S Mohan

Summary

Country: USA

Publications

  1. ncbi Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross
    Chandrasekhar Kesavan
    Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, CA 92357, USA
    Bone 39:634-43. 2006
  2. ncbi IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
    S Mohan
    Musculoskeletal Diseases Center, Jerry L Pettis VA Medical Center and Departments of Medicine, Biochemistry and Physiology, Loma Linda University, 11201 Benton Street, Loma Linda, California 92357, USA
    J Endocrinol 175:19-31. 2002
  3. ncbi ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts
    Subburaman Mohan
    Musculoskeletal Diseases Center, Jerry L Pettis VA Medical Center, 11201 Benton Street, Loma Linda, California 92357, USA
    Biochemistry 41:15394-403. 2002
  4. ncbi Mapping quantitative trait loci that influence serum insulin-like growth factor binding protein-5 levels in F2 mice (MRL/MpJ X SJL/J)
    Subburaman Mohan
    Musculoskeletal Disease Center, J L Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocrinology 144:3491-6. 2003
  5. ncbi Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice
    S Mohan
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA 92357, USA
    Bone 27:471-8. 2000
  6. ncbi Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism
    N Miyakoshi
    Musculoskeletal Disease Center, J. L. Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocrinology 142:2641-8. 2001
  7. ncbi Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice
    C Richman
    JL Pettis Veterans Administration Medical Center and Loma Linda University, California 92357, USA
    J Bone Miner Res 16:386-97. 2001
  8. ncbi High osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is associated with low apoptosis in C3H/HeJ osteoblasts
    M H C Sheng
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA
    Calcif Tissue Int 78:293-301. 2006
  9. ncbi Detecting novel bone density and bone size quantitative trait loci using a cross of MRL/MpJ and CAST/EiJ inbred mice
    H Yu
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Calcif Tissue Int 80:103-10. 2007
  10. ncbi Disruption of four-and-a-half LIM 2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice
    K E Govoni
    Musculoskeletal Disease Center, 151, Jerry L Pettis Memorial Veterans Affairs Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Calcif Tissue Int 79:112-7. 2006

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross
    Chandrasekhar Kesavan
    Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, CA 92357, USA
    Bone 39:634-43. 2006
    ..Knowledge of the genes underlying these loci could provide novel approaches to improve skeletal mass...
  2. ncbi IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
    S Mohan
    Musculoskeletal Diseases Center, Jerry L Pettis VA Medical Center and Departments of Medicine, Biochemistry and Physiology, Loma Linda University, 11201 Benton Street, Loma Linda, California 92357, USA
    J Endocrinol 175:19-31. 2002
    ..One mechanism to account for such complexity with a relatively small number of genes is strikingly illustrated by the multifunctional IGFBP class of proteins...
  3. ncbi ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts
    Subburaman Mohan
    Musculoskeletal Diseases Center, Jerry L Pettis VA Medical Center, 11201 Benton Street, Loma Linda, California 92357, USA
    Biochemistry 41:15394-403. 2002
    ....
  4. ncbi Mapping quantitative trait loci that influence serum insulin-like growth factor binding protein-5 levels in F2 mice (MRL/MpJ X SJL/J)
    Subburaman Mohan
    Musculoskeletal Disease Center, J L Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocrinology 144:3491-6. 2003
    ....
  5. ncbi Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice
    S Mohan
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA 92357, USA
    Bone 27:471-8. 2000
    ..In conclusion, our findings suggest that PTH(1-34) and PTH(1-31) may exhibit different anabolic effects at the periosteum vs. endosteum in the long bones of mice...
  6. ncbi Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism
    N Miyakoshi
    Musculoskeletal Disease Center, J. L. Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocrinology 142:2641-8. 2001
    ..This study demonstrates that systemic administration of IGFBP-4 increases bone formation parameters in mice by increasing IGF bioavailability in the circulation via an IGFBP-4 protease-dependent mechanism...
  7. ncbi Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice
    C Richman
    JL Pettis Veterans Administration Medical Center and Loma Linda University, California 92357, USA
    J Bone Miner Res 16:386-97. 2001
    ....
  8. ncbi High osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is associated with low apoptosis in C3H/HeJ osteoblasts
    M H C Sheng
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA
    Calcif Tissue Int 78:293-301. 2006
    ..In conclusion, these studies support the premise that higher bone density and bone formation rate in C3H mice could be due in part to lower apoptosis in C3H osteoblasts...
  9. ncbi Detecting novel bone density and bone size quantitative trait loci using a cross of MRL/MpJ and CAST/EiJ inbred mice
    H Yu
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Calcif Tissue Int 80:103-10. 2007
    ..This study demonstrates the utility of crosses involving inbred strains of mice which exhibit a similar phenotype in QTL identification...
