I M Modlin

Summary

Country: USA

Publications

  1. pmc Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia
    Ben Lawrence
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 208602, USA
    BMC Res Notes 5:318. 2012
  2. pmc The identification of gut neuroendocrine tumor disease by multiple synchronous transcript analysis in blood
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e63364. 2013
  3. pmc Diagnosis and management of non-erosive reflux disease--the Vevey NERD Consensus Group
    I M Modlin
    Yale University, New Haven, CT 06520 8062, USA
    Digestion 80:74-88. 2009
  4. ncbi request reprint Edkins and a century of acid suppression
    I M Modlin
    Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Digestion 72:129-45. 2005
  5. ncbi request reprint Current status of gastrointestinal carcinoids
    Irvin M Modlin
    Gastric Pathobiology Research Group, GI Surgical Division, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Gastroenterology 128:1717-51. 2005
  6. ncbi request reprint Information assimilation and distribution challenges and goals for real and virtual journals
    Irvin M Modlin
    Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Clin Gastroenterol 39:181-8. 2005
  7. ncbi request reprint An analysis of rare carcinoid tumors: clarifying these clinical conundrums
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, 333 Cedar Street, P O Box 208062, New Haven, CT 06520 8062, USA
    World J Surg 29:92-101. 2005
  8. pmc Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Natl Cancer Inst 100:1282-9. 2008
  9. ncbi request reprint GERD 2004: issues from the past and a consensus for the future
    Irvin Modlin
    Department of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8062, USA
    Best Pract Res Clin Gastroenterol 18:55-66. 2004
  10. pmc Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines
    Ignat Drozdov
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer 115:4934-45. 2009

Detail Information

Publications97

  1. pmc Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia
    Ben Lawrence
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 208602, USA
    BMC Res Notes 5:318. 2012
    ..We hypothesized that detection of CgA mRNA transcripts would be a more sensitive method of detecting these metastases...
  2. pmc The identification of gut neuroendocrine tumor disease by multiple synchronous transcript analysis in blood
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e63364. 2013
    ..Application of this sensitive and specific PCR-based blood test to NENs will allow accurate detection of disease, and potentially define disease progress enabling monitoring of treatment efficacy...
  3. pmc Diagnosis and management of non-erosive reflux disease--the Vevey NERD Consensus Group
    I M Modlin
    Yale University, New Haven, CT 06520 8062, USA
    Digestion 80:74-88. 2009
    ..Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world...
  4. ncbi request reprint Edkins and a century of acid suppression
    I M Modlin
    Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Digestion 72:129-45. 2005
    ....
  5. ncbi request reprint Current status of gastrointestinal carcinoids
    Irvin M Modlin
    Gastric Pathobiology Research Group, GI Surgical Division, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Gastroenterology 128:1717-51. 2005
    ..Overall 5-year survival for carcinoids of the appendix is 98%, gastric (types I/II) is 81%, rectum is 87%, small intestinal is 60%, colonic carcinoids is 62%, and gastric type III/IV is 33%...
  6. ncbi request reprint Information assimilation and distribution challenges and goals for real and virtual journals
    Irvin M Modlin
    Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Clin Gastroenterol 39:181-8. 2005
    ....
  7. ncbi request reprint An analysis of rare carcinoid tumors: clarifying these clinical conundrums
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, 333 Cedar Street, P O Box 208062, New Haven, CT 06520 8062, USA
    World J Surg 29:92-101. 2005
    ..Familiarity with such unusual sites of origin will facilitate appropriate recognition and characterization of such tumors, allowing for timely intervention...
  8. pmc Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Natl Cancer Inst 100:1282-9. 2008
    ....
  9. ncbi request reprint GERD 2004: issues from the past and a consensus for the future
    Irvin Modlin
    Department of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8062, USA
    Best Pract Res Clin Gastroenterol 18:55-66. 2004
    ..A future consensus thus requires the identification of the appropriate tools to detect Barrett's early, identify the specific molecular markers associated with neoplastic transformation and establish a definitive therapeutic algorithm...
  10. pmc Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines
    Ignat Drozdov
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer 115:4934-45. 2009
    ..Given the expression of 5-HT receptors on NETs, the authors hypothesized that 5-HT autoregulated NET proliferation...
  11. ncbi request reprint From the lumen to the laparoscope
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, Conn 06520, USA
    Arch Surg 139:1110-26. 2004
    ....
