CHARLES WYSOCKI

..It is emphasized that no bioassay-guided study has led to the isolation of true human pheromones, a step that will elucidate specific functions to human chemical signals...

..Regardless, the current experiments suggest that eugenol can in fact stimulate the trigeminal nerve but in a complex concentration-dependent manner. Implications and strategies for selection of model odorants are discussed...

..Sensitivity in both chemosensory pathways declined with advancing age, especially in people older than 60 years...

..Neither the number of training trials-to-criterion nor the rate of learning differed significantly for VNX and sham-operated mice. We conclude that the VNO is not necessary for learning to discriminate between MHC odortypes...

..The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well...

..Current studies use a structure-activity approach to determine how molecular parameters correlate with how well a compound integrates over time...

..Further, preliminary analyses suggest that, for data pooled across both chemical series, n varies systematically with molecular parameters related to solubility and diffusion...

..That just one molecular parameter can help predict degree of integration suggests that a structure-activity approach to understanding temporal integration shows promise...

..These results suggest that an imperfect, mass-integrator model can describe short-term integration of nasal lateralization of ethanol...

..These results suggest that an imperfect mass-integrator model may be able to describe short-term integration of nasal irritation from ammonia at both the threshold and supra-threshold levels...

..Thus, for carbon dioxide, the nasal trigeminal system functions as an imperfect integrator at threshold-level...

..In short: (i). the method developed here provides a temporally fine-grained tool to study the time-course of nasal irritation, and (ii). nasal irritation from carbon dioxide shows relatively rapid temporal dynamics...

..These results demonstrate that male axillary secretions contain one or more constituents that act as primer and modulator pheromones...

..These results suggest that androstanone and DMCMC, although apparent perceptual analogs of androstenone, may be using different pathways of olfaction within the central nervous system (CNS)...

..Results indicate that differences in body odor are detected and responded to on the basis of, in part, an individual's gender and sexual orientation. Possible mechanisms underlying these findings are discussed...

..Electrophysiologically, the epithelium of the VNO of such mice does not respond detectably to specific pheromonal ligands. The behavioural impairment and chemosensory deficit support a role of V1r receptors as pheromone receptors...

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..To do this, we will assess individual behavioral responses to odors and characterize the genes for olfactory receptors that are found within the person's genome. ..

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..Animal models would provide ideal tools for understanding olfactory processing at the biochemical and physiological levels. To these ends, a model of androstenone anosmia is being developed and tested to determine its adequacy...