CHARLES WYSOCKI

Summary

Affiliation: Monell Chemical Senses Center
Country: USA

Publications

  1. ncbi request reprint Facts, fallacies, fears, and frustrations with human pheromones
    Charles J Wysocki
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Anat Rec A Discov Mol Cell Evol Biol 281:1201-11. 2004
  2. pmc Personal receptor repertoires: olfaction as a model
    Tsviya Olender
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 13:414. 2012
  3. pmc Stimulus selection for intranasal sensory isolation: eugenol is an irritant
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:509-14. 2012
  4. ncbi request reprint Nasal trigeminal chemosensitivity across the adult life span
    Charles J Wysocki
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Percept Psychophys 65:115-22. 2003
  5. ncbi request reprint Mice (Mus musculus) lacking a vomeronasal organ can discriminate MHC-determined odortypes
    Charles J Wysocki
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Horm Behav 46:241-6. 2004
  6. pmc Temporal integration in nasal lateralization of homologous alcohols
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104 3308, USA
    Toxicol Sci 99:254-9. 2007
  7. pmc Temporal integration in nasal lateralization of homologous propionates
    Paul M Wise
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Inhal Toxicol 21:819-27. 2009
  8. doi request reprint Dynamics of nasal chemesthesis
    Paul M Wise
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Ann N Y Acad Sci 1170:206-14. 2009
  9. pmc Dynamics of nasal irritation from pulsed homologous alcohols
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104 3308, USA
    Chem Senses 35:823-9. 2010
  10. ncbi request reprint Temporal integration in nasal lateralization of ethanol
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104 3308, USA
    Chem Senses 31:227-35. 2006

Research Grants

  1. INTERDISCIPLINARY TRAINING IN THE CHEMICAL SENSES
    CHARLES WYSOCKI; Fiscal Year: 2007
  2. Individual Differences in Olfaction
    CHARLES WYSOCKI; Fiscal Year: 2007
  3. INDIVIDUAL VARIATION IN OLFACTION
    CHARLES WYSOCKI; Fiscal Year: 1999
  4. INDIVIDUAL VARIATION IN OLFACTION
    CHARLES WYSOCKI; Fiscal Year: 1993

