W Gu

Summary

Affiliation: Millennium Pharmaceuticals
Country: USA

Publications

  1. ncbi Identification and functional analysis of novel human melanocortin-4 receptor variants
    W Gu
    Millennium Pharmaceuticals, Cambridge, Massachusetts 02139, USA
    Diabetes 48:635-9. 1999
  2. ncbi Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    D Huszar
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Cell 88:131-41. 1997

Detail Information

Publications2

  1. ncbi Identification and functional analysis of novel human melanocortin-4 receptor variants
    W Gu
    Millennium Pharmaceuticals, Cambridge, Massachusetts 02139, USA
    Diabetes 48:635-9. 1999
    ..Furthermore, our results also suggest that sequence polymorphism in the MC4-R coding region is unlikely to be a common cause of obesity in the population studied, given the low frequency of functionally significant mutations...
  2. ncbi Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    D Huszar
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Cell 88:131-41. 1997
    ..Our data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R...