Affiliation: Millennium Pharmaceuticals
- Identification and functional analysis of novel human melanocortin-4 receptor variantsW Gu
Millennium Pharmaceuticals, Cambridge, Massachusetts 02139, USA
Diabetes 48:635-9. 1999..Furthermore, our results also suggest that sequence polymorphism in the MC4-R coding region is unlikely to be a common cause of obesity in the population studied, given the low frequency of functionally significant mutations...
- Targeted disruption of the melanocortin-4 receptor results in obesity in miceD Huszar
Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
Cell 88:131-41. 1997..Our data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R...