Lawrence
    Department of Chemistry and Biochemistry and Microbiology, Montana State University, Bozeman, MT 59717, USA
    J Biol Chem 284:12599-603. 2009
  3. ncbi The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily
    Smita K Menon
    Thermal Biology Institute, Montana State University, Bozeman, MT 59717, USA
    J Virol 84:5890-7. 2010

Research Grants

  1. CRYSTALLOGRAPHIC STUDIES OF IRE BINDING PROTEIN
    Charles Lawrence; Fiscal Year: 2004
  2. Structural and Functional Studies of Iron Transport and Homeostasis
    CHARLES MARTIN LAWRENCE; Fiscal Year: 2010

Collaborators

  • Smita K Menon
  • Brian J Eilers
  • Mark J Young

Detail Information

Publications3

  1. ncbi Recognition of archaeal CRISPR RNA: No P in the alindromic repeat?
    C Martin Lawrence
    Department of Chemistry and Biochemistry and Thermal Biology Institute, Montana State University, Bozeman, MT 59717, USA
    Structure 19:142-4. 2011
    ..2011) show that the CRISPR endonuclease Cas6 wraps an unstructured CRISPR RNA repeat around its surface to achieve recognition and cleavage, suggesting that palindromic RNA is not a feature of many CRISPR subtypes...
  2. ncbi Structural and functional studies of archaeal viruses
    C Martin Lawrence
    Department of Chemistry and Biochemistry and Microbiology, Montana State University, Bozeman, MT 59717, USA
    J Biol Chem 284:12599-603. 2009
    ..Here, we review progress in understanding these fascinating viruses at the molecular level and the evolutionary insights coming from these studies...
  3. ncbi The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily
    Smita K Menon
    Thermal Biology Institute, Montana State University, Bozeman, MT 59717, USA
    J Virol 84:5890-7. 2010
    ..The greatest structural similarity is found to the archaeal Holliday junction cleavage enzymes, strongly suggesting a role in DNA replication, repair, or recombination. Other roles associated with nuclease activity are also considered...

Research Grants7

  1. CRYSTALLOGRAPHIC STUDIES OF IRE BINDING PROTEIN
    Charles Lawrence; Fiscal Year: 2004
    ..The greater insight provided by these studies into the specific interactions of IRPs with IREs may lead us a step closer towards the development of treatments for disease of iron metabolism. ..
  2. Structural and Functional Studies of Iron Transport and Homeostasis
    CHARLES MARTIN LAWRENCE; Fiscal Year: 2010
    ..For this reason, the Steap proteins represent potential targets of drug therapy in a variety of human disorders. ..