Yuji Mishina

Summary

Country: USA

Publications

  1. ncbi request reprint Generation of Bmpr/Alk3 conditional knockout mice
    Yuji Mishina
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genesis 32:69-72. 2002
  2. pmc Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass
    Nobuhiro Kamiya
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Bone Miner Res 23:2007-17. 2008
  3. pmc Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest
    Aya Nomura-Kitabayashi
    Laboratory of Reproductive and Developmental Toxicology, National Institutes of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Am J Physiol Heart Circ Physiol 297:H1617-28. 2009
  4. pmc BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis
    Yoshihiro Komatsu
    Molecular Developmental Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Dev Dyn 236:512-7. 2007
  5. pmc Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Dev Biol 341:246-54. 2010
  6. pmc Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Dev Dyn 240:2474-81. 2011
  7. pmc Bmp2 is required for cephalic neural tube closure in the mouse
    Trisha Castranio
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Dev Dyn 238:110-22. 2009
  8. pmc Bmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development
    Takashi Uchimura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Genesis 47:374-84. 2009
  9. ncbi request reprint BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, MD C4 10, C458, Research Triangle Park, NC 27709, USA
    Development 133:3767-75. 2006
  10. pmc Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton
    Minsub Shim
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:16206-17. 2010

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Generation of Bmpr/Alk3 conditional knockout mice
    Yuji Mishina
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genesis 32:69-72. 2002
  2. pmc Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass
    Nobuhiro Kamiya
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Bone Miner Res 23:2007-17. 2008
    ..We conclude that BMPRIA signaling in osteoblasts affects both bone formation and resorption to reduce endogenous bone mass in vivo...
  3. pmc Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest
    Aya Nomura-Kitabayashi
    Laboratory of Reproductive and Developmental Toxicology, National Institutes of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Am J Physiol Heart Circ Physiol 297:H1617-28. 2009
    ..This study provides definitive evidence that the outflow cushions perform a valve-like function critical for survival of the early mouse embryo...
  4. pmc BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis
    Yoshihiro Komatsu
    Molecular Developmental Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Dev Dyn 236:512-7. 2007
    ..These results indicate that deletion of exon 7 for Alk2 leads to a functionally null mutation in vivo, and Alk2 is crucial for sustaining the proper gastrulation events in early mouse embryogenesis...
  5. pmc Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Dev Biol 341:246-54. 2010
    ..Thus, our results suggest that BMP signaling regulates the expression patterns of Dkk1 for anterior migration of the AVE...
  6. pmc Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Dev Dyn 240:2474-81. 2011
    ..These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development...
  7. pmc Bmp2 is required for cephalic neural tube closure in the mouse
    Trisha Castranio
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Dev Dyn 238:110-22. 2009
    ..Our data exposes BMP2 as a unique player in the developing NT for dorsal patterning and identity, and normal cephalic neural tube closure in a dose-dependent manner...
  8. pmc Bmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development
    Takashi Uchimura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Genesis 47:374-84. 2009
    ..These results suggest that the dosage of both BMP2 and 4 is critical for functional heart formation during embryogenesis and after birth...
  9. ncbi request reprint BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, MD C4 10, C458, Research Triangle Park, NC 27709, USA
    Development 133:3767-75. 2006
    ..This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development...
  10. pmc Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton
    Minsub Shim
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:16206-17. 2010
    ..Our results demonstrate that the aberrant COX-2 signaling during embryonic development is teratogenic and suggest a possible association of COX-2 with fetal malformations of unknown etiology...
  11. ncbi request reprint Optimized beta-galactosidase staining method for simultaneous detection of endogenous gene expression in early mouse embryos
    Satoshi Kishigami
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Genesis 44:57-65. 2006
    ..Further, we successfully combined beta-gal staining with S-gal and in situ hybridization using DIG-labeled probes in both whole and sections of early stage embryos due to the sensitivity and color compatibility of S-gal...
