DANIELLE RENEE REED

Summary

Affiliation: Monell Chemical Senses Center
Country: USA

Publications

  1. pmc Genetic analysis of chemosensory traits in human twins
    Antti Knaapila
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:869-81. 2012
  2. pmc A genome-wide study on the perception of the odorants androstenone and galaxolide
    Antti Knaapila
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:541-52. 2012
  3. pmc Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38
    Julie A Mennella
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104, USA
    BMC Genet 11:60. 2010
  4. pmc Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 17:1065-77. 2006
  5. pmc Reduced body weight is a common effect of gene knockout in mice
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, USA
    BMC Genet 9:4. 2008
  6. pmc QTL for body composition on chromosome 7 detected using a chromosome substitution mouse strain
    Danielle R Reed
    Obesity (Silver Spring) 16:483-7. 2008
  7. pmc Animal models of gene-nutrient interactions
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 16:S23-7. 2008
  8. pmc Gustation genetics: sweet gustducin!
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 35:549-50. 2010
  9. pmc The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:4278-85. 2010
  10. pmc Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104 3308, USA
    Physiol Behav 103:523-9. 2011

Research Grants

  1. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2010
  2. Mapping adiposity genes in mice
    DANIELLE REED; Fiscal Year: 2009
  3. MAPPING GENES FOR ADIPOSITY IN MICE
    DANIELLE REED; Fiscal Year: 2007
  4. MAPPING GENES FOR ADIPOSITY IN MICE
    DANIELLE REED; Fiscal Year: 2007
  5. MAPPING GENES FOR BODY WEIGHT AND FATNESS IN MICE
    DANIELLE REED; Fiscal Year: 2002
  6. GENETICS OF BITTER TASTE PERCEPTION IN HUMANS
    DANIELLE REED; Fiscal Year: 2002
  7. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2010

