K R Gee

Summary

Affiliation: Molecular Probes
Country: USA

Publications

  1. ncbi request reprint Chemical and physiological characterization of fluo-4 Ca(2+)-indicator dyes
    K R Gee
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Cell Calcium 27:97-106. 2000
  2. ncbi request reprint Redox-dependent trafficking of 2,3,4,5, 6-pentafluorodihydrotetramethylrosamine, a novel fluorogenic indicator of cellular oxidative activity
    C S Chen
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Free Radic Biol Med 28:1266-78. 2000
  3. ncbi request reprint New ratiometric fluorescent calcium indicators with moderately attenuated binding affinities
    K R Gee
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Bioorg Med Chem Lett 10:1515-8. 2000
  4. ncbi request reprint Synthesis of novel fluorinated coumarins: excellent UV-light excitable fluorescent dyes
    W C Sun
    Molecular Probes, Inc, Eugene, Oregon 97402 9165, USA
    Bioorg Med Chem Lett 8:3107-10. 1998
  5. ncbi request reprint Caged Q-rhodamine dextran: a new photoactivated fluorescent tracer
    K R Gee
    Molecular Probes, Inc, 4849 Pitchford Avenue, Eugene, OR 97402, USA
    Bioorg Med Chem Lett 11:2181-3. 2001
  6. ncbi request reprint Measuring zinc in living cells. A new generation of sensitive and selective fluorescent probes
    K R Gee
    Molecular Probes, Inc, 4849 Pitchford Avenue, Eugene, OR 97478, USA
    Cell Calcium 31:245-51. 2002
  7. ncbi request reprint Control of NO concentration in solutions of nitrosothiol compounds by light
    V R Zhelyaskov
    World Precision Instruments, Inc, International Trade Center, Sarasota, FL 34240 9258, USA
    Photochem Photobiol 67:282-8. 1998
  8. ncbi request reprint Fluorescent Bocillins: synthesis and application in the detection of penicillin-binding proteins
    K R Gee
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Electrophoresis 22:960-5. 2001
  9. ncbi request reprint Fluorescent BODIPY-GTP analogs: real-time measurement of nucleotide binding to G proteins
    D P McEwen
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632, USA
    Anal Biochem 291:109-17. 2001

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Chemical and physiological characterization of fluo-4 Ca(2+)-indicator dyes
    K R Gee
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Cell Calcium 27:97-106. 2000
    ..Because of its higher fluorescence emission intensity, fluo-4 can be used at lower intracellular concentrations, making its use a less invasive practice...
  2. ncbi request reprint Redox-dependent trafficking of 2,3,4,5, 6-pentafluorodihydrotetramethylrosamine, a novel fluorogenic indicator of cellular oxidative activity
    C S Chen
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Free Radic Biol Med 28:1266-78. 2000
    ..Based on its subcellular distribution and its oxidation by a broad range of oxidizing species, PF-H(2)TMRos is demonstrated to be a novel indicator for cellular oxidative stresses...
  3. ncbi request reprint New ratiometric fluorescent calcium indicators with moderately attenuated binding affinities
    K R Gee
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Bioorg Med Chem Lett 10:1515-8. 2000
    ..Two new excitation ratioable fluorescent calcium indicators, benzothiaza-1 and 2, were also synthesized. Kd values of 400 nM to 5.3 microM [Ca2+] were observed in these families of new probes...
  4. ncbi request reprint Synthesis of novel fluorinated coumarins: excellent UV-light excitable fluorescent dyes
    W C Sun
    Molecular Probes, Inc, Eugene, Oregon 97402 9165, USA
    Bioorg Med Chem Lett 8:3107-10. 1998
    ..63 to 0.89) equal to or higher than that of the parent compound (0.63), which, in combination with their lower pKaS and higher photostability, make them superior fluorescent dyes for use as reporter molecules in biological systems...
  5. ncbi request reprint Caged Q-rhodamine dextran: a new photoactivated fluorescent tracer
    K R Gee
    Molecular Probes, Inc, 4849 Pitchford Avenue, Eugene, OR 97402, USA
    Bioorg Med Chem Lett 11:2181-3. 2001
    ..The resulting fluorescent cell was imaged by fluorescence microscopy through a single round of cell division...
  6. ncbi request reprint Measuring zinc in living cells. A new generation of sensitive and selective fluorescent probes
    K R Gee
    Molecular Probes, Inc, 4849 Pitchford Avenue, Eugene, OR 97478, USA
    Cell Calcium 31:245-51. 2002
    ..Experiments in neuronal and non-neuronal cell cultures show the new indicators to retain their sensitivity to and selectivity for zinc after conversion to cell-permeable forms...
  7. ncbi request reprint Control of NO concentration in solutions of nitrosothiol compounds by light
    V R Zhelyaskov
    World Precision Instruments, Inc, International Trade Center, Sarasota, FL 34240 9258, USA
    Photochem Photobiol 67:282-8. 1998
    ..Generation of superoxide as a product of a photolytic decomposition reaction of S-nitrosothiols and further oxidation of NO is the most likely mechanism for light suppression of NO concentration...
  8. ncbi request reprint Fluorescent Bocillins: synthesis and application in the detection of penicillin-binding proteins
    K R Gee
    Molecular Probes, Inc, Eugene, OR 97402, USA
    Electrophoresis 22:960-5. 2001
    ..These reagents allow for facile detection of 2-4 ng of purified PBP with the aid of a fluorescent scanner...
  9. ncbi request reprint Fluorescent BODIPY-GTP analogs: real-time measurement of nucleotide binding to G proteins
    D P McEwen
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632, USA
    Anal Biochem 291:109-17. 2001
    ..The visible excitation and emission spectra and high fluorescence levels of these probes permit robust real-time detection of nucleotide binding...