Neil Howell

Summary

Affiliation: MitoKor Inc
Country: USA

Publications

  1. ncbi request reprint African Haplogroup L mtDNA sequences show violations of clock-like evolution
    Neil Howell
    MitoKor Inc, San Diego, California, USA
    Mol Biol Evol 21:1843-54. 2004
  2. ncbi request reprint Co-segregation and heteroplasmy of two coding-region mtDNA mutations within a matrilineal pedigree
    Neil Howell
    MitoKor Inc, 12780 High Bluff Drive, Suite 210, San Diego, CA 92130, USA
    Hum Genet 116:28-32. 2005
  3. ncbi request reprint LHON and other optic nerve atrophies: the mitochondrial connection
    Neil Howell
    MitoKor, San Diego, Calif, USA
    Dev Ophthalmol 37:94-108. 2003
  4. ncbi request reprint Low penetrance of the 14484 LHON mutation when it arises in a non-haplogroup J mtDNA background
    Neil Howell
    MitoKor, San Diego, California 92121, USA
    Am J Med Genet A 119:147-51. 2003
  5. pmc Sequence analysis of the mitochondrial genomes from Dutch pedigrees with Leber hereditary optic neuropathy
    Neil Howell
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 72:1460-9. 2003
  6. pmc The pedigree rate of sequence divergence in the human mitochondrial genome: there is a difference between phylogenetic and pedigree rates
    Neil Howell
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 72:659-70. 2003
  7. ncbi request reprint Lightning strikes twice: Leber hereditary optic neuropathy families with two pathogenic mtDNA mutations
    Neil Howell
    MitoKor, San Diego, California 92121, USA
    J Neuroophthalmol 22:262-9. 2002
  8. ncbi request reprint mtDNA mutations and common neurodegenerative disorders
    Neil Howell
    MIGENIX Corporation, San Diego, CA 92130, USA
    Trends Genet 21:583-6. 2005
  9. pmc Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups
    Corinna Herrnstadt
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 70:1152-71. 2002
  10. ncbi request reprint Relative rates of evolution in the coding and control regions of African mtDNAs
    Neil Howell
    MIGENIX Corp, San Diego, CA, USA
    Mol Biol Evol 24:2213-21. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint African Haplogroup L mtDNA sequences show violations of clock-like evolution
    Neil Howell
    MitoKor Inc, San Diego, California, USA
    Mol Biol Evol 21:1843-54. 2004
    ..The results of the clock tests, the network analyses, and the branch length comparisons all caution against the use of simple mtDNA clocks...
  2. ncbi request reprint Co-segregation and heteroplasmy of two coding-region mtDNA mutations within a matrilineal pedigree
    Neil Howell
    MitoKor Inc, 12780 High Bluff Drive, Suite 210, San Diego, CA 92130, USA
    Hum Genet 116:28-32. 2005
    ..In other branches, either the double wildtype or double mutant genotype has become essentially homoplasmic...
  3. ncbi request reprint LHON and other optic nerve atrophies: the mitochondrial connection
    Neil Howell
    MitoKor, San Diego, Calif, USA
    Dev Ophthalmol 37:94-108. 2003
    ..This mitochondrial link provides new avenues of experimental investigation to these major causes of loss of vision...
  4. ncbi request reprint Low penetrance of the 14484 LHON mutation when it arises in a non-haplogroup J mtDNA background
    Neil Howell
    MitoKor, San Diego, California 92121, USA
    Am J Med Genet A 119:147-51. 2003
    ..These results, in conjunction with other studies that are reviewed, indicate that 14484 LHON mutations have a low penetrance when they arise in a haplogroup H mtDNA background...
  5. pmc Sequence analysis of the mitochondrial genomes from Dutch pedigrees with Leber hereditary optic neuropathy
    Neil Howell
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 72:1460-9. 2003
    ..Finally, analysis of the mtDNA sequences from those pedigrees that did not carry classic LHON mutations suggested candidate pathogenic mutations at nts 9804, 13051, and 14325...
  6. pmc The pedigree rate of sequence divergence in the human mitochondrial genome: there is a difference between phylogenetic and pedigree rates
    Neil Howell
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 72:659-70. 2003
    ..In three of these individuals, there were four instances in which an mtDNA mutation was found in one tissue but not in the other. These results are discussed in terms of the occurrence of somatic mtDNA mutations...
  7. ncbi request reprint Lightning strikes twice: Leber hereditary optic neuropathy families with two pathogenic mtDNA mutations
    Neil Howell
    MitoKor, San Diego, California 92121, USA
    J Neuroophthalmol 22:262-9. 2002
    ..To report the clinical and mitochondrial genetic analyses of two families, each of which carries both the 11778 and 14484 Leber hereditary optic neuropathy (LHON) mutations in mitochondrial DNA...
  8. ncbi request reprint mtDNA mutations and common neurodegenerative disorders
    Neil Howell
    MIGENIX Corporation, San Diego, CA 92130, USA
    Trends Genet 21:583-6. 2005
    ..However, when these new studies are considered in relation to the sum of previous evidence, the role of mtDNA mutations in the development of either AD or PD still remains to be established...
  9. pmc Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups
    Corinna Herrnstadt
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 70:1152-71. 2002
    ..It is likely that homoplasy in the coding region will confound evolutionary analysis of small sequence sets. By a linkage-disequilibrium approach, additional evidence for the absence of human mtDNA recombination is presented here...