Detail Information

Publications34

  1. pmc Genetic analysis of chemosensory traits in human twins
    Antti Knaapila
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:869-81. 2012
    ..Our study demonstrates that person-to-person differences in the taste and smell perception of simple foods and drinks are partially accounted for by genetic variation within chemosensory pathways...
  2. pmc A genome-wide study on the perception of the odorants androstenone and galaxolide
    Antti Knaapila
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:541-52. 2012
    ....
  3. pmc Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38
    Julie A Mennella
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104, USA
    BMC Genet 11:60. 2010
    ..The purpose of this study was to investigate the effect of TAS2R38 haplotypes and age on human bitter taste perception...
  4. pmc Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 17:1065-77. 2006
    ..4) but not female mice (LOD = 0.2). Refining obesity as a phenotype may uncover clues about gene function that will assist in positional cloning efforts...
  5. pmc Reduced body weight is a common effect of gene knockout in mice
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, USA
    BMC Genet 9:4. 2008
    ..Body weights were not available for all strains so we also obtained body weight information by contacting a random sample of investigators responsible for a knockout strain...
  6. pmc QTL for body composition on chromosome 7 detected using a chromosome substitution mouse strain
    Danielle R Reed
    Obesity (Silver Spring) 16:483-7. 2008
    ..As a step toward identifying the responsible genes, we compared a chromosome 7 substitution strain C57BL/6J-Chr7(129S1/SvImJ)/Na (CSS-7) to its host (C57BL/6J) strain...
  7. pmc Animal models of gene-nutrient interactions
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 16:S23-7. 2008
    ..Animal models provide a way to study the genetic determinants of food selection with experimental rigor and therefore complement human genetics studies...
  8. pmc Gustation genetics: sweet gustducin!
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 35:549-50. 2010
    ..These findings raise questions about how variation in the TAS1R3 and GNAT3 gene shape the human sweet tooth and its unwelcome consequences, diabetes and obesity...
  9. pmc The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:4278-85. 2010
    ....
  10. pmc Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104 3308, USA
    Physiol Behav 103:523-9. 2011
    ..These results can be used to guide the choice of appropriate rat strains for future studies of the genetic architecture of obesity and body size...
  11. pmc Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains
    D R Reed
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:938-46. 2004
    ..Here, we present data for future studies directed to experimentally confirm the function of these polymorphisms and highlight some of the difficulties of identifying specific DNA sequence variants that underlie quantitative trait loci...
  12. pmc Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 14:302-13. 2003
    ..These results reinforce the concept that obesity is a complex trait. Genetic loci and their interactions, in conjunction with sex, age, and diet, determine body size and adiposity in mice...
  13. pmc Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross
    Hongguang Shao
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 18:839-51. 2007
    ..The location and type of QTLs detected in this new cross will assist in future efforts to identify the genetic variation that determines the ratio of lean to fat weight as well as body size in mice...
  14. pmc A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot
    Amanda H McDaniel
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 17:1078-92. 2006
    ..We conclude that the Adip5 locus is specific to the gonadal adipose depot and that a gene or genes near the linkage peak may account for this QTL...
  15. pmc Forty mouse strain survey of body composition
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Physiol Behav 91:593-600. 2007
    ..These data illustrate the diversity of body weight and composition in inbred mice. They will serve as a reference standard and assist in the selection of strains for future work...
  16. pmc Involvement of T1R3 in calcium-magnesium taste
    Michael G Tordoff
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Physiol Genomics 34:338-48. 2008
    ..Our results imply that, in addition to its established roles in the detection of sweet and umami compounds, T1R3 functions as a gustatory calcium-magnesium receptor...
  17. pmc Excretion and perception of a characteristic odor in urine after asparagus ingestion: a psychophysical and genetic study
    Marcia Levin Pelchat
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104 3308, USA
    Chem Senses 36:9-17. 2011
    ....
  18. pmc Twin study of the heritability of recognition thresholds for sour and salty taste
    Paul M Wise
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 32:749-54. 2007
    ..This result suggests that environment plays a larger role than genetics in determining individual differences in recognition thresholds for saltiness...
  19. pmc Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content
    Michael G Tordoff
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Physiol Behav 91:632-43. 2007
    ..We conclude that the avidity for calcium is determined by different genetic architecture and thus different physiological mechanisms in different strains...
  20. pmc Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Genome Res 12:1257-68. 2002
    ..However, there were a few modifiers of the primary linkages and a number of interactions among unlinked loci. This demonstrates a significant role of the genetic background in the variation of ethanol consumption...
  21. pmc Food intake, water intake, and drinking spout side preference of 28 mouse strains
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, Pennsylvania 19104, USA
    Behav Genet 32:435-43. 2002
    ..The strain differences described here provide useful information for designing mutagenesis screens and choosing strains for genetic mapping studies...
  22. pmc Genetic, physical, and comparative map of the subtelomeric region of mouse Chromosome 4
    Xia Li
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 13:5-19. 2002
    ..These data will facilitate genetic and comparative mapping studies and identification of a large number of novel candidate genes for the trait loci mapped to this region...
  23. pmc Genetic and environmental determinants of bitter perception and sweet preferences
    Julie A Mennella
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Pediatrics 115:e216-22. 2005
    ....
  24. pmc No relationship between sequence variation in protein coding regions of the Tas1r3 gene and saccharin preference in rats
    Ke Lu
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 30:231-40. 2005
    ..DNA variants in intron 4 and 5 are more common but appear to be innocuous...
  25. pmc Forty mouse strain survey of water and sodium intake
    Michael G Tordoff
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Physiol Behav 91:620-31. 2007
    ..The results illustrate the diversity of voluntary sodium intake in mice and will assist in the selection of appropriate strains for focused genetic and physiological analyses...
  26. pmc Diverse tastes: Genetics of sweet and bitter perception
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA reed monell org
    Physiol Behav 88:215-26. 2006
    ..We discuss this literature in the context of how taste genes may differ among people and give rise to individuated taste experience, and what is currently known about the genetic effects on taste perception in humans...
  27. pmc Cats lack a sweet taste receptor
    Xia Li
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    J Nutr 136:1932S-1934S. 2006
  28. pmc Genetics of taste and smell: poisons and pleasures
    DANIELLE RENEE REED
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Prog Mol Biol Transl Sci 94:213-40. 2010
    ..Understanding the exact genes and genetic differences that affect food intake may provide important clues in obesity treatment by allowing caregivers to tailor dietary recommendations to the chemosensory landscape of each person...
  29. pmc Psychophysical dissection of genotype effects on human bitter perception
    Julie A Mennella
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104 3308, USA
    Chem Senses 36:161-7. 2011
    ..Human PROP sensitivity is determined by the combination of each of these 3 polymorphisms within the TAS2R38 gene...
  30. pmc The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
    Bernd Bufe
    German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Curr Biol 15:322-7. 2005
    ..The molecular mechanisms of perceived bitterness variability have therapeutic implications, such as helping patients to consume beneficial bitter-tasting compounds-for example, pharmaceuticals and selected phytochemicals...
  31. pmc Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice
    Masashi Inoue
    Laboratory of Cellular Neurobiology, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    J Neurosci 24:2296-303. 2004
    ..This study describes the range of ligand sensitivity of the T1R3 receptor using an in vivo approach and, to our knowledge, is the first genetic mapping study of activity in gustatory nerves...
  32. pmc Heritability and genetic covariation of sensitivity to PROP, SOA, quinine HCl, and caffeine
    Jonathan L Hansen
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia
    Chem Senses 31:403-13. 2006
    ..The results suggest that the perception of PROP and the perception of SOA, quinine, and caffeine are influenced by two distinct sets of genes...
  33. pmc Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake
    Valerie B Duffy
    School of Allied Health, University of Connecticut, 358 Mansfield Rd, Box U 101, Storrs, CT 06269 2101, USA
    Alcohol Clin Exp Res 28:1629-37. 2004
    ..g., bitterness) and more positive (eg, sweetness) sensations from alcohol. We determined whether the TAS2R38 gene at 7q36 predicted PROP bitterness, alcohol sensation and use...
  34. pmc Research issues in genetic testing of adolescents for obesity
    Mary E Segal
    Research Center for Health Care Decision making, Inc, Wyndmoor, PA 19038, USA
    Nutr Rev 62:307-20. 2004
    ..The public health arena will be important in educating families about possible future genetic tests for obesity...

