Affiliation: Millennium Pharmaceuticals
- Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane TranslocationM Han
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
Structure 9:869-80. 2001..They compete with G proteins for binding to activated phosphorylated receptors, initiate receptor internalization, and activate additional signaling pathways...
- Rhodopsin: structural basis of molecular physiologyS T Menon
Howard Hughes Medical Institute, Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, New York 10021, USA
Physiol Rev 81:1659-88. 2001..Future high-resolution structural studies of rhodopsin and other GPCRs will form a basis to elucidate the detailed molecular mechanism of GPCR-mediated signal transduction...
- Yeast histone H2A and H2B amino termini have interchangeable functionsT Schuster
Cell 45:445-51. 1986..This supports the argument that the N-terminal end of one protein complements the function of the other...
- Specific interaction between the initiator protein (Rep) and origin of plasmid ColE2-P9M Han
Department of Biology, Faculty of Science, Shinshu University, Matsumoto, Nagano 390 8621, Japan
J Bacteriol 189:1061-71. 2007..Based on the results presented in this paper, we propose a model for Rep-Ori interaction in which Rep binds to Ori as a monomer...
- Functional genomics of plant photosynthesis in the fast lane using Chlamydomonas reinhardtiiR M Dent
Dept of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA
Trends Plant Sci 6:364-71. 2001..Chlamydomonas is therefore the organism of choice for elucidating detailed functions of the hundreds of genes involved in plant photosynthesis...
- A novel mutation in the ABCR gene in four patients with autosomal recessive Stargardt diseaseK Zhang
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Ophthalmol 128:720-4. 1999..To identify additional mutations in the ABCR gene and describe the clinical features of four affected siblings with autosomal recessive Stargardt disease...
- A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval inductionD S Sieburth
Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309 0347, USA
Genes Dev 13:2562-9. 1999..Double mutant analysis suggests that sur-6 PP2A-B acts downstream or in parallel to ras, but likely upstream of raf, and functions with ksr-1 in a common pathway to positively regulate Ras signaling...
- UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans developmentC J Malone
Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder CO 80309 0347, USA
Development 126:3171-81. 1999..We propose that UNC-84 functions to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage...
- A Caenorhabditis elegans homologue of hunchback is required for late stages of development but not early embryonic patterningD S Fay
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, 80309 0347, USA
Dev Biol 205:240-53. 1999..The pattern of hbl-1 expression is similar to that reported for the leech hunchback homologue Lzf-2, suggesting that these proteins may have similar biological functions in diverse species with cellular embryos...
- COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegansW Hanna-Rose
Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Development 126:169-79. 1999..Thus, it appears that COG-2 is a transcription factor that regulates a late-stage aspect of uterine seam cell differentiation that specifically affects anchor cell-uterine seam cell fusion...
- SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegansD S Sieburth
Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, 80309 0347, USA
Cell 94:119-30. 1998..A structural and functional SUR-8 homolog in humans specifically binds K-Ras and N-Ras but not H-Ras in vitro...
- Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval inductionT Gu
Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
Mol Cell Biol 18:4556-64. 1998..SUR-5 also has some sequence similarity to acetyl coenzyme A synthetases and is predicted to contain ATP/GTP and AMP binding sites. Our results suggest that sur-5 gene function may be conserved through evolution...
- Localization of the retinal protonated Schiff base counterion in rhodopsinM Han
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
Biophys J 65:899-906. 1993..These data constrain the location and the orientation of the Glu113 side chain, which is known to be the counterion in rhodopsin, and argue for a strong interaction centered at C12 of the retinylidene chain...
- Mismatch repair gene mutations in Chinese HNPCC patientsJ Q Sheng
Department of Gastroenterology, General Hospital of Beijing Military Region, Beijing, China
Cytogenet Genome Res 122:22-7. 2008..By doing so, five large fragment deletions were detected in the MSH2 gene. No large fragment deletions were detected in the MLH1 gene. We conclude that the MLH1 and MSH2 genes in Chinese HNPCC families exhibit broad mutation spectra...