  10. ncbi Disruption of four-and-a-half LIM 2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice
    K E Govoni
    Musculoskeletal Disease Center, 151, Jerry L Pettis Memorial Veterans Affairs Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Calcif Tissue Int 79:112-7. 2006
    ..In conclusion, FHL2 is an important regulator of peak bone mass, lack of FHL2 produces gender- and site-specific effects on bone accretion and IGFBP-5 expression, and FHL2 is important for optimal osteoblast differentiation in vitro...
  11. ncbi Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts
    K E Govoni
    Musculoskeletal Disease Center 151, Jerry L Pettis Memorial Veterans Affairs Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Growth Horm IGF Res 16:49-56. 2006
    ..05). In conclusion, our findings are consistent with the hypothesis that FHL-2 and ADAM-9 are important modulators of IGFBP-5 actions and are, in part, regulated in a coordinated manner in bone...
  12. ncbi Identification of wound healing/regeneration quantitative trait loci (QTL) at multiple time points that explain seventy percent of variance in (MRL/MpJ and SJL/J) mice F2 population
    G L Masinde
    Molecular Genetics Division, Musculoskeletal Disease Center, J L Pettis Veterans Administration Medical Center and Loma Linda University, Loma Linda, California 92357, USA
    Genome Res 11:2027-33. 2001
    ..Therefore, loci-to-loci interactions may play a major role in wound healing. Information from these studies may help in the identification of genes that could be involved in wound healing/regeneration...
  13. ncbi Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease
    X Qin
    Musculoskeletal Disease Center, J L Pettis Memorial Veterans Medical Center, Loma Linda, California 92357, USA
    Arch Biochem Biophys 379:209-16. 2000
    ..Taken together, these findings provided strong evidence that the interaction between IGF-II and IGFBP-4, rather than the direct interaction between IGF-II and IGFBP-4 protease, is required for optimal IGFBP-4 proteolysis...
  14. ncbi Quantitative trait loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in F2 mice
    G L Masinde
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, 11201 Benton Street, Loma Linda, CA 92357, USA
    Calcif Tissue Int 71:421-8. 2002
    ..Several QTL were identified for both femur and total body BMD but only two QTL were common for both of these phenotypes. This suggests that genes regulating bone density differ depending on the skeletal site analyzed...
  15. ncbi Circadian and longitudinal variation of serum C-telopeptide, osteocalcin, and skeletal alkaline phosphatase in C3H/HeJ mice
    A K Srivastava
    Musculoskeletal Disease Center, Jerry L. Pettis VA Medical Center, Loma Linda, CA 92357, USA
    Bone 29:361-7. 2001
    ..The results highlight the importance of: (i) the timing of sample collection for appropriate interpretation of the bone marker data; and (ii) using the appropriate number of samples based on the variance obtained herein...
  16. ncbi Impaired skeletal growth in mice with haploinsufficiency of IGF-I: genetic evidence that differences in IGF-I expression could contribute to peak bone mineral density differences
    S Mohan
    Musculoskeletal Diseases Center, JLP Veterans Administration Medical Center, 11201 Benton St, Loma Linda, California 92357, USA
    J Endocrinol 185:415-20. 2005
    ....
  17. ncbi Mapping quantitative trait loci that influence blood levels of alkaline phosphatase in MRL/MpJ and SJL/J mice
    A K Srivastava
    Musculoskeletal Disease Center, JLP VA Medical Center, Loma Linda, CA, 92357, USA
    Bone 35:1086-94. 2004
    ..The findings that ALP and BMD traits share the same loci on chromosome 6 suggest a role for genetic determinants of bone formation in overall BMD accretion...
  18. ncbi Analysis of gene expression in the wound repair/regeneration process
    X Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, California 92357, USA
    Mamm Genome 12:52-9. 2001
    ....
  19. ncbi Complex genetic regulation of bone mineral density and insulin-like growth factor-I in C57BL/6J-Chr #A/J/NaJ chromosome substitution strains
    K E Govoni
    Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda, California 92357, USA
    Physiol Genomics 35:159-64. 2008
    ..A-6 (females) contributed to increased IGF-I and male B.A-3 and female B.A-8 contributed to reduced IGF-I. Overall, we identified several sex-dependent and -independent chromosomes that regulate aBMD and IGF-I in adult mice...
  20. ncbi Genetic regulation of femoral bone mineral density: complexity of sex effect in chromosome 1 revealed by congenic sublines of mice
    B Edderkaoui
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, and Department of Biochemistry, Loma Linda University, CA 92357, USA
    Bone 41:340-5. 2007
    ....
  21. ncbi Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice
    G L Masinde
    Molecular Genetics Division, Musculoskeletal Disease Center, J L Pettis VA Medical Center and Loma Linda University, Loma Linda, CA 92357, USA
    Bone 32:554-60. 2003
    ....