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Facts, fallacies, fears, and frustrations with human pheromones
    Charles J Wysocki
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Anat Rec A Discov Mol Cell Evol Biol 281:1201-11. 2004
    ..It is emphasized that no bioassay-guided study has led to the isolation of true human pheromones, a step that will elucidate specific functions to human chemical signals...
  2. pmc Personal receptor repertoires: olfaction as a model
    Tsviya Olender
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 13:414. 2012
    ..To this end, we focused on the complete inventory of human olfactory receptor coding regions as a model for personal receptor repertoires...
  3. pmc Stimulus selection for intranasal sensory isolation: eugenol is an irritant
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:509-14. 2012
    ..Regardless, the current experiments suggest that eugenol can in fact stimulate the trigeminal nerve but in a complex concentration-dependent manner. Implications and strategies for selection of model odorants are discussed...
  4. ncbi request reprint Nasal trigeminal chemosensitivity across the adult life span
    Charles J Wysocki
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Percept Psychophys 65:115-22. 2003
    ..Sensitivity in both chemosensory pathways declined with advancing age, especially in people older than 60 years...
  5. ncbi request reprint Mice (Mus musculus) lacking a vomeronasal organ can discriminate MHC-determined odortypes
    Charles J Wysocki
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Horm Behav 46:241-6. 2004
    ..Neither the number of training trials-to-criterion nor the rate of learning differed significantly for VNX and sham-operated mice. We conclude that the VNO is not necessary for learning to discriminate between MHC odortypes...
  6. pmc Temporal integration in nasal lateralization of homologous alcohols
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104 3308, USA
    Toxicol Sci 99:254-9. 2007
    ..That just one molecular parameter can help predict degree of integration suggests that a structure-activity approach to understanding temporal integration shows promise...
  7. pmc Temporal integration in nasal lateralization of homologous propionates
    Paul M Wise
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Inhal Toxicol 21:819-27. 2009
    ..Further, preliminary analyses suggest that, for data pooled across both chemical series, n varies systematically with molecular parameters related to solubility and diffusion...
  8. doi request reprint Dynamics of nasal chemesthesis
    Paul M Wise
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Ann N Y Acad Sci 1170:206-14. 2009
    ..Current studies use a structure-activity approach to determine how molecular parameters correlate with how well a compound integrates over time...
  9. pmc Dynamics of nasal irritation from pulsed homologous alcohols
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104 3308, USA
    Chem Senses 35:823-9. 2010
    ..The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well...
  10. ncbi request reprint Temporal integration in nasal lateralization of ethanol
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104 3308, USA
    Chem Senses 31:227-35. 2006
    ..These results suggest that an imperfect, mass-integrator model can describe short-term integration of nasal lateralization of ethanol...
  11. ncbi request reprint Differential responses to odorant analogs after recovery from nerve transection
    Karen K Yee
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104 3308, USA
    Physiol Behav 76:661-7. 2002
    ..These results suggest that androstanone and DMCMC, although apparent perceptual analogs of androstenone, may be using different pathways of olfaction within the central nervous system (CNS)...
  12. ncbi request reprint Temporal integration of nasal irritation from ammonia at threshold and supra-threshold levels
    Paul M Wise
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, 19104 3308, USA
    Toxicol Sci 87:223-31. 2005
    ..These results suggest that an imperfect mass-integrator model may be able to describe short-term integration of nasal irritation from ammonia at both the threshold and supra-threshold levels...
  13. ncbi request reprint Temporal integration in nasal lateralization and nasal detection of carbon dioxide
    Paul M Wise
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 29:137-42. 2004
    ..Thus, for carbon dioxide, the nasal trigeminal system functions as an imperfect integrator at threshold-level...
  14. ncbi request reprint Time-intensity ratings of nasal irritation from carbon dioxide
    Paul M Wise
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 28:751-60. 2003
    ..In short: (i). the method developed here provides a temporally fine-grained tool to study the time-course of nasal irritation, and (ii). nasal irritation from carbon dioxide shows relatively rapid temporal dynamics...
  15. ncbi request reprint Male axillary extracts contain pheromones that affect pulsatile secretion of luteinizing hormone and mood in women recipients
    George Preti
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 68:2107-13. 2003
    ..These results demonstrate that male axillary secretions contain one or more constituents that act as primer and modulator pheromones...
  16. ncbi request reprint Preference for human body odors is influenced by gender and sexual orientation
    Yolanda Martins
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Psychol Sci 16:694-701. 2005
    ..Results indicate that differences in body odor are detected and responded to on the basis of, in part, an individual's gender and sexual orientation. Possible mechanisms underlying these findings are discussed...
  17. ncbi request reprint Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes
    Karina Del Punta
    The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 419:70-4. 2002
    ..Electrophysiologically, the epithelium of the VNO of such mice does not respond detectably to specific pheromonal ligands. The behavioural impairment and chemosensory deficit support a role of V1r receptors as pheromone receptors...
  18. doi request reprint Biological basis of the third-cousin crush
    Johan N Lundstrom
    Science 320:1160-1. 2008

Research Grants17

  1. INTERDISCIPLINARY TRAINING IN THE CHEMICAL SENSES
    CHARLES WYSOCKI; Fiscal Year: 2007
    ....
  2. Individual Differences in Olfaction
    CHARLES WYSOCKI; Fiscal Year: 2007
    ..To do this, we will assess individual behavioral responses to odors and characterize the genes for olfactory receptors that are found within the person's genome. ..
  3. INDIVIDUAL VARIATION IN OLFACTION
    CHARLES WYSOCKI; Fiscal Year: 1999
    ....
  4. INDIVIDUAL VARIATION IN OLFACTION
    CHARLES WYSOCKI; Fiscal Year: 1993
    ..Animal models would provide ideal tools for understanding olfactory processing at the biochemical and physiological levels. To these ends, a model of androstenone anosmia is being developed and tested to determine its adequacy...