GARY FRANK MITCHELL

Summary

Country: USA

Publications

  1. ncbi request reprint Arterial stiffness and wave reflection in hypertension: pathophysiologic and therapeutic implications
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske Street, Holliston, MA 01746, USA
    Curr Hypertens Rep 6:436-41. 2004
  2. pmc Relation of season and temperature to endothelium-dependent flow-mediated vasodilation in subjects without clinical evidence of cardiovascular disease (from the Framingham Heart Study)
    Michael E Widlansky
    Cardiology Department, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 100:518-23. 2007
  3. doi request reprint Hemodynamics of increased pulse pressure in older women in the community-based Age, Gene/Environment Susceptibility-Reykjavik Study
    Gary F Mitchell
    Cardiovascular Engineering Inc, 51 Sawyer Road, Suite 100, Waltham, MA 02453, USA
    Hypertension 51:1123-8. 2008
  4. doi request reprint Clinical achievements of impedance analysis
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Drive, Suite 201A, Norwood, MA 02062, USA
    Med Biol Eng Comput 47:153-63. 2009
  5. pmc Arterial stiffness in mild-to-moderate CKD
    Ashish Upadhyay
    Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2044-53. 2009
  6. pmc Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium
    Gary F Mitchell
    Cardiovascular Engineering Inc, 1 Edgewater Drive, Norwood, MA 02062, USA
    Circ Cardiovasc Genet 5:81-90. 2012
  7. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
  8. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
  9. ncbi request reprint Pulse pressure, arterial compliance and cardiovascular morbidity and mortality
    G F Mitchell
    Cardiovascular Engineering, Inc, Dover, MA 02030, USA
    Curr Opin Nephrol Hypertens 8:335-42. 1999
  10. pmc Long-term trandolapril treatment is associated with reduced aortic stiffness: the prevention of events with angiotensin-converting enzyme inhibition hemodynamic substudy
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Hypertension 49:1271-7. 2007