  22. ncbi Structure-function analysis of the human insulin-like growth factor binding protein-4
    X Qin
    Department of Mineral Metabolism, J L Pettis Memorial Veterans Medical Center, Loma Linda, California 92357, USA
    J Biol Chem 273:23509-16. 1998
    ..Therefore, the N-terminal sequence (Leu72-Ser91) and the C-terminal sequence (Cys205-Val214) are necessary to form the high affinity IGF binding domain, which is the major structural determinant of the IGFBP-4 function...
  23. ncbi Evidence that anabolic effects of PTH on bone require IGF-I in growing mice
    N Miyakoshi
    Musculoskeletal Disease Center, J L Pettis VA Medical Center, Loma Linda, California 92357, USA
    Endocrinology 142:4349-56. 2001
    ..These data to our knowledge provide the first direct evidence that the anabolic effects of PTH on bone formation in vivo require IGF-I action in growing mice...
  24. ncbi Evidence that IGF-binding protein-5 functions as a growth factor
    N Miyakoshi
    Musculoskeletal Disease Center, Jerry L Pettis Veterans Administration Medical Center, Loma Linda, California, USA
    J Clin Invest 107:73-81. 2001
    ..These results provide the first direct evidence to our knowledge that IGFBP-5 functions as a growth factor that stimulates its actions in part via an IGF-independent mechanism...
  25. ncbi A genomewide screening of N-ethyl-N-nitrosourea-mutagenized mice for musculoskeletal phenotypes
    A K Srivastava
    Musculoskeletal Disease Center, Jerry L. Pettis Veterans Medical Center, and Department of Medicine, Loma Linda University, Loma Linda, CA 92357, USA
    Bone 33:179-91. 2003
    ..So far, this ENU mutagenesis program has identified four outliers that can undergo positional cloning...
  26. ncbi Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro
    D Byun
    Musculoskeletal Disease Center, J. L. Pettis Memorial Veterans Affairs Medical Center and Loma Linda University, Loma Linda, California 92357, USA
    J Clin Endocrinol Metab 86:847-54. 2001
    ....
  27. ncbi The role of IGF system in the rise and fall in bone density with age
    D Baylink
    Department of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    J Musculoskelet Neuronal Interact 7:304-5. 2007
  28. ncbi Bone cell mitogenic action of fluoroaluminate and aluminum fluoride but not that of sodium fluoride involves upregulation of the insulin-like growth factor system
    K H William Lau
    Musculoskeletal Disease Center 151, Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Bone 30:705-11. 2002
    ..The findings of this study provide strong evidence that the bone cell mitogenic activity of AlF(4)(-) and AlF(3), but not that of NaF, is mediated by the upregulation of the IGF regulatory system...
  29. ncbi Chemical mutagenesis induced two high bone density mouse mutants map to a concordant distal chromosome 4 locus
    S Mohan
    Musculoskeletal Disease Center 151, Loma Linda VA Healthcare Systems, Loma Linda, CA 92357, USA
    Bone 41:860-8. 2007
    ..The large phenotype in the mutant mice compared to generally observed QTL effects (<5%) would increase the probability of identifying the mutant gene...
  30. ncbi Genetic variation in bone-regenerative capacity among inbred strains of mice
    X Li
    Molecular Genetics Division, Musculoskeletal Disease Center, J. L. Pettis VA Medical Center and Loma Linda University, Loma Linda, CA 92357, USA
    Bone 29:134-40. 2001
    ..It was, however, significantly correlated with total bone mineral density (R = 0.49, p < 0.01), indicating that high bone density is associated not only with prevention of bone fracture, but also with promotion of bone regeneration...
  31. ncbi Localization of the IGF binding domain and evaluation of the role of cysteine residues in IGF binding in IGF binding protein-4
    D Byun
    Musculoskeletal Disease Center, J L Pettis Memorial Veterans' Medical Centre, Loma Linda, California 92357, USA
    J Endocrinol 169:135-43. 2001
    ..Based on these data, we speculate that the structural determinants of IGF-I and IGF-II binding in IGFBP-4 are very similar, if not identical...
  32. ncbi Quantitative assessment of forearm muscle size, forelimb grip strength, forearm bone mineral density, and forearm bone size in determining humerus breaking strength in 10 inbred strains of mice
    X Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center, and Loma Linda University, CA 92357, USA
    Calcif Tissue Int 68:365-9. 2001
    ..These data suggest that evaluation of these three parameters together, rather than BMD alone, is a more effective, noninvasive approach for predicting fracture risk...