Research Grants15

  1. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2010
    ..By finding influential DNA variation in one specific region (on mouse chromosome 9), we hope to learn how this variation contributes to obesity in humans. ..
  2. Mapping adiposity genes in mice
    DANIELLE REED; Fiscal Year: 2009
    ..By finding influential DNA variation in one specific region (on mouse chromosome 9), we hope to learn how this variation contributes to obesity in humans. ..
  3. MAPPING GENES FOR ADIPOSITY IN MICE
    DANIELLE REED; Fiscal Year: 2007
    ..Understanding the role of each molecule important in obesity will be a significant step towards the development of safe and effective therapeutics. 'ERFORMANCE ..
  4. MAPPING GENES FOR ADIPOSITY IN MICE
    DANIELLE REED; Fiscal Year: 2007
    ..Understanding the role of each molecule important in obesity will be a significant step towards the development of safe and effective therapeutics. ..
  5. MAPPING GENES FOR BODY WEIGHT AND FATNESS IN MICE
    DANIELLE REED; Fiscal Year: 2002
    ..Orthologs of these genes may be involved in human obesity, and may have a significant impact on human health. ..
  6. GENETICS OF BITTER TASTE PERCEPTION IN HUMANS
    DANIELLE REED; Fiscal Year: 2002
    ..In Specific Aim 3, the P.I. will initiate an evaluation of candidate genes located within the region identified, by screening for variabilities associated with PROP-taster status. ..
  7. Mapping adiposity genes in mice
    DANIELLE RENEE REED; Fiscal Year: 2010
    ..By finding influential DNA variation in one specific region (on mouse chromosome 9), we hope to learn how this variation contributes to obesity in humans. ..