R G Kurumbail

Summary

Affiliation: Monsanto Company
Country: USA

Publications

  1. ncbi Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
    R G Kurumbail
    G D Searle, St Louis, Missouri 63198, USA
    Nature 384:644-8. 1996
  2. ncbi A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors
    M C Walker
    Searle Discovery Research, Pharmacia Corp, 700 Chesterfield Parkway N, St Louis, MO 63198, USA
    Biochem J 357:709-18. 2001
  3. ncbi Three-dimensional structure of human cytomegalovirus protease
    H S Shieh
    Department of Medicinal and Structural Chemistry, Monsanto Searle, Searle Discovery Research, St Louis, Missouri 63198, USA
    Nature 383:279-82. 1996
  4. ncbi Structural insights into the stereochemistry of the cyclooxygenase reaction
    J R Kiefer
    Searle Discovery Research, Monsanto Company, St Louis, Missouri 63198, USA
    Nature 405:97-101. 2000
  5. ncbi Cyclooxygenase enzymes: catalysis and inhibition
    R G Kurumbail
    Pharmacia Discovery Research, Pharmacia, Mailstop BB4K, 700 Chesterfield Parkway North, St Louis, Missouri 63198, USA
    Curr Opin Struct Biol 11:752-60. 2001

Collaborators

Detail Information

Publications5

  1. ncbi Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
    R G Kurumbail
    G D Searle, St Louis, Missouri 63198, USA
    Nature 384:644-8. 1996
    ..0 to 2.5 A resolution. These structures explain the structural basis for the selective inhibition of COX-2, and demonstrate some of the conformational changes associated with time-dependent inhibition...
  2. ncbi A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors
    M C Walker
    Searle Discovery Research, Pharmacia Corp, 700 Chesterfield Parkway N, St Louis, MO 63198, USA
    Biochem J 357:709-18. 2001
    ..A generalized mechanism for inhibition, consisting of three sequential reversible steps, can account for the various types of kinetic behaviour observed with these inhibitors...
  3. ncbi Three-dimensional structure of human cytomegalovirus protease
    H S Shieh
    Department of Medicinal and Structural Chemistry, Monsanto Searle, Searle Discovery Research, St Louis, Missouri 63198, USA
    Nature 383:279-82. 1996
    ..Correlations of the structure with the sequences of herpesvirus proteases suggest that dimerization may confer specificity and recognition in substrate binding...
  4. ncbi Structural insights into the stereochemistry of the cyclooxygenase reaction
    J R Kiefer
    Searle Discovery Research, Monsanto Company, St Louis, Missouri 63198, USA
    Nature 405:97-101. 2000
    ..Here we report the co-crystal structures of murine apo-cyclooxygenase-2 in complex with arachidonic acid and prostaglandin. These structures suggest the molecular basis for the stereospecificity of prostaglandin G2 synthesis...
  5. ncbi Cyclooxygenase enzymes: catalysis and inhibition
    R G Kurumbail
    Pharmacia Discovery Research, Pharmacia, Mailstop BB4K, 700 Chesterfield Parkway North, St Louis, Missouri 63198, USA
    Curr Opin Struct Biol 11:752-60. 2001
    ..Detailed kinetics, spectroscopic and crystallographic studies have shed new light on the complex mechanism of inhibition of these fascinating enzymes. Finally, novel substrates of cyclooxygenase-2 have been identified...