C Herrnstadt

Summary

Affiliation: MitoKor Inc
Country: USA

Publications

  1. ncbi request reprint A novel mitochondrial DNA-like sequence in the human nuclear genome
    C Herrnstadt
    MitoKor, San Diego, California, 92121, USA
    Genomics 60:67-77. 1999
  2. pmc Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups
    Corinna Herrnstadt
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 70:1152-71. 2002
  3. pmc Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease
    R E Davis
    MitoKor, 11494 Sorrento Valley Road, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 94:4526-31. 1997
  4. pmc The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event
    Doron M Behar
    Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
    Am J Hum Genet 78:487-97. 2006
  5. ncbi request reprint African Haplogroup L mtDNA sequences show violations of clock-like evolution
    Neil Howell
    MitoKor Inc, San Diego, California, USA
    Mol Biol Evol 21:1843-54. 2004
  6. pmc Origin and diffusion of mtDNA haplogroup X
    Maere Reidla
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia
    Am J Hum Genet 73:1178-90. 2003
  7. ncbi request reprint Low penetrance of the 14484 LHON mutation when it arises in a non-haplogroup J mtDNA background
    Neil Howell
    MitoKor, San Diego, California 92121, USA
    Am J Med Genet A 119:147-51. 2003
  8. pmc Sequence analysis of the mitochondrial genomes from Dutch pedigrees with Leber hereditary optic neuropathy
    Neil Howell
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 72:1460-9. 2003
  9. pmc The pedigree rate of sequence divergence in the human mitochondrial genome: there is a difference between phylogenetic and pedigree rates
    Neil Howell
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 72:659-70. 2003
  10. ncbi request reprint Lightning strikes twice: Leber hereditary optic neuropathy families with two pathogenic mtDNA mutations
    Neil Howell
    MitoKor, San Diego, California 92121, USA
    J Neuroophthalmol 22:262-9. 2002

Collaborators

Detail Information

Publications13

  1. ncbi request reprint A novel mitochondrial DNA-like sequence in the human nuclear genome
    C Herrnstadt
    MitoKor, San Diego, California, 92121, USA
    Genomics 60:67-77. 1999
    ....
  2. pmc Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups
    Corinna Herrnstadt
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 70:1152-71. 2002
    ..It is likely that homoplasy in the coding region will confound evolutionary analysis of small sequence sets. By a linkage-disequilibrium approach, additional evidence for the absence of human mtDNA recombination is presented here...
  3. pmc Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease
    R E Davis
    MitoKor, 11494 Sorrento Valley Road, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 94:4526-31. 1997
    ..We suggest that specific point mutations in the CO1 and CO2 genes cause the CO defect in AD. A CO defect may represent a primary etiologic event, directly participating in a cascade of events that results in AD...
  4. pmc The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event
    Doron M Behar
    Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
    Am J Hum Genet 78:487-97. 2006
    ..We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium...
  5. ncbi request reprint African Haplogroup L mtDNA sequences show violations of clock-like evolution
    Neil Howell
    MitoKor Inc, San Diego, California, USA
    Mol Biol Evol 21:1843-54. 2004
    ..The results of the clock tests, the network analyses, and the branch length comparisons all caution against the use of simple mtDNA clocks...
  6. pmc Origin and diffusion of mtDNA haplogroup X
    Maere Reidla
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia
    Am J Hum Genet 73:1178-90. 2003
    ..The position of X2a in the phylogenetic tree suggests an early split from the other X2 clades, likely at the very beginning of their expansion and spread from the Near East...
  7. ncbi request reprint Low penetrance of the 14484 LHON mutation when it arises in a non-haplogroup J mtDNA background
    Neil Howell
    MitoKor, San Diego, California 92121, USA
    Am J Med Genet A 119:147-51. 2003
    ..These results, in conjunction with other studies that are reviewed, indicate that 14484 LHON mutations have a low penetrance when they arise in a haplogroup H mtDNA background...
  8. pmc Sequence analysis of the mitochondrial genomes from Dutch pedigrees with Leber hereditary optic neuropathy
    Neil Howell
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 72:1460-9. 2003
    ..Finally, analysis of the mtDNA sequences from those pedigrees that did not carry classic LHON mutations suggested candidate pathogenic mutations at nts 9804, 13051, and 14325...
  9. pmc The pedigree rate of sequence divergence in the human mitochondrial genome: there is a difference between phylogenetic and pedigree rates
    Neil Howell
    MitoKor, San Diego, CA 92121, USA
    Am J Hum Genet 72:659-70. 2003
    ..In three of these individuals, there were four instances in which an mtDNA mutation was found in one tissue but not in the other. These results are discussed in terms of the occurrence of somatic mtDNA mutations...
  10. ncbi request reprint Lightning strikes twice: Leber hereditary optic neuropathy families with two pathogenic mtDNA mutations
    Neil Howell
    MitoKor, San Diego, California 92121, USA
    J Neuroophthalmol 22:262-9. 2002
    ..To report the clinical and mitochondrial genetic analyses of two families, each of which carries both the 11778 and 14484 Leber hereditary optic neuropathy (LHON) mutations in mitochondrial DNA...
  11. ncbi request reprint Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?
    Joanna L Elson
    Mitochondrial Research Group, School of Neurology, Neurobiology, and Psychiatry, The University of Newcastle upon Tyne, and Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Hum Genet 119:241-54. 2006
    ..At most, a small proportion of AD patients carry a pathogenic mtDNA mutation and a small proportion of cognitively normal aged individuals carry a mtDNA mutation that reduces the risk of AD...
  12. pmc Errors, phantoms and otherwise, in human mtDNA sequences
    Corinna Herrnstadt
    Am J Hum Genet 72:1585-6. 2003
  13. ncbi request reprint A high frequency of mtDNA polymorphisms in HeLa cell sublines
    Corinna Herrnstadt
    MitoKor, 11494 Sorrento Valley Road, San Diego, CA 92121, USA
    Mutat Res 501:19-28. 2002
    ..Preliminary analysis of single-cell derived subclone lines revealed the occurrence of another polymorphism and provided evidence for a large number of mtDNA segregation units...