G A Carlson

Summary

Affiliation: Montana State University
Country: USA

Publications

  1. pmc A systems approach to prion disease
    Daehee Hwang
    Institute for Systems Biology, Seattle, WA 98103, USA
    Mol Syst Biol 5:252. 2009
  2. pmc Failure to transmit disease from gray tremor mutant mice
    G A Carlson
    McLaughlin Research Institute, Great Falls, Montana 59405, USA
    J Virol 71:2342-5. 1997
  3. ncbi request reprint Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice
    G A Carlson
    McLaughlin Research Institute, Great Falls, MT 59405, USA
    Hum Mol Genet 6:1951-9. 1997
  4. ncbi request reprint Genetics of prion diseases and prion diversity in mice
    G A Carlson
    McLaughlin Research Institute, Great Falls, Montana 59405
    Philos Trans R Soc Lond B Biol Sci 343:363-9. 1994
  5. pmc Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse
    G A Carlson
    McLaughlin Research Institute, Great Falls, Montana 59401
    Genetics 133:979-88. 1993
  6. ncbi request reprint Quantitative trait loci affecting prion incubation time in mice
    D A Stephenson
    McLaughlin Research Institute, Great Falls, Montana 59405, USA
    Genomics 69:47-53. 2000
  7. pmc Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice
    G A Carlson
    McLaughlin Research Institute, Great Falls, MT 59405
    Proc Natl Acad Sci U S A 91:5690-4. 1994
  8. pmc Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells
    Rajeev Kumar
    McLaughlin Research Institute, Great Falls, MT 59405, USA
    J Gen Virol 89:1525-32. 2008
  9. ncbi request reprint Postexposure prophylaxis against transmissible spongiform encephalopathies: CpG oligodeoxynucleotides in mice
    George A Carlson
    McLaughlin Research Institute, Great Falls, MT 59405, USA
    Lancet 360:184. 2002
  10. pmc Prion infection of mouse neurospheres
    Ranjit K Giri
    McLaughlin Research Institute, Great Falls, MT 59405, USA
    Proc Natl Acad Sci U S A 103:3875-80. 2006

Research Grants

  1. 24-Capillary Reveal Mutation Discovery System
    George Carlson; Fiscal Year: 2003
  2. CNS Stem Cells for Alzheimer's Disease Therapy
    George Carlson; Fiscal Year: 2005