  12. ncbi request reprint Gastroesophageal reflux disease: then and now
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Clin Gastroenterol 38:390-402. 2004
    ..In this respect, Barrett's esophagus still presents a major biologic and management conundrum for the physicians and scientists alike...
  13. ncbi request reprint The functional characterization of normal and neoplastic human enterochromaffin cells
    Irvin M Modlin
    Department of Surgery, TMP202, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 91:2340-8. 2006
    ....
  14. ncbi request reprint Therapeutic options for gastrointestinal carcinoids
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Clin Gastroenterol Hepatol 4:526-47. 2006
    ..The keystone of current therapy remains the long-acting somatostatin analogues that alleviate symptomatology and substantially improve quality of life with minimal adverse effects...
  15. doi request reprint Non-erosive reflux disease--defining the entity and delineating the management
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, PO Box 208062, New Haven, CT 06520 8062, USA
    Digestion 78:1-5. 2008
    ..Defining the current state of knowledge in NERD should help improve the elucidation and management of this condition in the future...
  16. doi request reprint Symptom evaluation in gastroesophageal reflux disease
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University, New Haven, CT 06520 8062, USA
    J Clin Gastroenterol 42:558-63. 2008
    ..Symptom-based evaluative tools should greatly aid the objective evaluation of GERD symptoms, monitor precisely how patients respond to therapy and thereby lead to improvements in GERD management...
  17. ncbi request reprint GERD evaluation: time for a new paradigm?
    Irvin M Modlin
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Gastroenterol 41:237-41. 2007
    ..We propose that accurate symptom delineation complemented with endoscopy performed in selected groups of patients will become the mainstay in diagnosis of GERD and the assessment of therapy efficacy...
  18. ncbi request reprint Pharmacotherapy of neuroendocrine cancers
    I M Modlin
    Yale University School of Medicine, Department of Gastroenterological Surgery, 333 Cedar Street, PO Box 208062, New Haven, CT 06520 8062, USA
    Expert Opin Pharmacother 9:2617-26. 2008
    ..Neuroendocrine tumors (NETs) of the diffuse neuroendocrine cell system often present a considerable diagnostic and therapeutic challenge...
  19. ncbi request reprint Siegfried oberndorfer and the evolution of carcinoid disease
    Irvin M Modlin
    Gastric Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Arch Surg 142:187-97. 2007
    ..This exploration of his life and times seeks to give Oberndorfer his well-deserved place in the pantheon of pathology and memorialize his unique observations that led to the discovery of the carcinoid tumor...
  20. ncbi request reprint Evolution of the diffuse neuroendocrine system--clear cells and cloudy origins
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroendocrinology 84:69-82. 2006
    ..Their key role in the regulation of gastrointestinal function is, however, indubitable...
  21. doi request reprint Principal component analysis, hierarchical clustering, and decision tree assessment of plasma mRNA and hormone levels as an early detection strategy for small intestinal neuroendocrine (carcinoid) tumors
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg Oncol 16:487-98. 2009
    ..Including NET-related circulating hormones and growth factors in the algorithm increased the sensitivity of detection of SI-NETs from 58 to 82%...
  22. ncbi request reprint Primary carcinoid tumor of the parotid gland: A case report and review of the literature
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
    Ear Nose Throat J 85:533-9. 2006
    ..In particular, it is important to differentiate them from metastatic tumors from other sites...
  23. pmc Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg 244:52-60. 2006
    ..To use differential gene expression of candidate markers to discriminate benign appendiceal carcinoids (APCs) from malignant and mixed cell APCs...
  24. doi request reprint Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours
    I M Modlin
    Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Aliment Pharmacol Ther 31:169-88. 2010
    ..They currently provide the most efficient treatment to achieve symptomatic relief and have recently been demonstrated to inhibit tumour growth...
  25. doi request reprint A nomogram to assess small-intestinal neuroendocrine tumor ('carcinoid') survival
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CN 06520 8062, USA
    Neuroendocrinology 92:143-57. 2010
    ..The development of a mathematically validated nomogram provides a platform for objective assessment of SI NET disease, a finite basis for precise prognostication and a tool to guide management strategy...