  33. ncbi A new monoclonal antibody ELISA for detection and characterization of C-telopeptide fragments of type I collagen in urine
    A K Srivastava
    Musculoskeletal Disease Center, Jerry L. Pettis VA Medical Center and Loma Linda University, CA 92357, USA
    Calcif Tissue Int 69:327-36. 2001
    ..The preliminary clinical data suggest that the new assay may be useful for further investigation of the clinical importance of measurement of these type I collagen degradation products...
  34. ncbi Opposing changes in osteocalcin levels in bone vs serum during the acquisition of peak bone density in C3H/HeJ and C57BL/6J mice
    X Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, 11201 Benton Street (151, Loma Linda, CA 92357, USA
    Calcif Tissue Int 71:416-20. 2002
    ....
  35. ncbi Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6
    T Yan
    Musculoskeletal Disease Center 151, J L Pettis Memorial Veterans Medical Center, 11201 Benton St, Loma Linda, CA 92357, USA
    Growth Horm IGF Res 11:368-77. 2001
    ..These findings provide evidence that atRA recruits IGFBP-6 to inhibit the human osteoblast phenotype...
  36. ncbi Genetic control of the rate of wound healing in mice
    X Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, Loma Linda, CA 92357, USA
    Heredity 86:668-74. 2001
    ..Information gained from this investigation provides insight into further study of molecular mechanisms underlying the rate of wound healing in mammals...
  37. ncbi Construction of a BAC contig for a 3 cM biologically significant region of mouse chromosome 1
    W K Gu
    Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, CA, USA
    Genetica 114:1-9. 2002
    ..This region also contains L1 retrotransposon sequences, providing a potential mechanism for the repetitive sequences described in the literature...
  38. ncbi Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation
    D Latour
    Department of Medicine, Loma Linda University, California 92357
    Mol Endocrinol 4:1806-14. 1990
    ..hIGFBP-4 mRNA was also expressed in skin fibroblasts, and thus, this inhibitory IGFBP could be an important physiological regulator of IGF actions in bone cells and other cell types as well...
  39. ncbi T-box 3 negatively regulates osteoblast differentiation by inhibiting expression of osterix and runx2
    K E Govoni
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA 92357, USA
    J Cell Biochem 106:482-90. 2009
    ....
  40. ncbi Effect of insulin-like growth factor-1 (IGF-1) plus alendronate on bone density during puberty in IGF-1-deficient MIDI mice
    L Stabnov
    Musculoskeletal Disease Center, Jerry L. Pettis Veterans Administration Medical Center, Loma Linda, CA 92357, USA
    Bone 30:909-16. 2002
    ....
  41. ncbi A urine midmolecule osteocalcin assay shows higher discriminatory power than a serum midmolecule osteocalcin assay during short-term alendronate treatment of osteoporotic patients
    A K Srivastava
    Musculoskeletal Disease Center, Jerry L. Pettis Veterans Medical Center and Department of Medicine, Loma Linda University, Loma Linda, CA 92357, USA
    Bone 31:62-9. 2002
    ....
  42. ncbi Serum insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases
    S Mohan
    Jerry L Pettis Veterans Medical Center, Department of Medicine, Loma Linda, CA 92357, USA
    Endocrine 7:87-91. 1997
    ..In addition, skeletal content of IGFBP-5 declined with age. The age-related changes in IGFBP-4 and IGFBP-5 production could contribute, in part, to the decrease in osteoblast cell proliferation and deficiency in bone formation...
  43. ncbi Bone mass gained in response to external loading is preserved for several weeks following cessation of loading in 10 week C57BL/6J mice
    C Kesavan
    Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, CA 92357, USA
    J Musculoskelet Neuronal Interact 10:274-80. 2010
    ..Dynamic loads lead to increases in bone mass. How long these gains are maintained after cessation of loading, however, is not fully understood...
  44. ncbi Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats
    R Gysin
    Department of Medicine, Loma Linda University, CA 92357, USA
    Gene Ther 9:991-9. 2002
    ..5 x 10(6) implanted BMP4 cells. In conclusion, the retroviral-based BMP4 gene therapy system that we have developed has the potential for regeneration of large skeletal defects...
  45. ncbi The diagnosis and treatment of osteoporosis: future prospects
    D J Baylink
    Dept of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    Mol Med Today 5:133-40. 1999
    ..One area of focus for future therapeutics in osteoporosis will be on osteogenic agents, which should have a high likelihood of success because the skeleton has the innate capacity to regenerate itself...
  46. ncbi Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging
    S Mohan
    Department of Medicine, Loma Linda University, CA, USA
    Prog Growth Factor Res 6:465-73. 1995
    ....
  47. ncbi Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions
    S Rajaram
    Mineral Metabolism Laboratory, Jerry L. Pettis Memorial Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocr Rev 18:801-31. 1997
  48. ncbi Bone response to loading in mice with targeted disruption of the cartilage oligomeric matrix protein gene
    A Sengul
    Musculoskeletal Disease Center, VA Loma Linda Healthcare System, Loma Linda, CA, USA
    Physiol Res 61:637-41. 2012
    ..9 % and 21 % vs. unloaded bones) was not significantly different from control mice (7 % and 24 % vs. unloaded bones). Our results imply that COMP is not a key upstream mediator of the anabolic effects of ML on the skeleton...