  12. pmc Abnormal glucose metabolism in heterozygous mutant mice for a type I receptor required for BMP signaling
    Gregory J Scott
    Knock Out Core, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Genesis 47:385-91. 2009
    ..Together, our data suggest that BMP signaling through BMPRIA plays an important role in glucose metabolism and possibly working through the GSIS pathway...
  13. ncbi request reprint BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo
    Satoshi Kishigami
    Molecular Developmental Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Dev Biol 276:185-93. 2004
    ..These functions maintain the midline, restrict expression of left-side markers, and are required for left-right pattern formation during embryogenesis in the mouse...
  14. ncbi request reprint Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2
    Tomokazu Fukuda
    Molecular Developmental Biology Group, Laboratory of Reproductive and Developmental Toxicology, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Genesis 44:159-67. 2006
    ..The conditional overexpression system described here provides versatility in investigating gene functions in a tissue-specific manner without having to generate independent tissue-specific transgenic lines...
  15. pmc Conditional transgenic system for mouse aurora a kinase: degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein
    Tomokazu Fukuda
    Hormones and Cancer Group, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Mail Drop D4 04, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 25:5270-81. 2005
    ....
  16. ncbi request reprint BMP signaling and early embryonic patterning
    Satoshi Kishigami
    Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cytokine Growth Factor Rev 16:265-78. 2005
    ..The purpose of this review is to describe the diverse function of BMPs through different receptor signaling systems during embryonic patterning including gastrulation and establishment of the left-right asymmetry...
  17. pmc Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells
    Deborah A Greer Card
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 28:6426-38. 2008
    ..The transcriptional activation of miR-302 and the translational repression of its targets, such as cyclin D1, may provide a link between Oct4/Sox2 and cell cycle regulation in pluripotent cells...
  18. pmc BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway
    Nobuhiro Kamiya
    Laboratory of Reproductive and Developmental Toxicology, NIEHS NIH, Research Triangle Park, NC 27709, USA
    Development 135:3801-11. 2008
    ....
  19. ncbi request reprint Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling
    Yuji Mishina
    Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:27560-6. 2004
    ..These results demonstrate essential and age-dependent roles for BMP signaling mediated by BMPRIA (a type IA receptor for BMP) in osteoblasts for bone remodeling...
  20. ncbi request reprint The DVE changes distal epiblast fate from definitive endoderm to neurectoderm by antagonizing nodal signaling
    Shigeto Miura
    Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences NIH, Research Triangle Park, North Carolina, USA
    Dev Dyn 236:1602-10. 2007
    ..The data suggest that down-regulation of Nodal signaling in the distal epiblast of E5.5 embryo may be an initial step of neural development...
  21. pmc Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators
    Yukitomo Arao
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 108:14986-91. 2011
    ..The functionality of the mutant ERα in the pituitary appears to be different from that in the uterus, indicating that ERα uses AF-1 differently in the uterus and the pituitary for TAM action...
  22. doi request reprint SOX8 Regulates Permeability of the Blood-Testes Barrier That Affects Adult Male Fertility in the Mouse
    Ajeet Pratap Singh
    Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina
    Biol Reprod 88:133. 2013
    ..These results suggest that Sox8 is essential in Sertoli cells for germ cell differentiation, partly by controlling the microenvironment of the seminiferous epithelium...
  23. pmc Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family
    Deborah J Stumpo
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 24:6445-55. 2004
    ..We postulate that lack of Zfp36L1 expression during mid-gestation results in the abnormal stabilization of one or more mRNAs whose encoded proteins lead directly or indirectly to abnormal placentation and fetal death...
  24. ncbi request reprint Function of bone morphogenetic protein signaling during mouse development
    Yuji Mishina
    Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxycology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA
    Front Biosci 8:d855-69. 2003
    ..Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article...
  25. pmc BMP receptor signaling is required for postnatal maintenance of articular cartilage
    Ryan B Rountree
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 2:e355. 2004
    ....
  26. pmc Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3
    Vinciane Gaussin
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:2878-83. 2002
    ..Hence, ALK3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis...