  26. ncbi request reprint Historical perspectives on the treatment of gastroesophageal reflux disease
    Irvin M Modlin
    Yale University School of Medicine, Department of Surgery, TMP 202, 333 Cedar Street, New Haven, CT 06520, USA
    Gastrointest Endosc Clin N Am 13:19-55, vii-viii. 2003
    ..Similarly, a specific pharmacotherapeutic probe targeting the lower esophageal sphincter, while long fantasized, remains to be identified...
  27. doi request reprint Chromogranin A--biological function and clinical utility in neuro endocrine tumor disease
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT, USA
    Ann Surg Oncol 17:2427-43. 2010
    ..We review here the utility of CgA measurement in NETs and describe its biological role and the clinical value of its measurement...
  28. ncbi request reprint Surgery of chronic pancreatitis: chronicle of confusion and despair
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, 333 Cedar Street, PO Box 208026, New Haven, Connecticut 06520, USA
    World J Surg 26:1382-96. 2002
    ..As Theodor Billroth, the greatest of the surgical innovators remarked: "An awareness of the past is necessary to comprehend the present, and without it no consideration of the future is possible."..
  29. ncbi request reprint Gastrointestinal carcinoids: the evolution of diagnostic strategies
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Gastroenterol 40:572-82. 2006
    ....
  30. doi request reprint Gastroenteropancreatic neuroendocrine tumours
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University, New Haven, CT 06520 8062, USA
    Lancet Oncol 9:61-72. 2008
    ..Progress is unlikely to occur without development of centers of excellence, with dedicated combined clinical teams to coordinate multicentre studies, maintain clinical and tissue databases, and refine molecularly targeted therapeutics...
  31. doi request reprint The archaic distinction between functioning and nonfunctioning neuroendocrine neoplasms is no longer clinically relevant
    Irvin M Modlin
    Gastrointestinal Pathobiology Group, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, USA
    Langenbecks Arch Surg 396:1145-56. 2011
    ..All current evidences indicate that their diagnosis and treatment should follow the same common principles...
  32. doi request reprint The CCK(2) receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development
    M Kidd
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine New Haven, CT 06520 8062, USA
    Regul Pept 162:52-60. 2010
    ..We conclude that specifically targeting the CCK(2) receptor inhibits gastrin-mediated ECL cell secretion and ECL cell proliferation and tumor development in vivo...
  33. ncbi request reprint Somatostatin receptor regulation of gastric enterochromaffin-like cell transformation to gastric carcinoid
    J F Borin
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Surgery 120:1026-32. 1996
    ..This study was undertaken to evaluate and characterize the precise somatostatin receptor (SSTR) subtype on the mastomys enterochromaffin-like (ECL) cell and to define its role in the regulation of ECL cell secretion and proliferation...
  34. pmc The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion
    A Chin
    Gastrointestinal Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Physiol Gastrointest Liver Physiol 302:G397-405. 2012
    ....
  35. ncbi request reprint PACAP mediates the neural proliferative pathway of Mastomys enterochromaffin-like cell transformation
    J M Läuffer
    Surgical Gastric Pathobiology Research Group, Yale University School of Medicine, and West Haven Veterans Administration Medical Center, New Haven, CT 06520 8062, USA
    Regul Pept 102:157-64. 2001
    ..The role of this neurotransmitter during gastrin-mediated ECL cell tumor formation and gastrin-autonomous ECL cell neoplasia is unknown...
  36. ncbi request reprint The elucidation of peptic esophagitis: from Hamperl to heartburn
    M V Malfertheiner
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Z Gastroenterol 45:1164-8. 2007
    ....
  37. ncbi request reprint The role of genetic markers--NAP1L1, MAGE-D2, and MTA1--in defining small-intestinal carcinoid neoplasia
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, 333 Cedar Street, P O Box 208062, New Haven, Connecticut 06520 8062, USA
    Ann Surg Oncol 13:253-62. 2006
    ..We hypothesized that carcinoid malignancy could be defined by using quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) and immunohistochemical approaches that evaluate potential marker genes...
  38. ncbi request reprint CTGF, intestinal stellate cells and carcinoid fibrogenesis
    M Kidd
    Yale University School of Medicine, New Haven, CT 06520 8062, USA
    World J Gastroenterol 13:5208-16. 2007
    ..To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFbeta1 and CTGF, in the mediation of fibrosis via activation of an "intestinal" stellate cell...
