Mark LeSage

Summary

Affiliation: Minneapolis Medical Research Foundation
Country: USA

Publications

  1. ncbi request reprint Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:413-21. 2007
  2. pmc Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 85:575-83. 2006
  3. pmc Toward a nonhuman model of contingency management: effects of reinforcing abstinence from nicotine self-administration in rats with an alternative nondrug reinforcer
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN, 55404, USA
    Psychopharmacology (Berl) 203:13-22. 2009
  4. ncbi request reprint Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats
    Mark G LeSage
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 184:409-16. 2006
  5. ncbi request reprint Effects of continuous nicotine infusion on nicotine self-administration in rats: relationship between continuously infused and self-administered nicotine doses and serum concentrations
    Mark G LeSage
    Minneapolis Medical Research Foundation, D3 860, 914 South 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 170:278-86. 2003
  6. pmc Effects of anorectic drugs on food intake under progressive-ratio and free-access conditions in rats
    Mark G LeSage
    Louisiana State University Health Sciences Center in Shreveport, USA
    J Exp Anal Behav 82:275-92. 2004
  7. ncbi request reprint Reinstatement of nicotine self-administration in rats by presentation of nicotine-paired stimuli, but not nicotine priming
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 79:507-13. 2004
  8. ncbi request reprint Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats
    Jason T Ross
    Minneapolis Medical Research Foundation, 914 South 8th Street, Minneapolis, MN 55404, USA
    Eur J Pharmacol 559:173-9. 2007
  9. ncbi request reprint Prevalence, magnitude, and correlates of an extinction burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:395-402. 2007
  10. doi request reprint Developing the science base for reducing tobacco harm
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Nicotine Tob Res 9:S537-53. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:413-21. 2007
    ..Animal models could be useful for this purpose...
  2. pmc Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 85:575-83. 2006
    ....
  3. pmc Toward a nonhuman model of contingency management: effects of reinforcing abstinence from nicotine self-administration in rats with an alternative nondrug reinforcer
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN, 55404, USA
    Psychopharmacology (Berl) 203:13-22. 2009
    ..Moreover, abstinence contingencies per se under free-operant conditions have not been examined...
  4. ncbi request reprint Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats
    Mark G LeSage
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 184:409-16. 2006
    ..It is not known whether such a vaccine can attenuate nicotine's reinforcing effects...
  5. ncbi request reprint Effects of continuous nicotine infusion on nicotine self-administration in rats: relationship between continuously infused and self-administered nicotine doses and serum concentrations
    Mark G LeSage
    Minneapolis Medical Research Foundation, D3 860, 914 South 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 170:278-86. 2003
    ..One reason for this limited efficacy may be that typical serum nicotine concentrations provided by NRT do not match the peak arterial nicotine concentrations achieved from smoking...
  6. pmc Effects of anorectic drugs on food intake under progressive-ratio and free-access conditions in rats
    Mark G LeSage
    Louisiana State University Health Sciences Center in Shreveport, USA
    J Exp Anal Behav 82:275-92. 2004
    ..The present findings suggest that the effects of some anorectic drugs depend upon the access conditions for food; increasing the effort to obtain food may enhance their ability to decrease food-maintained behavior...
  7. ncbi request reprint Reinstatement of nicotine self-administration in rats by presentation of nicotine-paired stimuli, but not nicotine priming
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 79:507-13. 2004
    ....
  8. ncbi request reprint Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats
    Jason T Ross
    Minneapolis Medical Research Foundation, 914 South 8th Street, Minneapolis, MN 55404, USA
    Eur J Pharmacol 559:173-9. 2007
    ....
  9. ncbi request reprint Prevalence, magnitude, and correlates of an extinction burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:395-402. 2007
    ..e., an "extinction burst"). However, the presence of an extinction burst in animal models of nicotine self-administration (NSA) has not been studied extensively...
  10. doi request reprint Developing the science base for reducing tobacco harm
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Nicotine Tob Res 9:S537-53. 2007
    ..A description of the ongoing activities and challenges in these areas is provided, along with projected directions for the future...
  11. doi request reprint Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Exp Clin Psychopharmacol 16:86-97. 2008
    ..This model may be useful for characterizing underlying factors and potential consequences of compensatory smoking...
  12. pmc Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 S 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 209:203-12. 2010
