DANIELLE RENEE REED

..Our study demonstrates that person-to-person differences in the taste and smell perception of simple foods and drinks are partially accounted for by genetic variation within chemosensory pathways...

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..The purpose of this study was to investigate the effect of TAS2R38 haplotypes and age on human bitter taste perception...

..4) but not female mice (LOD = 0.2). Refining obesity as a phenotype may uncover clues about gene function that will assist in positional cloning efforts...

..Body weights were not available for all strains so we also obtained body weight information by contacting a random sample of investigators responsible for a knockout strain...

..As a step toward identifying the responsible genes, we compared a chromosome 7 substitution strain C57BL/6J-Chr7(129S1/SvImJ)/Na (CSS-7) to its host (C57BL/6J) strain...

..Animal models provide a way to study the genetic determinants of food selection with experimental rigor and therefore complement human genetics studies...

..These findings raise questions about how variation in the TAS1R3 and GNAT3 gene shape the human sweet tooth and its unwelcome consequences, diabetes and obesity...

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..These results can be used to guide the choice of appropriate rat strains for future studies of the genetic architecture of obesity and body size...

..Here, we present data for future studies directed to experimentally confirm the function of these polymorphisms and highlight some of the difficulties of identifying specific DNA sequence variants that underlie quantitative trait loci...

..These results reinforce the concept that obesity is a complex trait. Genetic loci and their interactions, in conjunction with sex, age, and diet, determine body size and adiposity in mice...

..The location and type of QTLs detected in this new cross will assist in future efforts to identify the genetic variation that determines the ratio of lean to fat weight as well as body size in mice...

..We conclude that the Adip5 locus is specific to the gonadal adipose depot and that a gene or genes near the linkage peak may account for this QTL...

..These data illustrate the diversity of body weight and composition in inbred mice. They will serve as a reference standard and assist in the selection of strains for future work...

..Our results imply that, in addition to its established roles in the detection of sweet and umami compounds, T1R3 functions as a gustatory calcium-magnesium receptor...

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..This result suggests that environment plays a larger role than genetics in determining individual differences in recognition thresholds for saltiness...

..We conclude that the avidity for calcium is determined by different genetic architecture and thus different physiological mechanisms in different strains...

..However, there were a few modifiers of the primary linkages and a number of interactions among unlinked loci. This demonstrates a significant role of the genetic background in the variation of ethanol consumption...

..The strain differences described here provide useful information for designing mutagenesis screens and choosing strains for genetic mapping studies...

..These data will facilitate genetic and comparative mapping studies and identification of a large number of novel candidate genes for the trait loci mapped to this region...

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..DNA variants in intron 4 and 5 are more common but appear to be innocuous...

..The results illustrate the diversity of voluntary sodium intake in mice and will assist in the selection of appropriate strains for focused genetic and physiological analyses...

..We discuss this literature in the context of how taste genes may differ among people and give rise to individuated taste experience, and what is currently known about the genetic effects on taste perception in humans...

..Understanding the exact genes and genetic differences that affect food intake may provide important clues in obesity treatment by allowing caregivers to tailor dietary recommendations to the chemosensory landscape of each person...

..Human PROP sensitivity is determined by the combination of each of these 3 polymorphisms within the TAS2R38 gene...

..The molecular mechanisms of perceived bitterness variability have therapeutic implications, such as helping patients to consume beneficial bitter-tasting compounds-for example, pharmaceuticals and selected phytochemicals...

..This study describes the range of ligand sensitivity of the T1R3 receptor using an in vivo approach and, to our knowledge, is the first genetic mapping study of activity in gustatory nerves...

..The results suggest that the perception of PROP and the perception of SOA, quinine, and caffeine are influenced by two distinct sets of genes...

..g., bitterness) and more positive (eg, sweetness) sensations from alcohol. We determined whether the TAS2R38 gene at 7q36 predicted PROP bitterness, alcohol sensation and use...

..The public health arena will be important in educating families about possible future genetic tests for obesity...

..By finding influential DNA variation in one specific region (on mouse chromosome 9), we hope to learn how this variation contributes to obesity in humans. ..

..By finding influential DNA variation in one specific region (on mouse chromosome 9), we hope to learn how this variation contributes to obesity in humans. ..

..Understanding the role of each molecule important in obesity will be a significant step towards the development of safe and effective therapeutics. 'ERFORMANCE ..

..Understanding the role of each molecule important in obesity will be a significant step towards the development of safe and effective therapeutics. ..

..Orthologs of these genes may be involved in human obesity, and may have a significant impact on human health. ..

..In Specific Aim 3, the P.I. will initiate an evaluation of candidate genes located within the region identified, by screening for variabilities associated with PROP-taster status. ..

..By finding influential DNA variation in one specific region (on mouse chromosome 9), we hope to learn how this variation contributes to obesity in humans. ..