  49. ncbi Ras association domain family 1C protein stimulates human lung cancer cell proliferation
    Yousef G Amaar
    Surgical Oncology Laboratory, Loma Linda University, Loma Linda, California, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1185-90. 2006
    ..This suggests that RASSF1C and RASSF1A have different effector targets. Together, our findings suggest that RASSF1C, unlike RASSF1A, is not a tumor suppressor but rather stimulates lung cancer cell proliferation...
  50. ncbi Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo
    Xuezhong Qin
    Musculoskeletal Disease Center, J L Pettis Veterans Affairs Medical Center 151, 11201 Benton Street, and Department of Medicine, Loma Linda University, California 92357, USA
    Endocrinology 147:5653-61. 2006
    ..Thus, enhancing IGF bioavailability by PAPP-A can be a powerful strategy in the treatment of certain metabolic diseases such as osteoporosis...
  51. ncbi Digit tip regrowth and differential gene expression in MRL/Mpj, DBA/2, and C57BL/6 mice
    Robert B Chadwick
    Musculoskeletal Disease Center, JL Pettis VA Medical Center, Molecular Genetics Division, Loma Linda, CA 92357, USA
    Wound Repair Regen 15:275-84. 2007
    ..This enhanced regrowth is likely due to strain-specific increased expression of genes involved in growth and development...
  52. ncbi Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation
    Kristen E Govoni
    Musculoskeletal Disease Center (151 Jerry L. Pettis Memorial Veterans Affairs Medical Center, 11201 Benton St, Loma Linda, CA 92357, USA
    Am J Physiol Endocrinol Metab 291:E128-36. 2006
    ....
  53. ncbi Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein
    Charu Dogra
    Molecular Genetics Division, Musculoskeletal Disease Center, Jerry L Pettis Veterans Administration Medical Center, 11201 Benton Street 151, Loma Linda, CA 92357, USA
    J Biol Chem 281:10327-36. 2006
    ..Overall, our data suggest that TWEAK inhibits myogenesis through the activation of NF-kappaB signaling pathway and degradation of MyoD protein...
  54. ncbi Mapping the dominant wound healing and soft tissue regeneration QTL in MRL x CAST
    Hongrun Yu
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA
    Mamm Genome 16:918-24. 2005
    ..05. These interactions explained about 4% of the F2 phenotypic variance. We conclude that soft tissue regeneration is controlled by multiple genes and locus vs. locus interactions...
  55. ncbi Inhibition of mechanosensitive cation channels inhibits myogenic differentiation by suppressing the expression of myogenic regulatory factors and caspase-3 activity
    Nia Wedhas
    Molecular Genetics Division, Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, California 92354, USA
    FASEB J 19:1986-97. 2005
    ..Our data suggest that inhibition of MSC suppresses myogenic differentiation by inhibiting the caspase-3 activity and the expression of myogenic regulatory factors...
  56. ncbi Identification and characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a potential regulator of osteoblast cell proliferation
    Yousef G Amaar
    Musculoskeletal Disease Center, PO Box 151, Jerry L Pettis Veterans Affairs Medical Center, 11201 Benton St, Loma Linda, CA 92357, USA
    Am J Physiol Cell Physiol 290:C900-6. 2006
    ..On the basis of these findings, we predict that IGFBP5-IP may act as intracellular mediator of growth promoting actions of IGFBP5 and perhaps other osteoregulatory agents in bone cells...
  57. ncbi Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: congenic analysis and fine mapping
    Hongrun Yu
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA
    Wound Repair Regen 15:922-7. 2007
    ..Based on the 2-LOD intervals, the total QTL region was confined to a combined length of no more than 28.2 Mb. Application of a Bayesian shrinkage estimation indicated that a major locus was located in a region of just 1.3 Mb...
  58. ncbi The selective cyclooxygenase-2 inhibitor celecoxib reduces bone resorption, but not bone formation, in ovariectomized mice in vivo
    Yuji Kasukawa
    Division of Orthopedic Surgery, Department of Neuro and Locomotor Science, Akita University School of Medicine, Japan
    Tohoku J Exp Med 211:275-83. 2007
    ..Also, celecoxib did not prevent the decrease of femoral BMD in OVX mice. The present study suggests the possibility that celecoxib may be used to prevent bone loss caused by estrogen deficiency...