    ..The hypocretin (hcrt) system has been implicated in addiction-relevant effects of several drugs, but its role in nicotine dependence has been little studied...
  13. ncbi request reprint Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: time course and influence of nicotine dosing regimen
    Daniel E Keyler
    Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Biochem Pharmacol 69:1385-95. 2005
    ..These data comment on the safety of vaccination against nicotine during pregnancy, and suggest that vaccination may reduce the distribution of nicotine to fetal brain under some nicotine dosing conditions...
  14. pmc Effects of high dose transdermal nicotine replacement in cigarette smokers
    Dorothy Hatsukami
    Transdisciplinary Tobacco Use Research Center, University of Minnesota, Department of Psychiatry, Minneapolis, MN 55414, United States
    Pharmacol Biochem Behav 86:132-9. 2007
    ..In most of these studies, only conventional doses of NRT have been tested and higher doses may be required to result in significant reductions in smoking and in biomarkers of exposure...
  15. ncbi request reprint Effects of nicotine withdrawal on performance under a progressive-ratio schedule of sucrose pellet delivery in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, MN 55404, USA
    Pharmacol Biochem Behav 83:585-91. 2006
    ..Therefore, PR schedules of natural reinforcement may provide information on the motivational effects of nicotine withdrawal complimentary to that obtained from ICSS threshold studies...
  16. ncbi request reprint Continuous nicotine infusion reduces nicotine self-administration in rats with 23-h/day access to nicotine
    Mark G LeSage
    Minneapolis Medical Research Foundation, D 3 Lab, Mail Code 860, 825 South 8th Street, Minneapolis, MN 55415, USA
    Pharmacol Biochem Behav 72:279-89. 2002
    ..The highest nicotine infusion rate had no sustained effect on food-maintained responding, demonstrating its specificity for suppression of NSA. These data provide a model for studying NRT in the rat...
  17. pmc Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies
    Mark G LeSage
    Minneapolis Medical Research Foundation, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    AAPS J 8:E65-75. 2006
    ..Taken together, the work completed to date provides substantial evidence that immunologic interventions could play an important role in future treatment strategies for tobacco dependence...
  18. pmc Correlates of individual differences in compensatory nicotine self-administration in rats following a decrease in nicotine unit dose
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 205:599-611. 2009
    ..Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon and assessing the feasibility of harm reduction interventions...
  19. pmc Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 93:105-11. 2009
    ..The Nic311 doses used have been shown to attenuate the behavioral effects of nicotine, suggesting that the use of passive immunization to treat nicotine addiction is not likely to precipitate withdrawal...
  20. pmc Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, United States
    Pharmacol Biochem Behav 96:217-27. 2010
    ....
  21. pmc Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South Eighth Street, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 91:461-7. 2009
    ..These results demonstrate that VCL and CYT partially generalize to and partially antagonize nicotine's discriminative stimulus effects, consistent with a partial agonist mechanism of action...
  22. doi request reprint Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA
    J Pharmacol Exp Ther 325:985-93. 2008
    ..These data indicate that providing higher serum NicAb concentrations improves the efficacy of immunotherapy against nicotine and that supplementing vaccination with passive immunization is a potential strategy to accomplish this...
  23. ncbi request reprint Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats
    Martin Skott
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
    J Orthop Res 24:1472-9. 2006
    ..Serum levels of nicotine were between 40-50 ng/mL in the group given nicotine alone and the group given tobacco extract plus nicotine (equivalent to serum levels observed in persons smoking one to two packs of cigarettes per day)...
  24. ncbi request reprint Translational research in medication development for nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 6:746-62. 2007
    ....

Research Grants7

  1. Modeling Behavioral Treatments for Stimulant Abuse
    Mark LeSage; Fiscal Year: 2007
    ..These studies should provide a useful preclinical model of CM interventions and be helpful in elucidating behavioral and pharmacological variables that could enhance their efficacy. ..
  2. Modeling Behavioral Treatments for Stimulant Abuse
    Mark LeSage; Fiscal Year: 2009
    ..These studies should provide a useful preclinical model of CM interventions and be helpful in elucidating behavioral and pharmacological variables that could enhance their efficacy. ..
  3. Determinants of Nicotine Reinforcement Thresholds and Demand Elasticity in Rats
    Mark G LeSage; Fiscal Year: 2010
    ..As such, the present study could contribute to the scientific basis for evaluation of reduced nicotine tobacco products and their clinical and public health consequences. ..