Alexander Bachmanov

Summary

Affiliation: Monell Chemical Senses Center
Country: USA

Publications

  1. ncbi request reprint Genetics of taste receptors
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market Street, PA 19104, USA
    Curr Pharm Des 20:2669-83. 2014
  2. pmc NaCl taste thresholds in 13 inbred mouse strains
    Yutaka Ishiwatari
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:497-508. 2012
  3. pmc Behavioral genetics and taste
    John D Boughter
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    BMC Neurosci 8:S3. 2007
  4. pmc Voluntary sodium chloride consumption by mice: differences among five inbred strains
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Behav Genet 28:117-24. 1998
  5. pmc Genetic approach to characterize interaction of sweeteners with sweet taste receptors in vivo
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 30:i82-3. 2005
  6. pmc Taste receptor genes
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Annu Rev Nutr 27:389-414. 2007
  7. pmc Amino acid and carbohydrate preferences in C57BL/6ByJ and 129P3/J mice
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Physiol Behav 93:37-43. 2008
  8. pmc Glutamate taste and appetite in laboratory mice: physiologic and genetic analyses
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Am J Clin Nutr 90:756S-763S. 2009
  9. pmc Chemosensory factors influencing alcohol perception, preferences, and consumption
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Alcohol Clin Exp Res 27:220-31. 2003
  10. pmc Food intake, water intake, and drinking spout side preference of 28 mouse strains
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, Pennsylvania 19104, USA
    Behav Genet 32:435-43. 2002

Research Grants

  1. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2003
  2. Genetics of Taste Perception
    Alexander Bachmanov; Fiscal Year: 2009
  3. Genetics of Taste Perception
    Alexander Bachmanov; Fiscal Year: 2009
  4. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2007
  5. GENETICS OF SWEET TASTE PERCEPTION
    Alexander Bachmanov; Fiscal Year: 2006
  6. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2006
  7. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2005
  8. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2004
  9. Genetics of Taste Perception
    Alexander A Bachmanov; Fiscal Year: 2010