  27. ncbi request reprint BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice
    Munehiro Yuhki
    Laboratory for Cell Culture Development, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Development 131:1825-33. 2004
    ..Our results strongly suggest that BMPR1A signaling is essential for inner root sheath differentiation and is indispensable for HF renewal in adult skin...
  28. ncbi request reprint BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways
    Byeong S Yoon
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 133:4667-78. 2006
    ..These results provide a genetic in vivo demonstration that the progression of chondrocytes through the growth plate is controlled by antagonistic BMP and FGF signaling pathways...
  29. ncbi request reprint Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
    ..We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size...
  30. pmc Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
    Natalia Soshnikova
    Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13125Berlin, Germany
    Genes Dev 17:1963-8. 2003
    ..Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling...
  31. ncbi request reprint Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    ..Our data uncover a Bmp4-Bmpr1a genetic pathway that functions in lip fusion, and reveal that Bmp signaling has distinct roles in lip and palate fusion...
  32. ncbi request reprint Genetic studies of the AMH/MIS signaling pathway for Müllerian duct regression
    Soazik P Jamin
    Department of Molecular Genetics, MD Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Endocrinol 211:15-9. 2003
    ..These results suggest that when AMH is overexpressed, other TGF-beta family type I receptors can potentially transduce AMH signals...
  33. pmc Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation
    Jianping Sun
    Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Pathol 172:571-82. 2008
    ..Therefore, our data suggest that deficiency of appropriate BMP signaling in lung epithelial cells results in prenatal lung malformation, neonatal atelectasis, and respiratory failure...
  34. ncbi request reprint Requirement of Bmpr1a for Müllerian duct regression during male sexual development
    Soazik P Jamin
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 32:408-10. 2002
    ..Because Bmpr1a is evolutionarily conserved, these findings indicate that a component of the BMP signaling pathway has been co-opted during evolution for male sexual development in amniotes...
  35. ncbi request reprint Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Development 131:2257-68. 2004
    ..These results provide definitive genetic evidence that epithelial Bmpr1a is required for completion of tooth morphogenesis, and regulates terminal differentiation and proliferation in postnatal hair follicles...
  36. ncbi request reprint Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord
    Lara Wine-Lee
    Mammalian Neurogenetics Group, Center for Childhood Communication, 712 Abramsom Research Center, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Development 131:5393-403. 2004
    ..These results provide genetic evidence that BMP signaling is crucial for the development of dorsal neuronal cell types...
  37. pmc BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium
    Rolf W Stottmann
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 131:2205-18. 2004
    ..These results demonstrate that BMP2/4 signaling in mammalian neural crest derivatives is essential for outflow tract development and may regulate a crucial proliferation signal for the ventricular myocardium...
  38. ncbi request reprint Distinct developmental programs require different levels of Bmp signaling during mouse retinal development
    Deepa Murali
    Department of Biochemistry and Molecular Biology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 132:913-23. 2005
    ....
  39. ncbi request reprint BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    Xi C He
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nat Genet 36:1117-21. 2004
    ..Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number...
  40. pmc Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo
    Byeong S Yoon
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:5062-7. 2005
    ..In summary, our study demonstrates that BMPR1A and BMPR1B are functionally redundant during early chondrogenesis and that BMP signaling is required for chondrocyte proliferation, survival, and differentiation in vivo...
  41. ncbi request reprint BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning
    Shannon Davis
    Department of Cell Biology, Duke University Medical Center, Durham NC 27710, USA
    Dev Biol 270:47-63. 2004
    ..Our results reveal critical roles for BMP signaling in endodermal morphogenesis and ectodermal patterning...
  42. pmc Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus
    Vinciane Gaussin
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 S Orange Ave, MSB Room G 609, Newark, NJ 07103, USA
    Circ Res 97:219-26. 2005
    ..In conclusion, our mouse model demonstrated critical roles for Alk3 signaling in the AV myocardium during the development of AV valves and the annulus fibrosus...