Detail Information

Publications33

  1. ncbi request reprint Arterial stiffness and wave reflection in hypertension: pathophysiologic and therapeutic implications
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske Street, Holliston, MA 01746, USA
    Curr Hypertens Rep 6:436-41. 2004
    ..This review summarizes current work on the genesis of increased pulse pressure and abnormal pulsatile load in hypertension, and underscores areas for future research...
  2. pmc Relation of season and temperature to endothelium-dependent flow-mediated vasodilation in subjects without clinical evidence of cardiovascular disease (from the Framingham Heart Study)
    Michael E Widlansky
    Cardiology Department, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 100:518-23. 2007
    ..Endothelial dysfunction may be 1 of the mechanisms influencing seasonal variation in cardiovascular events...
  3. doi request reprint Hemodynamics of increased pulse pressure in older women in the community-based Age, Gene/Environment Susceptibility-Reykjavik Study
    Gary F Mitchell
    Cardiovascular Engineering Inc, 51 Sawyer Road, Suite 100, Waltham, MA 02453, USA
    Hypertension 51:1123-8. 2008
    ..4+/-1.4 mm Hg, P=0.75). Thus, reduced aortic diameter and impaired matching between diameter and flow accounts for the sex difference in pulse pressure in an unselected community-based cohort of older people...
  4. doi request reprint Clinical achievements of impedance analysis
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Drive, Suite 201A, Norwood, MA 02062, USA
    Med Biol Eng Comput 47:153-63. 2009
    ..Analysis of a limited number of summary variables obtained by measuring aortic input impedance may provide novel insights and inform development of new treatments aimed at preventing or reversing abnormal pulsatile hemodynamics...
  5. pmc Arterial stiffness in mild-to-moderate CKD
    Ashish Upadhyay
    Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2044-53. 2009
    ..Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD...
  6. pmc Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium
    Gary F Mitchell
    Cardiovascular Engineering Inc, 1 Edgewater Drive, Norwood, MA 02062, USA
    Circ Cardiovasc Genet 5:81-90. 2012
    ..Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events...
  7. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  8. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  9. ncbi request reprint Pulse pressure, arterial compliance and cardiovascular morbidity and mortality
    G F Mitchell
    Cardiovascular Engineering, Inc, Dover, MA 02030, USA
    Curr Opin Nephrol Hypertens 8:335-42. 1999
    ....
  10. pmc Long-term trandolapril treatment is associated with reduced aortic stiffness: the prevention of events with angiotensin-converting enzyme inhibition hemodynamic substudy
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Hypertension 49:1271-7. 2007
    ....
  11. ncbi request reprint Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 51 Sawyer Rd, Suite 100, Waltham, MA 02453, USA
    Circulation 115:2628-36. 2007
    ..Increased aortic stiffness is associated with numerous common diseases of aging, including heart disease, stroke, and renal disease. However, the prevalence and correlates of abnormally high aortic stiffness are incompletely understood...
  12. ncbi request reprint Aortic diameter, wall stiffness, and wave reflection in systolic hypertension
    Gary F Mitchell
    Cardiovascular Engineering Inc, University Office Park, Bldg 2, Suite 100, 51 Sawyer Road, Waltham, MA 02453, USA
    Hypertension 51:105-11. 2008
    ..Among individuals with systolic hypertension, increased PP is primarily attributable to increased wall stiffness and reduced aortic diameter rather than premature wave reflection...
  13. pmc Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    J Appl Physiol (1985) 105:1652-60. 2008
    ....
  14. pmc Arterial stiffness and cardiovascular events: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    Circulation 121:505-11. 2010
    ..Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community...
  15. pmc Hemodynamic correlates of blood pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering Inc, 1 Edgewater Drive, Norwood, MA 02062, USA
    Circulation 122:1379-86. 2010
    ..The relative contributions of increased forward versus reflected pressure wave amplitude or earlier arrival of the reflected wave to elevated pulse pressure remain controversial...
  16. ncbi request reprint Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Hypertension 49:1285-90. 2007
    ..The present study was suggestive of modest relations between common genetic variants at the NOS3 locus and arterial stiffness...
  17. ncbi request reprint Pulse pressure and risk of new-onset atrial fibrillation
    Gary F Mitchell
    Cardiovascular Engineering Inc, Waltham, Mass 02453, USA
    JAMA 297:709-15. 2007
    ..Increased pulse pressure, a reflection of aortic stiffness, increases cardiac load and may increase AF risk...
  18. ncbi request reprint Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Circulation 112:3722-8. 2005
    ..Aortic stiffness and small-artery structure and function share various risk factors; however, relations between these 2 measures of vascular function are complex and incompletely understood...
  19. ncbi request reprint Pulsatile hemodynamics in hypertension
    G F Mitchell
    Cardiovascular Engineering, Inc, Dover, Massachusetts, USA
    Curr Opin Cardiol 14:361-9. 1999
    ..A better understanding of abnormalities in pulsatile load in hypertension will facilitate risk stratification in and treatment of patients with hypertension...
  20. ncbi request reprint Pulsatile hemodynamics in congestive heart failure
    G F Mitchell
    Cardiovascular Engineering Inc, Holliston, MA 01746, USA
    Hypertension 38:1433-9. 2001
    ..This increased pulsatile load represents an important therapeutic target in CHF...
  21. ncbi request reprint Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Holliston, Mass 01746, USA
    Circulation 105:2955-61. 2002
    ....
  22. ncbi request reprint Determinants of elevated pulse pressure in middle-aged and older subjects with uncomplicated systolic hypertension: the role of proximal aortic diameter and the aortic pressure-flow relationship
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, Mass 01746, USA
    Circulation 108:1592-8. 2003
    ....
  23. ncbi request reprint Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 43:1239-45. 2004
    ..This phenomenon may facilitate forward transmission of potentially deleterious pressure pulsations into the periphery...
  24. ncbi request reprint Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 44:134-9. 2004
    ..The associations between many risk factors and brachial artery flow-mediated dilation may be attributable to reduced stimulus for dilation rather than impaired local conduit artery response during hyperemia...
  25. pmc Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Norwood, MA 02062, USA
    Brain 134:3398-407. 2011
    ....
  26. ncbi request reprint Changes in aortic stiffness and augmentation index after acute converting enzyme or vasopeptidase inhibition
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Hypertension 46:1111-7. 2005
    ..Our findings indicate that AI is a complex surrogate marker that is inversely related to changes in proximal aortic stiffness in systolic hypertension...
  27. ncbi request reprint Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Holliston, Mass 01746, USA
    Circulation 112:194-9. 2005
    ..However, few prior community-based studies have evaluated the genetics of arterial stiffness and separate mean and pulsatile components of blood pressure...
  28. ncbi request reprint Pulsatile hemodynamic effects of candesartan in patients with chronic heart failure: the CHARM Program
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske Street, Holliston, MA 01746, USA
    Eur J Heart Fail 8:191-7. 2006
    ..Abnormal large artery function and increased pulsatile load are exacerbated by excess angiotensin-II acting through the AT1 receptor and contribute to the pathogenesis and progression of chronic heart failure (CHF)...
  29. ncbi request reprint Augmentation index and central aortic stiffness in middle-aged to elderly individuals
    Mitul Vyas
    Cardiovascular Engineering, Inc, Waltham, Massachusetts 02453, USA
    Am J Hypertens 20:642-7. 2007
    ..We evaluated this hypothesis by investigating relations between AI and other direct measures of aortic stiffness...
  30. pmc Visceral and subcutaneous adiposity and brachial artery vasodilator function
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 17:2054-9. 2009
    ..265), above and beyond traditional risk factors. VAT, but not SAT was associated with FMD% after adjusting for clinical covariates. Nevertheless, the differential association with VAT as compared to SAT was minimal...
  31. pmc Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease
    Naomi M Hamburg
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:82-8. 2008
    ..In conclusion, our observations are consistent with the hypothesis that MS and insulin resistance impair vascular function predominantly through the influence of the component metabolic abnormalities that comprise MS...
  32. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  33. ncbi request reprint Evaluation and management of patients with uncontrolled systolic hypertension: is another new paradigm really needed?
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Holliston, Mass, USA
    Am Heart J 149:776-84. 2005

Research Grants3

  1. A central aortic pulse wave velocity measurement device
    Gary Mitchell; Fiscal Year: 2005
    ..This innovative technology will enable accurate diagnosis and risk stratification in a primary care setting and will facilitate further research aimed at evaluating interventions that may reduce conduit vessel stiffness. ..
  2. AORTA, BRAIN AND KIDNEY STRUCTURE AND FUNCTION IN THE AGES-REYKJAVIK STUDY
    Gary Mitchell; Fiscal Year: 2009
    ..This study will identify factors that contribute to aortic stiffening and will define the adverse effects of abnormal stiffness on structure and function of brain and kidneys. ..
  3. AORTA, BRAIN AND KIDNEY STRUCTURE AND FUNCTION IN THE AGES-REYKJAVIK STUDY
    GARY FRANK MITCHELL; Fiscal Year: 2010
    ..This study will identify factors that contribute to aortic stiffening and will define the adverse effects of abnormal stiffness on structure and function of brain and kidneys. ..