Detail Information

Publications43

  1. ncbi request reprint Genetics of taste receptors
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market Street, PA 19104, USA
    Curr Pharm Des 20:2669-83. 2014
    ....
  2. pmc NaCl taste thresholds in 13 inbred mouse strains
    Yutaka Ishiwatari
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:497-508. 2012
    ..The strain differences in NaCl taste sensitivity found in this study provide a basis for genetic analysis of this phenotype...
  3. pmc Behavioral genetics and taste
    John D Boughter
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    BMC Neurosci 8:S3. 2007
    ..Recent advances in development of genomic resources make behavioral genetics a powerful approach for understanding mechanisms of taste...
  4. pmc Voluntary sodium chloride consumption by mice: differences among five inbred strains
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Behav Genet 28:117-24. 1998
    ..High (> or = 300 mM) NaCl concentrations were strongly avoided by all mice, except for the NZB/B1NJ strain. It is suggested that separate genes underlie the strain differences in acceptance of dilute and concentrated NaCl solutions...
  5. pmc Genetic approach to characterize interaction of sweeteners with sweet taste receptors in vivo
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 30:i82-3. 2005
  6. pmc Taste receptor genes
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Annu Rev Nutr 27:389-414. 2007
    ..Candidate mechanisms for detection of salts, acids, fat, complex carbohydrates, and water have also been proposed, but further studies are needed to prove their identity...
  7. pmc Amino acid and carbohydrate preferences in C57BL/6ByJ and 129P3/J mice
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Physiol Behav 93:37-43. 2008
    ..Results of this study set the stage for genetic analysis of differences between B6 and 129 mice in taste responsiveness and macronutrient consumption...
  8. pmc Glutamate taste and appetite in laboratory mice: physiologic and genetic analyses
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Am J Clin Nutr 90:756S-763S. 2009
    ..Our animal model studies raise the question of whether humans also vary in glutamate metabolism in a manner that influences their glutamate preference, consumption, and postingestive processing...
  9. pmc Chemosensory factors influencing alcohol perception, preferences, and consumption
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Alcohol Clin Exp Res 27:220-31. 2003
    ..Bachmanov and Michael Tordoff); and (6) Human genetic variation in taste: connections with alcohol sensation and intake (Valerie B. Duffy and Linda M. Bartoshuk). The symposium concluded with a general discussion...
  10. pmc Food intake, water intake, and drinking spout side preference of 28 mouse strains
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, Pennsylvania 19104, USA
    Behav Genet 32:435-43. 2002
    ..The strain differences described here provide useful information for designing mutagenesis screens and choosing strains for genetic mapping studies...
  11. pmc Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Genome Res 12:1257-68. 2002
    ..However, there were a few modifiers of the primary linkages and a number of interactions among unlinked loci. This demonstrates a significant role of the genetic background in the variation of ethanol consumption...
  12. pmc Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains
    Alexander A Bachmanov
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104, USA
    Behav Genet 32:445-57. 2002
    ..These results provide a valuable resource for investigators who wish to identify genes involved in the regulation of mineral consumption and balance...
  13. pmc High-resolution genetic mapping of the sucrose octaacetate taste aversion (Soa) locus on mouse Chromosome 6
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Mamm Genome 12:695-9. 2001
    ..Positions of the markers were further resolved by using radiation hybrid mapping. The results show that the Soa locus is contained in an approximately 1-cM (3.3-4.9 Mb) region including the Prp locus...
  14. pmc Sweetener preference of C57BL/6ByJ and 129P3/J mice
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 26:905-13. 2001
    ..Glycyrrhizic acid, neohesperidin, thaumatin and cyclamate are not palatable to B6 or 129 mice...
  15. pmc Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice
    A A Bachmanov
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Physiol Behav 72:603-13. 2001
    ..There were no differences in BW and adiposity between control and margarine-exposed 129P3/J mice. The results suggest that diet-induced adiposity in the B6 mice depends on age and does not depend on hyperphagia...
  16. pmc Consumption of electrolytes and quinine by mouse strains with different blood pressures
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    Physiol Behav 64:323-30. 1998
    ..5-150 mM NaCl, the BPL/1 mice preferred 10-100 mM KCl, and the BPN/3 mice preferred 1-10 mM CaCl2...
  17. ncbi request reprint Influence of test duration on the sensitivity of the two-bottle choice test
    Michael G Tordoff
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104, USA
    Chem Senses 27:759-68. 2002
    ..Tests lasting 4 or 6 days are more sensitive, but conducting 6 day tests provides little additional benefit and sometimes is detrimental relative to conducting 4 day tests...
  18. pmc Taste perception of monosodium glutamate and inosine monophosphate by 129P3/J and C57BL/6ByJ mice
    Yuko Murata
    Monell Chemical Senses Center, Philadelphia, PA, 19104 3308, USA
    Physiol Behav 98:481-8. 2009
    ..The amiloride-sensitive salt taste component is more prevalent in MSG than in IMP taste, and in B6 compared with 129 mice...
  19. pmc A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot
    Amanda H McDaniel
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 17:1078-92. 2006
    ..We conclude that the Adip5 locus is specific to the gonadal adipose depot and that a gene or genes near the linkage peak may account for this QTL...
  20. pmc No relationship between sequence variation in protein coding regions of the Tas1r3 gene and saccharin preference in rats
    Ke Lu
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 30:231-40. 2005
    ..DNA variants in intron 4 and 5 are more common but appear to be innocuous...
  21. pmc Forty mouse strain survey of body composition
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Physiol Behav 91:593-600. 2007
    ..These data illustrate the diversity of body weight and composition in inbred mice. They will serve as a reference standard and assist in the selection of strains for future work...
  22. pmc Genetic, physical, and comparative map of the subtelomeric region of mouse Chromosome 4
    Xia Li
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 13:5-19. 2002
    ..These data will facilitate genetic and comparative mapping studies and identification of a large number of novel candidate genes for the trait loci mapped to this region...
  23. pmc QTL for body composition on chromosome 7 detected using a chromosome substitution mouse strain
    Danielle R Reed
    Obesity (Silver Spring) 16:483-7. 2008
    ..As a step toward identifying the responsible genes, we compared a chromosome 7 substitution strain C57BL/6J-Chr7(129S1/SvImJ)/Na (CSS-7) to its host (C57BL/6J) strain...