  59. ncbi Transgenic overexpression of pregnancy-associated plasma protein-A increases the somatic growth and skeletal muscle mass in mice
    Mark Rehage
    Musculoskeletal Disease Center, J L Pettis Veterans Affairs Medical Center 151, 11201 Benton Street, Loma Linda, CA 92357, USA
    Endocrinology 148:6176-85. 2007
    ..Moreover, our studies provide the first experimental evidence that IGFBP degradation is a key determinant in modulating the local action of IGFs in muscle...
  60. ncbi A chemical mutagenesis screen to identify modifier genes that interact with growth hormone and TGF-beta signaling pathways
    Subburaman Mohan
    Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, CA 92357, USA
    Bone 42:388-95. 2008
    ..The discovery of mutants in a selected pathway will provide a valuable tool to not only to discover novel genes involved in a particular process but will also prove useful for the elucidation of the biology of that process...
  61. ncbi Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion
    Kristen E Govoni
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Affairs Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Endocrinology 148:5706-15. 2007
    ..In conclusion, both local and endocrine IGF-I actions are involved in regulating growth of various tissues including bone, but they act via different mechanisms...
  62. ncbi Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross
    Chandrasekhar Kesavan
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Bone 41:223-30. 2007
    ....
  63. ncbi Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity
    Matilda H C Sheng
    Musculoskeletal Disease Center 151, Jerry L Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA
    FEBS Lett 582:1451-8. 2008
    ..These findings indicate that OA is a novel osteoclastic protein and plays a role in osteoclast differentiation and/or activity...
  64. ncbi Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression
    Johan Svensson
    Department of Internal Medicine, Sahlgrenska University Hospital, Grona Straket 8, SE 413 45 Goteborg, Sweden
    J Endocrinol 193:359-66. 2007
    ..However, the LI-IGF-I(-/-) mice did not develop kidney failure or nephrosclerosis. One may speculate that liver-derived endocrine IGF-I induces renal IGF-II expression, resulting in symmetrical renal growth...
  65. ncbi Potential involvement of the interaction between insulin-like growth factor binding protein (IGFBP)-6 and LIM mineralization protein (LMP)-1 in regulating osteoblast differentiation
    Cassandra Strohbach
    Jerry L Pettis Memorial VA Center, Musculoskeletal Disease Center, Loma Linda, CA 92357, USA
    J Cell Biochem 104:1890-905. 2008
    ....
  66. ncbi Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice
    Kristen E Govoni
    Jerry L Pettis Veterans Affairs Medical Center and Loma Linda University, Loma Linda, California 92357, USA
    Physiol Genomics 30:354-62. 2007
    ..20). In conclusion, IGF-I from cells expressing procollagen type IIalphaI regulates bone accretion that occurs during postnatal growth period...
  67. ncbi Loss of sex-specific difference in femoral bone parameters in male leptin knockout mice
    Xiaoguang Wang
    Musculoskeletal Disease Center 151, J L Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Calcif Tissue Int 80:374-82. 2007
    ....
  68. ncbi Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells
    Weirong Xing
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda, CA 92357, USA
    J Biol Chem 282:22052-61. 2007
    ..Our data provided the first experimental evidence that AA modulated osterix expression via a novel mechanism involving Nrf1 nuclear translocation and Nrf1 binding to ARE to activate genes critical for cell differentiation...
  69. ncbi Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains
    Jon E Wergedal
    Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, CA, USA
    J Lipid Res 48:1724-34. 2007
    ..The identification of shared loci from multiple crosses increases confidence toward finding the QTL gene...
  70. ncbi Identification of mouse Duffy antigen receptor for chemokines (Darc) as a BMD QTL gene
    Bouchra Edderkaoui
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, and Department of Medicine and Biochemistry, Loma Linda University, California 92357, USA
    Genome Res 17:577-85. 2007
    ....
  71. ncbi Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ x SJL/J inbred mice
    Apurva K Srivastava
    Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, CA 92357, USA
    J Lipid Res 47:123-33. 2006
    ..Knowledge of the genes in these quantitative trait loci will enhance our understanding of obesity and lipid metabolism...
  72. ncbi Low IGF-I in synovial fluid and serum in patients with aseptic prosthesis loosening
    Martin K Andersson
    Department of Orthopaedic Surgery, Karolinska University Hospital Solna, Sweden
    Acta Orthop 76:320-5. 2005
    ..INTERPRETATION: Low levels of IGF-I in synovial fluid possibly result from low serum levels and may be a mechanism leading to aseptic prosthesis loosening...
  73. ncbi Evidence that sensitivity to growth hormone (GH) is growth period and tissue type dependent: studies in GH-deficient lit/lit mice
    Yuji Kasukawa
    Musculoskeletal Disease Center, Jerry L Pettis Veterans Affairs Medical Center, Loma Linda, California 92357, USA
    Endocrinology 144:3950-7. 2003
    ..Our findings demonstrate that the sensitivity to GH in target tissues is growth period and tissue type dependent and that continuous GH treatment is necessary to maintain body fat loss but not BMD gain during a 3-7 wk follow-up...
