Affiliation: Mississippi State University
Chambers J, Chambers H, Meek E, Funck K, Bhavaraju M, Gwaltney S, et al
. Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates. Toxicol Sci. 2015;143:46-53 pubmed publisher
..PON1 enhancement of degradation of OPs could be a unique and unprecedented mechanism of antidotal action. ..
Mangum L, HOWELL G, Chambers J. Exposure to p,p'-DDE enhances differentiation of 3T3-L1 preadipocytes in a model of sub-optimal differentiation. Toxicol Lett. 2015;238:65-71 pubmed publisher
..05% ethanol). Our results indicate that DDE is capable of enhancing adipogenesis and intracellular lipid accumulation in 3T3-L1 cells through upregulation of molecular targets responsible for lipid storage. ..
Meek E, Chambers H, Pringle R, Chambers J. The effect of PON1 enhancers on reducing acetylcholinesterase inhibition following organophosphate anticholinesterase exposure in rats. Toxicology. 2015;336:79-83 pubmed publisher
Mangum L, CROW J, Stokes J, HOWELL G, Ross M, Pruett S, et al
. Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction. Toxicol Sci. 2016;150:169-77 pubmed publisher
Chambers J, Meek E, Bennett J, Bennett W, Chambers H, Leach C, et al
. Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates. Toxicology. 2016;339:51-7 pubmed publisher
..Therefore this oxime platform has exceptional promise as therapy that could both prevent nerve agent-induced lethality and attenuate nerve agent-induced seizures. ..
Coban A, Carr R, Chambers H, Willeford K, Chambers J. Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase. Toxicol Lett. 2016;248:39-45 pubmed publisher
..e., cyclosarin>VX>sarin), and that these are more potent than insecticidal organophosphates. ..
Chambers J, Chambers H, Funck K, Meek E, Pringle R, Ross M. Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX. Chem Biol Interact. 2016;259:154-159 pubmed publisher
..These novel oximes have the potential to be developed into improved antidotes for nerve agent therapy. ..
Ward A, Dail M, Chambers J. In Vitro effect of DDE exposure on the regulation of lipid metabolism and secretion in McA-RH7777 hepatocytes: A potential role in dyslipidemia which may increase the risk of type 2 diabetes mellitus. Toxicol In Vitro. 2016;37:9-14 pubmed publisher
..These in vitro results on biochemical markers of liver cell dyslipidemia support the concept that DDE exposure may play a role in the dyslipidemia frequently observed in T2D. ..