  24. pmc Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 14:302-13. 2003
    ..These results reinforce the concept that obesity is a complex trait. Genetic loci and their interactions, in conjunction with sex, age, and diet, determine body size and adiposity in mice...
  25. pmc Mouse taste preference tests: why only two bottles?
    Michael G Tordoff
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104 3308, USA
    Chem Senses 28:315-24. 2003
    ....
  26. pmc Avoidance of hydrolyzed casein by mice
    Kristin L Field
    Monell Chemical Senses Center, Philadelphia, PA, 19104, USA
    Physiol Behav 93:189-99. 2008
    ..Our study suggests that mice may be a useful model for understanding the mechanisms of HC rejection...
  27. pmc Cats lack a sweet taste receptor
    Xia Li
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    J Nutr 136:1932S-1934S. 2006
  28. pmc Taste function in mice with a targeted mutation of the pkd1l3 gene
    Theodore M Nelson
    Monell Chemical Senses Center, PA 19104, USA
    Chem Senses 35:565-77. 2010
    ..Therefore, further studies are needed to elucidate the function of PKD1L3 in taste bud cells...
  29. pmc Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content
    Michael G Tordoff
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Physiol Behav 91:632-43. 2007
    ..We conclude that the avidity for calcium is determined by different genetic architecture and thus different physiological mechanisms in different strains...
  30. pmc Forty mouse strain survey of water and sodium intake
    Michael G Tordoff
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Physiol Behav 91:620-31. 2007
    ..The results illustrate the diversity of voluntary sodium intake in mice and will assist in the selection of appropriate strains for focused genetic and physiological analyses...
  31. pmc Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 17:1065-77. 2006
    ..4) but not female mice (LOD = 0.2). Refining obesity as a phenotype may uncover clues about gene function that will assist in positional cloning efforts...
  32. pmc The maintenance diets of C57BL/6J and 129X1/SvJ mice influence their taste solution preferences: implications for large-scale phenotyping projects
    Michael G Tordoff
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    J Nutr 132:2288-97. 2002
    ..They illustrate that attention must be paid to the effects of diet on phenotype in screens of mutagenized mice and other genetic studies...
  33. pmc Involvement of T1R3 in calcium-magnesium taste
    Michael G Tordoff
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Physiol Genomics 34:338-48. 2008
    ..Our results imply that, in addition to its established roles in the detection of sweet and umami compounds, T1R3 functions as a gustatory calcium-magnesium receptor...
  34. pmc Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences
    Hong Wang
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    J Comp Neurol 512:384-98. 2009
    ....
  35. pmc A high-throughput method to measure NaCl and acid taste thresholds in mice
    Yutaka Ishiwatari
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 34:277-93. 2009
    ....
  36. pmc Differences in postingestive metabolism of glutamate and glycine between C57BL/6ByJ and 129P3/J mice
    Hong Ji
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 31:475-82. 2007
    ..This study strongly supports the hypothesis that the metabolic fate of a nutrient plays an important regulatory role in control of its intake. This is the first detailed study of mouse strain differences in amino acid metabolism...
  37. pmc Protein hydrolysates are avoided by herbivores but not by omnivores in two-choice preference tests
    Kristin L Field
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e4126. 2009
    ..Recent, but taxonomically limited, evidence suggests that other animals also avoid consuming HC when alternatives exist...
  38. pmc Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice
    Masashi Inoue
    Laboratory of Cellular Neurobiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Physiol Genomics 32:82-94. 2007
    ....
  39. pmc Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice
    Masashi Inoue
    Laboratory of Cellular Neurobiology, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    J Neurosci 24:2296-303. 2004
    ..This study describes the range of ligand sensitivity of the T1R3 receptor using an in vivo approach and, to our knowledge, is the first genetic mapping study of activity in gustatory nerves...
  40. pmc Gustatory neural responses to umami taste stimuli in C57BL/6ByJ and 129P3/J mice
    Masashi Inoue
    Laboratory of Cellular Neurobiology, Department of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    Chem Senses 29:789-95. 2004
    ..Strain differences in gustatory neural responses to nucleotides but not glutamate suggest that these compounds may activate distinct taste transduction mechanisms...
  41. pmc Is glycine "sweet" to mice? Mouse strain differences in perception of glycine taste
    Satoshi Manita
    Laboratory of Cellular Neurobiology, School of Life Sciences, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    Chem Senses 31:785-93. 2006
    ....
  42. pmc Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice
    Noriatsu Shigemura
    Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R66-75. 2008
    ..This suggests that the R616W variation in the alphaENaC subunit affects amiloride sensitivity of the ENaC channel and provides evidence that ENaC is involved in amiloride-sensitive salt taste responses in mice...
  43. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..

Research Grants10

  1. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2003
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  2. Genetics of Taste Perception
    Alexander Bachmanov; Fiscal Year: 2009
    ..We also propose to expand our scope to include sour taste- related genes. These studies, when completed, may provide important new avenues for interventions designed to modify excess food consumption. ..
  3. Genetics of Taste Perception
    Alexander Bachmanov; Fiscal Year: 2009
    ..We also propose to expand our scope to include sour taste- related genes. These studies, when completed, may provide important new avenues for interventions designed to modify excess food consumption. ..
  4. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2007
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  5. GENETICS OF SWEET TASTE PERCEPTION
    Alexander Bachmanov; Fiscal Year: 2006
    ..The results of this work will further understanding of sweetness perception, the sense of taste, and sensory biology. ..
  6. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2006
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  7. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2005
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  8. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2004
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  9. Genetics of Taste Perception
    Alexander A Bachmanov; Fiscal Year: 2010
    ..We also propose to expand our scope to include sour taste- related genes. These studies, when completed, may provide important new avenues for interventions designed to modify excess food consumption. ..