- High level expression of proteins using sequences from the ferritin heavy chain gene locusHolly L Prentice
Momenta Pharmaceuticals, Inc, Cambridge, MA 02142, United States
J Biotechnol 128:50-60. 2007..The ferritin HC vector was able to generate cell lines with significantly higher expression levels than those under the control of the viral promoters...
- Improving performance of mammalian cells in fed-batch processes through "bioreactor evolution"Holly L Prentice
Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
Biotechnol Prog 23:458-64. 2007..These increases were obtained without any appreciable impact on product quality, demonstrating the usefulness of this simple approach to improve the performance of recombinant cell lines...