  74. ncbi Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms
    Subburaman Mohan
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Affairs Medical Center and Department of Medicine, Loma Linda University, Loma Linda, California, USA
    Endocrinology 144:929-36. 2003
    ....
  75. ncbi Effects of liver-derived insulin-like growth factor I on bone metabolism in mice
    Klara Sjögren
    RCEM, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Bone Miner Res 17:1977-87. 2002
    ..In summary, liver-derived IGF-I exerts a small but significant effect on cortical periosteal bone growth and on adult axial skeletal growth while it is not required for the maintenance of the trabecular bone in adult mice...
  76. ncbi Effect of low-dose of recombinant human growth hormone on bone metabolism in elderly women with osteoporosis
    Toshitsugu Sugimoto
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Endocrinol 147:339-48. 2002
    ..However, controversy still exists as to the effect of GH treatment on bone mineral density (BMD) in elderly patients with osteoporosis...
  77. ncbi Differential regulation of pregnancy associated plasma protein (PAPP)-A during pregnancy in human and mouse
    Xuezhong Qin
    Musculoskeletal Disease Center, J Pettis Memorial Veterans Medical Center, Loma Linda, CA 92357, USA
    Growth Horm IGF Res 12:359-66. 2002
    ..2) The lack of an increase in serum IGFBP-4 proteolytic activity during mouse pregnancy is due to the low level of PAPP-A expression in the placenta...
  78. ncbi Insulin-like growth factor I effect on the number of osteoblast progenitors is impaired in ovariectomized mice
    Yuji Kasukawa
    Musculoskeletal Disease Center, JL Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA
    J Bone Miner Res 17:1579-87. 2002
    ..This study showed that IGF-I is an important regulator of osteoblast-progenitor number in the BMCs of mice both ex vivo and in vivo and that the IGF-I response to increase the number of osteoblast progenitors was impaired in OVX mice...
  79. ncbi Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ x SJL/J) F(2) mice
    Godfred L Masinde
    Molecular Genetics Division, Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center and Loma Linda University, CA 92357, USA
    Funct Integr Genomics 2:120-5. 2002
    ..Three significant epistatic interactions between different QTL positions from muscle size and body length were identified ( P <0.01) on chromosomes 2, 9, 14 and 17, which explained 16.1% of the variance in F(2) mice...
  80. ncbi Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice
    Godfred L Masinde
    Molecular Genetics Division, Musculoskeletal Disease Center, J L Pettis VA Medical Center and Loma Linda University, 11201 Benton Street 151, CA 92357, USA
    Funct Integr Genomics 2:98-104. 2002
    ..Interacting loci on chr 2 may influence LBM by regulating body length. Therefore, epistatic interactions as well as single QTL effects play an important role in the regulation of LBM...
  81. ncbi A time course of bone response to jump exercise in C57BL/6J mice
    Yoshihisa Umemura
    School of Health and Sport Sciences, Chukyo University, Toyota, Japan
    J Bone Miner Metab 20:209-15. 2002
    ..We conclude that a shorter exercise regimen, of 3 weeks, induced a bone response that was greater than or equal to that of 4 weeks of jump exercise reported earlier...
  82. ncbi IGF-I, IGF-II, 'free' IGF-I and IGF-binding proteins-2 to -6 during high-dose oestrogen treatment in constitutionally tall girls
    Raoul P A Rooman
    Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium
    Eur J Endocrinol 146:823-9. 2002
    ..To investigate the effect of high-dose oestrogen treatment on IGF-I, IGF-II, free-dissociable IGF-I and the IGF-binding proteins (IGFBP)-2 to -6 in girls with constitutional tall stature...
  83. ncbi Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 Mice: single QTL effects, epistasis, and pleiotropy
    Xinmin Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, Loma Linda, California 92357, USA
    Genomics 79:734-40. 2002
    ..Identification of the genes unique to FBS may have an impact on prediction of osteoporosis in human...
  84. ncbi Gene expression between a congenic strain that contains a quantitative trait locus of high bone density from CAST/EiJ and its wild-type strain C57BL/6J
    Weikuan Gu
    Musculoskeletal Disease Center, JL Pettis VA Medical Center, 11201 Benton Street (151, Loma Linda, CA 92357, USA
    Funct Integr Genomics 1:375-86. 2002
    ....
  85. ncbi Chromosomal regions harboring genes for the work to femur failure in mice
    Xinmin Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center, 11201 Benton Street 151, Loma Linda, CA 92357, USA
    Funct Integr Genomics 1:367-74. 2002
    ..If this is also true in humans, this finding will challenge the predictive value of BMD for the risk of fracture...