  43. ncbi request reprint BMP signaling is required locally to pattern the dorsal telencephalic midline
    Jean M Hebert
    Department of Biological Sciences, Stanford University, 385 Serra Mall, CA 94305, USA
    Neuron 35:1029-41. 2002
    ..Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates...
  44. ncbi request reprint Receptor knock-out and gene targeting. Generation of knock-out mice
    Ichiro Sora
    Department of Neuroscience, Division of Psychobiology, Tohoku University Graduate School of Medicine, Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Methods Mol Med 84:205-16. 2003
  45. pmc Generation of a conditional null allele for Dmp1 in mouse
    Jian Q Feng
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75246, USA
    Genesis 46:87-91. 2008
    ..These homozygous Cre-recombined null mice display an identical phenotype to conventional null mice. This animal model will be useful to reveal distinct roles of DMP1 in different tissues at different ages...
  46. pmc BMP receptor ALK3 controls collecting system development
    Sunny Hartwig
    Division of Nephrology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Am Soc Nephrol 19:117-24. 2008
    ..In summary, normal kidney development requires ALK3-dependent BMP signaling, which controls ureteric bud branching...
  47. pmc Sox8 is a critical regulator of adult Sertoli cell function and male fertility
    Moira K O'Bryan
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Dev Biol 316:359-70. 2008
    ..These data show that SOX8 is a critical regulator of adult Sertoli cell function and is required for both its cytoarchitectural and paracrine interactions with germ cells...
  48. pmc SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
    Nesrine El-Bizri
    Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
    Development 135:2981-91. 2008
    ..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
  49. ncbi request reprint Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas, City, Kansas City, Missouri 64108, USA
    J Biol Chem 279:19141-8. 2004
    ..Taken together, these studies suggest that DMP-1 is essential for later dentinogenesis during postnatal development...
  50. ncbi request reprint Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling [corrected]
    Kentaro Suzuki
    Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Development 130:6209-20. 2003
    ..The DUE region can be marked only until 14.0 dpc (days post coitum) in mouse development, while GT outgrowth continues thereafter. Possible signaling crosstalk among the whole distal GT regions were also investigated...
  51. ncbi request reprint Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis
    Akihide Takeuchi
    Department of Basic Gerontology, National Institute for Longevity Sciences, 36 3 Gengo, Morioka cho, Obu City, Aichi 474 8522, Japan
    Nat Genet 33:172-6. 2003
    ..Phosphorylation of p53 is impaired in Zfp148(+/-) embryonic stem cells and in fetal germ cells from chimeric Zfp148(+/-) embryos. Thus, Zfp148 may be required for regulating p53 in the development of germ cells...
  52. ncbi request reprint BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies
    Gemma Martinez
    Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
    Int J Dev Biol 46:525-33. 2002
    ..Noggin did not alter metanephric development in vitro, but did block the effect of BMP4. The experiments described in this study have shown that BMP4 has distinct roles from BMP2 in metanephric development...
  53. pmc Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling
    Nesrine El-Bizri
    Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, CA 94305, USA
    Circ Res 102:380-8. 2008
    ....
  54. pmc Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor
    Dina Myers Stroud
    Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA
    Circulation 116:2535-43. 2007
    ..To test the hypothesis that bone morphogenetic protein signaling also plays a role in AV node formation, we investigated conduction system function and AV node morphology in adult mice with conditional deletion of Alk3 in the AV canal...
  55. pmc Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th St, Kansas City, MI 64108, USA
    J Biol Chem 280:6197-203. 2005
    ..In addition, blood vessel invasion is impaired in the epiphyses of Dmp1(-/-) mice. These findings show that DMP1 is essential for normal postnatal chondrogenesis and subsequent osteogenesis...
  56. ncbi request reprint Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells
    Maxwell C Eblaghie
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 291:67-82. 2006
    ..Our results support a model in which Bmp signaling primarily regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells...
