Matthew K Ross
Affiliation: Mississippi State University
Ross M, Crow J. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. J Biochem Mol Toxicol. 2007;21:187-96 pubmed
..Identification of the factors that lead to altered CE activities in HLMs will be important to characterize since several pharmaceutical agents, environmental toxicants, and endobiotics are metabolized by these enzymes. ..
Mangum L, Hou X, Borazjani A, Lee J, Ross M, Crow J. Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPAR?/RXR and RAR/RXR: down-regulation of CYP27A1-LXR? signaling. Biochem J. 2018;475:621-642 pubmed publisher
Grunewald Z, Lee S, Kirkland R, ROSS M, de La Serre C. Cannabinoid receptor type-1 partially mediates metabolic endotoxemia-induced inflammation and insulin resistance. Physiol Behav. 2018;: pubmed publisher
..Therefore, we concluded that CB1 contributes to LPS-mediated inflammation and insulin resistance, suggesting that blocking CB1 signaling may have therapeutic benefits in reducing inflammation-induced metabolic abnormalities. ..
Szafran B, Lee J, Borazjani A, Morrison P, Zimmerman G, Andrzejewski K, et al
. Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. Molecules. 2018;23: pubmed publisher
..In conclusion, these data suggest that IL-6 did not influence 2-AG hydrolytic activity in human PBMCs; however, monocytic MAGL was shown to be the predominant 2-AG hydrolytic enzyme. ..
Ross M, Wang R. Expanding the Toolkit for the Serine Hydrolases. Chem Biol. 2015;22:808-9 pubmed publisher
Chambers J, Chambers H, Funck K, Meek E, Pringle R, Ross M. Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX. Chem Biol Interact. 2016;259:154-159 pubmed publisher
..These novel oximes have the potential to be developed into improved antidotes for nerve agent therapy. ..
Ross M, Pluta K, Bittles V, Borazjani A, Allen Crow J. Interaction of the serine hydrolase KIAA1363 with organophosphorus agents: Evaluation of potency and kinetics. Arch Biochem Biophys. 2016;590:72-81 pubmed publisher
..Together, the results define the kinetics of inhibition of KIAA1363 by active metabolites of agrochemicals and indicate that KIAA1363 is highly sensitive to inhibition by these compounds. ..
Matthews A, Lee J, Borazjani A, Mangum L, Hou X, Ross M. Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase. Am J Physiol Cell Physiol. 2016;311:C960-C974 pubmed publisher
..Thus oxyradical stress may be counteracted by the enhanced endocannabinoid tone. ..
Lee J, Hou X, Kummari E, Borazjani A, Edelmann M, Ross M. Endocannabinoid hydrolases in avian HD11 macrophages identified by chemoproteomics: inactivation by small-molecule inhibitors and pathogen-induced downregulation of their activity. Mol Cell Biochem. 2018;444:125-141 pubmed publisher
..Together these results define ABHD6 and FAAH as 2AG hydrolases in avian macrophages that can be inactivated pharmacologically and decreased in activity during Salmonella Typhimurium infection. ..