  10. ncbi request reprint Relative rates of evolution in the coding and control regions of African mtDNAs
    Neil Howell
    MIGENIX Corp, San Diego, CA, USA
    Mol Biol Evol 24:2213-21. 2007
    ..Finally, we obtained preliminary evidence for "nonideal" evolution in the control region, including haplogroup-specific substitution patterns and a decoupling between relative rates of substitution in the control and coding regions...
  11. ncbi request reprint A high frequency of mtDNA polymorphisms in HeLa cell sublines
    Corinna Herrnstadt
    MitoKor, 11494 Sorrento Valley Road, San Diego, CA 92121, USA
    Mutat Res 501:19-28. 2002
    ..Preliminary analysis of single-cell derived subclone lines revealed the occurrence of another polymorphism and provided evidence for a large number of mtDNA segregation units...
  12. ncbi request reprint Development of 17alpha-estradiol as a neuroprotective therapeutic agent: rationale and results from a phase I clinical study
    James A Dykens
    MIGENIX Corporation, 12780 High Bluff Dr, San Diego, CA 92130, USA
    Ann N Y Acad Sci 1052:116-35. 2005
    ..Positive safety and pharmacokinetic data from a successful phase I clinical study with oral 17alpha-E2 (sodium sulfate conjugate) are presented here, and several options for its future clinical assessment are discussed...
  13. ncbi request reprint Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?
    Joanna L Elson
    Mitochondrial Research Group, School of Neurology, Neurobiology, and Psychiatry, The University of Newcastle upon Tyne, and Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Hum Genet 119:241-54. 2006
    ..At most, a small proportion of AD patients carry a pathogenic mtDNA mutation and a small proportion of cognitively normal aged individuals carry a mtDNA mutation that reduces the risk of AD...
  14. pmc The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event
    Doron M Behar
    Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
    Am J Hum Genet 78:487-97. 2006
    ..We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium...
  15. pmc Clinical expression of Leber hereditary optic neuropathy is affected by the mitochondrial DNA-haplogroup background
    Gavin Hudson
    Mitochondrial Research Group, Department of Ophthalmology and Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Am J Hum Genet 81:228-33. 2007
    ..Substitutions on MTCYB provide an explanation for these findings, which demonstrate that common genetic variants have a marked effect on the expression of an ostensibly monogenic mtDNA disorder...
  16. pmc Origin and diffusion of mtDNA haplogroup X
    Maere Reidla
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia
    Am J Hum Genet 73:1178-90. 2003
    ..The position of X2a in the phylogenetic tree suggests an early split from the other X2 clades, likely at the very beginning of their expansion and spread from the Near East...
  17. ncbi request reprint Genotypes from patients indicate no paternal mitochondrial DNA contribution
    Robert W Taylor
    School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Ann Neurol 54:521-4. 2003
    ..Our findings suggest that paternal transmission of mtDNA is rare and should not alter our genetic advice to families...
  18. ncbi request reprint A novel sporadic mutation in cytochrome c oxidase subunit II as a cause of rhabdomyolysis
    Robert McFarland
    Mitochondrial Research Group, Department of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Framlington Place, NE2 4HH, UK
    Neuromuscul Disord 14:162-6. 2004
    ..We believe that this study demonstrates the importance of whole mitochondrial genome sequencing and of access to large sequence databases...
  19. ncbi request reprint Changes in the human mitochondrial genome after treatment of malignant disease
    Theresa M Wardell
    Department of Neurology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Mutat Res 525:19-27. 2003
    ..Our studies have shown that in patients who have been treated for cancer there is an increased level of mtDNA damage...
  20. pmc Associating mitochondrial DNA variation with complex traits
    Joanna L Elson
    Am J Hum Genet 80:378-82; author reply 382-3. 2007
  21. ncbi request reprint X-inactivation pattern in multiple tissues from two Leber's hereditary optic neuropathy (LHON) patients
    Elena Pegoraro
    Department of Neurological and Psychiatric Sciences, University of Padova, Italy
    Am J Med Genet A 119:37-40. 2003
    ..We found no evidence of skewed X-inactivation in the affected tissues, thus weakening further the hypothesized involvement of a specific X chromosome locus in the pathophysiological expression of LHON...
  22. pmc Errors, phantoms and otherwise, in human mtDNA sequences
    Corinna Herrnstadt
    Am J Hum Genet 72:1585-6. 2003
  23. ncbi request reprint Mitochondrial DNA and survival after sepsis: a prospective study
    Simon V Baudouin
    University Department of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Lancet 366:2118-21. 2005
    ..We investigated whether haplogroup H, the most common type of mitochondrial DNA (mtDNA) in Europe, contributes to the subtle genetic variation in survival after sepsis...
  24. pmc Comparative genomics and the evolution of human mitochondrial DNA: assessing the effects of selection
    J L Elson
    Mitochondrial Research Group, School of Neurology, Neurobiology, and Psychiatry, The Medical School, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Am J Hum Genet 74:229-38. 2004
    ..Finally, our results and those of other investigators do not support a simple model in which climatic adaptation has been a major force during human mtDNA evolution...