  39. ncbi request reprint Global expression analysis of ECL cells in Mastomys natalensis gastric mucosa identifies alterations in the AP-1 pathway induced by gastrin-mediated transformation
    M Kidd
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Physiol Genomics 20:131-42. 2004
    ..These results suggest that expression of this receptor and an altered composition of AP-1 with a loss of inhibition play a role in ECL cell transformation...
  40. doi request reprint IL1beta- and LPS-induced serotonin secretion is increased in EC cells derived from Crohn's disease
    M Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Neurogastroenterol Motil 21:439-50. 2009
    ..Inhibition of EC cell-mediated 5HT secretion may be an alternative therapeutic strategy in the amelioration of inflammatory bowel disease symptomatology...
  41. ncbi request reprint Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development
    M Kidd
    Department of Surgery, Yale University School of Medicine, TMP202, 333 Cedar St, New Haven, CT 06520 8062, USA
    Am J Physiol Gastrointest Liver Physiol 292:G191-200. 2007
    ..Identification of CCN2 in gastric carcinoid tissue may be useful both as an indicator of ECL cell transformation and may define gastrin autonomy, a criteria of gastric carcinoid malignancy...
  42. ncbi request reprint Enterochromaffin-like cells and gastric argyrophil carcinoidosis
    I M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
    Acta Oncol 30:493-8. 1991
    ..The pathobiological relevance of ECL cells and the mechanisms of their inducible hyperplasia and neoplasia may be of considerable significance in understanding the regulatory role of gastric endocrine cells...
  43. ncbi request reprint Adrenergic and cromolyn sodium modulation of ECL cell histamine secretion
    G P Lawton
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520
    J Surg Res 58:96-104. 1995
    ..Isoproterenol (beta-adrenergic agonist) stimulated histamine secretion (EC50, 6 x 10(-8) M) and was inhibited by propranolol (IC50 5 x 10(-10) M).(ABSTRACT TRUNCATED AT 250 WORDS)..
  44. ncbi request reprint Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor-beta1-mediated regulatory abnormalities including up-regulation of C-Myc and MTA1
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 109:2420-31. 2007
    ..Whether this phenomenon is common to small intestinal carcinoid tumors was investigated...
  45. ncbi request reprint Utility of molecular genetic signatures in the delineation of gastric neoplasia
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer 106:1480-8. 2006
    ..This strategy provides a molecular basis to define neuroendocrine gastric carcinoids (GCs), neuronal stromal tumors (GISTs), or epithelial cell (gastric adenocarcinomas [GCAs])-derived tumors...
  46. pmc Autoregulation of enterochromaffin-like cell histamine secretion via the histamine 3 receptor subtype
    M Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520-8062, USA
    Yale J Biol Med 69:9-19. 1996
    ..Our observations support the proposal that a histamine-mediated short-loop autocrine regulatory mechanism of ECL cell secretion exists...
  47. ncbi request reprint Molecular strategies and 111in-labelled somatostatin analogues in defining the management of neuroendocrine tumour disease: a new paradigm for surgical management
    I M Modlin
    Department of Surgery, Yale University School of Medicine, 333 Cedar Street, P O Box 208062 New Haven, Connecticut 06520 8062, USA
    Surgeon 1:137-43. 2003
    ..This approach was successfully used to discover novel strategies that can be both effective and appropriate adjuncts to surgery for patients with neuroendocrine tumour disease...
  48. ncbi request reprint A comparison of the effects of gastrin, somatostatin and dopamine receptor ligands on rat gastric enterochromaffin-like cell secretion and proliferation
    M Kidd
    Department of Surgery, Yale University School of Medicine New Haven, Connecticut 06520 8062, United Sates
    Regul Pept 143:109-17. 2007
    ....
  49. ncbi request reprint A three-decade analysis of 3,911 small intestinal neuroendocrine tumors: the rapid pace of no progress
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 102:1464-73. 2007
    ..We examined patterns, incidence, prognosis, and outcomes of these tumors over a 30-yr period...
  50. doi request reprint Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants
    Mark Kidd
    1Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 295:G260-72. 2008
    ..Luminal EC cell regulation is likely to be as important as G cell regulation in gastric acid secretion; development of agents to target EC cell function is therefore a critical therapeutic goal...
  51. ncbi request reprint Perspectives and reflections on integrated digestive surgery
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Best Pract Res Clin Gastroenterol 16:885-914. 2002
    ....