  57. ncbi request reprint Genetically modified bone morphogenetic protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouse
    Charlotte Israelsson
    Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, Uppsala, Sweden
    J Neurosci Res 84:47-57. 2006
    ..Altogether, the data suggest that BMP signalling is dispensable in adult cortical neurons but that augmented BMP signalling affects molecular changes associated with neuronal lesions...
  58. ncbi request reprint BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning
    Dmitry A Ovchinnikov
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Dev Biol 295:103-15. 2006
    ..These findings suggest that signaling through BMPR-IA in limb mesenchyme is essential for distal outgrowth and also influences AP and DV patterning...
  59. ncbi request reprint Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts
    Lanying Song
    Division of Genetic and Translational Medicine, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dev Biol 301:276-86. 2007
    ..Taken together, our study supports the notion that Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis...
  60. ncbi request reprint Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion
    Jiwang Zhang
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Stem Cells 24:2826-39. 2006
    ..Subsequently, PTEN, through phosphatidyl inositol 3-kinase-Akt, inhibits the activity of beta-catenin, the convergence point of the BMP and Wnt signaling pathways...
  61. pmc BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways
    Xiaoxia Qi
    Cecil H and Ida Green Center for Reproductive Biology Sciences and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:6027-32. 2004
    ..These results uncover a paradigm for BMP signaling in the biology of pluripotent stem cells...
  62. ncbi request reprint BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion
    Joan Goulley
    Umeå Center for Molecular Medicine, University of Umea, SE 901 87 Umea, Sweden
    Cell Metab 5:207-19. 2007
    ..Thus, BMP4-BMPR1A signaling in beta cells plays a key role in GSIS...
  63. ncbi request reprint BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling
    Sangeeta Pajni-Underwood
    Laboratory of Cancer and Developmental Biology National Institutes of Health, Frederick, MD 21702, USA
    Development 134:2359-68. 2007
    ..We conclude that during normal embryogenesis, BMP signaling to the AER indirectly regulates interdigit PCD by regulating AER-FGFs, which act as survival factors for the interdigit mesenchyme...
  64. pmc Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect
    Jianping Sun
    Developmental Biology Program, Department of Surgery, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, MS 35, Los Angeles, CA 90027, USA
    Biochem Biophys Res Commun 360:238-43. 2007
    ....
  65. ncbi request reprint BMPR1a signaling determines numbers of oligodendrocytes and calbindin-expressing interneurons in the cortex
    Jayshree Samanta
    Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 27:7397-407. 2007
    ..Thus, our findings indicate that BMPR1a mediates the suppressive effects of BMP signaling on oligodendrocyte lineage commitment and on the specification of calbindin-positive interneurons in the dorsomedial cortex...
  66. ncbi request reprint Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage
    Benoit A Auclair
    Canadian Institutes of Health Research Team on Digestive Epithelium, Département d Anatomie et Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Gastroenterology 133:887-96. 2007
    ..The aim of this study was to investigate the role of epithelial Bmp signaling in intestinal morphogenesis and maintenance of adult epithelial cell functions...
  67. ncbi request reprint BMP signalling inhibits premature neural differentiation in the mouse embryo
    Aida Di-Gregorio
    Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Development 134:3359-69. 2007
    ..Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo...
  68. ncbi request reprint Sox8 and Sertoli-cell function
    Claire L Kennedy
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Ann N Y Acad Sci 1120:104-13. 2007
    ..We conclude that SOX8 transactivated genes have key roles in adult Sertoli-cell function and its elimination results in progressive male infertility...
  69. ncbi request reprint Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis
    Yuki Okada
    Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nature 450:119-23. 2007
    ..Thus, our work uncovers a role for JHDM2A in spermatogenesis and reveals transition nuclear protein and protamine genes as direct targets of JHDM2A...
  70. ncbi request reprint Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity
    Jie Hu
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9051, USA
    Dev Biol 276:158-71. 2004
    ..Thus, these genetic data reveal a region-specific requirement of different classes of BMPs for epididymal epithelium to survive and have significant implications on male reproductive health and perhaps birth control...