Y Pan

Summary

Affiliation: Millennium Pharmaceuticals
Country: USA

Publications

  1. ncbi request reprint Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
    Y Pan
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Nature 387:611-7. 1997
  2. ncbi request reprint Identification and gene organization of three novel members of the IL-1 family on human chromosome 2
    S J Busfield
    Millennium Pharmaceuticals Inc, 640 Memorial Drive, Cambridge, Massachusetts, 02139, USA
    Genomics 66:213-6. 2000
  3. ncbi request reprint Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation
    J A Gonzalo
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    J Immunol 163:403-11. 1999
  4. ncbi request reprint A new nomenclature for IL-1-family genes
    J E Sims
    Trends Immunol 22:536-7. 2001
  5. ncbi request reprint [IL-1 beta mRNA and TNF-alpha mRNA expression in gingival tissues of patients with adult periodontitis]
    L Yin
    College of Stomatology, China Medical University
    Hua Xi Kou Qiang Yi Xue Za Zhi 19:318-21. 2001
  6. ncbi request reprint Cell adhesion molecule expression in cultured human iris endothelial cells
    M D Silverman
    Department of Ophthalmology, Casey Eye Institute, Portland, OR, USA
    Invest Ophthalmol Vis Sci 42:2861-6. 2001
  7. ncbi request reprint PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression
    H Huang
    Department of Urology Research, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 276:38830-6. 2001
  8. ncbi request reprint Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice
    Y Pan
    Department of Molecular Genetics, Weizmann Institute of Science, 76100, Rehovot, Israel
    Brain Res Dev Brain Res 126:125-9. 2001
  9. ncbi request reprint Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus
    Y Pan
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Nat Genet 2:103-6. 1992
  10. ncbi request reprint IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis
    B E Brito
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201 4197, USA
    Invest Ophthalmol Vis Sci 40:2583-9. 1999

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation
    Y Pan
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Nature 387:611-7. 1997
    ..Consequently we propose that neurotactin represents a new delta-chemokine family and that it may play a role in brain inflammation processes...
  2. ncbi request reprint Identification and gene organization of three novel members of the IL-1 family on human chromosome 2
    S J Busfield
    Millennium Pharmaceuticals Inc, 640 Memorial Drive, Cambridge, Massachusetts, 02139, USA
    Genomics 66:213-6. 2000
    ..These genes may prove to have an important role in inflammatory responses...
  3. ncbi request reprint Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation
    J A Gonzalo
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    J Immunol 163:403-11. 1999
    ..These results also highlight the relevance of factors, such as mMDC, that regulate the migration and accumulation of leukocytes within the tissue during the development of the key physiological endpoint of asthma, airway hyperreactivity...
  4. ncbi request reprint A new nomenclature for IL-1-family genes
    J E Sims
    Trends Immunol 22:536-7. 2001
  5. ncbi request reprint [IL-1 beta mRNA and TNF-alpha mRNA expression in gingival tissues of patients with adult periodontitis]
    L Yin
    College of Stomatology, China Medical University
    Hua Xi Kou Qiang Yi Xue Za Zhi 19:318-21. 2001
    ..01). CONCLUSION: As the inflammatory and bone absorption mediators, IL-1 beta and TNF-alpha might play important roles in the pathogenesis and development of adult periodontitis...
  6. ncbi request reprint Cell adhesion molecule expression in cultured human iris endothelial cells
    M D Silverman
    Department of Ophthalmology, Casey Eye Institute, Portland, OR, USA
    Invest Ophthalmol Vis Sci 42:2861-6. 2001
    ..In addition, this is the first demonstration of the regulated expression of ICAM-2 in any ocular microvascular cells...
  7. ncbi request reprint PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression
    H Huang
    Department of Urology Research, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 276:38830-6. 2001
    ..These findings suggest that the PTEN gene and its regulated pathway are potential therapeutic targets in prostate cancer...
  8. ncbi request reprint Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice
    Y Pan
    Department of Molecular Genetics, Weizmann Institute of Science, 76100, Rehovot, Israel
    Brain Res Dev Brain Res 126:125-9. 2001
    ..The results imply that midbrain-hindbrain neuronal cultures of knockout mice, that do not express serotonin transporters, acquire the capacity to take up serotonin, apparently via dopamine transporters...
  9. ncbi request reprint Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus
    Y Pan
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Nat Genet 2:103-6. 1992
    ..Other mutations include three missense mutations, a frameshift and one small in-frame deletion. These results represent one of the first examples of recessive mutations affecting a G protein-coupled receptor...
  10. ncbi request reprint IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis
    B E Brito
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201 4197, USA
    Invest Ophthalmol Vis Sci 40:2583-9. 1999
    ..To determine the role of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in the induction of uveitis by a reverse passive Arthus reaction (RPAR)...
  11. ncbi request reprint Murine endotoxin-induced uveitis, but not immune complex-induced uveitis, is dependent on the IL-8 receptor homolog
    B E Brito
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland, USA
    Curr Eye Res 19:76-85. 1999
    ....
  12. ncbi request reprint Regional localization of the mouse argininosuccinate lyase gene to chromosome 5
    V R Sutton
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mamm Genome 8:871. 1997
  13. ncbi request reprint High pH accelerates GABA deactivation on perch-rho1B receptors
    H Qian
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 West Taylor Street, Chicago, IL 60612, USA
    Neuroscience 142:1221-30. 2006
    ..Analysis of the pH sensitivities of the various chimeric receptors revealed that the alkaline-sensitive residues are located in the N-terminal region of the perch-rho(1B) subunit...