John Bertin

Summary

Affiliation: Millennium Pharmaceuticals
Country: USA

Publications

  1. ncbi Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB
    J Bertin
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 274:12955-8. 1999
  2. ncbi CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B
    J Bertin
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 275:41082-6. 2000
  3. ncbi Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1
    Jill M Grenier
    Millennium Pharmaceuticals Inc, 75 Sidney Street, Cambridge, MA 02139, USA
    FEBS Lett 530:73-8. 2002
  4. ncbi PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing
    Lin Wang
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 277:29874-80. 2002
  5. ncbi PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B
    Gulam A Manji
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 277:11570-5. 2002
  6. ncbi Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Immunol 7:576-82. 2006
  7. ncbi Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    Fayyaz S Sutterwala
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:317-27. 2006
  8. ncbi Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    Thirumala Devi Kanneganti
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Nature 440:233-6. 2006
  9. ncbi Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein
    Ha Na Woo
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    FEBS Lett 578:239-44. 2004
  10. ncbi Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28, rue du Dr Roux, 75724Paris Cedex 15, France
    Science 300:1584-7. 2003

Collaborators

Detail Information

Publications23

  1. ncbi Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB
    J Bertin
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 274:12955-8. 1999
    ..In addition, coexpression of CARD4 augmented caspase-9-induced apoptosis. Thus, CARD4 coordinates downstream NF-kappaB and apoptotic signaling pathways and may be a component of the host innate immune response...
  2. ncbi CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B
    J Bertin
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 275:41082-6. 2000
    ..CARD9 also self-associates and contains extensive coiled-coil motifs that may function as oligomerization domains. We propose here that CARD9 is an upstream activator of BCL10 and NF-kappaB signaling...
  3. ncbi Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1
    Jill M Grenier
    Millennium Pharmaceuticals Inc, 75 Sidney Street, Cambridge, MA 02139, USA
    FEBS Lett 530:73-8. 2002
    ..These findings suggest that PYPAF5 functions in immune cells to coordinate the transduction of pro-inflammatory signals to the activation of NF-kappaB and pro-caspase-1...
  4. ncbi PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing
    Lin Wang
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 277:29874-80. 2002
    ..These findings indicate that PYPAF family members participate in inflammatory signaling by regulating the activation of NF-kappa B and cytokine processing...
  5. ncbi PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B
    Gulam A Manji
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 277:11570-5. 2002
    ..Furthermore, coexpression of PYPAF1 with ASC results in a potent synergistic activation of NF-kappaB. These findings suggest that PYPAF1 and ASC function as upstream activators of NF-kappaB signaling...
  6. ncbi Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Immunol 7:576-82. 2006
    ..Thus, detection of flagellin through Ipaf induces caspase-1 activation independently of Toll-like receptor 5 in salmonella-infected and lipopolysaccharide-tolerized macrophages...
  7. ncbi Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    Fayyaz S Sutterwala
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:317-27. 2006
    ..These data suggest that NALP3 plays a specific role in the caspase-1 activation pathway...
  8. ncbi Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    Thirumala Devi Kanneganti
    University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Nature 440:233-6. 2006
    ..These results reveal a critical role for cryopyrin in host defence through bacterial RNA-mediated activation of caspase-1, and provide insights regarding the pathogenesis of autoinflammatory syndromes...
  9. ncbi Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein
    Ha Na Woo
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    FEBS Lett 578:239-44. 2004
    ..These results suggest that BinCARD interacts with Bcl10 to inhibit Bcl10-mediated activation of NF-kappa B and to suppress Bcl10 phosphorylation...
  10. ncbi Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28, rue du Dr Roux, 75724Paris Cedex 15, France
    Science 300:1584-7. 2003
    ..Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing...
  11. ncbi The death effector domains (DEDs) of the molluscum contagiosum virus MC159 v-FLIP protein are not functionally interchangeable with each other or with the DEDs of caspase-8
    Tara Garvey
    Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1888, USA
    Virology 300:217-25. 2002
    ..These mutants bound to both FADD and caspase-8, but could not block apoptosis or the formation of death effector filaments. Thus, the DEDs of MC159 are not functionally interchangeable with each other or with those of caspase-8...
  12. ncbi CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis
    Marjaneh Razmara
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:13952-8. 2002
    ..Overexpression of CARD-8 can also induce apoptosis in transfected cells. The results suggest that CARD-8 represents a new signaling molecule involved in the regulation of caspase-1 and NF-kappaB activation...
  13. pmc Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function
    Tara L Garvey
    Medical Virology Section, Laboratory of Clinical Investigation, Molecular Development of the Immune System Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 76:697-706. 2002
    ..Thus, charged or hydrophobic amino acids in three regions of the MC159 DEDs (hydrophobic patch 1, alpha2, and alpha6) are critical for the protein's ability to interact with cellular proteins and to block apoptosis...
  14. ncbi Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    Jérôme Viala
    Groupe d Immunité Innée et Signalisation, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    Nat Immunol 5:1166-74. 2004
    ..pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens...
  15. doi Sensing intracellular pathogens-NOD-like receptors
    Svend T Rietdijk
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, NL 1105 AZ, The Netherlands
    Curr Opin Pharmacol 8:261-6. 2008
    ..In this review, we will discuss the role of NLRs in pattern recognition of microbial components and their role in health and disease...
  16. pmc The NLR gene family: a standard nomenclature
    Jenny P Y Ting
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 28:285-7. 2008
  17. ncbi MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3
    Qilin Pan
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    J Leukoc Biol 82:177-83. 2007
    ..Together, our data provide a new understanding of this important pathway of IL-1beta production and allow for further studies of the role of these proteins within the broader context of inflammatory disease...
  18. pmc Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
    Maria Lara-Tejero
    Section of Microbial Pathogenesis, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    J Exp Med 203:1407-12. 2006
    ..We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection...
  19. ncbi Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes
    Nesrin Ozören
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Immunol 176:4337-42. 2006
    ..ASC, but not TLR2, is required for caspase-1 activation independent of NF-kappaB in Listeria-infected macrophages...
  20. ncbi A requirement for CARMA1 in TCR-induced NF-kappa B activation
    Donghai Wang
    Department of Microbiology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, NY 14214, USA
    Nat Immunol 3:830-5. 2002
    ..Reconstitution of the CARMA1-deficient cells with CARMA1 fully rescued this signaling defect. Together, our results show that CARMA1 is an essential signaling component that mediates TCR-induced NF-kappa B activation...
  21. pmc Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
    Joao Gamelas Magalhaes
    Unité de Pathogénie Microbienne Moléculaire INSERM U389, Paris, France
    EMBO Rep 6:1201-7. 2005
    ..This study thereby identifies Nod1 as the long sought after sensor of TCT in mammals...
  22. ncbi Nod1 participates in the innate immune response to Pseudomonas aeruginosa
    Leonardo H Travassos
    Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ CEP 21 941 590, Brazil
    J Biol Chem 280:36714-8. 2005
    ..aeruginosa. Finally, we demonstrate that the cytokine secretion kinetics and bacterial killing are altered in Nod1-deficient cells infected with P. aeruginosa in the early stages of infection...
  23. doi Elesclomol induces cancer cell apoptosis through oxidative stress
    Jessica R Kirshner
    Synta Pharmaceuticals Corp, 45 Hartwell Avenue, Lexington, MA 02421, USA
    Mol Cancer Ther 7:2319-27. 2008
    ..Thus, the induction of oxidative stress by elesclomol exploits this unique characteristic of cancer cells by increasing ROS levels beyond a threshold that triggers cell death...