  52. ncbi request reprint Gastrointestinal neuroendocrine (carcinoid) tumours: current diagnosis and management
    Irvin M Modlin
    School of Medicine, Yale University, New Haven, Conn, USA
    Med J Aust 193:46-52. 2010
    ..The overarching requirement for best management of patients with NETs is to ensure that they have ready access to experienced multidisciplinary clinician groups located within centres of appropriate subspecialty expertise...
  53. ncbi request reprint Ernest Starling and the discovery of secretin
    I M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Gastroenterol 32:187-92. 2001
    ....
  54. doi request reprint Carcinoid heart disease
    B I Gustafsson
    Department of Gastroenterological Surgery, Yale University School of Medicine New Haven, CT06520 8062, USA
    Int J Cardiol 129:318-24. 2008
    ....
  55. ncbi request reprint Isolation, functional characterization, and transcriptome of Mastomys ileal enterochromaffin cells
    M Kidd
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, CT, USA
    Am J Physiol Gastrointest Liver Physiol 291:G778-91. 2006
    ..Application of this methodology to normal and diseased human ileum will facilitate the elucidation of the pathophysiology of EC cells...
  56. doi request reprint Inhibition of proliferation of small intestinal and bronchopulmonary neuroendocrine cell lines by using peptide analogs targeting receptors
    Mark Kidd
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 112:1404-14. 2008
    ....
  57. pmc Q RT-PCR detection of chromogranin A: a new standard in the identification of neuroendocrine tumor disease
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg 243:273-80. 2006
    ..Message and protein expression of CgA was examined to evaluate the sensitivity of a PCR-based approach in the detection of covert neuroendocrine (NE) tissue...
  58. ncbi request reprint Siegfried Oberndorfer: origins and perspectives of carcinoid tumors
    Irvin M Modlin
    Gastric Pathobiology Research Group, Department of Surgery, Yale University School of Medinice, New Haven, CT 06520 8062, USA
    Hum Pathol 35:1440-51. 2004
    ..It also serves to memorialize the extraordinary accomplishments of Oberndorfer, whose vision exceeded his times...
  59. pmc Calcium modulation of the effects of serotonin, carbachol, and histamine on rabbit ileal ion transport
    S P Chough
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520-8062, USA
    Yale J Biol Med 66:525-40. 1993
    ..Findings from this study support previous work which has suggested that multiple calcium pathways may be involved in mediating chloride secretion in mammalian intestine...
  60. ncbi request reprint Biology and management of gastric carcinoid tumours: a review
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Eur J Surg 168:669-83. 2002
    ..Gastric carcinoids, however, can be managed initially by endoscopic excision of accessible tumours, followed by regular endoscopic surveillance...
  61. ncbi request reprint Amsterdam and Netherlands gastroenterology: a historical perspective
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Best Pract Res Clin Gastroenterol 16:971-98. 2002
  62. ncbi request reprint Friedrich Feyrter: a precise intellect in a diffuse system
    Manish C Champaneria
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Neuroendocrinology 83:394-404. 2006
    ..We describe the life and times of this gifted scientist, teacher, and pathologist, often referred to as the 'Father of Neuroendocrinology'...
  63. ncbi request reprint Microsatellite instability and gene mutations in transforming growth factor-beta type II receptor are absent in small bowel carcinoid tumors
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 103:229-36. 2005
    ..The authors postulated that a similar mechanism occurred during the malignant evolution of small bowel carcinoid tumors...
  64. ncbi request reprint Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy
    Bjorn I Gustafsson
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Int J Oncol 33:1121-31. 2008
    ..We present an overview of the epidemiology of these uncommon cancers, and address their clinical behavior, and current diagnostic and therapeutic options...
  65. pmc The centenary of Lester Dragstedt--fifty years of therapeutic vagotomy
    I M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520-8062, USA
    Yale J Biol Med 67:63-80. 1994
    ..Dragstedt was a creative scientist, a superlative clinical surgeon, and a teacher honored by his pupils. The example of his life confirms the benefit of scientific inquiry when applied to clinical and surgical practice...
  66. ncbi request reprint [Efficacy and safety of intravenously administered pantoprazole in the treatment of gastrinoma]
    I M Modlin
    Department of Gastroenterology, Yale University, New Haven, USA
    Recenti Prog Med 92:456-61. 2001
    ..The control of gastric acid secretion was maintained for a mean of 10.9 hours after the infusion of P. We conclude that the use of intravenous P allows a safe and efficient control of the acid ipersecretion in patients with ZES...