  86. ncbi Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I
    Ming Zhao Cheng
    The Royal Veterinary College, University of London, United Kingdom
    J Bone Miner Res 17:593-602. 2002
    ..In both human cell types (unlike rat cells) the effects of strain and IGF-II as well as estradiol and IGF-I can be blocked at the IGF-I receptor...
  87. ncbi Two different pathways for the maintenance of trabecular bone in adult male mice
    Marie K Lindberg
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Bone Miner Res 17:555-62. 2002
    ..These results indicate that AR and ER-alpha are redundant in the maintenance of the trabecular bone in male mice. In contrast, ER-beta is of no importance for the regulation of trabecular bone in male mice...
  88. ncbi Lack of insulin-like growth factor I exaggerates the effect of calcium deficiency on bone accretion in mice
    Yuji Kasukawa
    Musculoskeletal Disease Center, J L Petttis Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California 92357, USA
    Endocrinology 144:4682-9. 2003
    ....
  89. ncbi A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis
    Leah Rae Donahue
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 18:1612-21. 2003
    ..In addition, SED patients have been identified with a similar molecular mutation in human COL2A1. This mouse model offers a useful tool for molecular and biological studies of bone development and pathology...
  90. ncbi Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice
    Sofia Moverare
    Center for Bone Research, Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, S 41345 Goteborg, Sweden
    Proc Natl Acad Sci U S A 100:13573-8. 2003
    ..Because these two pathways are clearly distinct from each other, one may speculate that a combined treatment of selective ER modulators and selective AR modulators might be beneficial in the treatment of osteoporosis...
  91. ncbi Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice
    Weirong Xing
    Musculoskeletal Disease Center, JL Pettis Memorial Veterans Administration Medical Center, Loma Linda, California 92357, USA
    J Cell Biochem 96:1049-60. 2005
    ..Further studies on these previously unknown genes will improve our understanding of the molecular pathways and mechanisms involved in bone's response to mechanical stress...
  92. ncbi Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism
    Ashok Kumar
    Musculoskeletal Disease Center, JL Pettis Memorial Veterans Affairs Medical Center, CA 92357, USA
    J Biol Chem 280:37782-9. 2005
    ....
  93. ncbi Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency
    Subburaman Mohan
    Molecular Genetics Division, Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California, USA
    J Bone Miner Res 20:1597-610. 2005
    ....
  94. ncbi Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains
    Chandrasekhar Kesavan
    Musculoskeletal Disease Center, Veterans Affairs Loma Linda Healthcare System, Loma Linda, CA 92357, USA
    J Appl Physiol 99:1951-7. 2005
    ..We conclude that mechanical loading-induced molecular pathways are activated to a greater extent in the B6 than in the C3H mice, resulting in a higher anabolic response in the B6 mice...
  95. ncbi Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation
    Yousef G Amaar
    Musculoskeletal Disease Center, Jerry L Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA
    J Bone Miner Res 20:1430-9. 2005
    ..We identified RASSF1C, a member of the RASSF1 gene products, as a IGFBP-5 binding partner and as a potential mediator of IGFBP-5 effects on ERK phosphorylation and cell proliferation...
  96. ncbi Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature
    Raoul P A Rooman
    Department of Pediatrics, Antwerp University Hospital, Belgium
    Eur J Endocrinol 152:597-604. 2005
    ..We therefore studied the changes in the circulating components of the insulin-like growth factor (IGF) system during high dose sex steroid therapy...
  97. ncbi Reduced bone mineral density in SOCS-2-deficient mice
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg University, 41345 Gothenburg, Sweden
    Pediatr Res 57:223-6. 2005
    ..These effects are not consistent with an augmented GH/IGF-I signaling and, therefore, the mechanism behind the reduced BMD remains to be elucidated...
  98. ncbi Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice
    Dervis A M Salih
    Laboratory of Molecular Signaling, The Babraham Institute, Cambridge, United Kingdom CB2 4AT
    Endocrinology 146:931-40. 2005
    ..These findings have implications for the gender-biased progression of osteoporosis...
  99. ncbi Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease
    Frank Fischer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat Munster, Germany
    Clin Endocrinol (Oxf) 61:595-602. 2004
    ..IGFs and their binding proteins (IGFBPs) are produced both systemically and locally by cells of the cardiovascular system. As growth promoters, they may play a role in atherosclerosis...
  100. ncbi Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells
    Jesika S Faridi
    Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Growth Factors 22:169-77. 2004
    ..These data provide direct evidence that the IGF-II modulation of cathepsin D routing is IGF-II/M6P receptor mediated...
  101. ncbi Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency
    Donald Fleenor
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 146:103-12. 2005
    ..The combination of perinatal growth failure and late-onset obesity and insulin resistance suggests that the lactogen-resistant/GH-deficient mouse may serve as a model for the development of the metabolic syndrome...