Collaborators

Detail Information

Publications26

  1. pmc A systems approach to prion disease
    Daehee Hwang
    Institute for Systems Biology, Seattle, WA 98103, USA
    Mol Syst Biol 5:252. 2009
    ..Our systems analysis provides a comprehensive basis for developing models for prion replication and disease, and suggests some possible therapeutic approaches...
  2. pmc Failure to transmit disease from gray tremor mutant mice
    G A Carlson
    McLaughlin Research Institute, Great Falls, Montana 59405, USA
    J Virol 71:2342-5. 1997
    ..Positive transmission by other investigators may reflect the microbiological status of their donor or recipient mice...
  3. ncbi request reprint Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice
    G A Carlson
    McLaughlin Research Institute, Great Falls, MT 59405, USA
    Hum Mol Genet 6:1951-9. 1997
    ..In contrast, FGF2 transgene overexpression enhances the lethal effects of APP. Differential survival does not appear to reflect genetic differences in APP processing, but rather host responses to APP or its derivatives...
  4. ncbi request reprint Genetics of prion diseases and prion diversity in mice
    G A Carlson
    McLaughlin Research Institute, Great Falls, Montana 59405
    Philos Trans R Soc Lond B Biol Sci 343:363-9. 1994
    ....
  5. pmc Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse
    G A Carlson
    McLaughlin Research Institute, Great Falls, Montana 59401
    Genetics 133:979-88. 1993
    ..Thus, Prn-pb transgenes and Prn-i may modulate scrapie pathogenesis by different mechanisms...
  6. ncbi request reprint Quantitative trait loci affecting prion incubation time in mice
    D A Stephenson
    McLaughlin Research Institute, Great Falls, Montana 59405, USA
    Genomics 69:47-53. 2000
    ..Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility...
  7. pmc Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice
    G A Carlson
    McLaughlin Research Institute, Great Falls, MT 59405
    Proc Natl Acad Sci U S A 91:5690-4. 1994
    ..Our results suggest that scrapie "strain-specific" incubation times can be explained by differences in the relative efficiency of allotypic interactions that lead to conversion of PrPC into PrPSc...
  8. pmc Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells
    Rajeev Kumar
    McLaughlin Research Institute, Great Falls, MT 59405, USA
    J Gen Virol 89:1525-32. 2008
    ..The increased supply of PrPC available for conversion would lead to increased PrPSc formation...
  9. ncbi request reprint Postexposure prophylaxis against transmissible spongiform encephalopathies: CpG oligodeoxynucleotides in mice
    George A Carlson
    McLaughlin Research Institute, Great Falls, MT 59405, USA
    Lancet 360:184. 2002
  10. pmc Prion infection of mouse neurospheres
    Ranjit K Giri
    McLaughlin Research Institute, Great Falls, MT 59405, USA
    Proc Natl Acad Sci U S A 103:3875-80. 2006
    ..Neurosphere lines from Tg4053 mice provide a sensitive in vitro bioassay for mouse prions; neurosphere lines from other Tg mice overexpressing PrP might be used to assay prions from other species, including humans...
  11. ncbi request reprint The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease
    Marcus A Westerman
    Department of Neurology, Center for Clinical and Molecular Neurobiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:1858-67. 2002
    ..These studies also provide a methodological framework within which to investigate these Abeta assemblies in vivo...
  12. pmc Genes contributing to prion pathogenesis
    GULTEKIN TAMGUNEY
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA
    J Gen Virol 89:1777-88. 2008
    ....
  13. pmc Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
    Peter Mastrangelo
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 3H2
    Proc Natl Acad Sci U S A 102:8972-7. 2005
    ..Instead, our studies define functionally distinct gamma-secretase variants. We speculate that extrinsic components, in combination with core complexes, may tailor functional variants of this enzyme to their preferred substrates...
  14. ncbi request reprint NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide
    Laibaik Park
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:1769-77. 2005
    ..Thus, a gp91phox-containing NADPH oxidase is the critical link between Abeta and cerebrovascular dysfunction, which may underlie the alteration in cerebral blood flow regulation observed in AD patients...
  15. ncbi request reprint Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression
    Joseph Krezowski
    McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405, USA
    Hum Mol Genet 13:1989-97. 2004
    ....
  16. ncbi request reprint Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice
    Feng Li
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    J Neurochem 89:1308-12. 2004
    ..These results indicate that oxidative stress can promote the pathogenesis of AD and further support the feasibility of antioxidant approaches for AD therapy...
  17. ncbi request reprint Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein
    Kiyoshi Niwa
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Physiol Heart Circ Physiol 283:H315-23. 2002
    ..The resulting alterations in cerebral perfusion may play a role in the brain dysfunction and periventricular white-matter changes associated with Alzheimer's dementia...
  18. pmc In vivo reduction of amyloid-beta by a mutant copper transporter
    Amie L Phinney
    Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada M5S 3H2
    Proc Natl Acad Sci U S A 100:14193-8. 2003
    ..These data suggest that the beneficial effect of the txJ mutation on CNS Abeta burden may proceed by a previously undescribed mechanism, likely involving increased clearance of peripheral pools of Abeta peptide...
  19. ncbi request reprint Mammalian prion proteins: enigma, variation and vaccination
    David Westaway
    Centre for Research in Neurodegenerative Diseases, Dept of Laboratory Medicine and Pathobiology, University of Toronto, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario M5S 3H2, Canada
    Trends Biochem Sci 27:301-7. 2002
    ..Despite our incomplete understanding of PrP(C), immunological targeting of this PrP(Sc) precursor has produced encouraging results, indicating a potential point of intervention against these fatal diseases...
  20. doi request reprint In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons
    Tara L Spires-Jones
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:862-7. 2008
    ....
  21. pmc The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections
    Joel C Watts
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada
    EMBO J 26:4038-50. 2007
    ..Sho may prove useful in deciphering several unresolved facets of prion biology...
  22. pmc Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation
    Tetsuro Murakami
    Department of Neurology, Neuroscience, Biophysiological Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558 Japan
    Am J Pathol 169:1365-75. 2006
    ..These transgenic mice may aid therapeutic development for FTDP-17 and other diseases featuring accumulations of four-repeat tau, such as Alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy...
  23. pmc Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
    Tara L Spires
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Pathol 168:1598-607. 2006
    ..Together, these results imply that neurofibrillary tangles do not necessarily lead to neuronal death...
  24. ncbi request reprint Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex
    Laibaik Park
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Cereb Blood Flow Metab 24:334-42. 2004
    ..Thus, vascular oxidative stress is an early event in the course of the brain dysfunction produced by APP overexpression and Abeta, and, as such, could be the target of early therapeutic interventions based on antioxidants...
  25. ncbi request reprint Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
    Kiyoshi Niwa
    Center for Clinical and Molecular Neurobiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Neurobiol Dis 9:61-8. 2002
    ..These observations support the hypothesis that cerebrovascular and metabolic abnormalities are early events in the pathogenesis of Alzheimer's disease...
  26. pmc Implementing large-scale ENU mutagenesis screens in North America
    Amander T Clark
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Genetica 122:51-64. 2004
    ..The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening...

Research Grants3

  1. 24-Capillary Reveal Mutation Discovery System
    George Carlson; Fiscal Year: 2003
    ..The Spectrumedix Reveal 2410 will not only accelerate current research at McLaughlin Research Institute, but help in recruiting new biomedical researchers in the field of neurogenetics. ..
  2. CNS Stem Cells for Alzheimer's Disease Therapy
    George Carlson; Fiscal Year: 2005
    ..The objectives of this grant are to test human neural stern cells as candidate therapeutics for the treatment of Alzheimer's disease. ..