  67. ncbi request reprint Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and rapamycin
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, TMP202, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Mol Endocrinol 38:181-92. 2007
    ....
  68. ncbi request reprint A 50-year analysis of 562 gastric carcinoids: small tumor or larger problem?
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 99:23-32. 2004
    ..We sought to examine if there has been an increase in gastric carcinoid incidence time correlative with these parameters...
  69. ncbi request reprint A 5-decade analysis of 13,715 carcinoid tumors
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 97:934-59. 2003
    ....
  70. ncbi request reprint Neuroendocrine tumors of the diffuse neuroendocrine system
    Bjorn I Gustafsson
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Curr Opin Oncol 20:1-12. 2008
    ..25% of all malignancies; their incidence is increasing by approximately 6% per year. The present review provides an overview on neuroendocrine tumors and focuses on general features and current diagnostic and therapeutic options...
  71. ncbi request reprint Van Swieten and the renaissance of the Vienna Medical School
    M Kidd
    Gastric Surgical Pathobiology Research Group, Yale University School of Medicine, 333 Cedar Street, PO Box 208026, New Haven, Connecticut 06520-8062, USA
    World J Surg 25:444-50. 2001
    ..He propelled Austrian medicine to a level commensurate with that of other European states of the day by 27 years of dedicated and industrious service...
  72. doi request reprint Evolution of one-handed piano compositions
    Ignat Drozdov
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Hand Surg Am 33:780-6. 2008
    ....
  73. pmc Predicting neuroendocrine tumor (carcinoid) neoplasia using gene expression profiling and supervised machine learning
    Ignat Drozdov
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 115:1638-50. 2009
    ....
  74. doi request reprint Nikolai Konstantinovich Kulchitsky (1856-1925)
    Ignat Drozdov
    Yale University School of Medicine, USA
    J Med Biogr 17:47-54. 2009
    ..Kulchitsky's mysterious demise in a bizarre lift-shaft accident at UCL on his 69th birthday tragically terminated a life of service to science...
  75. doi request reprint Neuroendocrine tumor epidemiology: contrasting Norway and North America
    Oyvind Hauso
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer 113:2655-64. 2008
    ..Norway also holds a robust and detailed cancer registry: the Norwegian Registry of Cancer (NRC)...
  76. ncbi request reprint Carcinoid tumors and fibrosis: an association with no explanation
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 99:2466-78. 2004
    ..In addition, we have provided more current mechanistic information in regard to the biological basis of fibrosis associated with small bowel carcinoid tumors...
  77. doi request reprint From Leningrad to London: the saga of Kulchitsky and the legacy of the enterochromaffin cell
    Ignat Drozdov
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
    Neuroendocrinology 89:1-12. 2009
    ....
  78. doi request reprint Bronchopulmonary neuroendocrine tumors
    Bjorn I Gustafsson
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Cancer 113:5-21. 2008
    ..This review provides a broad overview on BP-NETs and focuses on the evolution of the disease, general features, and current diagnostic and therapeutic options...
  79. doi request reprint KRJ-I and BON cell lines: defining an appropriate enterochromaffin cell neuroendocrine tumor model
    Zakiya Luna Siddique
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine New Haven, New Haven, CT 06520 8062, USA
    Neuroendocrinology 89:458-70. 2009
    ....
  80. pmc EGFR/TGFα and TGFβ/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets
    M Kidd
    Gastrointestinal Pathobiology Research Group, Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Neuroendocrinology 97:35-44. 2013
    ..In summary, growth factors are essential for NEN proliferation, and although interventions targeting these proteins are effective in experimental models, only limited clinical efficacy has been identified...
  81. pmc Plasma and tissue alterations of peptide YY and enteroglucagon in rats after colectomy
    A P Vukasin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
    Yale J Biol Med 65:1-15. 1992
    ....
  82. pmc The pathobiology of the human enterochromaffin-like cell
    I M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
    Yale J Biol Med 65:775-92; discussion 827-9. 1992
    ..It is possible that the future pharmacotherapy of acid secretory disease may require regulation not only of parietal cell but of ECL-cell function...
