R E Davis
Affiliation: MitoKor Inc
- Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer diseaseR E Davis
MitoKor, 11494 Sorrento Valley Road, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 94:4526-31. 1997..We suggest that specific point mutations in the CO1 and CO2 genes cause the CO defect in AD. A CO defect may represent a primary etiologic event, directly participating in a cascade of events that results in AD...
- A novel mitochondrial DNA-like sequence in the human nuclear genomeC Herrnstadt
MitoKor, San Diego, California, 92121, USA
Genomics 60:67-77. 1999....
- Use of cytoplasmic hybrid cell lines for elucidating the role of mitochondrial dysfunction in Alzheimer's disease and Parkinson's diseaseS S Ghosh
MitoKor, San Diego, California 92121, USA
Ann N Y Acad Sci 893:176-91. 1999..These data suggest that the transfer of a mtDNA defect from disease donor platelets is the likely cause of the cybrid biochemical phenotype, and highlight the potential value of these cell lines as cellular disease models...