TIMOTHY DELOREY

Summary

Affiliation: Molecular Research Institute
Country: USA

Publications

  1. ncbi Augmentation of the noradrenergic system in alpha-2 adrenergic receptor deficient mice: anatomical changes associated with enhanced fear memory
    M Frances Davies
    Department of Anesthesia, Stanford University, CA, USA
    Brain Res 986:157-65. 2003
  2. ncbi Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala
    M Frances Davies
    Department of Anesthesia, Stanford University of Anesthesiology, Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA, USA
    Neuropsychopharmacology 29:229-39. 2004
  3. ncbi Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder
    Timothy M DeLorey
    Molecular Research Institute, 1000 Elwell Court, Suite 105, Palo Alto, CA 94303, USA
    Behav Brain Res 187:207-20. 2008
  4. ncbi New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout
    Carolyn Ferguson
    Departments of Anesthesiology and Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BMC Neurosci 8:85. 2007
  5. ncbi Gabrb3 gene deficient mice exhibit increased risk assessment behavior, hypotonia and expansion of the plexus of locus coeruleus dendrites
    Ezzat Hashemi
    Molecular Research Institute, Mountain View, CA 94043, USA
    Brain Res 1129:191-9. 2007
  6. ncbi GABRB3 gene deficient mice: a potential model of autism spectrum disorder
    Timothy M DeLorey
    Molecular Research Institute, Mountain View, California 94043, USA
    Int Rev Neurobiol 71:359-82. 2005
  7. ncbi Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit
    Danni Harris
    Moltech Corporation, 1000 Elwell Court, Palo Alto, California 94303, USA
    J Med Chem 51:3788-803. 2008
  8. ncbi Transcutaneous blood gas CO2 monitoring of induced ventilatory depression in mice
    Peyman Sahbaie
    Molecular Research Institute, Mountain View, California 94043, USA
    Anesth Analg 103:620-5. 2006
  9. ncbi Sleep states and sleep electroencephalographic spectral power in mice lacking the beta 3 subunit of the GABA(A) receptor
    Jonathan P Wisor
    Stanford University Sleep Research Center, 701 Welch Road, Suite 2226 Palo Alto, CA 94304, USA
    Brain Res 955:221-8. 2002
  10. ncbi Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome
    Adrian Handforth
    Department of Neurology, VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Epilepsia 46:1860-70. 2005

Research Grants

  1. Attenuation of Memory Impairment Using BDZR Ligands
    TIMOTHY DELOREY; Fiscal Year: 2005
  2. GABAA RECEPTORS: DEVELOPMENTAL INFLUENCE ON BEHAVIOR
    TIMOTHY DELOREY; Fiscal Year: 2006

Collaborators

Detail Information

Publications10

  1. ncbi Augmentation of the noradrenergic system in alpha-2 adrenergic receptor deficient mice: anatomical changes associated with enhanced fear memory
    M Frances Davies
    Department of Anesthesia, Stanford University, CA, USA
    Brain Res 986:157-65. 2003
    ..This study suggests that alpha2A ARs are involved in the development of the central noradrenergic system and raises the possibility that alterations in alpha2A AR expression may contribute to variations in fear and stress responses...
  2. ncbi Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala
    M Frances Davies
    Department of Anesthesia, Stanford University of Anesthesiology, Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA, USA
    Neuropsychopharmacology 29:229-39. 2004
    ..The ability of alpha(2) agonists to suppress fear memory may be a valuable property clinically in order to suppress the formation of memories during stressful situations...
  3. ncbi Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder
    Timothy M DeLorey
    Molecular Research Institute, 1000 Elwell Court, Suite 105, Palo Alto, CA 94303, USA
    Behav Brain Res 187:207-20. 2008
    ..The primary aim of this study was to assess whether gabrb3 gene deficient (gabrb3(-/-)) mice exhibit abnormal social behavior, a core deficit associated with autism spectrum disorder...
  4. ncbi New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout
    Carolyn Ferguson
    Departments of Anesthesiology and Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BMC Neurosci 8:85. 2007
    ..To overcome many of these limitations, a mouse line with a conditionally inactivated beta3 gene was engineered...
  5. ncbi Gabrb3 gene deficient mice exhibit increased risk assessment behavior, hypotonia and expansion of the plexus of locus coeruleus dendrites
    Ezzat Hashemi
    Molecular Research Institute, Mountain View, CA 94043, USA
    Brain Res 1129:191-9. 2007
    ....
  6. ncbi GABRB3 gene deficient mice: a potential model of autism spectrum disorder
    Timothy M DeLorey
    Molecular Research Institute, Mountain View, California 94043, USA
    Int Rev Neurobiol 71:359-82. 2005
  7. ncbi Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit
    Danni Harris
    Moltech Corporation, 1000 Elwell Court, Palo Alto, California 94303, USA
    J Med Chem 51:3788-803. 2008
    ..Surprisingly, both weak inverse agonist and antagonists that display binding selectivity toward the alpha5beta2gamma2 isoform were able to attenuate contextual memory impairment...
  8. ncbi Transcutaneous blood gas CO2 monitoring of induced ventilatory depression in mice
    Peyman Sahbaie
    Molecular Research Institute, Mountain View, California 94043, USA
    Anesth Analg 103:620-5. 2006
    ..Consequently, the Ptcco2 method can be used as a means to rapidly and quantitatively assess the ventilatory depressive properties of a wide spectrum of drugs, under varying conditions in numerous mouse models...
  9. ncbi Sleep states and sleep electroencephalographic spectral power in mice lacking the beta 3 subunit of the GABA(A) receptor
    Jonathan P Wisor
    Stanford University Sleep Research Center, 701 Welch Road, Suite 2226 Palo Alto, CA 94304, USA
    Brain Res 955:221-8. 2002
    ..The former but not the latter response to midazolam was intact in the knockout. These results further support a role for GABAergic transmission in regulating REM sleep and EEG spectral phenomena associated with NREM sleep...
  10. ncbi Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome
    Adrian Handforth
    Department of Neurology, VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Epilepsia 46:1860-70. 2005
    ....

Research Grants5

  1. Attenuation of Memory Impairment Using BDZR Ligands
    TIMOTHY DELOREY; Fiscal Year: 2005
    ..This will lay the groundwork for pursuing the most promising lead compounds in a Phase II application aimed at addressing the serious problem of cognitive decline observed in aging and SDAT. ..
  2. GABAA RECEPTORS: DEVELOPMENTAL INFLUENCE ON BEHAVIOR
    TIMOTHY DELOREY; Fiscal Year: 2006
    ..This proposal addresses several issues of fundamental importance regarding the influence of neural development on behavior. ..