  83. ncbi request reprint Multiple gastrointestinal stromal tumors and synchronous ileal carcinoids
    Michele Buragas
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Clin Pract Oncol 2:166-70; quiz 1 p following 170. 2005
    ..A gastric-wedge resection revealed an ulcerated 4.5 cm mass in the stomach, and exploration of the abdomen revealed two ileal carcinoid tumors, jejunal diverticula and reactive mesenteric lymphadenopathy...
  84. doi request reprint Delineation of the chemomechanosensory regulation of gastrin secretion using pure rodent G cells
    Mark Kidd
    Gastrointestinal Pathobiology Research Group, Department of Gastroenterology, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Gastroenterology 137:231-41, 241.e1-10. 2009
    ..Gastrin is a key regulator of gastric acid secretion. We aimed to isolate pure G cells to identify the mechanistic basis of luminal- and strain-mediated regulation...
  85. ncbi request reprint The molecular genetics of gastroenteropancreatic neuroendocrine tumors
    Michelle N Zikusoka
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 104:2292-309. 2005
    ..On the basis of the evolution of genetic information, enteric neuroendocrine lesions (carcinoids) and PETs may need to be classified as two distinct entities rather than grouped together as the single entity "GEP-NETs."..
  86. ncbi request reprint Carcinoid tumors of the stomach
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Surg Oncol 12:153-72. 2003
    ..In addition, the clinical rationale of current diagnostic and therapeutic strategies will be examined, providing a logical basis for the formulation of appropriate management strategies for patient care...
  87. ncbi request reprint Transforming growth factor-alpha (TGF alpha) inhibition of parietal cell secretion: structural requirements for activity
    J R Goldenring
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06510
    Regul Pept 43:37-47. 1993
    ..In addition, in contrast with previous investigations on the mitogenic action of TGF alpha, third loop fragments of TGF alpha retain the capacity to inhibit aminopyrine accumulation...
  88. ncbi request reprint George Sachs-"I did it my way"
    Irvin M Modlin
    Simon Petras, Mt Athos, Greece
    J Clin Gastroenterol 40:867-9. 2006
  89. ncbi request reprint Siegfried Oberndorfer: a tribute to his work and life between Munich, Kiel, Geneva, and Istanbul
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S3-7. 2007
    ..This article pursues the questions why this discovery was so unique and what role it played in the later life of Siegfried Oberndorfer...
  90. ncbi request reprint Summation: irritable bowel and the irritable physician
    Steven F Moss
    Department of Medicine, Division of Gastroenterology, Rhode Island Hospital Brown University, Providence, Rhode Island, USA
    J Clin Gastroenterol 35:S68-70. 2002
  91. ncbi request reprint GERD 2003 -- a consensus on the way ahead
    Steven F Moss
    Brown University, Providence, R I, USA
    Digestion 67:111-7. 2003
    ..Intestinal metaplasia in the lower esophagus is probably very common. Whether and how to, first, screen for, and then, perform surveillance in Barrett's esophagus remains highly problematic and contentious...
  92. ncbi request reprint In situ RNA-RNA hybridisation of phospholipase C beta 3 shows lack of expression in neuroendocrine tumours
    Peter Stalberg
    Department of Surgical Sciences, University Hospital, S 751 85 Uppsala, Sweden
    Anticancer Res 23:2227-32. 2003
    ....
  93. ncbi request reprint Costs of gerd: facts and fiction
    Hans R Koelz
    Gastroenterology 125:981-2. 2003
  94. ncbi request reprint Multiple gastric carcinoids
    Irvin M Modlin
    J Am Coll Surg 198:174. 2004
  95. ncbi request reprint 40 mg pantoprazole and 40 mg esomeprazole are equivalent in the healing of esophageal lesions and relief from gastroesophageal reflux disease-related symptoms
    Anton Gillessen
    Ruhr Universitat Bochum, Universitätsklinik Marienhospital Herne, Germany
    J Clin Gastroenterol 38:332-40. 2004
    ..There is considerable interest regarding the dose equivalence between various proton pump inhibitors...
  96. ncbi request reprint Whistler summary: "the slow rate of rapid progress"
    Richard H Hunt
    J Clin Gastroenterol 41:539-45. 2007
  97. doi request reprint American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease
    Peter J Kahrilas
    Department of Medicine, Gastroenterology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1383-1391, 1391.e1-5. 2008